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708 results on '"Vibha, Deepti"'

4. The role of susceptibility-weighted imaging & contrast-enhanced MRI in the diagnosis of primary CNS vasculitis: a large case series

Author

Agarwal, Sushant, Sebastian, Leve Joseph Devarajan, Gaikwad, Shailesh, Srivastava, M. V. Padma, Sharma, M. C., Singh, Manmohan, Bhatia, Rohit, Agarwal, Ayush, Sharma, Jyoti, Dash, Deepa, Goyal, Vinay, Srivastava, Achal K., Tripathi, Manjari, Suri, Vaishali, Singh, Mamta B., Sarkar, Chitra, Suri, Ashish, Singh, Rajesh K., Vibha, Deepti, Pandit, Awadh K., Rajan, Roopa, Gupta, Anu, Elavarasi, A., Radhakrishnan, Divya M., Das, Animesh, Tandon, Vivek, Doddamani, Ramesh, Upadhyay, Ashish, Vishnu, Venugopalan Y., and Garg, Ajay

Published
2024
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17. Tubercular Meningitis Presenting with an Atypical Imaging Finding: Have We Seen it All?

Author

Chakaraborty, Sohini, Singh, Rajesh, Vibha, Deepti, Sebastian, Leve D., Gaikwad, Shailesh, and Tripathi, Manjari

Subjects
Meningitis, Stroke (Disease), Diagnostic imaging, Health
Abstract

Byline: Sohini. Chakaraborty, Rajesh. Singh, Deepti. Vibha, Leve. D. Sebastian, Shailesh. Gaikwad, Manjari. Tripathi Sir, A 26-year female, postpartum, presented with intermittent low-grade fever and headache for 1 week and [...]

Published
2023

18. Chronic T cell encephalitis responsive to immunotherapy

Author

Elavarasi, Arunmozhimaran, Shukla, Garima, Vibha, Deepti, Suri, Vaishali, and Bal, Chandra

Subjects
Encephalitis -- Diagnosis -- Care and treatment, Immunotherapy -- Patient outcomes, Health
Abstract

Byline: Arunmozhimaran. Elavarasi, Garima. Shukla, Deepti. Vibha, Vaishali. Suri, Chandra. Bal Chronic encephalitis manifesting as an epilepsy syndrome most commonly presents as Rasmussen's syndrome, usually characterized by epilepsia partialis continua, [...]

Published
2022

22. Primary CNS vasculitis (PCNSV): a cohort study

Author

Agarwal, Ayush, Sharma, Jyoti, Srivastava, M. V. Padma, Sharma, M. C., Bhatia, Rohit, Dash, Deepa, Goyal, Vinay, Srivastava, Achal K., Tripathi, Manjari, Suri, Vaishali, Singh, Mamta B., Agarwal, Sushant, Sarkar, Chitra, Joseph, Leve, Singh, Manmohan, Suri, Ashish, Singh, Rajesh K., Vibha, Deepti, Pandit, Awadh K., Rajan, Roopa, Gupta, Anu, Elavarasi, A., Radhakrishnan, Divya M., Das, Animesh, Gaikwad, Shailesh, Tandon, Vivek, Doddamani, Ramesh, Upadhyay, Ashish, Garg, Ajay, and Vishnu, Venugopalan Y.

Published
2022
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25. Broadening the genetic horizons of CADASIL: New variants of the NOTCH3 gene revealed and their association with CADASIL

Author

Mishra, Biswamohan, Vibha, Deepti, and Tripathi, Manjari

Subjects
Genes -- Genetic aspects, Health
Abstract

Byline: Biswamohan. Mishra, Deepti. Vibha, Manjari. Tripathi Commentary Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an angiopathy caused by pathogenic mutation in the NOTCH3 gene on [...]

Published
2023

27. Concordance of Epileptiform Discharges on Video-electroencephalogram (EEG) with the Brain Imaging of Focal Lesions in Drug Resistant Epilepsy: Experience from a Tertiary Centre in India (P6-1.012)

Author

Sidharth, S, primary, Tripathi, Manjari, additional, Vibha, Deepti, additional, Singh, Rajesh Kumar, additional, Elavarasi, Arunmozhimaran, additional, Parihar, Jasmine, additional, Chandra, P Sarat, additional, Gaikwad, Shailesh, additional, and Tripathi, Madhavi, additional

Published
2024
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29. Clinical profile and outcome of non-COVID strokes during pandemic and the pre pandemic period: COVID-Stroke Study Group (CSSG) India

Author

Bhatia, Rohit, Sylaja, P.N., Srivastava, M.V. Padma, Komakula, Snigdha, Iype, Thomas, Parthasarathy, Rajsrinivas, Khurana, Dheeraj, Pardasani, Vibhor, Pamidimukkala, Vijaya, Kumaravelu, S., Pandian, Jeyaraj, Kushwaha, Suman, Chowdhury, Debashish, Gupta, Salil, Rajendran, Srijithesh P., Reddy, Rajshekar, Roy, Jayanta, Sharma, Arvind, Nambiar, Vivek, Rai, Nirendra Kumar, Upadhyay, Ashish Datt, Parkipandla, Sathish, Singh, Mamta Bhushan, Vibha, Deepti, Vishnu, Venugopalan Y., Rajan, Roopa, Gupta, Anu, Pandit, Awadh Kishore, Agarwal, Ayush, Gaikwad, Shailesh B., Garg, Ajay, Joseph, Leve, Sreedharan, Sapna Erat, Reddy, Sritheja, Sreela, Krishna, Ramachandran, Dileep, George, Githin Benoy, Panicker, Praveen, Suresh, M.K., Gupta, Vipul, Ray, Sucharita, Suri, Vikas, Ahuja, Chirag, Kajal, Kamal, Lal, Vivek, Singh, Rakesh K., Oza, Harsh, Halani, Hiral, Sanivarapu, Srinivasareddy, Sahonta, Rajeshwar, Duggal, Ashish, Dixit, Prashant, Kulkarni, Girish Baburao, Taallapalli, A.V.R., Parmar, Mamta, Chalasani, Vamsi, Kashyap, Manshi, Misra, Biswamohan, Pachipala, Sudheer, Yogeesh, P.M., Salunkhe, Manish, and Gupta, Pranjal

Published
2021
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31. Comparative contribution of magnetoencephalography (MEG) and single-photon emission computed tomography (SPECT) in pre-operative localization for epilepsy surgery: A prospective blinded study

Author

Kaur, Kirandeep, Garg, Ajay, Tripathi, Madhavi, Chandra, Sarat P., Singh, Gaurav, Viswanathan, Vibhin, Bharti, Kamal, Singh, Vivek, Ramanujam, Bhargavi, Bal, Chandra Sekhar, Sharma, Mehar Chand, Pandey, Ravindra, Vibha, Deepti, Singh, Rajesh Kumar, Mandal, Pravat Kumar, and Tripathi, Manjari

Published
2021
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32. Biosimilar tenecteplase versus alteplase in acute ischemic stroke: A real world study

Author

Mohan, Ayush, Komakula, Snigdha, Murali, Suhas, Anand, Pooja, Shah, Dyuti, Vishnu, V., Pandit, Awadh, Agarwal, Ayush, Vibha, Deepti, Singh, Mamta, Srivastava, M. Padma, and Bhatia, Rohit

Subjects
Stroke (Disease) -- Drug therapy, Biosimilar pharmaceuticals -- Testing -- Comparative analysis, Tissue plasminogen activator -- Testing -- Comparative analysis, Health
Abstract

Byline: Ayush. Mohan, Snigdha. Komakula, Suhas. Murali, Pooja. Anand, Dyuti. Shah, V. Vishnu, Awadh. Pandit, Ayush. Agarwal, Deepti. Vibha, Mamta. Singh, M. Padma Srivastava, Rohit. Bhatia Background and Purpose: There [...]

Published
2023

33. Safety and Efficacy of Injection Tenecteplase in 4.5 to 24 Hours Imaging Eligible Window Patients with Acute Ischemic Stroke (EAST-AIS) - Study Protocol.

Author

Pandit, Awadh Kishor, Jatwani, Arti, Tangri, Poorvi, Srivastava, Madakasira Vasantha Padma, Bhatia, Rohit, Kale, Shashank Sharad, Gaikwad, Shailesh, Srivastava, Achal Kumar, Garg, Ajay, Joseph, Leve Sebastian, Vibha, Deepti, Vishnu, Venugopalan Y., Singh, Rajesh Kumar, Radhakrishnan, Divya M., Das, Animesh, and Agarwal, Ayush

Subjects
PATIENT safety, COMPUTED tomography, FIBRINOLYTIC agents, RANDOMIZED controlled trials, MAGNETIC resonance imaging, INJECTIONS, ISCHEMIC stroke, DRUG efficacy, THROMBECTOMY
Abstract

Background and Aims: Tenecteplase is used as the standard of care treatment for thrombolysis in acute ischemic stroke (AIS) patients within 4.5 h of symptom onset. Documented reports were less certain to claim the benefits of it in an extended window period. EAST-AIS (CTRI/2022/03/040718) trial is designed to determine the success rate of thrombolysis in an extended window period for good clinical outcomes. Study Design: It is a randomized, placebo-controlled trial of tenecteplase administered within 4.5-24 h of stroke onset (with or without large vessel occlusion) based on evidence of salvageable tissue through baseline computed tomography perfusion (CTP) or magnetic resonance imaging (MRI) scan. Criteria of patient inclusion are as follows: patients of both genders (male and female), age >18 years, pre-stroke modified Ranking Scale (mRS) <2, baseline NIHSS >5, CTP showing penumbra--ischemic core ratio >1.8, absolute difference in volume >10 ml, and ischemic core volume <70 ml. The sample size for the study is 100 patients: 50 in the tenecteplase arm (0.25 mg/kg body weight; maximum- 25 mg) and 50 in the placebo arm (controls). Study Outcomes: The study's primary objective is safety endpoints along with the efficacy of tenecteplase assessed using the mRS score at 90 days of stroke onset. Conclusion: The result obtained from EAST-AIS will determine the safety and efficacy of tenecteplase injection administered 4.5-24 h following the symptom onset for AIS patients within the territory of Internal Carotid Artery (ICA), Middle Cerebral Artery (MCA), or Anterior Cerebral Artery (ACA) occlusion. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Prognostic biomarkers of intracerebral hemorrhage identified using targeted proteomics and machine learning algorithms.

Author

Misra, Shubham, Kawamura, Yuki, Singh, Praveen, Sengupta, Shantanu, Nath, Manabesh, Rahman, Zuhaibur, Kumar, Pradeep, Kumar, Amit, Aggarwal, Praveen, Srivastava, Achal K., Pandit, Awadh K., Mohania, Dheeraj, Prasad, Kameshwar, Mishra, Nishant K., and Vibha, Deepti

Subjects
MACHINE learning, CEREBRAL hemorrhage, PROGNOSIS, PROTEOMICS, REGRESSION analysis, HAPTOGLOBINS
Abstract

Early prognostication of patient outcomes in intracerebral hemorrhage (ICH) is critical for patient care. We aim to investigate protein biomarkers' role in prognosticating outcomes in ICH patients. We assessed 22 protein biomarkers using targeted proteomics in serum samples obtained from the ICH patient dataset (N = 150). We defined poor outcomes as modified Rankin scale score of 3–6. We incorporated clinical variables and protein biomarkers in regression models and random forest-based machine learning algorithms to predict poor outcomes and mortality. We report Odds Ratio (OR) or Hazard Ratio (HR) with 95% Confidence Interval (CI). We used five-fold cross-validation and bootstrapping for internal validation of prediction models. We included 149 patients for 90-day and 144 patients with ICH for 180-day outcome analyses. In multivariable logistic regression, UCH-L1 (adjusted OR 9.23; 95%CI 2.41–35.33), alpha-2-macroglobulin (aOR 5.57; 95%CI 1.26–24.59), and Serpin-A11 (aOR 9.33; 95%CI 1.09–79.94) were independent predictors of 90-day poor outcome; MMP-2 (aOR 6.32; 95%CI 1.82–21.90) was independent predictor of 180-day poor outcome. In multivariable Cox regression models, IGFBP-3 (aHR 2.08; 95%CI 1.24–3.48) predicted 90-day and MMP-9 (aOR 1.98; 95%CI 1.19–3.32) predicted 180-day mortality. Machine learning identified additional predictors, including haptoglobin for poor outcomes and UCH-L1, APO-C1, and MMP-2 for mortality prediction. Overall, random forest models outperformed regression models for predicting 180-day poor outcomes (AUC 0.89), and 90-day (AUC 0.81) and 180-day mortality (AUC 0.81). Serum biomarkers independently predicted short-term poor outcomes and mortality after ICH. Further research utilizing a multi-omics platform and temporal profiling is needed to explore additional biomarkers and refine predictive models for ICH prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Prevalence and Risk Factors of Cerebral Microbleeds in Community-Dwelling Adults in Urban Delhi.

Author

Jali, Vidishaa, Mishra, Nalini K., Vibha, Deepti, Dwivedi, Sada N., Srivastava, Achal K., Verma, Vivek, Kumar, Amit, Nair, Pallavi, and Prasad, Kameshwar

Subjects
RISK assessment, CROSS-sectional method, INDEPENDENT living, RESEARCH funding, BRAIN, LOGISTIC regression analysis, HYPERTENSION, SMOKING, MAGNETIC resonance imaging, DISEASE prevalence, ODDS ratio, METROPOLITAN areas, CONFIDENCE intervals, COMPARATIVE studies, STROKE, CEREBRAL hemorrhage, COGNITION, DISEASE risk factors, OLD age
Abstract

Background: Several observational studies have reported the prevalence of cerebral microbleeds (CMBs) and their risk factors in an elderly population. Any information in this regard is currently lacking from India. Aim of this study was to estimate the prevalence, risk factors of CMBs, and association with cognition in an Indian urban population aged 50 years and above. Methods: Household surveys were conducted as part of ongoing Longitudinal Cognition and Aging Research on Population of the National Capital Region (LoCARPoN) study in areas of urban Delhi. Magnetic resonance imaging of the brain was performed in 2599 participants. Using standard neuropsychological battery, mean Z-scores for each domain (memory, executive, information) were derived. Binary and stepwise logistic regression models were used to determine associated risk factors for the presence of CMB and its association with cognitive domains. Results: The prevalence of CMBs was 14.42% (95% confidence interval [CI]: 13.06-15.73). Of these, 203 (7.81%) participants had single CMBs and 172 (6.61%) had multiple microbleeds (≥2). Higher prevalence was observed in older age (6070 years: odds ratio [OR]: 1.25 [95% CI: 0.93-1.67]; 70-80 years: OR: 2.05 [95% CI: 1.48-2.84]; ≥80 years: OR: 3.27 [95% CI: 1.97-5.44]) compared to individuals in the age group 50-60 years. History of stroke (OR: 2.97 [95% CI: 1.56-5.66]), hypertension (OR: 1.36 [95% CI: 1.05-1.75]), and smoking (OR: 1.43 [95% CI: 1.11-1.85]) was associated with at least one CMB. Multiple CMBs were associated with worse scores in memory and executive domains. Conclusion: Older age, hypertension, history of stroke, and history of smoking emerged as important risk factors for the presence of multiple CMBs. Follow-up study is required to determine implications of CMBs. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Association of obstructive sleep apnea and sleep quality with cognitive function: a study of middle-aged and elderly persons in India

Author

Haldar, Partha, primary, Tripathi, Manjari, additional, Prasad, Kameshwar, additional, Kant, Shashi, additional, Dwivedi, Sada Nand, additional, Vibha, Deepti, additional, Pandit, Awadh Kishor, additional, Srivastava, Achal Kumar, additional, Kumar, Amit, additional, Ikram, MArfan, additional, and Henning, Tiemeier, additional

Published
2023
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45. Efficacy and safety of injection Tenecteplase in 4.5 to 24 hours imaging eligible window patients with acute ischemic stroke (EAST-AIS) – An interim analysis

Author

Tangri, Poorvi, primary, Pandit, Awadh Kishor, additional, Arora, Bhoomika, additional, Jatwani, Arti, additional, Padma Srivastava, M.V., additional, Bhatia, Rohit, additional, Srivastava, Achal Kumar, additional, Vibha, Deepti, additional, Vishnu, V.Y., additional, Singh, Rajesh, additional, Radhakrishnan, Divya, additional, Das, Animesh, additional, and Agarwal, Ayush, additional

Published
2023
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46. Efficacy and safety of injection Tenecteplase in 4.5–24 hours imaging eligible window patients with acute ischemic stroke

Author

Arora, Bhoomika, primary, Tangri, Poorvi, additional, Pandit, Awadh, additional, Jatwani, Arti, additional, Padma Srivastava, M.V., additional, Bhatia, Rohit, additional, Srivastava, Achal Kumar, additional, Vibha, Deepti, additional, Vishnu, V.Y., additional, Singh, Rajesh, additional, Radhakrishnan, Divya, additional, Das, Animesh, additional, and Agarwal, Ayush, additional

Published
2023
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47. Determinants of one year outcome of central nervous system (CNS) tubercular mass lesions: An ambispective cohort study

Author

Vibha, Deepti, primary, Kushwaha, Suman, additional, Singh, Rajesh, additional, Tripati, Manjari, additional, Das, Animesh, additional, Nath, Manabesh, additional, Arunmozhimaran, Elavarasi, additional, Srivastava, Achal Kumar, additional, Radhakrishnan, Divya, additional, Ramanujam, Bhargavi, additional, and Pandit, Awadh, additional

Published
2023
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