1. Evaluation of noninvasive hemoglobin monitoring in children with congenital heart diseases
- Author
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Beshoy Nawar, Victor F Jacob, Ahmed Hasanin, Wafaa Mohamed Alsadek, Sarah Abdelsalam Elmetwally, Hany Elhadi, Mohamed Kamel, and Maha Mostafa
- Subjects
Heart Defects, Congenital ,Male ,medicine.medical_specialty ,Correlation coefficient ,Heart disease ,Anemia ,Hemoglobins ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,030225 pediatrics ,Internal medicine ,Preoperative Care ,medicine ,Humans ,Oximetry ,Prospective Studies ,Oxygen saturation ,business.industry ,Infant ,Reproducibility of Results ,medicine.disease ,Confidence interval ,Anesthesiology and Pain Medicine ,Quartile ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cardiology ,Arterial line ,Female ,Hemoglobin ,business - Abstract
Background Noninvasive measurement of blood hemoglobin could save time and decrease the risk of anemia and infection. The accuracy of CO-oximetry-derived noninvasive hemoglobin (Sp-Hb) had been evaluated in pediatric population; however, its accuracy in children with congenital heart disease has not been studied till date. We evaluated the accuracy of Sp-Hb in relation to laboratory-measured hemoglobin (Lab-Hb) in children with congenital heart disease. Methods This prospective observational study included children with congenital heart disease undergoing procedural intervention. Sp-Hb measurements were obtained using Radical-7 Masimo pulse CO-oximeter and were compared against simultaneous Lab-Hb measurements obtained from the arterial line. Children were divided in cyanotic and acyanotic, and separate analysis was performed for each group. The values of both measurements were analyzed using Spearman's correlation coefficient and Bland-Altman analysis. Correlation was performed between Sp-Hb and Lab-Hb bias and each of arterial oxygen saturation and perfusion index. Results One-hundred and eleven pairs of readings were obtained from 65 children. The median (quartiles) age and weight of the children were 1 (1.2-4) years and 11 (8-17) kg, respectively. There was moderate correlation between Lab-Hb and Sp-Hb with a correlation coefficient (95% confidence interval [CI]) of 0.75 (0.63-0.83) in acyanotic children and 0.62 (0.37-0.79) in cyanotic children. The mean bias (95% limits of agreements) was -0.4 g/dL (-2.4 to 1.6 g/dL) and 1 g/dL (-2.7 to 4.6 g/dL) in acyanotic and cyanotic children, respectively. The mean bias between Sp-Hb and Lab-Hb showed a weak negative correlation with oxygen saturation (r [95% CI]): (-0.36 [-0.51--0.18]), and a weak positive correlation with the perfusion index (r [95% CI]): (0.19 [0.01-0.37]). Conclusion The large bias and the wide limits of agreement between Sp-Hb and Lab-Hb denote that Masimo-derived Sp-Hb is not accurate in children with congenital heart disease especially in the cyanotic group; the error in Sp-Hb increases when oxygen saturation decreases.
- Published
- 2020