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1,886 results on '"Vieth M"'

2. Mismatch repair deficiency, chemotherapy and survival for resectable gastric cancer: an observational study from the German staR cohort and a meta-analysis

Author

Stolze, T., Franke, S., Haybaeck, J., Moehler, M., Grimminger, P. P., Lang, H., Roth, W., Gockel, I., Kreuser, N., Bläker, H., Wittekind, C., Lordick, F., Vieth, M., Veits, L., Waidmann, O., Lingohr, P., Peitz, U., Schildberg, C., Kruschewski, M., Vassos, N., Goni, E., Bruns, C. J., Ridwelski, K., Wolff, S., Lippert, H., Schumacher, J., Malfertheiner, P., and Venerito, M.

Published
2023
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3. P097 Spatially resolved insights into fistulating Crohn's disease pathogenesis: Unveiling molecular heterogeneity

Author

Mcgregor, C, primary, Yin, Z, additional, Bridges, E, additional, Gupta, T, additional, Aulicino, A, additional, Siejka-Zielinska, P, additional, Lee, C H J, additional, Bornschein, J, additional, Bignell, M, additional, George, B, additional, Vieth, M, additional, Tandon, R, additional, Fryer, E, additional, Antanaviciute, A, additional, and Simmons, A, additional

Published
2024
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11. Barrett – eine „never ending story“

Author

Vieth, M. and Tannapfel, A.

Abstract

Zusammenfassung: Verglichen mit anderen Tumoren des Gastrointestinaltraktes ist das Barrett-Karzinom zwar ein seltener Tumor, doch in den letzten Jahren zeigt sich eine ausgeprägte Zunahme der Inzidenz. Noch nicht abschließend geklärt ist die Entstehung der Barrett-Schleimhaut. Die Molekularpathologie hat wichtige molekulare Mechanismen und epigenetische Veränderungen der Barrett-Schleimhaut auf dem Weg zum Karzinom aufgedeckt. Insgesamt muss man jedoch festhalten, dass es durch die Vielfalt der Prozesse, die an der Karzinogenese beteiligt sind, schwierig ist, die Entstehung der Barrett-Neoplasie so auf molekularer Ebene zu interpretieren, dass diese Erkenntnisse auch für die tägliche Routine nutzbar sind.

Published
2024
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14. Deep learning for multi-class semantic segmentation enables colorectal cancer detection and classification in digital pathology images

Author

Bokhorst, J.M., Nagtegaal, I.D., Fraggetta, F., Vatrano, S., Mesker, W., Vieth, M., Laak, J.A.W.M. van der, and Ciompi, F.

Subjects
All institutes and research themes of the Radboud University Medical Center, Multidisciplinary, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

In colorectal cancer (CRC), artificial intelligence (AI) can alleviate the laborious task of characterization and reporting on resected biopsies, including polyps, the numbers of which are increasing as a result of CRC population screening programs ongoing in many countries all around the globe. Here, we present an approach to address two major challenges in the automated assessment of CRC histopathology whole-slide images. We present an AI-based method to segment multiple ($$n=14$$ n = 14 ) tissue compartments in the H &E-stained whole-slide image, which provides a different, more perceptible picture of tissue morphology and composition. We test and compare a panel of state-of-the-art loss functions available for segmentation models, and provide indications about their use in histopathology image segmentation, based on the analysis of (a) a multi-centric cohort of CRC cases from five medical centers in the Netherlands and Germany, and (b) two publicly available datasets on segmentation in CRC. We used the best performing AI model as the basis for a computer-aided diagnosis system that classifies colon biopsies into four main categories that are relevant pathologically. We report the performance of this system on an independent cohort of more than 1000 patients. The results show that with a good segmentation network as a base, a tool can be developed which can support pathologists in the risk stratification of colorectal cancer patients, among other possible uses. We have made the segmentation model available for research use on https://grand-challenge.org/algorithms/colon-tissue-segmentation/.

Published
2023

16. Frühjahrssymposium Gastrointestinaltrakt

Author

Grabsch, H.I., Langer, R., Vieth, M., RS: GROW - R2 - Basic and Translational Cancer Biology, and Pathologie

Subjects
Pathology and Forensic Medicine
Published
2022

19. A VIRTUAL CHROMOENDOSCOPY ARTIFICIAL INTELLIGENCE SYSTEM TO DETECT ENDOSCOPIC AND HISTOLOGIC REMISSION IN ULCERATIVE COLITIS

Author

Iacucci, M., additional, Cannatelli, R., additional, Parigi, T.L., additional, Buda, A., additional, Labarile, N., additional, Nardone, O.M., additional, Tontini, G.E., additional, Rimondi, A., additional, Bazarova, A., additional, Bhandari, P., additional, Bisschops, R., additional, De Hertogh, G., additional, del Amor, R., additional, Ferraz, J.G, additional, Goetz, M., additional, Gui, X., additional, Hayee, B., additional, Kiesslich, R., additional, Lazarev, M., additional, Naranjo, V., additional, Panaccione, R., additional, Parra-Blanco, A., additional, Pastorelli, L., additional, Rath, T., additional, Røyset, E.S, additional, Vieth, M., additional, Villanacci, V., additional, Zardo, D., additional, Ghosh, S., additional, and Grisan, E., additional

Published
2022
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23. Mismatch repair deficiency, chemotherapy and survival for resectable gastric cancer: an observational study from the German staR cohort and a meta-analysis

Author

Stolze, T., primary, Franke, S., additional, Haybaeck, J., additional, Moehler, M., additional, Grimminger, P. P., additional, Lang, H., additional, Roth, W., additional, Gockel, I., additional, Kreuser, N., additional, Bläker, H., additional, Wittekind, C., additional, Lordick, F., additional, Vieth, M., additional, Veits, L., additional, Waidmann, O., additional, Lingohr, P., additional, Peitz, U., additional, Schildberg, C., additional, Kruschewski, M., additional, Vassos, N., additional, Goni, E., additional, Bruns, C. J., additional, Ridwelski, K., additional, Wolff, S., additional, Lippert, H., additional, Schumacher, J., additional, Malfertheiner, P., additional, and Venerito, M., additional

Published
2022
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24. OP16 The first virtual chromoendoscopy artificial intelligence system to detect endoscopic and histologic remission in Ulcerative Colitis

Author

Iacucci, M, primary, Cannatelli, R, additional, Parigi, T L, additional, Buda, A, additional, Labarile, N, additional, Nardone, O M, additional, Tontini, G E, additional, Rimondi, A, additional, Bazarova, A, additional, Bhandari, P, additional, Bisschops, R, additional, De Hertogh, G, additional, Del Amor, R, additional, Ferraz, J G, additional, Goetz, M, additional, Gui, X, additional, Hayee, B, additional, Kiesslich, R, additional, Lazarev, M, additional, Naranjo, V, additional, Panaccione, R, additional, Parra-Blanco, A, additional, Pastorelli, L, additional, Rath, T, additional, Røyset, E S, additional, Vieth, M, additional, Villanacci, V, additional, Zardo, D, additional, Ghosh, S, additional, and Grisan, E, additional

Published
2022
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25. OP15 A new simplified histology artificial intelligence system for accurate assessment of remission in Ulcerative Colitis

Author

Villanacci, V, primary, Parigi, T L, additional, Del Amor, R, additional, Mesguer Esbrì, P, additional, Gui, X, additional, Bazarova, A, additional, Bhandari, P, additional, Bisschops, R, additional, Danese, S, additional, De Hertogh, G, additional, Ferraz, J G, additional, Götz, M, additional, Grisan, E, additional, Hayee, B, additional, Kiesslich, R, additional, Lazarev, M, additional, Mandelli, G, additional, Monica, M A T, additional, Panaccione, R, additional, Parra-Blanco, A, additional, Pastorelli, L, additional, Rath, T, additional, Røyset, E S, additional, Shivaji, U, additional, Tontini, G E, additional, Vieth, M, additional, Zardo, D, additional, Ghosh, S, additional, Naranjo, V, additional, and Iacucci, M, additional

Published
2022
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26. P075 Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

Author

Leppkes, M, primary, Lindemann, A, additional, Gößwein, S, additional, Paulus, S, additional, Roth, D, additional, Hartung, A, additional, Liebing, E, additional, Zundler, S, additional, Acera, M G, additional, Patankar, J V, additional, Mascia, F, additional, Scheibe, K, additional, Hoffmann, M, additional, Uderhardt, S, additional, Schauer, C, additional, Foersch, S, additional, Neufert, C, additional, Vieth, M, additional, Schett, G, additional, Atreya, R, additional, Kühl, A A, additional, Bleich, A, additional, Becker, C, additional, Herrmann, M, additional, and Neurath, M F, additional

Published
2022
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28. A VIRTUAL CHROMOENDOSCOPY ARTIFICIAL INTELLIGENCE SYSTEM TO DETECT ENDOSCOPIC AND HISTOLOGIC REMISSION IN ULCERATIVE COLITIS

Author

Iacucci M., Cannatelli, R., Parigi, T. L., Buda, A., Labarile, N., Nardone, O. M., Tontini, G. E., Rimondi, A., Bazarova, A., Bhandari, P., Bisschops, R., Hertogh, G., Del Amor, R., Ferraz, J. G., Goetz, M., Gui, S. X., Hayee, B., Kiesslich, R., Lazarev, M., Naranjo, V., Panaccione, R., Parra-Blanco, A., Pastorelli, L., Rath, T., Røyset, E. S., Vieth, M., Villanacci, V., Zardo, D., Ghosh, S., and Enrico Grisan

Subjects
Gastroenterology, Radiology, Nuclear Medicine and imaging
Published
2022

34. Mismatch Reparatur Defizienz, Chemotherapie und Überleben bei resektablem Magenkarzinom: Eine Beobachtungsstudie der deutschen Zentren des staR-Projekts und eine Metaanalyse

Author

Stolze, T, additional, Franke, S, additional, Haybaeck, J, additional, Gockel, I, additional, Kreuser, N, additional, Bläker, H, additional, Wittekind, C, additional, Lordick, F, additional, Moehler, M, additional, Grimminger, PP, additional, Lang, H, additional, Roth, W, additional, Vieth, M, additional, Veits, L, additional, Waidmann, O, additional, Lingohr, P, additional, Peitz, U, additional, Schildberg, C, additional, Kruschewski, M, additional, Vassos, N, additional, Goni, E, additional, Bruns, C, additional, Ridwelski, K, additional, Lippert, H, additional, Schumacher, J, additional, Malfertheiner, P, additional, and Venerito, M, additional

Published
2021
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36. Neutrophils, eosinophils, and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms

Author

Irani, M. Z. (Mudar Zand), Talley, N. J. (Nicholas J.), Ronkainen, J. (Jukka), Aro, P. (Pertti), Andreasson, A. (Anna), Agreus, L. (Lars), Vieth, M. (Michael), Jones, M. P. (Mike P.), and Walker, M. M. (Marjorie M.)

Subjects
Eosinophils, Intra-epithelial lymphocytes, Neutrophils, Esophagitis, Gastroesophageal reflux disease
Abstract

Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, they have an increasingly recognised role in the pathogenesis of reflux esophagitis, and IEL quantification establishes the diagnosis of lymphocytic esophagitis. Knowledge regarding the upper limit of a normal IEL count in health is lacking. We studied 117 non-healthcare seeking adult volunteers from a random community sample (the Kalixanda study) with esophageal biopsies 2 cm above the gastroesophageal junction. Subjects were divided into four groups based on the presence or absence of gastro-esophageal reflux symptoms and/or esophagitis on endoscopy. Asymptomatic subjects with no endoscopic esophagitis were selected as controls, and the cell counts in this group were used to define the upper limit of normal of IELs, eosinophils and neutrophils. The entire sample was used to identify independent predictors of increased cellular counts by logistic regression analysis. None of the healthy controls had an IEL count of more than three per five high power fields (HPF), and therefore this was considered as the upper limit of normal; no controls had eosinophils or neutrophils in esophageal biopsies. Independent predictors of an elevated IEL count were spongiosis on histology (OR 11.17, 95% CI 3.32–37.58, P < 0.01) and current smoking (OR 4.84, 95% CI 1.13–2.71, P = 0.03). A receiver operating characteristics analysis concluded that a threshold of 3 IELs/5HPFs performs best in predicting reflux symptoms when a normal esophageal mucosa is visualized on endoscopy (sensitivity = 100.0%, specificity = 35.2%). The healthy esophageal mucosa does not contain more than three IELs per five HPF in the distal esophagus.

Published
2021

42. Contributors

Author

Abbasi, S., primary, Adolphi, N.L., additional, Aikawa, E., additional, Akbar, H., additional, Akilesh, S., additional, Aladjem, M.I., additional, Allocca, M., additional, Alpini, G., additional, Alroy, J., additional, Altman, B.J., additional, Andujar, P., additional, Antonello, Z.A., additional, Antsiferova, M., additional, Apica, B.S., additional, Ariel, I., additional, Aronow, B.J., additional, Ashley, J.W., additional, Badell, I.R., additional, Bagg, A., additional, Bajaj, M., additional, Banerjee, S., additional, Barbieri, J.S., additional, Bardes, E.E., additional, Barisoni, L., additional, Barletta, J.A., additional, Baskin, D.G., additional, Bastarrachea, R.A., additional, Bayat, A., additional, Bayrak-Toydemir, P., additional, Beck, A.H., additional, Beebe, D.C., additional, Beltran, H., additional, Benichou, G., additional, Bergman, M., additional, Bernard, S.A., additional, Bernardi, P., additional, Best, D.H., additional, Blair, H.C., additional, Bonaldo, P., additional, Bondy, J., additional, Bosman, F.T., additional, Bouma, B.E., additional, Brandi, M.L., additional, Bresler, S.C., additional, Brewer, M.T., additional, Britto, C.J., additional, Brock, J.E., additional, Brosens, L.A.A., additional, Budge, H., additional, Burd, E.M., additional, Burness, M.L., additional, Bushnell, T., additional, Byrd, J., additional, Calderone, A., additional, Campbell, M.J., additional, Cao, D., additional, Capell, W., additional, Cardigan, R., additional, Carey, P.M., additional, Carneiro, F., additional, Carp, S.A., additional, Carter, A.M., additional, Cascio, M.J., additional, Castellani, R.J., additional, Castellanos, J., additional, Caviglia, J.M., additional, Cecconi, F., additional, Chamarthy, S., additional, Chamma, E., additional, Chang, A., additional, Chang, A.Y., additional, Chang, N.C., additional, Chapman, D.G., additional, Charles, A.K., additional, Chen, D., additional, Chen, D.F., additional, Chen, P., additional, Cheng, J., additional, Chernock, R.D., additional, Cheruvu, S., additional, Chiang, J., additional, Childs, G.V., additional, Cho, Y.-B., additional, Choi, A.M.K., additional, Choi, J.K., additional, Cipriani, N.A., additional, Cleary, J.O.S.H., additional, Clementi, E., additional, Clines, G.A., additional, Cohen, M.L., additional, Coleman, W.B., additional, Coletta, D.K., additional, Collie, A.M.B., additional, Cooling, L., additional, Coron, E., additional, Côté, D., additional, Coussens, L.M., additional, Crielaard, B.J., additional, Cron, R.Q., additional, Crum, C.P., additional, Cruz, N.M., additional, Dairkee, S.H., additional, Daly, C.A., additional, Dang, C.V., additional, Danila, M.I., additional, Daradich, A., additional, Darnell, C.M., additional, Dartt, D.A., additional, Das, A., additional, D’Asta, F., additional, DeFronzo, R., additional, De Hertogh, G., additional, Dela Cruz, C.S., additional, de la Cruz-Merino, L., additional, De Palma, C., additional, Demetris, A.J., additional, DeMorrow, S., additional, Denechaud, P.-D., additional, Di Carli, M.F., additional, DiCarlo, E.F., additional, Dikic, I., additional, Dimberg, A., additional, Dowell, M.L., additional, Doyle, L.A., additional, Drachenberg, C.B., additional, Driskell, E., additional, Duda, D.G., additional, Duker, J., additional, Dyck, J.R.B., additional, Ecker, C., additional, Elifritz, J.M., additional, Elsheikh, T.M., additional, Ensari, A., additional, Ernst, L.M., additional, Esch, K.J., additional, Fajas-Coll, L., additional, Fang, Q., additional, Farhat, N.A., additional, Farshid, G., additional, Faye-Petersen, O.M., additional, Fehlings, M.G., additional, Fend, F., additional, Feng, X., additional, Fernandes, H., additional, Fernandez-Checa, J.C., additional, Ferreira, B.P., additional, Fidler, I.J., additional, Finn, J.A., additional, Fischer, A., additional, Fishbein, M.C., additional, Fleit, H.B., additional, Flomenbaum, M., additional, Folkins, A., additional, Francis, H., additional, Frank, K.M., additional, Frevert, C.W., additional, Frias, A.E., additional, Friedman, J.R., additional, Fukumura, D., additional, Furie, M.B., additional, Gaffo, A.L., additional, Galateau-Sallé, F., additional, Gallegos-Cabriales, E.C., additional, Gandhi, C.R., additional, Gannon, M., additional, García-Moliner, M.L., additional, Gardner, J.M., additional, Gasper, C.A., additional, Gaulard, P., additional, Gaut, J.P., additional, Gavia-García, G., additional, Gerrard, C., additional, Ghosh, A.P., additional, Giersch, A.B.S, additional, Gilbert, S.R., additional, Gill, J.R., additional, Giusti, F., additional, Glorioso, J.M., additional, González-Torres, M.C., additional, Goolsby, C.L., additional, Gora, M.J., additional, Gordon, I.O., additional, Gotlieb, A.I., additional, Gouw, A.M., additional, Goyal, A., additional, Grégoire, M., additional, Graham, B.B., additional, Granger, D.N., additional, Greene, A.K., additional, Greenlee, J.J., additional, Griffiths, R., additional, Guimarães, A.R., additional, Gulati, M., additional, Gullet, A., additional, Gupta, S., additional, Haider, N.B., additional, Halushka, M.K., additional, Hambuch, T.M., additional, Hamza, S.M., additional, Han, Y., additional, Hansen, W.P., additional, Hard, R., additional, Harris, B.T., additional, Harris, J.E., additional, Hartnett, M.E., additional, Hasserjian, R.P., additional, Hatch, G.M., additional, Hefti, M.M., additional, Heller, D.S., additional, Hemminger, J.A., additional, Hendrickson, J.E., additional, Henley, K.D., additional, Herzog, E., additional, Hess, J.R., additional, Hill, C.E., additional, Hipp, J., additional, Hobbs, R., additional, Höller, D., additional, Hodges, R.R., additional, Homer, R.J., additional, Horowitz, N., additional, Hsi, E.D., additional, Hsieh, A.L., additional, Hunt, J.M., additional, Hure, S., additional, Husain, A.N., additional, Hussey, S., additional, Hutcheson, J.D., additional, Hutson, R.M., additional, Illescas-Vacas, A., additional, Irvin, C.G., additional, Jaffer, F.A., additional, Jäger, R., additional, Jain, R.K., additional, Jain, S., additional, James, J., additional, Jansen, M., additional, Jarzembowski, J.A., additional, Jaurand, M.-C., additional, Jean, D., additional, Jegga, A.G., additional, Jellinger, K.A., additional, Jen, K.-Y., additional, Jo, V.Y., additional, Johnson, B., additional, Jones, R.L., additional, Kalfa, T.A., additional, Kamionek, M., additional, Kang, D., additional, Kantari, C., additional, Kantor, P.F., additional, Kanzaki, G., additional, Karns, R., additional, Katzman, P.J., additional, Kawai, T., additional, Kelley, T.W., additional, Kent, J.W., additional, Kerr, E.H., additional, Kew, R.R., additional, Khalighi, M., additional, Khanh Vu, T.H., additional, Khong, T.Y., additional, Kim, B.S., additional, Kim, J., additional, Klein, M.J., additional, Knechtle, S.J., additional, Konkle, B.A., additional, Kowalewska, J., additional, Kricka, L.J., additional, Krishnan, B., additional, Kumar, A., additional, Kumar, S., additional, Kvietys, P., additional, Kwong, R.Y., additional, Lafont, E., additional, Laga, A.C., additional, Lagarrigue, S., additional, Lakin, A., additional, Laszik, Z.G., additional, Lauwers, G.Y., additional, Laver, N.V., additional, Lawlor, M.W., additional, Lederer, J.A., additional, Lee, R.E., additional, Lee, W.M., additional, LeGallo, R., additional, Leich, E., additional, Lemmens, B., additional, Le Pimpec-Barthes, F., additional, Leval, L., additional, Levy, B.D., additional, Lewis, J.S., additional, Lewis, T.L., additional, Leyva-Illades, D., additional, Li, L., additional, Li, Y.-P., additional, Lianidou, E.S., additional, Liao, L., additional, Liapis, H., additional, Lin, J.B., additional, Lin, A.-L., additional, Lindsay, M.E., additional, Liu, E., additional, Longacre, T., additional, Lopez-Alvarenga, J.C., additional, Lopez-Mejía, I., additional, Lozanski, G., additional, Lucia, M.S., additional, Luk, E., additional, Lutty, G.A., additional, Maclellan, R.A., additional, Madabhushi, A., additional, Mahindra, A., additional, Malek, E., additional, Mammucari, C., additional, Mani, H., additional, Mao, S.A., additional, Marboe, C.C., additional, Marí, M., additional, Marini, F., additional, Markou, A., additional, Marshall, A.H., additional, Martin, S.J., additional, Marzioni, M., additional, Masli, S., additional, Matsukuma, K.E., additional, Matulonis, U.A., additional, Mayfield, J., additional, McCoy, J.P., additional, McDougle, C.J., additional, McGinnis, M.R., additional, McGuire, A., additional, McKinstry, K.K., additional, McManus, B.M., additional, Means, A.L., additional, Meny, G.M., additional, Merchant, N., additional, Meserve, E.E.K, additional, Mess, A.M., additional, Minervini, M.I., additional, Mitchell, R.N., additional, Monaco, S.E., additional, Monga, S.P., additional, Monica Way, H.-Y., additional, Montecucco, C., additional, Montone, K.T., additional, Morgan, E.A., additional, Morgan, T.K., additional, Morrissey, K., additional, Mortensen, R.M., additional, Moser, S.A., additional, Mosquera, J.M., additional, Mossman, B.T., additional, Motta, A.C.F., additional, Mullins, E., additional, Murphy, G.F., additional, Murray, L., additional, Mysorekar, I.U., additional, Nadel, B., additional, Nadon, A.S., additional, Nagathihalli, N., additional, Nájera-Medina, O., additional, Nalesnik, M.A., additional, Nast, C.C., additional, Natkunam, Y., additional, Nault, J.C., additional, Nava-González, E.J., additional, Nayar, R., additional, Nerenz, R.D., additional, Neumann, H., additional, Ni, H., additional, Nolte, K.B., additional, Norton, L., additional, Nowak, J., additional, Nucera, C., additional, Nyberg, S.L., additional, Oakes, S.A., additional, Offerhaus, G.J.A., additional, Ojha, S., additional, Okabe, H., additional, Oliveira, A.M., additional, Osborn, E.A., additional, O'Tierney-Ginn, P., additional, Ott, G., additional, Ozcan, A., additional, Padera, R.F., additional, Pagano, M.B., additional, Page, E.K., additional, Paintal, A.S., additional, Pairon, J.-C., additional, Papadimitriou, J.C., additional, Park, H.-J., additional, Park, J.Y., additional, Parsons, L.N., additional, Patra, D., additional, Peclovits, A., additional, Peeters, P.M., additional, Perkins, T.N., additional, Perry, G., additional, Perumbeti, A., additional, Petersen, C.A., additional, Petrache, I., additional, Petroff, M.G., additional, Pettus, J.R., additional, Picken, M.M., additional, Pierson, C.R., additional, Pittman, M.E., additional, Pogoriler, J., additional, Politi, K., additional, Pollack, S.M., additional, Quintanilla-Martínez, L., additional, Rai, M.F., additional, Ramkissoon, S., additional, Randhawa, P.S., additional, Rangel, J.R., additional, Rasola, A., additional, Reeves, B., additional, Reheman, A., additional, Remick, D.G., additional, Reynaert, N.L., additional, Richmond, J.M., additional, Rivella, S., additional, Rivenbark, A.G., additional, Rizzuto, R., additional, Roberts, K.A., additional, Robin, D.A., additional, Robinson, L.J., additional, Rockey, D.C., additional, Rosenwald, A., additional, Rossetto, O., additional, Roth, K.A., additional, Roy-Chowdhury, J., additional, Roy-Chowdhury, N., additional, Rubin, M.A., additional, Rudnicki, M.A., additional, Russell, D.S., additional, Ryter, S.W., additional, Saban, D.R., additional, Sacher, R.A., additional, Sacks, D.B., additional, Sagaert, X., additional, Sagdeo, A., additional, Sahay, B., additional, Sahin, A., additional, Samali, A., additional, Sampson, B., additional, Sánchez-Escribano, R., additional, Sandri, M., additional, Sanyal, A., additional, Sasatomi, E., additional, Sauer, V., additional, Scherpereel, A., additional, Schmidt, E.P., additional, Schwabe, R.F., additional, Scorrano, L., additional, Scott, M.G., additional, Scull, J.C., additional, Seidman, M.A., additional, Seki, A., additional, Sellati, T.J., additional, Serban, K., additional, Serhan, C.N., additional, Seshan, S.V., additional, Seth, A., additional, Seykora, J.T., additional, Sharma, N., additional, Shi, C., additional, Shi, S.-R., additional, Shimada, M., additional, Shimizu, A., additional, Singer, D.B., additional, Sitko, K., additional, Smallwood, R.F., additional, Smiraglia, D.J., additional, Smith, B.R., additional, Smola, H., additional, Soubeyrand, M., additional, Stahl, W.L., additional, Stajić, M., additional, Stanworth, S.J., additional, Stathatos, N., additional, Stemler, K.M., additional, Stevens, T.M., additional, Stine, Z.E., additional, Stoll, M.L., additional, Strati, A., additional, Strutt, T.M., additional, Sund, M., additional, Sung, M.M., additional, Symonds, M.E., additional, Tabar, S., additional, Takahashi, N., additional, Talmadge, J.E., additional, Tang, V., additional, Tangrea, M., additional, Tarango, C., additional, Tario, J.D., additional, Taylor, C.R., additional, Taylor, R., additional, Tearney, G.J., additional, Tefera, K., additional, Thomas, S., additional, 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Published
2014
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46. Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis

Author

Straumann, A, Lucendo, AJ, Miehlke, S, Vieth, M, Schlag, C, Biedermann, L, Vaquero, CS, Ciriza de Los Rios, C, Schmoecker, C, Madisch, A, Hruz, P, Hayat, J, von Arnim, U, Bredenoord, AJ, Schubert, S, Mueller, R, Greinwald, R, Schoepfer, A, Attwood, S, International EOS-2 Study Group, and University of Zurich

Subjects
10219 Clinic for Gastroenterology and Hepatology, 610 Medicine & health
Abstract

BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it is not clear whether these drugs are effective for long-term maintenance of remission. METHODS: We performed a double-blind trial to compare the efficacy and safety of 2 dosages of a budesonide orodispersible tablet (BOT) vs placebo in maintaining remission of EoE. Maintenance of remission was defined as absence of clinical and histologic relapse and no premature withdrawal for any reason. Two hundred and four adults with EoE in clinical and histologic remission, from 29 European study sites, were randomly assigned to groups given BOT 0.5 mg twice daily (n = 68), BOT 1.0 mg twice daily (n = 68), or placebo twice daily (n = 68) for up to 48 weeks. RESULTS: At end of treatment, 73.5% of patients receiving BOT 0.5 mg twice daily and 75% receiving BOT 1.0 mg twice daily were in persistent remission compared with 4.4% of patients in the placebo group (P < .001 for both comparisons of BOT with placebo). Median time to relapse in the placebo group was 87 days. The frequency of adverse events was similar in the BOT and placebo groups. Morning serum levels of cortisol were in the normal range at baseline and did not significantly change during treatment. Four patients receiving BOT developed asymptomatic, low serum levels of cortisol. Clinically manifested candidiasis was suspected in 16.2% of patients in the BOT 0.5 mg group and in 11.8% of patients in the BOT 1.0 mg group; all infections resolved with treatment. CONCLUSIONS: In a phase 3 trial, up to 48 weeks of treatment with BOT (0.5 mg or 1.0 mg twice daily) was superior to placebo in maintaining remission of EoE. Both dosages were equally effective and well tolerated. EudraCT number; 2014-001485-99; ClinicalTrials.gov number, NCT02434029.

Published
2020

50. OLGA staging for gastritis: A tutorial

Author

Rugge, M., Correa, P., Di Mario, F., El-Omar, E., Fiocca, R., Geboes, K., Genta, R.M., Graham, D.Y., Hattori, T., Malfertheiner, P., Nakajima, S., Sipponen, P., Sung, J., Weinstein, W., and Vieth, M.

Published
2008
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