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845 results on '"Viale, Agnes"'

1. Ovarian cancer mutational processes drive site-specific immune evasion

Author

Vázquez-García, Ignacio, Uhlitz, Florian, Ceglia, Nicholas, Lim, Jamie L. P., Wu, Michelle, Mohibullah, Neeman, Niyazov, Juliana, Ruiz, Arvin Eric B., Boehm, Kevin M., Bojilova, Viktoria, Fong, Christopher J., Funnell, Tyler, Grewal, Diljot, Havasov, Eliyahu, Leung, Samantha, Pasha, Arfath, Patel, Druv M., Pourmaleki, Maryam, Rusk, Nicole, Shi, Hongyu, Vanguri, Rami, Williams, Marc J., Zhang, Allen W., Broach, Vance, Chi, Dennis S., Da Cruz Paula, Arnaud, Gardner, Ginger J., Kim, Sarah H., Lennon, Matthew, Long Roche, Kara, Sonoda, Yukio, Zivanovic, Oliver, Kundra, Ritika, Viale, Agnes, Derakhshan, Fatemeh N., Geneslaw, Luke, Issa Bhaloo, Shirin, Maroldi, Ana, Nunez, Rahelly, Pareja, Fresia, Stylianou, Anthe, Vahdatinia, Mahsa, Bykov, Yonina, Grisham, Rachel N., Liu, Ying L., Lakhman, Yulia, Nikolovski, Ines, Kelly, Daniel, Gao, Jianjiong, Schietinger, Andrea, Hollmann, Travis J., Bakhoum, Samuel F., Soslow, Robert A., Ellenson, Lora H., Abu-Rustum, Nadeem R., Aghajanian, Carol, Friedman, Claire F., McPherson, Andrew, Weigelt, Britta, Zamarin, Dmitriy, and Shah, Sohrab P.

Published
2022
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2. ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis

Author

Guillet, Stephanie, primary, Lazarov, Tomi, additional, Jordan, Natasha, additional, Boisson, Bertrand, additional, Tello, Maria, additional, Craddock, Barbara, additional, Zhou, Ting, additional, Nishi, Chihiro, additional, Bareja, Rohan, additional, Yang, Hairu, additional, Rieux-Laucat, Frederic, additional, Fregel Lorenzo, Rosa Irene, additional, Dyall, Sabrina D., additional, Isenberg, David, additional, D'Cruz, David, additional, Lachmann, Nico, additional, Elemento, Olivier, additional, Viale, Agnes, additional, Socci, Nicholas D., additional, Abel, Laurent, additional, Nagata, Shigekazu, additional, Huse, Morgan, additional, Miller, W Todd, additional, Casanova, Jean-Laurent, additional, and Geissmann, Frédéric, additional

Published
2024
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3. Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation

Author

Warrick, Joshua I., Hu, Wenhuo, Yamashita, Hironobu, Walter, Vonn, Shuman, Lauren, Craig, Jenna M., Gellert, Lan L., Castro, Mauro A. A., Robertson, A. Gordon, Kuo, Fengshen, Ostrovnaya, Irina, Sarungbam, Judy, Chen, Ying-bei, Gopalan, Anuradha, Sirintrapun, Sahussapont J., Fine, Samson W., Tickoo, Satish K., Kim, Kwanghee, Thomas, Jasmine, Karan, Nagar, Gao, Sizhi Paul, Clinton, Timothy N., Lenis, Andrew T., Chan, Timothy A., Chen, Ziyu, Rao, Manisha, Hollman, Travis J., Li, Yanyun, Socci, Nicholas D., Chavan, Shweta, Viale, Agnes, Mohibullah, Neeman, Bochner, Bernard H., Pietzak, Eugene J., Teo, Min Yuen, Iyer, Gopa, Rosenberg, Jonathan E., Bajorin, Dean F., Kaag, Matthew, Merrill, Suzanne B., Joshi, Monika, Adam, Rosalyn, Taylor, III, John A., Clark, Peter E., Raman, Jay D., Reuter, Victor E., Chen, Yu, Funt, Samuel A., Solit, David B., DeGraff, David J., and Al-Ahmadie, Hikmat A.

Published
2022
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4. FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation

Author

Warrick, Joshua I., Hu, Wenhuo, Yamashita, Hironobu, Walter, Vonn, Shuman, Lauren, Craig, Jenna M., Gellert, Lan L., Castro, Mauro A. A., Robertson, A. Gordon, Kuo, Fengshen, Ostrovnaya, Irina, Sarungbam, Judy, Chen, Ying-bei, Gopalan, Anuradha, Sirintrapun, Sahussapont J., Fine, Samson W., Tickoo, Satish K., Kim, Kwanghee, Thomas, Jasmine, Karan, Nagar, Gao, Sizhi Paul, Clinton, Timothy N., Lenis, Andrew T., Chan, Timothy A., Chen, Ziyu, Rao, Manisha, Hollman, Travis J., Li, Yanyun, Socci, Nicholas D., Chavan, Shweta, Viale, Agnes, Mohibullah, Neeman, Bochner, Bernard H., Pietzak, Eugene J., Teo, Min Yuen, Iyer, Gopa, Rosenberg, Jonathan E., Bajorin, Dean F., Kaag, Matthew, Merrill, Suzanne B., Joshi, Monika, Adam, Rosalyn, Taylor, III, John A., Clark, Peter E., Raman, Jay D., Reuter, Victor E., Chen, Yu, Funt, Samuel A., Solit, David B., DeGraff, David J., and Al-Ahmadie, Hikmat A.

Published
2022
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6. Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients

Author

Tsui, Dana W. Y., Cheng, Michael L., Shady, Maha, Yang, Julie L., Stephens, Dennis, Won, Helen, Srinivasan, Preethi, Huberman, Kety, Meng, Fanli, Jing, Xiaohong, Patel, Juber, Hasan, Maysun, Johnson, Ian, Gedvilaite, Erika, Houck-Loomis, Brian, Socci, Nicholas D., Selcuklu, S. Duygu, Seshan, Venkatraman E., Zhang, Hongxin, Chakravarty, Debyani, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria, Ladanyi, Marc, Funt, Samuel A., Feldman, Darren R., Li, Bob T., Razavi, Pedram, Rosenberg, Jonathan, Bajorin, Dean, Iyer, Gopa, Abida, Wassim, Scher, Howard I., Rathkopf, Dana, Viale, Agnes, Berger, Michael F., and Solit, David B.

Published
2021
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7. NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.

Author

Garcia-Rendueles, Maria, Ricarte-Filho, Julio, Untch, Brian, Landa, Iňigo, Knauf, Jeffrey, Voza, Francesca, Smith, Vicki, Ganly, Ian, Persaud, Yogindra, Oler, Gisele, Fang, Yuqiang, Jhanwar, Suresh, Viale, Agnes, Heguy, Adriana, Huberman, Kety, Giancotti, Filippo, Ghossein, Ronald, Fagin, James, and Taylor, Barry

Subjects
Animals, Binding Sites, Cell Cycle Proteins, Cell Line, Tumor, Cell Transformation, Neoplastic, Chromosome Deletion, Chromosomes, Human, Pair 22, DNA Copy Number Variations, Disease Models, Animal, Drug Resistance, Neoplasm, Gene Deletion, Gene Expression Regulation, Neoplastic, Gene Order, Gene Targeting, Genes, ras, Humans, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinases, Models, Biological, Neoplasm Staging, Neurofibromin 2, Nuclear Proteins, Nucleotide Motifs, Position-Specific Scoring Matrices, Promoter Regions, Genetic, Protein Binding, Protein Kinase Inhibitors, Signal Transduction, Thyroid Neoplasms, Transcription Factors, Transcriptional Activation
Abstract

UNLABELLED: Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). The 22q tumor suppressor NF2, encoding merlin, is implicated in this interaction because of its frequent loss of function in human thyroid cancer cell lines. Nf2 deletion or Hras mutation is insufficient for transformation, whereas their combined disruption leads to murine PDTC with increased MAPK signaling. Merlin loss induces RAS signaling in part through inactivation of Hippo, which activates a YAP-TEAD transcriptional program. We find that the three RAS genes are themselves YAP-TEAD1 transcriptional targets, providing a novel mechanism of promotion of RAS-induced tumorigenesis. Moreover, pharmacologic disruption of YAP-TEAD with verteporfin blocks RAS transcription and signaling and inhibits cell growth. The increased MAPK output generated by NF2 loss in RAS-mutant cancers may inform therapeutic strategies, as it generates greater dependency on the MAPK pathway for viability. SIGNIFICANCE: Intensification of mutant RAS signaling through copy-number imbalances is commonly associated with transformation. We show that NF2/merlin inactivation augments mutant RAS signaling by promoting YAP/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK output and increased sensitivity to MEK inhibitors.

Published
2015

8. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Author

Weinreb, Ilan, Piscuoglio, Salvatore, Martelotto, Luciano G, Waggott, Daryl, Ng, Charlotte KY, Perez-Ordonez, Bayardo, Harding, Nicholas J, Alfaro, Javier, Chu, Kenneth C, Viale, Agnes, Fusco, Nicola, da Cruz Paula, Arnaud, Marchio, Caterina, Sakr, Rita A, Lim, Raymond, Thompson, Lester DR, Chiosea, Simion I, Seethala, Raja R, Skalova, Alena, Stelow, Edward B, Fonseca, Isabel, Assaad, Adel, How, Christine, Wang, Jianxin, de Borja, Richard, Chan-Seng-Yue, Michelle, Howlett, Christopher J, Nichols, Anthony C, Wen, Y Hannah, Katabi, Nora, Buchner, Nicholas, Mullen, Laura, Kislinger, Thomas, Wouters, Bradly G, Liu, Fei-Fei, Norton, Larry, McPherson, John D, Rubin, Brian P, Clarke, Blaise A, Weigelt, Britta, Boutros, Paul C, and Reis-Filho, Jorge S

Subjects
Agricultural, Veterinary and Food Sciences, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Agricultural Biotechnology, Cancer, Digestive Diseases, Adenocarcinoma, Amino Acid Sequence, Animals, Humans, Immunohistochemistry, Immunoprecipitation, Mice, Microscopy, Confocal, Models, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, Missense, NIH 3T3 Cells, Protein Kinase C, Salivary Gland Neoplasms, Sequence Alignment, Sequence Analysis, DNA, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

Published
2014

9. Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma

Author

Grommes, Christian, Tang, Sarah S., Wolfe, Julia, Kaley, Thomas J., Daras, Mariza, Pentsova, Elena I., Piotrowski, Anna F., Stone, Jacqueline, Lin, Andrew, Nolan, Craig P., Manne, Malbora, Codega, Paolo, Campos, Carl, Viale, Agnes, Thomas, Alissa A., Berger, Michael F., Hatzoglou, Vaios, Reiner, Anne S., Panageas, Katherine S., DeAngelis, Lisa M., and Mellinghoff, Ingo K.

Published
2019
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10. Supplementary Table S2 from Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach

Author

Doe-Tetteh, Seyram A., primary, Camp, Sabrina Y., primary, Reales, Dalicia, primary, Crowdis, Jett, primary, Noronha, Anne Marie, primary, Wolff, Bernadette, primary, Alano, Tina, primary, Galle, Jesse, primary, Selcuklu, S. Duygu, primary, Viale, Agnes, primary, Socci, Nicholas D., primary, Liu, Ying L., primary, Tew, William P., primary, Aghajanian, Carol, primary, Ladanyi, Marc, primary, He, Meng Xiao, primary, AlDubayan, Saud H., primary, Mazor, Roei David, primary, Shpilberg, Ofer, primary, Hershkovitz-Rokah, Oshrat, primary, Riancho, Jose A., primary, Hernandez, Jose L., primary, Gonzalez-Vela, M. Carmen, primary, Buthorn, Justin J., primary, Wilson, Manda, primary, Webber, Amy E., primary, Yabe, Mariko, primary, Petrova-Drus, Kseniya, primary, Rosenblum, Marc, primary, Durham, Benjamin H., primary, Abdel-Wahab, Omar, primary, Berger, Michael F., primary, Donoghue, Mark T.A., primary, Kung, Andrew L., primary, Glade Bender, Julia, primary, Shukla, Neerav N., primary, Funt, Samuel A., primary, Dogan, Ahmet, primary, Soslow, Robert A., primary, Al-Ahmadie, Hikmat, primary, Feldman, Darren R., primary, Van Allen, Eliezer M., primary, Diamond, Eli L., primary, and Solit, David B., primary

Published
2023
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11. Data from Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach

Author

Doe-Tetteh, Seyram A., primary, Camp, Sabrina Y., primary, Reales, Dalicia, primary, Crowdis, Jett, primary, Noronha, Anne Marie, primary, Wolff, Bernadette, primary, Alano, Tina, primary, Galle, Jesse, primary, Selcuklu, S. Duygu, primary, Viale, Agnes, primary, Socci, Nicholas D., primary, Liu, Ying L., primary, Tew, William P., primary, Aghajanian, Carol, primary, Ladanyi, Marc, primary, He, Meng Xiao, primary, AlDubayan, Saud H., primary, Mazor, Roei David, primary, Shpilberg, Ofer, primary, Hershkovitz-Rokah, Oshrat, primary, Riancho, Jose A., primary, Hernandez, Jose L., primary, Gonzalez-Vela, M. Carmen, primary, Buthorn, Justin J., primary, Wilson, Manda, primary, Webber, Amy E., primary, Yabe, Mariko, primary, Petrova-Drus, Kseniya, primary, Rosenblum, Marc, primary, Durham, Benjamin H., primary, Abdel-Wahab, Omar, primary, Berger, Michael F., primary, Donoghue, Mark T.A., primary, Kung, Andrew L., primary, Glade Bender, Julia, primary, Shukla, Neerav N., primary, Funt, Samuel A., primary, Dogan, Ahmet, primary, Soslow, Robert A., primary, Al-Ahmadie, Hikmat, primary, Feldman, Darren R., primary, Van Allen, Eliezer M., primary, Diamond, Eli L., primary, and Solit, David B., primary

Published
2023
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12. Supplementary Figure S1 from Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach

Author

Doe-Tetteh, Seyram A., primary, Camp, Sabrina Y., primary, Reales, Dalicia, primary, Crowdis, Jett, primary, Noronha, Anne Marie, primary, Wolff, Bernadette, primary, Alano, Tina, primary, Galle, Jesse, primary, Selcuklu, S. Duygu, primary, Viale, Agnes, primary, Socci, Nicholas D., primary, Liu, Ying L., primary, Tew, William P., primary, Aghajanian, Carol, primary, Ladanyi, Marc, primary, He, Meng Xiao, primary, AlDubayan, Saud H., primary, Mazor, Roei David, primary, Shpilberg, Ofer, primary, Hershkovitz-Rokah, Oshrat, primary, Riancho, Jose A., primary, Hernandez, Jose L., primary, Gonzalez-Vela, M. Carmen, primary, Buthorn, Justin J., primary, Wilson, Manda, primary, Webber, Amy E., primary, Yabe, Mariko, primary, Petrova-Drus, Kseniya, primary, Rosenblum, Marc, primary, Durham, Benjamin H., primary, Abdel-Wahab, Omar, primary, Berger, Michael F., primary, Donoghue, Mark T.A., primary, Kung, Andrew L., primary, Glade Bender, Julia, primary, Shukla, Neerav N., primary, Funt, Samuel A., primary, Dogan, Ahmet, primary, Soslow, Robert A., primary, Al-Ahmadie, Hikmat, primary, Feldman, Darren R., primary, Van Allen, Eliezer M., primary, Diamond, Eli L., primary, and Solit, David B., primary

Published
2023
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13. Gene Expression Profiles Accurately Predict Outcome Following Liver Resection in Patients with Metastatic Colorectal Cancer

Author

Ito, Hiromichi, Mo, Qianxing, Qin, Li-Xuan, Viale, Agnes, Maithel, Shishir K, Maker, Ajay V, Shia, Jinru, Kingham, Peter, Allen, Peter, DeMatteo, Ronald P, Fong, Yuman, Jarnagin, William R, and D’Angelica, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Colo-Rectal Cancer, Clinical Research, Clinical Trials and Supportive Activities, Genetics, Digestive Diseases, Liver Disease, Cancer, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Cohort Studies, Colorectal Neoplasms, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Hepatectomy, Humans, Liver Neoplasms, Male, Middle Aged, Prognosis, General Science & Technology
Abstract

PurposeThe aim of this study was to build a molecular prognostic model based on gene signatures for patients with completely resected hepatic metastases from colorectal cancer (MCRC).MethodsUsing the Illumina HumanHT-12 gene chip, RNA samples from the liver metastases of 96 patients who underwent R0 liver resection were analyzed. Patients were randomly assigned to a training (n = 60) and test (n = 36) set. The genes associated with disease-specific survival (DSS) and liver-recurrence-free survival (LRFS) were identified by Cox-regression and selected to construct a molecular risk score (MRS) using the supervised principle component method on the training set. The MRS was then evaluated in the independent test set.ResultsNineteen and 115 genes were selected to construct the MRS for DSS and LRFS, respectively. Each MRS was validated in the test set; 3-year DSS/LRFS rates were 42/32% and 79/80% for patients with high and low MRS, respectively (p = 0.007 for DSS and p = 0.046 for LRFS). In a multivariate model controlling for a previously validated clinical risk score (CRS), the MRS remained a significant predictor of DSS (p = 0.001) and LRFS (p = 0.03). When CRS and MRS were combined, the patients were discriminated better with 3-year DSS/LRFS rates of 90/89% in the low risk group (both risk scores low) vs 42/26% in the high risk group (both risk scores high), respectively (p = 0.002/0.004 for DSS/LRFS).ConclusionMRS based on gene expression profiling has high prognostic value and is independent of CRS. This finding provides a potential strategy for better risk-stratification of patients with liver MCRC.

Published
2013

14. Tumour lineage shapes BRCA-mediated phenotypes

Author

Jonsson, Philip, Bandlamudi, Chaitanya, Cheng, Michael L., Srinivasan, Preethi, Chavan, Shweta S., Friedman, Noah D., Rosen, Ezra Y., Richards, Allison L., Bouvier, Nancy, Selcuklu, S. Duygu, Bielski, Craig M., Abida, Wassim, Mandelker, Diana, Birsoy, Ozge, Zhang, Liying, Zehir, Ahmet, Donoghue, Mark T. A., Baselga, José, Offit, Kenneth, Scher, Howard I., O’Reilly, Eileen M., Stadler, Zsofia K., Schultz, Nikolaus, Socci, Nicholas D., Viale, Agnes, Ladanyi, Marc, Robson, Mark E., Hyman, David M., Berger, Michael F., Solit, David B., and Taylor, Barry S.

Published
2019
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16. Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid

Author

Miller, Alexandra M., Shah, Ronak H., Pentsova, Elena I., Pourmaleki, Maryam, Briggs, Samuel, Distefano, Natalie, Zheng, Youyun, Skakodub, Anna, Mehta, Smrutiben A., Campos, Carl, Hsieh, Wan-Ying, Selcuklu, S. Duygu, Ling, Lilan, Meng, Fanli, Jing, Xiaohong, Samoila, Aliaksandra, Bale, Tejus A., Tsui, Dana W. Y., Grommes, Christian, Viale, Agnes, Souweidane, Mark M., Tabar, Viviane, Brennan, Cameron W., Reiner, Anne S., Rosenblum, Marc, Panageas, Katherine S., DeAngelis, Lisa M., Young, Robert J., Berger, Michael F., and Mellinghoff, Ingo K.

Published
2019
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17. Comprehensive genomic characterization of squamous cell lung cancers

Author

Hammerman, Peter S, Lawrence, Michael S, Voet, Douglas, Jing, Rui, Cibulskis, Kristian, Sivachenko, Andrey, Stojanov, Petar, McKenna, Aaron, Lander, Eric S, Gabriel, Stacey, Getz, Gad, Sougnez, Carrie, Imielinski, Marcin, Helman, Elena, Hernandez, Bryan, Pho, Nam H, Meyerson, Matthew, Chu, Andy, Chun, Hye-Jung E, Mungall, Andrew J, Pleasance, Erin, Gordon Robertson, A, Sipahimalani, Payal, Stoll, Dominik, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron SN, Chuah, Eric, Coope, Robin JN, Corbett, Richard, Dhalla, Noreen, Guin, Ranabir, He, An, Hirst, Carrie, Hirst, Martin, Holt, Robert A, Lee, Darlene, Li, Haiyan I, Mayo, Michael, Moore, Richard A, Mungall, Karen, Ming Nip, Ka, Olshen, Adam, Schein, Jacqueline E, Slobodan, Jared R, Tam, Angela, Thiessen, Nina, Varhol, Richard, Zeng, Thomas, Zhao, Yongjun, Jones, Steven JM, Marra, Marco A, Saksena, Gordon, Cherniack, Andrew D, Schumacher, Stephen E, Tabak, Barbara, Carter, Scott L, Nguyen, Huy, Onofrio, Robert C, Crenshaw, Andrew, Ardlie, Kristin, Beroukhim, Rameen, Winckler, Wendy, Protopopov, Alexei, Zhang, Jianhua, Hadjipanayis, Angela, Lee, Semin, Xi, Ruibin, Yang, Lixing, Ren, Xiaojia, Zhang, Hailei, Shukla, Sachet, Chen, Peng-Chieh, Haseley, Psalm, Lee, Eunjung, Chin, Lynda, Park, Peter J, Kucherlapati, Raju, Socci, Nicholas D, Liang, Yupu, Schultz, Nikolaus, Borsu, Laetitia, Lash, Alex E, Viale, Agnes, Sander, Chris, Ladanyi, Marc, Todd Auman, J, Hoadley, Katherine A, Wilkerson, Matthew D, Shi, Yan, Liquori, Christina, Meng, Shaowu, Li, Ling, Turman, Yidi J, Topal, Michael D, and Tan, Donghui

Subjects
Human Genome, Biotechnology, Genetics, Rare Diseases, Cancer, Lung Cancer, Lung, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Adenocarcinoma of Lung, Carcinoma, Squamous Cell, DNA Mutational Analysis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, p16, Genes, p53, Genome, Human, Genomics, Humans, Lung Neoplasms, Molecular Targeted Therapy, Mutation, Mutation Rate, Phosphatidylinositol 3-Kinases, Signal Transduction, Cancer Genome Atlas Research Network, General Science & Technology
Abstract

Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers.

Published
2012

18. Stat3 Mediates Expression of Autotaxin in Breast Cancer

Author

Azare, Janeen, Doane, Ashley, Leslie, Kenneth, Chang, Qing, Berishaj, Marjan, Nnoli, Jennifer, Mark, Kevin, Al-Ahmadie, Hikmat, Gerald, William, Hassimi, Maryam, Viale, Agnes, Stracke, Mary, Lyden, David, and Bromberg, Jacqueline

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Cancer, Breast Cancer, Genetics, Breast Neoplasms, Cell Line, Tumor, Cluster Analysis, Female, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Humans, Lymph Nodes, Neoplasm Metastasis, Phosphoric Diester Hydrolases, Phosphorylation, Phosphotyrosine, STAT3 Transcription Factor, General Science & Technology
Abstract

We determined that signal transducer and activator of transcription 3 (Stat3) is tyrosine phosphorylated in 37% of primary breast tumors and 63% of paired metastatic axillary lymph nodes. Examination of the distribution of tyrosine phosphorylated (pStat3) in primary tumors revealed heterogenous expression within the tumor with the highest levels found in cells on the edge of tumors with relatively lower levels in the central portion of tumors. In order to determine Stat3 target genes that may be involved in migration and metastasis, we identified those genes that were differentially expressed in primary breast cancer samples as a function of pStat3 levels. In addition to known Stat3 transcriptional targets (Twist, Snail, Tenascin-C and IL-8), we identified ENPP2 as a novel Stat3 regulated gene, which encodes autotaxin (ATX), a secreted lysophospholipase which mediates mammary tumorigenesis and cancer cell migration. A positive correlation between nuclear pStat3 and ATX was determined by immunohistochemical analysis of primary breast cancer samples and matched axillary lymph nodes and in several breast cancer derived cell lines. Inhibition of pStat3 or reducing Stat3 expression led to a decrease in ATX levels and cell migration. An association between Stat3 and the ATX promoter, which contains a number of putative Stat3 binding sites, was determined by chromatin immunoprecipitation. These observations suggest that activated Stat3 may regulate the migration of breast cancer cells through the regulation of ATX.

Published
2011

20. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Author

Barretina, Jordi, Taylor, Barry S, Banerji, Shantanu, Ramos, Alexis H, Lagos-Quintana, Mariana, DeCarolis, Penelope L, Shah, Kinjal, Socci, Nicholas D, Weir, Barbara A, Ho, Alan, Chiang, Derek Y, Reva, Boris, Mermel, Craig H, Getz, Gad, Antipin, Yevgenyi, Beroukhim, Rameen, Major, John E, Hatton, Charles, Nicoletti, Richard, Hanna, Megan, Sharpe, Ted, Fennell, Tim J, Cibulskis, Kristian, Onofrio, Robert C, Saito, Tsuyoshi, Shukla, Neerav, Lau, Christopher, Nelander, Sven, Silver, Serena J, Sougnez, Carrie, Viale, Agnes, Winckler, Wendy, Maki, Robert G, Garraway, Levi A, Lash, Alex, Greulich, Heidi, Root, David E, Sellers, William R, Schwartz, Gary K, Antonescu, Cristina R, Lander, Eric S, Varmus, Harold E, Ladanyi, Marc, Sander, Chris, Meyerson, Matthew, and Singer, Samuel

Subjects
Pediatric, Biotechnology, Cancer, Human Genome, Genetics, Adult, Aged, Female, Genes, Tumor Suppressor, Genome, Histiocytoma, Malignant Fibrous, Humans, Liposarcoma, Male, Middle Aged, Mutation, Sarcoma, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States, show remarkable histologic diversity, with more than 50 recognized subtypes. However, knowledge of their genomic alterations is limited. We describe an integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes. Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8% of pleomorphic liposarcomas) and PIK3CA (18% of myxoid/round-cell liposarcomas, or MRCs). PIK3CA mutations in MRCs were associated with Akt activation and poor clinical outcomes. In myxofibrosarcomas and pleomorphic liposarcomas, we found both point mutations and genomic deletions affecting the tumor suppressor NF1. Finally, we found that short hairpin RNA (shRNA)-based knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4, decreased cell proliferation. Our study yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.

Published
2010

21. Data from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

Author

Al-Ahmadie, Hikmat, primary, Iyer, Gopa, primary, Hohl, Marcel, primary, Asthana, Saurabh, primary, Inagaki, Akiko, primary, Schultz, Nikolaus, primary, Hanrahan, Aphrothiti J., primary, Scott, Sasinya N., primary, Brannon, A. Rose, primary, McDermott, Gregory C., primary, Pirun, Mono, primary, Ostrovnaya, Irina, primary, Kim, Philip, primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schwartz, Gary K., primary, Reuter, Victor, primary, Bochner, Bernard H., primary, Rosenberg, Jonathan E., primary, Bajorin, Dean F., primary, Berger, Michael F., primary, Petrini, John H.J., primary, Solit, David B., primary, and Taylor, Barry S., primary

Published
2023
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22. Supplementary Figure S5 from Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas

Author

Montero-Conde, Cristina, primary, Ruiz-Llorente, Sergio, primary, Dominguez, Jose M., primary, Knauf, Jeffrey A., primary, Viale, Agnes, primary, Sherman, Eric J., primary, Ryder, Mabel, primary, Ghossein, Ronald A., primary, Rosen, Neal, primary, and Fagin, James A., primary

Published
2023
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23. Data from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
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24. Supplementary Figures S1 - S10, Tables S1 - S3 from NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

Author

Garcia-Rendueles, Maria E.R., primary, Ricarte-Filho, Julio C., primary, Untch, Brian R., primary, Landa, Iňigo, primary, Knauf, Jeffrey A., primary, Voza, Francesca, primary, Smith, Vicki E., primary, Ganly, Ian, primary, Taylor, Barry S., primary, Persaud, Yogindra, primary, Oler, Gisele, primary, Fang, Yuqiang, primary, Jhanwar, Suresh C., primary, Viale, Agnes, primary, Heguy, Adriana, primary, Huberman, Kety H., primary, Giancotti, Filippo, primary, Ghossein, Ronald, primary, and Fagin, James A., primary

Published
2023
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25. Supplementary Methods and References from Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas

Author

Montero-Conde, Cristina, primary, Ruiz-Llorente, Sergio, primary, Dominguez, Jose M., primary, Knauf, Jeffrey A., primary, Viale, Agnes, primary, Sherman, Eric J., primary, Ryder, Mabel, primary, Ghossein, Ronald A., primary, Rosen, Neal, primary, and Fagin, James A., primary

Published
2023
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26. Supplementary Figures 1 - 10 from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

Author

Al-Ahmadie, Hikmat, primary, Iyer, Gopa, primary, Hohl, Marcel, primary, Asthana, Saurabh, primary, Inagaki, Akiko, primary, Schultz, Nikolaus, primary, Hanrahan, Aphrothiti J., primary, Scott, Sasinya N., primary, Brannon, A. Rose, primary, McDermott, Gregory C., primary, Pirun, Mono, primary, Ostrovnaya, Irina, primary, Kim, Philip, primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schwartz, Gary K., primary, Reuter, Victor, primary, Bochner, Bernard H., primary, Rosenberg, Jonathan E., primary, Bajorin, Dean F., primary, Berger, Michael F., primary, Petrini, John H.J., primary, Solit, David B., primary, and Taylor, Barry S., primary

Published
2023
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27. Supplementary Figures from Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

Author

Harding, James J., primary, Lowery, Maeve A., primary, Shih, Alan H., primary, Schvartzman, Juan M., primary, Hou, Shengqi, primary, Famulare, Christopher, primary, Patel, Minal, primary, Roshal, Mikhail, primary, Do, Richard K., primary, Zehir, Ahmet, primary, You, Daoqi, primary, Selcuklu, S. Duygu, primary, Viale, Agnes, primary, Tallman, Martin S., primary, Hyman, David M., primary, Reznik, Ed, primary, Finley, Lydia W.S., primary, Papaemmanuil, Elli, primary, Tosolini, Alessandra, primary, Frattini, Mark G., primary, MacBeth, Kyle J., primary, Liu, Guowen, primary, Fan, Bin, primary, Choe, Sung, primary, Wu, Bin, primary, Janjigian, Yelena Y., primary, Mellinghoff, Ingo K., primary, Diaz, Luis A., primary, Levine, Ross L., primary, Abou-Alfa, Ghassan K., primary, Stein, Eytan M., primary, and Intlekofer, Andrew M., primary

Published
2023
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29. Supplementary Figure 1 from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
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30. Supplementary Methods, Supplementary Tables 1 through 7, and Supplementary Figures 1 through 7 from Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma

Author

Grommes, Christian, primary, Pastore, Alessandro, primary, Palaskas, Nicolaos, primary, Tang, Sarah S., primary, Campos, Carl, primary, Schartz, Derrek, primary, Codega, Paolo, primary, Nichol, Donna, primary, Clark, Owen, primary, Hsieh, Wan-Ying, primary, Rohle, Dan, primary, Rosenblum, Marc, primary, Viale, Agnes, primary, Tabar, Viviane S., primary, Brennan, Cameron W., primary, Gavrilovic, Igor T., primary, Kaley, Thomas J., primary, Nolan, Craig P., primary, Omuro, Antonio, primary, Pentsova, Elena, primary, Thomas, Alissa A., primary, Tsyvkin, Elina, primary, Noy, Ariela, primary, Palomba, M. Lia, primary, Hamlin, Paul, primary, Sauter, Craig S., primary, Moskowitz, Craig H., primary, Wolfe, Julia, primary, Dogan, Ahmet, primary, Won, Minhee, primary, Glass, Jon, primary, Peak, Scott, primary, Lallana, Enrico C., primary, Hatzoglou, Vaios, primary, Reiner, Anne S., primary, Gutin, Philip H., primary, Huse, Jason T., primary, Panageas, Katherine S., primary, Graeber, Thomas G., primary, Schultz, Nikolaus, primary, DeAngelis, Lisa M., primary, and Mellinghoff, Ingo K., primary

Published
2023
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31. Supplementary Figure 2 from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
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32. Supplementary Materials from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

Author

Al-Ahmadie, Hikmat, primary, Iyer, Gopa, primary, Hohl, Marcel, primary, Asthana, Saurabh, primary, Inagaki, Akiko, primary, Schultz, Nikolaus, primary, Hanrahan, Aphrothiti J., primary, Scott, Sasinya N., primary, Brannon, A. Rose, primary, McDermott, Gregory C., primary, Pirun, Mono, primary, Ostrovnaya, Irina, primary, Kim, Philip, primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schwartz, Gary K., primary, Reuter, Victor, primary, Bochner, Bernard H., primary, Rosenberg, Jonathan E., primary, Bajorin, Dean F., primary, Berger, Michael F., primary, Petrini, John H.J., primary, Solit, David B., primary, and Taylor, Barry S., primary

Published
2023
Full Text
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33. Data from NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

Author

Garcia-Rendueles, Maria E.R., primary, Ricarte-Filho, Julio C., primary, Untch, Brian R., primary, Landa, Iňigo, primary, Knauf, Jeffrey A., primary, Voza, Francesca, primary, Smith, Vicki E., primary, Ganly, Ian, primary, Taylor, Barry S., primary, Persaud, Yogindra, primary, Oler, Gisele, primary, Fang, Yuqiang, primary, Jhanwar, Suresh C., primary, Viale, Agnes, primary, Heguy, Adriana, primary, Huberman, Kety H., primary, Giancotti, Filippo, primary, Ghossein, Ronald, primary, and Fagin, James A., primary

Published
2023
Full Text
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34. Data from Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma

Author

Grommes, Christian, primary, Pastore, Alessandro, primary, Palaskas, Nicolaos, primary, Tang, Sarah S., primary, Campos, Carl, primary, Schartz, Derrek, primary, Codega, Paolo, primary, Nichol, Donna, primary, Clark, Owen, primary, Hsieh, Wan-Ying, primary, Rohle, Dan, primary, Rosenblum, Marc, primary, Viale, Agnes, primary, Tabar, Viviane S., primary, Brennan, Cameron W., primary, Gavrilovic, Igor T., primary, Kaley, Thomas J., primary, Nolan, Craig P., primary, Omuro, Antonio, primary, Pentsova, Elena, primary, Thomas, Alissa A., primary, Tsyvkin, Elina, primary, Noy, Ariela, primary, Palomba, M. Lia, primary, Hamlin, Paul, primary, Sauter, Craig S., primary, Moskowitz, Craig H., primary, Wolfe, Julia, primary, Dogan, Ahmet, primary, Won, Minhee, primary, Glass, Jon, primary, Peak, Scott, primary, Lallana, Enrico C., primary, Hatzoglou, Vaios, primary, Reiner, Anne S., primary, Gutin, Philip H., primary, Huse, Jason T., primary, Panageas, Katherine S., primary, Graeber, Thomas G., primary, Schultz, Nikolaus, primary, DeAngelis, Lisa M., primary, and Mellinghoff, Ingo K., primary

Published
2023
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35. Data from Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas

Author

Taylor, Barry S., primary, DeCarolis, Penelope L., primary, Angeles, Christina V., primary, Brenet, Fabienne, primary, Schultz, Nikolaus, primary, Antonescu, Cristina R., primary, Scandura, Joseph M., primary, Sander, Chris, primary, Viale, Agnes J., primary, Socci, Nicholas D., primary, and Singer, Samuel, primary

Published
2023
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36. Supplementary Tables and Legend from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
Full Text
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37. Supplementary Tables 1 - 6 from Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

Author

Al-Ahmadie, Hikmat, primary, Iyer, Gopa, primary, Hohl, Marcel, primary, Asthana, Saurabh, primary, Inagaki, Akiko, primary, Schultz, Nikolaus, primary, Hanrahan, Aphrothiti J., primary, Scott, Sasinya N., primary, Brannon, A. Rose, primary, McDermott, Gregory C., primary, Pirun, Mono, primary, Ostrovnaya, Irina, primary, Kim, Philip, primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schwartz, Gary K., primary, Reuter, Victor, primary, Bochner, Bernard H., primary, Rosenberg, Jonathan E., primary, Bajorin, Dean F., primary, Berger, Michael F., primary, Petrini, John H.J., primary, Solit, David B., primary, and Taylor, Barry S., primary

Published
2023
Full Text
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38. Supplementary Figure 3 from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
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39. Supplementary Tables 1-7 from Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas

Author

Taylor, Barry S., primary, DeCarolis, Penelope L., primary, Angeles, Christina V., primary, Brenet, Fabienne, primary, Schultz, Nikolaus, primary, Antonescu, Cristina R., primary, Scandura, Joseph M., primary, Sander, Chris, primary, Viale, Agnes J., primary, Socci, Nicholas D., primary, and Singer, Samuel, primary

Published
2023
Full Text
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40. Supplementary Methods from Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

Author

Harding, James J., primary, Lowery, Maeve A., primary, Shih, Alan H., primary, Schvartzman, Juan M., primary, Hou, Shengqi, primary, Famulare, Christopher, primary, Patel, Minal, primary, Roshal, Mikhail, primary, Do, Richard K., primary, Zehir, Ahmet, primary, You, Daoqi, primary, Selcuklu, S. Duygu, primary, Viale, Agnes, primary, Tallman, Martin S., primary, Hyman, David M., primary, Reznik, Ed, primary, Finley, Lydia W.S., primary, Papaemmanuil, Elli, primary, Tosolini, Alessandra, primary, Frattini, Mark G., primary, MacBeth, Kyle J., primary, Liu, Guowen, primary, Fan, Bin, primary, Choe, Sung, primary, Wu, Bin, primary, Janjigian, Yelena Y., primary, Mellinghoff, Ingo K., primary, Diaz, Luis A., primary, Levine, Ross L., primary, Abou-Alfa, Ghassan K., primary, Stein, Eytan M., primary, and Intlekofer, Andrew M., primary

Published
2023
Full Text
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41. Supplementary Methods, Figures 1-10 from Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas

Author

Taylor, Barry S., primary, DeCarolis, Penelope L., primary, Angeles, Christina V., primary, Brenet, Fabienne, primary, Schultz, Nikolaus, primary, Antonescu, Cristina R., primary, Scandura, Joseph M., primary, Sander, Chris, primary, Viale, Agnes J., primary, Socci, Nicholas D., primary, and Singer, Samuel, primary

Published
2023
Full Text
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42. Supplementary Figure 4 from Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Author

Abdel-Wahab, Omar, primary, Klimek, Virginia M., primary, Gaskell, Alisa A., primary, Viale, Agnes, primary, Cheng, Donavan, primary, Kim, Eunhee, primary, Rampal, Raajit, primary, Bluth, Mark, primary, Harding, James J., primary, Callahan, Margaret K., primary, Merghoub, Taha, primary, Berger, Michael F., primary, Solit, David B., primary, Rosen, Neal, primary, Levine, Ross L., primary, and Chapman, Paul B., primary

Published
2023
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43. Supplementary Table S1 from Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Author

Wei, Xiaomu, primary, Calvo-Vidal, M. Nieves, primary, Chen, Siwei, primary, Wu, Gang, primary, Revuelta, Maria V., primary, Sun, Jian, primary, Zhang, Jinghui, primary, Walsh, Michael F., primary, Nichols, Kim E., primary, Joseph, Vijai, primary, Snyder, Carrie, primary, Vachon, Celine M., primary, McKay, James D., primary, Wang, Shu-Ping, primary, Jayabalan, David S., primary, Jacobs, Lauren M., primary, Becirovic, Dina, primary, Waller, Rosalie G., primary, Artomov, Mykyta, primary, Viale, Agnes, primary, Patel, Jayeshkumar, primary, Phillip, Jude, primary, Chen-Kiang, Selina, primary, Curtin, Karen, primary, Salama, Mohamed, primary, Atanackovic, Djordje, primary, Niesvizky, Ruben, primary, Landgren, Ola, primary, Slager, Susan L., primary, Godley, Lucy A., primary, Churpek, Jane, primary, Garber, Judy E., primary, Anderson, Kenneth C., primary, Daly, Mark J., primary, Roeder, Robert G., primary, Dumontet, Charles, primary, Lynch, Henry T., primary, Mullighan, Charles G., primary, Camp, Nicola J., primary, Offit, Kenneth, primary, Klein, Robert J., primary, Yu, Haiyuan, primary, Cerchietti, Leandro, primary, and Lipkin, Steven M., primary

Published
2023
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44. Supplementary Figures 1 - 11, Tables 1 - 2 from Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy

Author

Voss, Martin H., primary, Hakimi, A. Ari, primary, Pham, Can G., primary, Brannon, A. Rose, primary, Chen, Ying-Bei, primary, Cunha, Luis F., primary, Akin, Oguz, primary, Liu, Han, primary, Takeda, Shugaku, primary, Scott, Sasinya N., primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schultz, Nikolaus, primary, Sander, Chris, primary, Reuter, Victor E., primary, Russo, Paul, primary, Cheng, Emily H., primary, Motzer, Robert J., primary, Berger, Michael F., primary, and Hsieh, James J., primary

Published
2023
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45. Supplementary Tables from A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases

Author

Balachandran, Vinod P., primary, Arora, Arshi, primary, Gönen, Mithat, primary, Ito, Hiromichi, primary, Turcotte, Simon, primary, Shia, Jinru, primary, Viale, Agnes, primary, Snoeren, Nikol, primary, van Hooff, Sander R., primary, Rinkes, Inne H.M. Borel, primary, Adam, René, primary, Kingham, T. Peter, primary, Allen, Peter J., primary, DeMatteo, Ronald P., primary, Jarnagin, William R., primary, and D'Angelica, Michael I., primary

Published
2023
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46. Supplementary Table 4 from Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy

Author

Voss, Martin H., primary, Hakimi, A. Ari, primary, Pham, Can G., primary, Brannon, A. Rose, primary, Chen, Ying-Bei, primary, Cunha, Luis F., primary, Akin, Oguz, primary, Liu, Han, primary, Takeda, Shugaku, primary, Scott, Sasinya N., primary, Socci, Nicholas D., primary, Viale, Agnes, primary, Schultz, Nikolaus, primary, Sander, Chris, primary, Reuter, Victor E., primary, Russo, Paul, primary, Cheng, Emily H., primary, Motzer, Robert J., primary, Berger, Michael F., primary, and Hsieh, James J., primary

Published
2023
Full Text
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47. Supplementary Table S2 from Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma

Author

Lee, Ju Youn, primary, Schizas, Michail, primary, Geyer, Felipe C., primary, Selenica, Pier, primary, Piscuoglio, Salvatore, primary, Sakr, Rita A., primary, Ng, Charlotte K.Y., primary, Carniello, Jose V. Scarpa, primary, Towers, Russell, primary, Giri, Dilip D., primary, de Andrade, Victor P., primary, Papanastasiou, Anastasios D., primary, Viale, Agnes, primary, Harris, Reuben S., primary, Solit, David B., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, and King, Tari A., primary

Published
2023
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48. Supplementary Data from Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

Author

Datta, Jashodeep, primary, Smith, J. Joshua, primary, Chatila, Walid K., primary, McAuliffe, John C., primary, Kandoth, Cyriac, primary, Vakiani, Efsevia, primary, Frankel, Timothy L., primary, Ganesh, Karuna, primary, Wasserman, Isaac, primary, Lipsyc-Sharf, Marla, primary, Guillem, Jose, primary, Nash, Garrett M., primary, Paty, Philip B., primary, Weiser, Martin R., primary, Saltz, Leonard B., primary, Berger, Michael F., primary, Jarnagin, William R., primary, Balachandran, Vinod, primary, Kingham, T. Peter, primary, Kemeny, Nancy E., primary, Cercek, Andrea, primary, Garcia-Aguilar, Julio, primary, Taylor, Barry S., primary, Viale, Agnes, primary, Yaeger, Rona, primary, Solit, David B., primary, Schultz, Nikolaus, primary, and D'Angelica, Michael I., primary

Published
2023
Full Text
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49. Supplementary Data from Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma

Author

Wei, Xiaomu, primary, Calvo-Vidal, M. Nieves, primary, Chen, Siwei, primary, Wu, Gang, primary, Revuelta, Maria V., primary, Sun, Jian, primary, Zhang, Jinghui, primary, Walsh, Michael F., primary, Nichols, Kim E., primary, Joseph, Vijai, primary, Snyder, Carrie, primary, Vachon, Celine M., primary, McKay, James D., primary, Wang, Shu-Ping, primary, Jayabalan, David S., primary, Jacobs, Lauren M., primary, Becirovic, Dina, primary, Waller, Rosalie G., primary, Artomov, Mykyta, primary, Viale, Agnes, primary, Patel, Jayeshkumar, primary, Phillip, Jude, primary, Chen-Kiang, Selina, primary, Curtin, Karen, primary, Salama, Mohamed, primary, Atanackovic, Djordje, primary, Niesvizky, Ruben, primary, Landgren, Ola, primary, Slager, Susan L., primary, Godley, Lucy A., primary, Churpek, Jane, primary, Garber, Judy E., primary, Anderson, Kenneth C., primary, Daly, Mark J., primary, Roeder, Robert G., primary, Dumontet, Charles, primary, Lynch, Henry T., primary, Mullighan, Charles G., primary, Camp, Nicola J., primary, Offit, Kenneth, primary, Klein, Robert J., primary, Yu, Haiyuan, primary, Cerchietti, Leandro, primary, and Lipkin, Steven M., primary

Published
2023
Full Text
View/download PDF

50. Supplementary Figure S2 from Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma

Author

Lee, Ju Youn, primary, Schizas, Michail, primary, Geyer, Felipe C., primary, Selenica, Pier, primary, Piscuoglio, Salvatore, primary, Sakr, Rita A., primary, Ng, Charlotte K.Y., primary, Carniello, Jose V. Scarpa, primary, Towers, Russell, primary, Giri, Dilip D., primary, de Andrade, Victor P., primary, Papanastasiou, Anastasios D., primary, Viale, Agnes, primary, Harris, Reuben S., primary, Solit, David B., primary, Weigelt, Britta, primary, Reis-Filho, Jorge S., primary, and King, Tari A., primary

Published
2023
Full Text
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