1. Prognostic Factors of Death in 151 Adults With Hemophagocytic Syndrome: Etiopathogenically Driven Analysis
- Author
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Pilar Brito-Zerón, MD, PhD, Belchin Kostov, PhD, Pedro Moral-Moral, MD, Aleida Martínez-Zapico, MD, Carmen Díaz-Pedroche, MD, PhD, Guadalupe Fraile, MD, Patricia Pérez-Guerrero, MD, Eva Fonseca, MD, Angel Robles, MD, María P. Vaquero-Herrero, MD, María Andrés Calvo, MD, María José Forner, MD, Cesar Morcillo, MD, José Larrañaga, MD, Monica Rodriguez-Carballeira, MD, Manuel Ruiz-Muñoz, MD, Robert Hurtado-García, MD, Sergio Prieto-González, MD, PhD, Asun Aljibe Aguilar, MD, Luis Caminal-Montero, MD, Pilar Hernández-Jiménez, MD, Cristina Rodríguez Fernández-Viagas, MD, Pedro Castro, MD, PhD, Victoria Morell Massó, MD, Alejandra Flores-Chavez, MD, and Manuel Ramos-Casals, MD, PhD
- Subjects
Medicine (General) ,R5-920 - Abstract
Objective: To characterize the etiologies and clinical features at diagnosis of patients with hemophagocytic lymphohistiocytosis (HLH) and correlate these baseline features with survival using an etiopathogenically guided multivariable model. Patients and Methods: The Spanish Group of Autoimmune Diseases HLH Study Group, formed in 2013, is aimed at collecting adult patients with HLH diagnosed in internal medicine departments between January 3, 2013, and October 28, 2017. Results: The cohort consisted of 151 patients (91 men; mean age, 51.4 years). After a mean follow-up of 17 months (range, 1-142 months), 80 patients died. Time-to-event analyses for death identified a worse survival curve for patients with neoplasia (P
- Published
- 2018
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