706 results on '"Viegas S"'
Search Results
2. Oral salbutamol for symptomatic treatment in MuSK antibody-positive myasthenia gravis: a single-centre experience
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Baheerathan, A., Dorsey, R., and Viegas, S.
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- 2024
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3. International Society Exposure Science Annual Meeting 2022—from exposure to human health: new developments and challenges in a changing environment
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Viegas, S., Schlüter, U., and Almeida-Silva, M.
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- 2023
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4. The Lexington Benchmarks for Numerical Simulations of Nebulae
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Ferland, G., Binette, L., Contini, M., Harrington, J., Kallman, T., Netzer, H., Péquignot, D., Raymond, J., Rubin, R., Shields, G., Sutherland, R., and Viegas, S.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the results of a meeting on numerical simulations of ionized nebulae held at the University of Kentucky in conjunction with the celebration of the 70th birthdays of Profs. Donald Osterbrock and Michael Seaton., Comment: http://adsabs.harvard.edu/abs/1995aelm.conf...83F. The Analysis of Emission Lines, Proc. STScI Symposium May 16--18, 1994, Eds. R.E. Williams & M. Livio, Cambridge University Press, p. 83
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- 2016
5. Roadmap for action for advancing aggregate exposure to chemicals in the EU.
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Lamon, L., Doyle, J., Paini, A., Moeller, R., Viegas, S., Cubadda, F., Hoet, P., van Nieuwenhuyse, A., Louro, H., Dusinska, M, Galea, K.S., Canham, R., Martins, C., Gama, A., Teófilo, V., Diniz‐da‐Costa, M., João Silva, M., Ventura, C., Alvito, P., and El Yamani, N.
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STAKEHOLDER analysis ,KNOWLEDGE gap theory - Abstract
The European Food Safety Authority (EFSA) has a goal to efficiently conduct aggregate exposure assessments (AEAs) for chemicals using both exposure models and human biomonitoring (HBM) data by 2030. To achieve EFSA's vision, a roadmap for action for advancing aggregate exposure (AE) in the EU was developed. This roadmap was created by performing a series of engagement and data collection activities to map the currently available methods, data, and tools for assessing AE of chemicals, against the needs and priorities of EFSA. This allowed for the creation of a AEA framework, identification of data and knowledge gaps in our current capabilities, and identification of the challenges and blockers that would hinder efforts to fill the gaps. The roadmap identifies interdependent working areas (WAs) where additional research and development are required to achieve EFSA's goal. It also proposes future collaboration opportunities and recommends several project proposals to meet EFSA's goals. Eight proposal projects supported by SWOT analysis are presented for EFSA's consideration. The project proposals inform high‐level recommendations for multi‐annual and multi‐partner projects. Recommendations to improve stakeholder engagement and communication of EFSA's work on AEA were gathered by surveying stakeholders on specific actions to improve EFSA's communication on AE, including webinars, virtual training, social media channels, and newsletters. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Outflows of very ionized gas in the center of Seyfert galaxies: kinematics and physical conditions
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Rodriguez-Ardila, Alberto, Prieto, M. A., Viegas, S., and Gruenwald, R.
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Astrophysics - Abstract
Mid-resolution spectra are used to deduce the size and kinematics of the coronal gas in a sample of Seyfert galaxies by means of observations of the [FeXI], [FeX], [FeVII], [SiVI] and [SiVII] lines. These coronal lines (CL) extend from the unresolved nucleus up to a few tens to a few hundreds of parsecs. The region of the highest ionized ions studied, [FeXI] and [FeX], is the least spatially extended, and concentrates at the center; intermediate ionization lines extend from the nucleus up to a few tens to a few hundred parsecs; lower [OIII]-like ions are known to extendin the kpc range. All together indicates a stratification in the ionized gas, usually interpreted in terms of nuclear photoionization as the driving ionization mechanism. However, CL profiles show various peculiarities: they are broader by a factor of two than lower ionization lines, the broadening being in terms of asymmetric blue wings, and their centroid position at the nucleus is blueshifted by a few hundreds of km/s. Moreover, in NGC1386 and NGC1068, a double peak [FeVII] line is detected in the nuclear and extended coronal region, this being the first report in of such type of profile in CL in active galactic nuclei. If interpreted as outflow signatures, the total broadening of the lines at zero intensity levels implies gas velocities up to 2000 km/s. Although the stratification of ions across the coronal region means that photoionization is the main power mechanism, the high velocities deduced from the profiles, the relatively large spatial extension of the emission, and the results from photoionization models indicate that an additional mechanism is at work. We suggest that shocks generated by the outflow could provide the additional required power for line formation., Comment: Accepted for publication in the Astrophysical Journal. 40 pages, 15 figures. Minor changes made on the affiliation of one co-author
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- 2006
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7. Slit Observations and Empirical Calculations for HII Regions
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Fernandes, I. F., Gruenwald, R., and Viegas, S. M.
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Astrophysics - Abstract
When analysing HII regions, a possible source of systematic error on empirically derived physical quantities is the limited size of the slit used for the observations. A grid of photoionization models was built through the Aangaba code varying the ionizing radiation spectrum emitted by a stellar cluster, as well as the gas abundance. The calculated line surface brightness was then used to simulate slit observations and to derive empirical parameters using the usual methods described in the literature. Depending on the fraction of the object covered by the slit, the parameters can be different from those obtained from observations of the whole object, an effect that is mainly dependent on the age of the ionizing stellar cluster. The low-ionization forbidden lines are more sensitive to the size of the area covered by the slit than the high-ionization forbidden lines or recombination lines. Regarding the temperature indicator T[OIII], the slit effects are small since this temperature is derived from [OIII] lines. On the other hand, for the abundance indicator R23, which depends also on the [OII] line, the slit effect is slightly higher. Therefore, the systematic error due to slit observations on the O abundance is low, being usually less than 10%, except for HII regions powered by stellar clusters with a relative low number of ionizing photons between 13.6 and 54.4 eV, which create a smaller O++ emitting volume. In this case, the systematic error on the empirical O abundance deduced from slit observations is more than 10% when the covered area is less than 50%., Comment: To be published in MNRAS, accepted in 09/09/2005, 17 pages and 6 figures
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- 2005
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8. The continuum and narrow line region of the NLS1 galaxy Mrk 766
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Rodriguez-Ardila, A., Contini, M., and Viegas, S. M.
- Subjects
Astrophysics - Abstract
We present the first spectroscopic observations in the interval 0.8-4.0 microns, complemented with HST/UV and optical spectroscopy, of the narrow line Seyfert 1 galaxy Mrk766. The NIR spectrum is characterized by permitted lines of HI, HeI, HeII and FeII, and forbidden lines of [SII], [SIII] and [FeII] among others. High ionized species such as [SiIX], [SiX], [SIX] and [MgVII] are also observed. The continuum has a complex shape, with contribution of the central engine, circumnuclear stellar population and dust. This last component is evidenced by the presence of an excess of emission peaking at 2.25 microns, fitted by blackbody function with T_bb=1200K. That temperature is close to the evaporation temperature of graphite grains. As such, it provides strong evidence of hot dust, probably very close to the nucleus. Consistent modeling of the line and broad band continuum spectrum by composite models, which account for the photoionizing flux of the central engine and shocks, shows that the shock velocities are between 100 and 500 km/s, the preshock densities between 100 and 1000 cm^-3 and the radiation fluxes from the active centre between 10^9 and 5x10^12 photons cm^-2 s^-1 eV^-1 at 1 Ryd with spectral indices $\alpha_{UV}$=-1.5 and $\alpha_X$=-0.4. Adopting silicon grains, dust-to-gas ratios are between 10^-{6} and 4x10$^{-4}$ by mass. The emitting clouds are at an average distance of 160 pc from the centre, with high velocity clouds closer and low velocity clouds farther from the centre. The N/H relative abundance could be twice solar. In constrast, Fe is depleted from the gaseous phase by a factor >2. Ratios of calculated to observed line ratios to Hbeta indicate an average contribution of the broad line region to the observed Hbeta of about 40%., Comment: 15 pages, 6 figures. Accepted to MNRAS
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- 2004
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9. Extended Coronal Emission Lines in Active Galactic Nuclei
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Rodriguez-Ardila, A., Prieto, A., and Viegas, S. M.
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Astrophysics - Abstract
VLT and NTT spectra are used to examine the nuclear and extended coronal line emission in a sample of well-known Seyfert 1 and 2 galaxies. The excellent spatial resolution obtained with VLT allowed us to map [SiVI] 1.963 $\mu$m and [SiVII] 2.48 $\mu$m on scales of up to 20 pc. Coronal line emission, extended to distances of $\sim$100 pc, is detected in some of the lines analyzed, particularly in [FeX] 6374\AA, [FeXI] 7891\AA, and [SiVII] 2.48$\mu$m. Most coronal lines are strongly asymmetric towards the blue and broader than low-ionization lines. This result is particularly important for Circinus, where previous observations had failed at detecting larger widths for high-ionization lines. Photoionization models are used to investigate the physical conditions and continuum luminosities necessary to produced the observed coronal emission. We found that an ionization parameter U> 0.10 is necessary to reproduce the observations, although the clouds should be located at distances < 30 pc., Comment: 4 pages, 6 figures, to appear in proceedings of IAU Symposium No. 222, The Interplay Among Black Holes, Stars and ISM in Galacti Nuclei
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- 2004
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10. The Infrared Continuum of Active Galaxies
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Contini, M., Viegas, S. M., and Prieto, M. A.
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Astrophysics - Abstract
We discuss the different physical processes contributing to the infrared continuum of AGN, assuming that both photoionization from the active center and shocks ionize and heat the gas and dust contained in an ensemble of clouds surrounding the nucleus. Radiation transfer of primary and secondary radiation throughout a cloud is calculated consistently with collisional processes due to the shock. We consider that the observed continuum corresponds to reprocessed radiation from both dust and gas in the clouds. The model is applied to the continuum of Seyfert galaxies from which best estimate of the nuclear, stellar subtracted, emission is available. The results show that radiation-dominated high velocity clouds are more numerous in Seyfert 1-1.5 whereas shock-dominated low velocity clouds are dominant in Seyfert type 2 in full agreement with the unified model for AGN. In type 2 objects, radiation is partly suppressed by a central dusty medium with a high dust-to-gas ratio. A grid of models is used to provide a phenomenological analysis of the observed infrared spectral energy distribution., Comment: 14 pages, 10 figures. in press in MNRAS
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- 2003
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11. The Infrared-X-ray continuum correlation in Active Galactic Nuclei
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Contini, M., Viegas, S. M., and Campos, P. E.
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Astrophysics - Abstract
The correlation between the soft X-ray and near infrared emission from AGN is analysed using composite models by the code SUMA. We find new evidences for differences in ranges of parameters which characterize the NLR of Seyfert galaxies and LINERs. Results obtained by modelling the Einstein and the ROSAT samples of galaxies are in full agreement. In order to fit the infrared and X-ray continua, an eta factor is defined, which accounts for the emitting area of the cloud. If the infrared emission is due to bremsstrahlung and comes from the same cloud producing the soft X-rays, the eta values obtained from both emissions must be the same. Therefore, if eta_IR < eta_soft-X there must be a strong contribution of soft X-rays from the active centre. From the eta values we expect to identify the objects that could present strong variability. \, Comment: 11 pages,13 figures, in press in MNRAS. in press in MNRAS
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- 2003
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12. Hidden starburst in Seyfert 1 Galaxies
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Rodriguez-Ardila, A. and Viegas, S.
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Astrophysics - Abstract
We report the detection of the 3.3 mu Polycyclic Aromatic Hydrocarbon (PAH) feature in two Seyfert 1 galaxies - NGC 3227 and Mrk 766, and one QSO - Mrk 478, observed with SpeX at IRTF at a spectral resolution not previously attained for this type of objects. Except for NGC 3227, this is the first time that the 3.3 mu PAH emission is detected in Mrk 766 and Mrk 478. The widths of the emission, reported also for the first time, are rather similar, ranging from 450 A to 550 A. The luminosity of the 3.3 mu PAH emission measured in the QSO Mrk 478 places it at a level similar of that found in starburst and infrared luminous galaxies and implies that this object is having a vigorous burst of star formation. The spatial resolution of the spectra allows us to constrain the location of the star-forming region to the inner 1 Kpc for the QSO and 150 pc for the Seyferts. Our results support the idea that these objects resides in molecular gas-rich galaxies and that their observed infrared excess is primarily due to star formation, as previously indicated by CO and H_2 observations. We also report, for Mrk 1239, the presence of a broad emission feature centred at 3.43 mu, not previosly detected in an extragalactic object and whose origin is not yet clear., Comment: 5 pages, 1 figure. Accepted to MNRAS pink pages
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- 2003
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13. The OI Line Emission in Active Galactic Nuclei Revisited
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Rodriguez-Ardila, A., Viegas, S. M., Pastoriza, M. G., Prato, L., and Donzelli, Carlos J.
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Astrophysics - Abstract
UV, visible, and near-infrared spectroscopy is used to study the transitions of neutral oxygen leading to the emission of broad OI $\lambda$8446, $\lambda$11287 and $\lambda$1304 in Active Galactic Nuclei. From the strength of the former two lines, contrary to the general belief, we found that in six out of seven galaxies, L-beta fluorescence is not the only mechanism responsible for the formation of these three lines. Because OI $\lambda$13165 is almost reduced to noise level, continuum fluorescence is ruled out as an additional excitation mechanism, but the presence of OI $\lambda$7774 in one of the objects suggests that collisional ionization may have an important role in the formation of OI $\lambda$8446. The usefulness of the OI lines as a reliable reddening indicator for the broad line region is discussed. The values of E(B-V) derived from the OI $\lambda 1304/\lambda$8446 ratio agree with those obtained using other reddening indicators. The observations point toward a break in the one-to-one photon relation between OI $\lambda$8446 and OI $\lambda$1304, attributable to several destruction mechanisms that may affect the latter line., Comment: 26 pages, 5 figures. Accepted for publication in ApJ
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- 2002
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14. The signature of high velocity gas in the spectra of NGC 4151
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Contini, M., Viegas, S. M., and Prieto, M. A.
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Astrophysics - Abstract
The multiwavelength emission spectrum and associated velocity field of the Seyfert prototype NGC 4151 is modeled. HST data has impressively revealed the existence of a large range of velocities (100 - 1500 \kms) dominating the emitting clouds in the extended emission line region of the galaxy. Following this observational result, a revision of the photoionization modeling approach applied to NGC 4151 is presented. It is concluded that a mixture of radiation dominated clouds and shock dominated clouds are required to explain the multiwavelength line and continuum spectra of the galaxy., Comment: 16 pages, LaTeX class for Astronomy and Astrophysics (including 3 Tables) + 8 PostScript figures. To appear in "Astronomy and Astrophysics"
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- 2002
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15. Infrared FeII Emission in Narrow-Line Seyfert 1 Galaxies
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Rodriguez-Ardila, A., Viegas, S. M., Pastoriza, M. G., and Prato, L.
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Astrophysics - Abstract
We obtained 0.8-2.4 micron spectra at a resolution of 320 km/s of four narrow-line Seyfert 1 galaxies in order to study the near-infrared properties of these objects. We focus on the analysis of the FeII emission in that region and the kinematics of the low-ionization broad lines. We found that the 1 micron FeII lines (9997 A, 10501 A, 10863 A and 11126 A) are the strongest FeII lines in the observed interval. For the first time, primary cascade lines of FeII arising from the decay of upper levels pumped by Ly-alpha fluorescence are resolved and identified in active galactic nuclei. Excitation mechanisms leading to the emission of the 1 micron FeII features are discussed. A combination of Ly-alpha fluorescence and collisional excitation are found to be the main contributors. The flux ratio between near-IR FeII lines varies from object to object, in contrast to what is observed in the optical region. A good correlation between the 1 micron and optical FeII emission is found. This suggests that the upper z4Fo and z4Do levels from which the bulk of the optical lines descend are mainly populated by the transitions leading to the 1 micron lines. The width and profile shape of FeII 11127, CaII 8642 and OI 8446 are very similar but significantly narrower than Pa-beta, giving strong observational support to the hypothesis that the region where FeII, CaII and OI are produced are co-spatial, interrelated kinematically and most probably located in the outermost portion of the BLR., Comment: Accepted for publication in ApJ - 35 pages
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- 2001
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16. A grid of Composite Models for the Simulation of Starburst Galaxy and HII Region Spectra
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Contini, M. and Viegas, S. M.
- Subjects
Astrophysics - Abstract
A grid of models for starburst spectra is presented and compared with power-law models which represent AGNs. The models are composite, i.e., they account for the radiation from the starburst and for the shocks created by super-winds. Some interesting fit of models to observations are also discussed. In particular, it is found that [OIII]/Hb ~can reach values as high as for the AGN when the emitting clouds are close to the starburst region. Moreover CIV lines can be high even if SiIV lines are relatively low. It is found that for some line ratios, which have similar values for starburst and AGN models, the width of the lines can distinguish between the two types., Comment: grpaper.tex + 10 tables PostScript + 9 figures PostScript Accepted for publication in ApJS
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- 2001
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17. Physical conditions in QSO absorbers from fine-structure absorption lines
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Silva, A. I. and Viegas, S. M.
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Astrophysics - Abstract
We calculate theoretical population ratios of the ground fine-structure levels of some atoms/ions which typically exhibit UV lines in the spectra of QSO absorbers redward the Ly-alpha forest: C0, C+, O0, Si+ and Fe+. The most reliable atomic data available is employed and a variety of excitation mechanisms considered: collisions with several particles in the medium, direct excitation by photons from the cosmic microwave background radiation (CMBR) and fluorescence induced by a UV field present. The theoretical population ratios are confronted with the corresponding column density ratios of C I and C II lines observed in damped Ly-alpha (DLA) and Lyman Limit (LL) systems collected in the recent literature to infer their physical conditions. The volumetric density of neutral hydrogen in DLA systems is constrained to be lower than tens of cm^-3 (or a few cm^-3 in the best cases) and the UV radiation field intensity must be lower than two orders of magnitude the radiation field of the Galaxy (one order of magnitude in the best cases). Their characteristic sizes are higher than a few pc (tens of pc in the best cases) and lower limits for their total masses vary from 10^0 to 10^5 solar masses. For the only LL system in our sample, the electronic density is constrained to be n_e<0.15 cm^-3. We suggest that the fine-structure lines may be used to discriminate between the current accepted picture of the UV extragalatic background as the source of ionization in these systems against a local origin for the ionizing radiation as supported by some authors. We also investigate the validity of the temperature-redshift relation of the CMBR predicted by the standard model and study the case for alternative models., Comment: 16 pages, 12 figures
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- 2000
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18. PopRatio: A program to calculate atomic level populations in astrophysical plasmas
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Silva, A. I. and Viegas, S. M.
- Subjects
Astrophysics ,Physics - Computational Physics - Abstract
We describe a Fortran 90 program to calculate population ratios of atomic levels. The program solves the equations of statistical equilibrium considering all possible bound-bound processes: spontaneous, collisional or radiation induced (the later either directly or by fluorescence). There is no limit on the number of levels or in the number of processes that may be taken into account. The program may find a wide range of applicability in astronomical problems, such as interpreting fine-structure absorption lines or collisionally excited emission lines (such as coronal emission lines) in the spectra of several objects, and also in calculating the cooling rates due to collisional excitation., Comment: 23 pages, no figures. Submitted to Computer Physics Communications. Code available at http://www.iagusp.usp.br/~alexsilv/popratio
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- 2000
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19. Temperature of the central stars of planetary nebulae and the effect of the nebular optical depth
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Gruenwald, R. and Viegas, S. M.
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Astrophysics - Abstract
The effect of the nebula optical depth on the determination of the temperature (T*) of the central stars in planetary nebulae is discussed. Based on photoionization models for planetary nebulae with different optical depths, we show, quantitatively, that the details of the distribution of the H and He II Zanstra temperatures are mainly explained by an optical depth effect; in particular, that the discrepancy is larger for low stellar temperatures. The results also show that for high stellar temperatures the He II Zanstra temperature underestimates the stellar temperature, even for high optical depths. The stellar temperature, as well as the optical depth, can be obtained from a Zanstra temperature ratio (ZR) plot ZR = Tz(He II)/Tz(H) versus Tz(He II). The effects of departures from a blackbody spectrum, as well as of the He abundance in the nebulae, are also discussed. For nebulae of very low optical depth and/or high stellar temperature the distribution ZR versus Tz(He II) only provides lower limits for T*. In order to obtain better values for the optical depth and T*, we propose the use of the line intensity ratio He II/He I versus Tz(He II) diagram., Comment: 24 pages, 4 figures; to appear in ApJ, Nov 2000
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- 2000
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20. A grid of composite models for the simulation of the emission-line spectra from the NLR of active galaxies
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Contini, M. and Viegas, S. M.
- Subjects
Astrophysics - Abstract
A grid of composite models for the narrow line region of active galaxies, which consistently account for both the effect of a photoionizing radiation from the active center and of a shock front, is presented. Theoretical results, calculated with the SUMA code, are given for different values of shock velocities, preshock densities, geometrical thickness of the clouds, and, particularly, for the ionizing radiation intensity in a large range. The input parameters are chosen within the ranges indicated by previous fits of several observed emission-line and continuum spectra from active galaxies. Shock velocities from 100 \kms ~to 1500 \kms ~and preshock densities from 100 \cm3 to 1000 \cm3 are considered. The line intensities of the most important ultraviolet, optical and infrared transitions are obtained and are listed in several tables., Comment: 14 pages Latex + 2 Postscript tables + 1 Postscript figures
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- 2000
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21. Morphology and kinematics of Planetary Nebulae II. A Diabolo model for NGC 3132
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Monteiro, H., Morisset, C., Gruenwald, R., and Viegas, S. M.
- Subjects
Astrophysics - Abstract
We use a 3D photoionization modeling tool to study the morpho-kinematic properties of the Planetary Nebula (PN) NGC 3132. We show that it is possible to reproduce the low resolution observations (spectra and images) with an ellipsoidal shell. However, high resolution observations, as those showing a density variation along the nebula and the [O III]5007 velocity profiles, definitively rule out this description. We show that a bipolar Diabolo shape with a 40 degres rotation of the symmetry axis relative to the line of sight successfully reproduces the observed images, as well as the high resolution observations., Comment: 9 pages, 7 figures, accepted in ApJ main serie
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- 2000
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22. The optical-ultraviolet continuum of Seyfert 2 galaxies
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Contini, M. and Viegas, S. M.
- Subjects
Astrophysics - Abstract
This paper aims to understand the continuum of Seyfert 2 galaxies. By fitting the single galaxies in the sample of Heckman et al. (1995) with composite models (shock+ photoionization from the active center), we show that five main components characterize the SED of the continuum. Shocks play an important role since they produce a high temperature zone where soft X-rays are emitted. We show that in the optical-UV range, the slope of the NLR emission reproduces the observed values, and may be the main component of the featureless continuum. The presence of star forming regions cannot be excluded in the circumnuclear region of various Seyfert galaxies. An attempt is made to find their fingerprints in the observed AGN spectra. Finally, it is demonstrated that multi-cloud models are necessary to interpret the spectra of single objects, even in the global investigation of a sample of galaxies., Comment: 26 pages, LaTeX (including 5 Tables) + 17 PostScript figures. To appear in "The Astrophysical Journal"
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- 2000
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23. Morphology and kinematics of Planetary Nebulae. I.A new modeling tool
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Morisset, C., Gruenwald, R., and Viegas, S. M.
- Subjects
Astrophysics - Abstract
We present a new modeling tool for planetary nebulae, based on 3D photoionization calculations. Our goal is to show that all the information provided by observations, regarding kinematics and morphology, have to be consistently accounted for, in order to get a real insight of the object. Only 3D simulations offer this possibility. From models for two theoretical PNe, we show that the enhancement in the equatorial zone observed in several PNe is not necessarily due to a density gradient, as usually interpreted. It is also shown that asymmetric velocity profiles often observed (e.g., Gesicki et al. 1998) can be easily reproduced. Observations providing a better insight on the morphology of the PN are discussed., Comment: 10 pages, 9 figures, accepted in ApJ Main Serie
- Published
- 1999
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24. A 3D morpho-kinematic study of NGC 3132
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Monteiro, H., Morisset, C., Gruenwald, R., and Viegas, S. M.
- Subjects
Astrophysics - Abstract
We present a new modeling tool for planetary nebulae (PNe), based on 3D photoionization calculations. From models for two theoretical PNe, we show that the enhancement in the equatorial zone observed in several PNe is not necessarily due to a density gradient, as usually interpreted. We study the morpho-kinematic properties of the PN NGC 3132 and show that a bipolar Diabolo shape successfully reproduces the observed images, as well as the high resolution observations., Comment: 4 pages, 6 figures, to appear in ``Asymmetrical Planetary Nebulae II: from Origins to Microstructures,'' ASP Conference Series, J.H. Kastner, N. Soker, & S.A. Rappaport, eds
- Published
- 1999
25. Ionization Corrections For Low-Metallicity H II Regions and the Primordial Helium Abundance
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Viegas, S. M., Gruenwald, R., and Steigman, G.
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Astrophysics - Abstract
Helium and hydrogen recombination lines observed in low-metallicity, extragalactic H II regions provide the data used to infer the primordial helium mass fraction, Y_P. The ionization corrections for unseen neutral helium (or hydrogen) are usually assumed to be absent; i.e., the ionization correction factor is taken to be unity (icf = 1). In this paper we revisit the question of the icf for H II regions ionized by clusters of young, hot, metal-poor stars. Our key result is that for the H II regions used in the determination of Y_P, there is a ``reverse'' ionization correction: icf < 1. We explore the effect on the icf of more realistic inhomogeneous H II region models and find that for those regions ionized by young stars, with ``hard'' radiation spectra, the icf is reduced further below unity. In Monte Carlos using H II region data from the literature (Izotov and Thuan 1998) we estimate a reduction in the published value of Y_P of order 0.003, which is roughly twice as large as the quoted statistical error in the Y_P determination., Comment: 23 pages, 2 postscript figures; ApJ accepted; minor changes
- Published
- 1999
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26. A Multi-Cloud Warm-Absorber Model for NGC 4051
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Contini, M. and Viegas, S. M.
- Subjects
Astrophysics - Abstract
A multi-cloud model is presented which explains the soft X-ray excess in NGC 4051 and, consistently, the optical line spectrum and the SED of the continuum. The clouds are heated and ionized by the photoionizing flux from the active center and by shocks. Diffuse radiation, partly absorbed throughout the clouds, nicely fits the bump in the soft X-ray domain, while bremsstrahlung radiation from the gaseous clouds contribute to the fit of the continuum SED. Debris of high density fragmented clouds are necessary to explain the absorption oxygen throats observed at 0.87 keV and 0.74 keV. The debris are heated by shocks of about 200-300 km/s. Low velocity (100 km/s)-density (100 cm-3) clouds contribute to the line and continuum spectra, as well as high velocity (1000 km/s)-density (8000 cm-3) clouds which are revealed by the FWHM of the line profiles. The SED in the IR is explained by reradiation of dust, however, the dust-to-gas ratio is not particularly high. Radio emission is well fitted by synchrotron radiation created at the shock front by Fermi mechanism., Comment: 19 pages + 3 figures PostScript
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- 1999
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27. Gas and Dust Emission from the Nuclear Region of the Circinus Galaxy
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Contini, M., Prieto, M. A., and Viegas, S. M.
- Subjects
Astrophysics - Abstract
Simultaneous modeling of the line and continuum emission from the nuclear region of the Circinus galaxy is presented. Composite models which include the combined effect of shocks and photoionization from the active center and from the circumnuclear star forming region are considered. The effects of dust reradiation, bremsstrahlung from the gas and synchrotron radiation are treated consistently. The proposed model accounts for two important observational features. First, the high obscuration of Circinus central source is produced by high velocity and dense clouds with characteristic high dust-to-gas ratios. Their large velocities, up to 1500 km\s, place them very close to the active center. Second, the derived size of the line emitting region is well in agreement with the observed limits for the coronal and narrow line region of Circinus., Comment: 36 pages, LaTex (including 4 Tables and 9 figures), $$ removed from Abstract To appear in "The Astrophysical Journal"
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- 1998
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28. The HBM4EU chromates study - Outcomes and impacts on EU policies and occupational health practices
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Santonen, T., Louro, H., Bocca, B., Bousoumah, R., Duca, R.C., Fucic, A., Galea, K.S., Godderis, L., Göen, T., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Ndaw, S., Poels, K., Porras, S.P., Ruggieri, F., Silva, M.J., Nieuwenhuyse, A. van, Verdonck, J., Wasowicz, W., Tavares, A., Sepai, O., Scheepers, P.T., Viegas, S., Santonen, T., Louro, H., Bocca, B., Bousoumah, R., Duca, R.C., Fucic, A., Galea, K.S., Godderis, L., Göen, T., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Ndaw, S., Poels, K., Porras, S.P., Ruggieri, F., Silva, M.J., Nieuwenhuyse, A. van, Verdonck, J., Wasowicz, W., Tavares, A., Sepai, O., Scheepers, P.T., and Viegas, S.
- Abstract
Contains fulltext : 291806.pdf (Publisher’s version ) (Open Access), Within the EU human biomonitoring initiative (HBM4EU), a targeted, multi-national study on occupational exposure to hexavalent chromium (Cr(VI)) was performed. Cr(VI) is currently regulated in EU under REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and under occupational safety and health (OSH) legislation. It has recently been subject to regulatory actions to improve its risk management in European workplaces. Analysis of the data obtained within the HBM4EU chromates study provides support both for the implementation of these regulatory actions and for national enforcement programs and may also contribute to the updating of occupational limit values (OELs) and biological limit values for Cr(VI). It also provides useful insights on the contribution of different risk management measures (RMMs) to further reduce the exposure to Cr(VI) and may support the evaluation of applications for authorisation under REACH. Findings on chrome platers' additional per- and polyfluoroalkyl substances (PFAS) exposure highlight the need to also pay attention to this substance group in the metals sector. A survey performed to evaluate the policy relevance of the HBM4EU chromates study findings supports the usefulness of the study results. According to the responses received from the survey, the HBM4EU chromates study was able to demonstrate the added value of the human biomonitoring (HBM) approach in assessment and management of occupational exposure to Cr(VI). For future occupational studies, we emphasise the need for engagement of policy makers and regulators throughout the whole research process to ensure awareness, relevance and uptake of the results in future policies.
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- 2023
29. the contribute of PMCardImpact project
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Martins, C, Lima, L, Gonçalves, S, Assunção, R, Serranheira, F, Viegas, S, Escola Nacional de Saúde Pública (ENSP), and Comprehensive Health Research Centre (CHRC) - Pólo ENSP
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SDG 3 - Good Health and Well-being - Abstract
publishersversion published
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- 2022
30. Exposure assessment of total DON in urine of Portuguese adult population under the HBM4EU aligned studies
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Alvito, P.C., Silva, M.J., Viegas, S., Vasco, E., Martins, C., Assunção, R., Silva, S., Gilles, L., Govarts, E., Schoeters, G., and Namorado, S.
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HBM4EU Aligned Studies ,Micotoxinas ,Portugal ,Avaliaçao do Risco ,Toxicologia ,Mycotoxins ,Determinantes da Saúde e da Doença - Abstract
P-22 | Risk prediction and assessment Mycotoxins are secondary metabolites of fungi that can be found in food commodities. Exposure to mycotoxins has been associated with several adverse health effects, including hepatotoxicity. nephrotoxicity, immunotoxicity, mutagenicity and carcinogenicity.As such, from a public health perspective it is important to monitor and to assess the risk associated to mycotoxins’ exposure. In the scope of the European Human Biomonitoring Initiative (HBM4EU), exposure to mycotoxins, namely to deoxynivalenol (DON) was analysed in adults from several European countries, including Portugal. Data was collected under the project “Exposure of the Portuguese Population to Environmental Chemicals: a study nested in INSEF 2015”. INSEF-ExpoQuim, was an epidemiological study nested in the first Portuguese Health Examination Survey (INSEF), that enrolled individuals aged 28–39 years, living in Portugal for more than 12 months and able to follow an interview in Portuguese. Fieldwork was developed between May 2019 and March 2020 and first morning urine samples were collected along with data on socio-demographic characteristics, living conditions and residential history, habits/ lifestyle, nutrition, health, occupation and substance specific information covering nearly all exposure pathways. Procedures followed the guidelines of HBM4EU. Total DON (sum of free DON + DONglucuronides after deconjugation) was determined in 295 urine samples by a qualified laboratory and using a harmonized analytical method. Results: showed that the Portuguese population was exposed to DON (mean = 9.8 mg/L; 95% CI: 8.7–10.9 mg/L). DON concentrations were significantly higher for samples collected in spring and summer. Individuals living in rural areas and with a lower education levels presented higher exposures to DON, as well as individuals with a higher bread consumption frequency (≥4 times per week). No differences were found regarding sex, age, occupation, income or consumption of other foods. Comparing this study’s data with the human biomonitoring guidance value (HBM-GV) determined for DON in the scope of HBM4EU (Total DON: 0.69 μg DON/kg bw/total 24 h ≈ 23 μg DON/L urine) 12.5% of the participants presented values above the HBM-GV. Overall, the results from this study showed that the Portuguese population is currently exposed to DON, with a significant proportion of individuals presenting exposures to values that warrant further assessment, including a close monitoring of exposure in the future and the development and implementation of policy measures aimed at minimizing exposure and improving the health of the population. This work was conducted under the HBM4EU project and was funded by the European Union’s Horizon 2020 research and innovation program under grant agreement no. 733032. Thanks are also due to FCT/MCTES through national funds, to CESAM (UIDP/ 50017/2020+UIDB/50017/2020). info:eu-repo/semantics/publishedVersion
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- 2022
31. HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
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Santonen, T., Porras, S.P., Bocca, B., Bousoumah, R., Duca, R.C., Galea, K.S., Godderis, L., Göen, T., Hardy, E., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Louro, H., Majery, N., Ndaw, S., Pinhal, H., Ruggieri, F., Silva, M.J., Nieuwenhuyse, A. van, Verdonck, J., Viegas, S., Anzion, R.B.M., Wasowicz, W., Sepai, O., Scheepers, P.T.J., Santonen, T., Porras, S.P., Bocca, B., Bousoumah, R., Duca, R.C., Galea, K.S., Godderis, L., Göen, T., Hardy, E., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Louro, H., Majery, N., Ndaw, S., Pinhal, H., Ruggieri, F., Silva, M.J., Nieuwenhuyse, A. van, Verdonck, J., Viegas, S., Anzion, R.B.M., Wasowicz, W., Sepai, O., and Scheepers, P.T.J.
- Abstract
Item does not contain fulltext, Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupatio
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- 2022
32. Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030
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Jeddi, M.Z., Hopf, Nancy B., Louro, H., Viegas, S., Galea, K.S., Pasanen-Kase, Robert, Scheepers, P.T.J., Goetz, Natalie von, Bessems, Jos, Jeddi, M.Z., Hopf, Nancy B., Louro, H., Viegas, S., Galea, K.S., Pasanen-Kase, Robert, Scheepers, P.T.J., Goetz, Natalie von, and Bessems, Jos
- Abstract
Contains fulltext : 282188.pdf (Publisher’s version ) (Open Access)
- Published
- 2022
33. Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient
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McColgan, P., Viegas, S., Gandhi, S., Bull, K., Tudor, R., Sheikh, F., Pinney, J., Fontana, M., Rowczenio, D., Gillmore, J. D., Gilbertson, J. A., Whelan, C. J., Shah, S., Jaunmuktane, Z., Holton, J. L., Schott, J. M., Werring, D. J., Hawkins, P. N., and Reilly, M. M.
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- 2015
- Full Text
- View/download PDF
34. Interstellar Matter Matiere Interstellaire
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Flower, D. R., Dopita, M. A., Bruhweiler, F. C., Burton, M. G., Elmegreen, D. M., Falgarone, E., Lozinskaya, T. A., Martin, P. G., Myers, P. C., Okuda, H., Pottasch, S. R., Reipurth, B., Rosa, M. R., van Dishoeck, E. F., Viegas, S. M., Wilson, T. L., and Appenzeller, Immo, editor
- Published
- 1997
- Full Text
- View/download PDF
35. Accessing indoor fungal contamination using conventional and molecular methods in Portuguese poultries
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Viegas, C., Malta-Vacas, J., Sabino, R., Viegas, S., and Veríssimo, C.
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- 2014
- Full Text
- View/download PDF
36. Shock and Photoionization Models for Infrared Lines from Active Galactic Nuclei
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Contini, M., Viegas, S. M., and Beckman, J. E., editor
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- 1993
- Full Text
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37. Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III-1 genetic clone family
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Florindo, C., Viegas, S., Paulino, A., Rodrigues, E., Gomes, J.P., and Borrego, M.J.
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- 2010
- Full Text
- View/download PDF
38. Joint Contact Area and Pressure
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Viegas, S. F., Patterson, R. M., Werner, F. W., An, Kai-Nan, editor, Berger, Richard A., editor, and Cooney, William P., III, editor
- Published
- 1991
- Full Text
- View/download PDF
39. P22-23: Expediting the uptake of Next-Generation Risk Assessment (NGRA) into EU chemicals legislation under PARC
- Author
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Herzler, M., Apruzzese, I., Bandow, N., Busquet, F., Cavoski, A., Colbourne, J., Di Consiglio, E., Dusinska, M., Flingelli, G., Holden, L., Hornek-Gausterer, R., Kaiser, A., Lee, R., Vicente, J. Lobo, L⊘fstedt, M., Longhin, E., Mouaziz, H., Namorado, S., von der Ohe, P., Rolfheim-Bye, S., Rousselle, C., Tcheremenskaia, O., Tsitsimpikou, C., Uhl, M., and Viegas, S.
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- 2023
- Full Text
- View/download PDF
40. OS02-05: Genotoxicity in peripheral blood leukocytes and reticulocytes of e-waste management workers
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Aimonen, K., João Silva, M., Tavares, A., Moreira, R., Louro, H., Catalán, J., Duca, R., Godderis, L., Mahiout, S., Martins, C., Martinsone, I., Matisane, L., Namorado, S., Van Nieuwenhuyse, A., Pinhal, H., Porras, S., Remes, J., Verdonck, J., Viegas, S., Scheepers, P., and Santonen, T.
- Published
- 2023
- Full Text
- View/download PDF
41. Mycotoxins under the Human Biomonitoting Initiative (HBM4EU): challenges in the near future
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Alvito, Paula, Vasco, Elsa, Assunção, Ricardo, Martins, Carla, Louro, H., Namorado, S., Viegas, S., and Silva, MJ
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Micotoxinas ,Segurança Alimentar ,food and beverages ,Toxicologia ,Avaliação do Risco ,Biomonitorização Humana - Abstract
Mycotoxins are natural toxins produced by several fungi genera that contaminate cereals, fruits and other food. The ingestion of contaminated food and feed may result not only in acute disease but also in chronic conditions, e.g., reproductive toxicity, inflammatory bowel diseases or cancer either in animals or humans. It is thus of high relevance to use a one health approach to monitor environmental, human and animal exposure to mycotoxins and their effects, in order to decrease mycotoxins-associated outcomes. In the Human Biomonitoring Initiative (HBM4EU, https://www.hbm4eu.eu/the-project/), following a systematic prioritization exercise which brought together national and EU level policy needs for knowledge on chemical exposure and health outcomes, mycotoxins (Deoxynivalenol and Fumonisin B1) were considered as priority substances around which the HBM4EU research programme is being developed. Within the three pillars of the HBM4EU, namely, 1. Science to Policy, 2. European HBM Platform and 3. Exposure and Health, answers to several identified policy questions related to mycotoxins exposure and effects are being debated, including the current levels of human exposure and time trends in Europe, geographical differences and highly exposed subgroups (including workers), the availability of toxicokinetics data, methods for analyzing mycotoxins and their metabolites in human samples, the potential for using effect biomarkers, the use of biomonitoring data under a risk assessment framework, derivation of HBM guidance values. During this presentation, challenges related to those questions and human biomonitoring of mycotoxins will be presented and discussed in the perspective of a one health approach. Work co-funded by the HBM4EU project, Grant Agreement No: 733032 and by national funds: FCT/MEC - FEDER, within the PT2020 Partnership Agreement and Compete 2020 through CESAM (UIDP/50017/2020+UIDB/50017/2020) and ToxOmics (UIDB/00009/2020). N/A
- Published
- 2020
42. One Health Day, Emerging Diseases - Mycotoxins under the Human Biomonitoting Initiative (HBM4EU): challenges in the near future: Book of abstracts
- Author
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Alvito, Paula, Vasco, Elsa, Assunção, Ricardo, Louro, Henriqueta, Namorado, Sónia, Viegas, S., and Silva, MJ
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Micotoxinas ,Segurança Alimentar ,Toxicologia ,Avaliação de Risco ,Biomonitorização Humana - Abstract
Livro de resumos d o encontro 'One Health Day' 2020. É uma iniciativa com carácter internacional coordenada por redes de investigação, como a One Health Comission e a One Health Platform Foundation, que escolheram o dia 3 de novembro como o Dia da Saúde Única. O conceito One Health remete à interdependência entre a saúde humana, dos animais e do ambiente. N/A
- Published
- 2020
43. Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica
- Author
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Viegas, S., Weir, A., Esiri, M., Kuker, W., Waters, P., Leite, M.I., Vincent, A., and Palace, J.
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Hypothalamus -- Research ,Hypothalamus -- Physiological aspects ,Hypothalamus -- Diseases ,Neuromyelitis optica -- Diagnosis ,Neuromyelitis optica -- Case studies ,Neuromyelitis optica -- Care and treatment ,Biopsy -- Usage ,Health ,Psychology and mental health - Published
- 2009
44. WEIGHT LOSS, ENCEPHALOPATHY, URINARY DIFFICULTIES AND NUMB FEET IN A NIGERIAN MAN
- Author
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McColgan, P, Viegas, S, Gandhi, S, Sheikh, F, Pinney, J, Fontana, M, Rowczenio, D, Shah, S, Jaumuktane, Z, Holton, J, Schott, J, Werring, D, Hawkins, P, and Reilly, MM
- Published
- 2013
- Full Text
- View/download PDF
45. Human biomonitoring in occupational setting – Cr VI
- Author
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Santonen, Tiina, Alimonti, A., Bocca, B., Duca, R.C., Galea, K.S., Godderis, L., Göen, T., Gomes, B., Hanser, O., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Sparkie, S., Leso, V., Louro, Henriqueta, Ndaw, S., Bousoumah, R., Porras, S. P., Robert, A., Ruggieri, F., Scheepers, P.T.J., van Dael, M., Silva, Maria João, Viegas, S., Wasowicz, W., and Sepai, O.
- Subjects
Occupational Exposure ,Environmental Genotoxicity ,Human Biomonitoring ,Genotoxicidade Ambiental ,Chromium VI - Abstract
As for environmental studies, occupational studies performed by different researchers in individual countries are usually not aligned with respect to sampling, analytical methodologies or data collection, which hampers the comparison of the findings and the use of the data e.g. in regulatory risk assessment at European level. In addition, many national human biomonitoring (HBM) studies can recruit only limited numbers of workers. Therefore, combining national surveys using harmonized study designs and methodologies can potentially greatly improve the information collected and bring added value for the global data interpretation. Hexavalent chromium (Cr(VI)) is an important occupational carcinogen. Although Cr(VI) compounds are authorized in Europe under the European regulation (EC 1907/2006) concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH), these compounds are still widely used in different applications. In addition, workers may be exposed to Cr(VI) formed during hot processes, like welding. These exposures are regulated in Europe by a binding occupational limit value (BOELV) recently set under EU Directive 2004/37/EC. It is, however, unclear how well workplaces comply with levels stated in legislation. The current study has been conducted in eight European countries using harmonized procedures. Up to 400 workers performing Cr(VI) surface treatment or welding activities were recruited. In addition to the collection of urinary chromium data, new methods for Cr biomonitoring were included, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC). Exposure biomarkers were complemented with early biological effect biomarkers and dermal and air monitoring data. According to preliminary results, chrome platers showed the highest urinary chromium levels, in some cases more than 10-times higher than levels measured in the control population. In the control population urinary chromium levels remained usually below 1 µg/g creatinine, in surface treatment workers the levels varied from these background levels up to 10 µg/g creatinine. In some cases, pre-shift chromium levels were also higher than in controls. Although welders showed elevated levels, their levels were lower than chrome platers. EBC samples exhibited the same trend as seen in urinary chromium: chrome platers showed higher levels than welders, although welders also had elevated levels compared to the controls. Analysis of the results from the air samples and wipe samples (collected from the hands of workers) provided information on the exposure routes, which will be used to give recommendations for the minimization of the exposure at workplaces. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032. N/A
- Published
- 2020
46. Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context-Challenges and Way Forward
- Author
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Viegas, S., Zare Jeddi, M., Hopf, N.B., Bessems, J., Palmen, N., S Galea, K., Jones, K., Kujath, P., Duca, R.C., Verhagen, H., Santonen, T., and Pasanen-Kase, R.
- Subjects
Biological Monitoring ,Environmental Exposure/analysis ,Environmental Monitoring ,Humans ,Occupational Exposure/analysis ,Occupational Health ,Risk Assessment ,Risk Management ,biological guidance value ,biological limit value ,biological monitoring ,exposure assessment ,occupational health ,risk assessment - Abstract
Recent advances in analytical chemistry have allowed a greater possibility of using quantitative approaches for measuring human exposure to chemicals. One of these approaches is biomonitoring (BM), which provides unequivocal evidence that both exposure and uptake of a chemical have taken place. BM has been a longstanding practice in occupational health for several reasons. BM integrates exposure from all routes. It can help identify unintentional and unexpected exposures and assess the effectiveness of existing risk-management measures. BM also provides relevant information to support policy development by delivering better evidence of workers' exposure to chemical substances, even within the framework of the present regulations. Thus, BM can allow for both the evaluation of the impact of regulation and identification of further needs for new or improved regulation. However, despite all these well-recognized advantages, BM is currently an underused exposure assessment tool. This paper provides an overview of the key aspects to be considered when using BM in the context of occupational health interventions. Additionally, this paper describes the potential of BM as an exposure assessment tool, distinguishing the role of BM in exposure assessment and health surveillance and clarifies ethical and communication aspects to guarantee that general data protection regulations are followed. In addition, actions and research needs are identified (particularly with reference to the European situation), which aim to encourage the increased use of BM as an exposure assessment tool.
- Published
- 2020
47. Serological and experimental studies in different forms of myasthenia gravis
- Author
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Vincent, A, Huda, S, Cao, M, Cetin, H, Koneczny, I, Rodriguez Cruz, PM, Jacobson, L, Viegas, S, Jacob, S, Woodhall, M, Nagaishi, A, Maniaol, A, Damato, V, Leite, MI, Cossins, J, Webster, R, Palace, J, and Beeson, D
- Abstract
Antibodies to the acetylcholine receptor (AChR) have been recognized for over 40 years and have been important in the diagnosis of myasthenia gravis (MG), and its recognition in patients of different ages and thymic pathologies. The 10–20% of patients who do not have AChR antibodies are now known to comprise different subgroups, the most commonly reported of which is patients with antibodies to muscle‐specific kinase (MuSK). The use of cell‐based assays has extended the repertoire of antibody tests to clustered AChRs, low‐density lipoprotein receptor–related protein 4, and agrin. Autoantibodies against intracellular targets, namely cortactin, titin, and ryanodine receptor (the latter two being associated with the presence of thymoma), may also be helpful as biomarkers in some patients. IgG4 MuSK antibodies are clearly pathogenic, but the coexisting IgG1, IgG2, and IgG3 antibodies, collectively, have effects that question the dominance of IgG4 as the sole pathologic factor in MuSK MG. After a brief historical review, we define the different subgroups and summarize the antibody characteristics. Experiments to demonstrate the in vitro and in vivo pathogenic roles of MuSK antibodies are discussed.
- Published
- 2020
48. Mycotoxins under the Human Biomonitoring Initiative (HBM4EU): shedding light on the exposure of European citizens to Mycotoxins
- Author
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Alvito, Paula, Assunção, Ricardo, Dirven, H., Mol, H., Martins, Carla, Mengelers, M., Plitcha, V., Vasco, Elsa, Viegas, S., and Silva, M.J.
- Subjects
Exposure to Chemicals ,Segurança Alimentar ,Saúde Humana ,Human Biomonitoring ,Toxicologia ,Mycotoxins ,Avaliação de Risco - Abstract
The Human Biomonitoring Initiative HBM4EU (https://www.hbm4eu.eu/the-project/) is a joint effort of 30 countries and the European Environment Agency under the Horizon 2020 funding programme of the European Commission. The project started in 2017 and has a duration of five years. The goal of HBM4EU is to generate evidence on the current exposure of European citizens to chemicals and on their possible health effects in order to assess the associated risks. Further, this project should provide policy makers scientifically founded advice on chemical safety and human health protection. Following a systematic prioritization exercise, which brought together national and EU level policy needs for knowledge on chemical exposure and health outcomes, mycotoxins (Deoxynivalenol and Fumonisin B1) were in the 2nd prioritisation round considered as priority substances around which the HBM4EU research programme will be developed. Within the three pillars of the HBM4EU, namely, 1. Science to Policy, 2. European HBM (Human Biomonitoring) Platform and 3. Exposure and Health, answers to several identified policy questions related to mycotoxins exposure and effects will be debated, namely the current levels of human exposure (including exposure to mixtures) and time trends in Europe, geographical differences and highly exposed subgroups (including workers), the availability of toxicokinetics data, methods for analyzing mycotoxins and their metabolites in human samples, the potential for using effect biomarkers and their link to adverse outcomes, the use of biomonitoring data under a risk assessment framework and derivation of HBM guidance values. All these topics will be considered and explored, providing new evidences that will constitute important contributes for the mycotoxins risk assessment in the EU and abroad. Activities related to translation of exposure to policy (WP5), laboratory analysis and quality assurance (WP9), data management and analysis (WP10), from HBM to exposure (WP12), establishing exposure-health relationships (WP13), effect biomarkers (WP14) and mixtures and human health risk (WP15) will be developed within a joint effort of chemical group leaders for mycotoxins, members of the mycotoxin group at HBM4EU and different Work Package leaders . One of the most relevant planned activities is the possibility for providing new exposure data through the development of an aligned study enrolling several European countries. This will guarantee an update on the exposure assessment to the prioritized mycotoxins in the European population allowing a more accurate risk assessment. Work co-funded by the HBM4EU project, Grant Agreement No: 733032 and by Portuguese national funds: FCT/MEC - FEDER, within the PT2020 Partnership Agreement and Compete 2020 through CESAM (UID/AMB/50017/2019) and ToxOmics (UID/BIM/00009/2013). N/A
- Published
- 2020
49. Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay.
- Author
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Sabiiti, W., Azam, K., Farmer, E.C.W., Kuchaka, D., Mtafya, B., Bowness, R., Oravcova, K., Honeyborne, I., Evangelopoulos, D., McHugh, T.D., Khosa, C., Rachow, A., Heinrich, N., Kampira, E., Davies, G., Bhatt, N., Ntinginya, E.N., Viegas, S., Jani, I., Kamdolozi, M., Mdolo, A., Khonga, M., Boeree, M.J., Phillips, P.P., Sloan, D., Hoelscher, M., Kibiki, G., Gillespie, S.H., Sabiiti, W., Azam, K., Farmer, E.C.W., Kuchaka, D., Mtafya, B., Bowness, R., Oravcova, K., Honeyborne, I., Evangelopoulos, D., McHugh, T.D., Khosa, C., Rachow, A., Heinrich, N., Kampira, E., Davies, G., Bhatt, N., Ntinginya, E.N., Viegas, S., Jani, I., Kamdolozi, M., Mdolo, A., Khonga, M., Boeree, M.J., Phillips, P.P., Sloan, D., Hoelscher, M., Kibiki, G., and Gillespie, S.H.
- Abstract
01 juli 2020, Contains fulltext : 220733.pdf (Publisher’s version ) (Open Access), In this comparative biomarker study, we analysed 1768 serial sputum samples from 178 patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load Assay (TB-MBLA) reduces time-to-TB-bacillary-load-result from days/weeks by culture to hours and detects early patient treatment response. By day 14 of treatment, 5% of patients had cleared bacillary load to zero, rising to 58% by 12th week of treatment. Fall in bacillary load correlated with mycobacterial growth indicator tube culture time-to-positivity (Spearmans r=-0.51, 95% CI (-0.56 to -0.46), p<0.0001). Patients with high pretreatment bacillary burdens (above the cohort bacillary load average of 5.5log(10)eCFU/ml) were less likely to convert-to-negative by 8th week of treatment than those with a low burden (below cohort bacillary load average), p=0.0005, HR 3.1, 95% CI (1.6 to 5.6) irrespective of treatment regimen. TB-MBLA distinguished the bactericidal effect of regimens revealing the moxifloxacin-20 mg rifampicin regimen produced a shorter time to bacillary clearance compared with standard-of-care regimen, p=0.008, HR 2.9, 95% CI (1.3 to 6.7). Our data show that the TB-MBLA could inform clinical decision making in real-time and expedite drug TB clinical trials.
- Published
- 2020
50. Fungi, MVOCs and dust exposure assessment in poultry production: P727
- Author
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Viegas, S., Sabino, R., Verissimo, C., Monteiro, A., and Viegas, C.
- Published
- 2012
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