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Abstract Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of the macromolecular network is dynamic and controls the permeability and circulation of the drug throughout the cell wall. Thus, our results indicate that echinocandin treatment triggers compensatory rearrangements in the cell wall that may help A. fumigatus to tolerate the drugs’ antifungal effects.

The compression, transmission and rendering of point clouds is essential for many use cases, notably immersive experience settings in eXtended Reality, telepresence and real-time communication where real world acquired 3D content is displayed in a virtual or real scene. Processing and display for these applications induce visual artifacts and the viewing conditions can impact the visual perception and Quality of Experience of users. Therefore, point cloud codecs, rendering methods, display settings and more need to be evaluated through visual Point Cloud Quality Assessment (PCQA) studies, both subjective and objective. However, the standardization of recommendations and methods to run such studies did not follow the evolution of the research field and new issues and challenges have emerged. In this paper, we make a systematic review of subjective and objective PCQA studies. We collected scientific papers from online libraries (IEEE Xplore, ACM DL, Scopus) and selected a set of relevant papers to analyze. From our observations, we discuss the progress and future challenges in PCQA toward efficient point cloud video coding and rendering for eXtended Reality. Main axes for development include the study of use case specific influential factors and the definition of new test conditions for subjective PCQA, and development of perceptual learning-based methods for objective PCQA metrics as well as more versatile evaluation of their performance and time complexity.

Hérnan Vigier

In 2019, Spain became the country with the third highest number of asylum applications in the EU and it continues to be one of the top destinations for international migration (Migration Policy Institute 2022). This is a particularly pressing issue in the southernmost regions of Spain, namely the Canary Islands, Ceuta, Melilla and Andalusia, which have become the main gateway to Europe for those arriving by sea (Martín-Ruel 2021). As a result, the need for interpreting in international protection settings has increased, as these services prove essential for overcoming cross-linguistic and cross-cultural barriers, facilitating better integration of asylum applicants and refugees into the host society, and safeguarding their language rights (Wallace and Hernández 2017). In this article, we propose that the interpreter training provided by Andalusian universities can be used to respond to the needs identified in the international protection sector, thus contributing to the professionalization of the activity, and enhancing graduate employability in this field. To that end, we first describe the profile of an ideal interpreter for the stakeholders in international protection settings, then analyze current interpreting training programs, and finally suggest how specific training may be incorporated to provide better services in this field.

Abstract Microalgae are a renewable and promising biomass for large-scale biofuel, food and nutrient production. However, their efficient exploitation depends on our knowledge of the cell wall composition and organization as it can limit access to high-value molecules. Here we provide an atomic-level model of the non-crystalline and water-insoluble glycoprotein-rich cell wall of Chlamydomonas reinhardtii. Using in situ solid-state and sensitivity-enhanced nuclear magnetic resonance, we reveal unprecedented details on the protein and carbohydrate composition and their nanoscale heterogeneity, as well as the presence of spatially segregated protein- and glycan-rich regions with different dynamics and hydration levels. We show that mannose-rich lower-molecular-weight proteins likely contribute to the cell wall cohesion by binding to high-molecular weight protein components, and that water provides plasticity to the cell-wall architecture. The structural insight exemplifies strategies used by nature to form cell walls devoid of cellulose or other glycan polymers.

NMR-assisted crystallography-the integrated application of solid-state NMR, X-ray crystallography, and first-principles computational chemistry-holds significant promise for mechanistic enzymology: by providing atomic-resolution characterization of stable intermediates in enzyme active sites, including hydrogen atom locations and tautomeric equilibria, NMR crystallography offers insight into both structure and chemical dynamics. Here, this integrated approach is used to characterize the tryptophan synthase α-aminoacrylate intermediate, a defining species for pyridoxal-5'-phosphate-dependent enzymes that catalyze β-elimination and replacement reactions. For this intermediate, NMR-assisted crystallography is able to identify the protonation states of the ionizable sites on the cofactor, substrate, and catalytic side chains as well as the location and orientation of crystallographic waters within the active site. Most notable is the water molecule immediately adjacent to the substrate β-carbon, which serves as a hydrogen bond donor to the ε-amino group of the acid-base catalytic residue βLys87. From this analysis, a detailed three-dimensional picture of structure and reactivity emerges, highlighting the fate of the L-serine hydroxyl leaving group and the reaction pathway back to the preceding transition state. Reaction of the α-aminoacrylate intermediate with benzimidazole, an isostere of the natural substrate indole, shows benzimidazole bound in the active site and poised for, but unable to initiate, the subsequent bond formation step. When modeled into the benzimidazole position, indole is positioned with C3 in contact with the α-aminoacrylate Cβ and aligned for nucleophilic attack. Here, the chemically detailed, three-dimensional structure from NMR-assisted crystallography is key to understanding why benzimidazole does not react, while indole does.

Docosahexaenoic acid (DHA, C22:6 ω3) may be involved in various neuroprotective mechanisms that could prevent Alzheimer’s disease (AD). Its influence has still been little explored regarding the dysfunction of the endolysosomal pathway, known as an early key event in the physiopathological continuum triggering AD. This dysfunction could result from the accumulation of degradation products of the precursor protein of AD, in particular the C99 fragment, capable of interacting with endosomal proteins and thus contributing to altering this pathway from the early stages of AD. This study aims to evaluate whether neuroprotection mediated by DHA can also preserve the endolysosomal function. AD-typical endolysosomal abnormalities were recorded in differentiated human SH-SY5Y neuroblastoma cells expressing the Swedish form of human amyloid precursor protein. This altered phenotype included endosome enlargement, the reduced secretion of exosomes, and a higher level of apoptosis, which confirmed the relevance of the cellular model chosen for studying the associated deleterious mechanisms. Second, neuroprotection mediated by DHA was associated with a reduced interaction of C99 with the Rab5 GTPase, lower endosome size, restored exosome production, and reduced neuronal apoptosis. Our data reveal that DHA may influence protein localization and interactions in the neuronal membrane environment, thereby correcting the dysfunction of endocytosis and vesicular trafficking associated with AD.

BackgroundPosttraumatic stress disorder (PTSD) is a psychiatric disorder that can manifest after a traumatic event where the individual perceives a threat to his or her life or that of others. Its estimated prevalence in the European population is 0.7% to 1.9%. According to the “dose-response” model, individuals who are most exposed to traumatic events are most at risk of developing PTSD. Hence, it is unsurprising that studies have observed a higher prevalence among the military population, ranging from 10% to 18%, or even up to 45%. This project’s overall goal is to evaluate the primary prevention actions that can strengthen the resilience of at-risk professionals, notably military personnel, in the short term, with the medium- to long-term aim of preventing the occurrence of PTSD and improving the patient’s prognosis. ObjectiveThis study’s objectives are (1) to design a primary prevention program for PTSD, tailored to the studied military population and compatible with operational constraints; and (2) to implement and validate the Primary Prevention of Posttraumatic Stress Disorder in Military Professionals (PREPARE) program in the short term with operational personnel belonging to the French Mountain Infantry Brigade. MethodsThis is a single-center, prospective, randomized, parallel-group controlled cohort study. The cohort is divided into 2 groups: the nonintervention group receives no training, and the intervention group follows a dedicated prevention program (structured into 8 workshops and 2 debriefing and practice reinforcement workshops). Each participant is evaluated 4 times (at inclusion, +4 months, +6 months, and +12 months). During each visit, participants complete several psychosocial questionnaires (which take 15-80 minutes to complete). Samples (a 30-mL blood sample and three 5-mL saliva samples) are collected on 3 occasions: at inclusion, +4 months, and +12 months. Emotional reactivity (electrocardiogram and electrodermal activity) is measured before, during, and after the classic and the emotional Stroop task. ResultsThe project is currently ongoing, and results are expected to be published by the end of 2024. ConclusionsThe study adopts an integrative approach to the processes that play a role in the risk of developing PTSD. Our biopsychosocial perspective makes it possible to target levers related to factors specific to the individual and socio-professional factors. The following dimensions are addressed: (1) biophysiology (by studying markers of the neurobiological stress response, wear and tear, and vulnerability phenomena and reinforcing the flexibility of the autonomic nervous system), (2) psychology (by facilitating and measuring the development of flexible coping strategies to deal with stress and evaluating the moderating role of the individual’s sense of duty in the development of PTSD), and (3) social (by facilitating community strategies aimed at reducing stigmatization and supporting the use of care by professionals in difficulty, in the institutional context). Trial RegistrationClinicalTrials.gov NCT05094531; https://clinicaltrials.gov/study/NCT05094531 International Registered Report Identifier (IRRID)DERR1-10.2196/47175

The benefits of financial inclusion could be particularly important in Latin America, where the levels of ownership and use of different instruments lag behind those of developed countries. An improvement in the ownership and use of formal financial instruments could result in a reduction in informality, the promotion of formal savings and productive credit, and, therefore, an inclusive economic growth. The objective of this paper is to analyze the financial inclusion of a group of Latin American countries in order to detect the most used financial instruments and the main socioeconomic determinants that explain their ownership or use. At the same time, the evolution of the main variables was also studied for the years 2011, 2014, 2017 and 2021. Micro-data from the Global Findex database was examined (except for 2021, in which only macro-data are available). Statistical models and multivariate econometrics are applied to understand the individual socioeconomic characteristics of people who are still very unlikely to own and use formal financial instruments. Finally, the main reasons for not having an account were analyzed in order to delve into the main restrictions on which the financial market must focus to achieve greater financial inclusion.

IntroductionLong-duration space missions will be a real challenge for maintaining astronauts' adaptability. Research on transcutaneous vagus nerve stimulation (taVNS) is expanding rapidly, and its modalities constitute a major research challenge. A growing number of reviews stress the need to validate biomarkers for monitoring effects to enhance our understanding of the processes by which taVNS acts. Heart rate variability (HRV) appears to be a relevant candidate that informs on the autonomic nervous system (ANS). This is a promising technique to minimize the pathogenic effects of such large-scale missions and thus might be a relevant countermeasure. This study aimed to investigate the impact of taVNS on cognitive, psychological, and physiological functioning, including ANS functioning, and the benefits of increasing the number of taVNS sessions.MethodA total of 44 healthy participants were randomly assigned to one of the two cross-over protocols: a single session protocol (one taVNS and one sham simulation) or a repeated session protocol (three taVNS and three sham simulations). Cognitive, psychological, and physiological measures were performed before (pre) and after (post) each intervention. Sleep monitoring was only recorded before the first and after the last intervention in each protocol. For the repeated session protocol only, participants were allocated to two groups according to their parasympathetic activation gain during the three interventions: high parasympathetic delta (HPd) and low parasympathetic delta (LPd).ResultsParticipants in the repeated session protocol increased their HRV, cognitive performance, and sleep efficiency. In particular, taVNS induced higher parasympathetic activation and cardiac flexibility compared to the sham simulation in the repeated session protocol. Nevertheless, the perception of stress may indicate a nocebo effect of the repeated session. The HPd profile had higher interoceptive awareness, HRV highlighted by non-linear measures, and cognitive performance, but presented a decrease in some indicators of sleep efficiency compared to the LPd profile.ConclusiontaVNS seems to induce positive health outcomes, especially when the stimulation is repeated three times per week. Our findings highlight the benefits of parasympathetic activation during taVNS on psychophysiological and cognitive functioning. Further research is needed to validate these results on a large sample, using longitudinal measures over several months. This intervention appears promising as a countermeasure to extreme missions and occupations.

Temporal Lobe Epilepsy (TLE) is the most common form of epilepsy in adults. In TLE, recurrent mossy fiber (rMF) sprouting from dentate gyrus granule cells (DGCs) forms an aberrant epileptogenic network between dentate granule cells (DGCs) that operates via ectopically expressed kainate receptors (KARs). It was previously shown that KARs expressed at the rMF-DGC synapses play a prominent role in epileptiform network events in TLE. However, it is not well understood how KARs influence neuronal network dynamics and contribute to the generation of epileptiform network activity in the dentate gyrus. To address this question, we monitored the activity of DGCs using single-cell resolution calcium imaging performed in a reliable in vitro model of TLE. Under our experimental conditions, the most prominent DGC activity patterns were interictal-like epileptiform network events, which were correlated with high levels of neuronal synchronization. The pharmacological blockade of KARs reduced the frequency as well as the number of neurons involved in these events, without altering their spatiotemporal dynamics. Analysis of the microstructure of synchrony showed that blockade of KARs diminished the fraction of neurons forming the main functional cluster. Therefore, we propose that KARs act as modulators in the epileptic network by facilitating the recruitment of neurons into coactive cell assemblies, thereby contributing to the occurrence of epileptiform network events.

Al sector de la traducció judicial s’està observant un creixement considerable de la demanda a causa de l’augment del nombre de procediments amb persones que no parlen la llengua utilitzada per les autoritats, especialment a la Unió Europea (UE) des que es va aprovar recentment la legislació que consagra el dret a la traducció de documents essencials en els procediments penals (Brannan, 2017). En el cas de la traducció de textos jurídics, la traducció automàtica (TA) no es veu amb optimisme pel seu menyspreu al propòsit i el destinatari de la traducció (per exemple, Wiesmann, 2019; Roiss, 2021), malgrat el seu potencial per estalviar temps i els avantatges que ofereix pel que fa a la terminologia i la fraseologia (Killman, 2014) o la sintaxi (per exemple, Heiss i Soffritti, 2018; Mileto, 2019; Wrede et al., 2020). L’objectiu d’aquest article és analitzar si es pot aprofitar la TA en una especialitat de la traducció tan exigent com demandada, la traducció judicial. En concret, aquest article avalua la qualitat de les traduccions a l’anglès d’una ordre de detenció preventiva en espanyol produïdes per tres sistemes de traducció automàtica neuronal (TAN) diferents (DeepL, eTranslation i Google Translate) seguint les directrius d’avaluació de la TAUS.

Human-induced environmental disturbances during the Holocene have provided support for the Early Anthropogenic Hypothesis (EAH), which proposes that with the advent of agro-pastoralism and associated deforestation, humans have modified CO2 and CH4 concentrations into the atmosphere. However, only limited evidence exists for human driven chemical alteration of the Earth’s Critical Zone (ECZ) in early antiquity. Here, we explore the impact of human activities on both erosion and chemical weathering patterns in the Nile basin during a time interval that includes the rise of the Aksumite Kingdom and Late Antique Egypt (${\sim }$3–${\sim }$1 ka BP). By coupling lithium and neodymium isotopes ($\delta ^7\mathrm{Li}$, $\varepsilon \mathrm{Nd}$) in clay-size fractions of two marine sediment cores from the Nile Deep Sea Fan (NDSF), we reconstruct the variability of sediment provenance and silicate weathering intensity in the Nile basin over the last 9000 years. Our high temporal resolution data show that for the last ${\sim }$3000 years, the Rosetta Nile Deep Sea Fan has been increasingly fed with clays delivered from the Ethiopian basaltic highlands ($\varepsilon \mathrm{Nd}= {\sim }{-}1$), despite the absence of hydrological intensification and major climatic drivers over that region. Concomitantly, the clay Li isotopic composition shifted towards lower ${\delta }^{7}\mathrm{Li}$ values (${\delta }^{7}\mathrm{Li} = 1$ to ${-}$2), yielding unprecedented negative values for at least the last 100,000 years. Combined with other archaeological, paleo-pedological and organic chemistry inferences, the Li–Nd isotope proxy records indicate a link between the intensification of continental weathering and intensified land-use and water management during the Pre-Aksumite (${\sim }$3 to ${\sim }$2 ka BP) and Aksumite (${\sim }$2 to ${\sim }$1 ka BP) periods. Therefore, our results provide direct support to the hypothesis of an early and large scale anthropogenic forcing on continental chemical weathering. A comparison with previously published records for Central Africa, Central Europe and China suggests that the impact of the intensification of early agriculture on the ECZ may have operated at a global scale starting around four thousand years ago.

Summary: Lithium (Li) has a wide range of uses in science, medicine, and industry, but its isotopy is underexplored, except in nuclear science and in geoscience. 6Li and 7Li isotopic ratio exhibits the second largest variation on earth’s surface and constitutes a widely used tool for reconstructing past oceans and climates. As large variations have been measured in mammalian organs, plants or marine species, and as 6Li elicits stronger effects than natural Li (∼95% 7Li), a central issue is the identification and quantification of biological influence of Li isotopes distribution. We show that membrane ion channels and Na+-Li+/H+ exchangers (NHEs) fractionate Li isotopes. This systematic 6Li enrichment is driven by membrane potential for channels, and by intracellular pH for NHEs, where it displays cooperativity, a hallmark of dimeric transport. Evidencing that transport proteins discriminate between isotopes differing by one neutron opens new avenues for transport mechanisms, Li physiology, and paleoenvironments.

La présente contribution propose de nouvelles avancées dans le but de relever l’un des défis majeurs posé par la classe des prépositions complexes à la communauté des chercheurs en linguistique : la possibilité d’en dresser une liste. En vue du développement d’une méthode entièrement automatisée pour extraire des candidats appartenant à cette classe, nous proposons une étude expérimentale où sont croisées deux approches pour caractériser les prépositions complexes : d’une part, l’application d’une grille multicritère proposée par Vigier & Kahng (2022) (suite à Stosic & Fagard (2019)) qui nécessite de combiner des tests manuels avec des mesures statistiques extraites de corpus ; d’autre part l’extraction automatisée d’une série d’indices textométriques, dont certains sont originaux, comme le taux d’insertion ou une mesure de dispersion composite. Nos observations montrent que sur une liste de candidats comportant de nombreux intrus, quelques indices peuvent se révéler discriminants, tels que le taux d’insertion, la dispersion par année ou par fichier, ainsi que, dans une moindre mesure, des mesures d’association statistique comme le t-score et log rapport de vraisemblance. Mais nous montrons également, en étudiant une liste de candidats construits avec la préposition « en », que ces observations sont à nuancer et dépendent notamment du comportement syntaxique des prépositions mises en jeu.

Measurement(s) Fisheries simulation database Technology Type(s) Data collection and curating, modelling Sample Characteristic - Organism Merluccius merluccius • Solea solea • Nephrops norvegicus Sample Characteristic - Environment Mixed demersal fisheries Sample Characteristic - Location Bay of Biscay

Abstract Most cancer patients exhibit autonomic dysfunction with attenuated heart rate variability (HRV) levels compared to healthy controls. This research aimed to create and evaluate a machine learning (ML) model enabling discrimination between cancer patients and healthy controls based on 5-min-ECG recordings. We selected 12 HRV features based on previous research and compared the results between cancer patients and healthy individuals using Wilcoxon sum-rank test. Recursive Feature Elimination (RFE) identified the top five features, averaged over 5 min and employed them as input to three different ML. Next, we created an ensemble model based on a stacking method that aggregated the predictions from all three base classifiers. All HRV features were significantly different between the two groups. SDNN, RMSSD, pNN50%, HRV triangular index, and SD1 were selected by RFE and used as an input to three different ML. All three base-classifiers performed above chance level, RF being the most efficient with a testing accuracy of 83%. The ensemble model showed a classification accuracy of 86% and an AUC of 0.95. The results obtained by ML algorithms suggest HRV parameters could be a reliable input for differentiating between cancer patients and healthy controls. Results should be interpreted in light of some limitations that call for replication studies with larger sample sizes.

Summary: Cell type is hypothesized to be a key determinant of a neuron’s role within a circuit. Here, we examine whether a neuron’s transcriptomic type influences the timing of its activity. We develop a deep-learning architecture that learns features of interevent intervals across timescales (ms to >30 min). We show that transcriptomic cell-class information is embedded in the timing of single neuron activity in the intact brain of behaving animals (calcium imaging and extracellular electrophysiology) as well as in a bio-realistic model of the visual cortex. Further, a subset of excitatory cell types are distinguishable but can be classified with higher accuracy when considering cortical layer and projection class. Finally, we show that computational fingerprints of cell types may be universalizable across structured stimuli and naturalistic movies. Our results indicate that transcriptomic class and type may be imprinted in the timing of single neuron activity across diverse stimuli.

Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March–April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique – Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France. Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Results: Up to a fourth of patients admitted in March–April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March–April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.

The plant biomass is a composite formed by a variety of polysaccharides and an aromatic polymer named lignin. Here, the authors use solid-state NMR spectroscopy to unveil the carbohydrate-aromatic interface that leads to the variable architecture of lignocellulose biomaterials.

Introduction: Gene fusion testing of ALK, ROS1, RET, NTRK, and MET exon 14 skipping mutations is guideline recommended in nonsquamous NSCLC (NS-NSCLC). Nevertheless, assessment is often hindered by the limited availability of tissue and prolonged next-generation sequencing (NGS) testing, which can protract the initiation of a targeted therapy. Therefore, the development of faster gene fusion assessment is critical for optimal clinical decision-making. Here, we compared two ultrafast gene fusion assays (UFGFAs) using NGS (Genexus, Oncomine Precision Assay, Thermo Fisher Scientific) and a multiplex reverse-transcriptase polymerase chain reaction (Idylla, GeneFusion Assay, Biocartis) approach at diagnosis in a retrospective series of 195 NS-NSCLC cases and five extrapulmonary tumors with a known NTRK fusion. Methods: A total of 195 NS-NSCLC cases (113 known gene fusions and 82 wild-type tumors) were included retrospectively. To validate the detection of a NTRK fusion, we added five NTRK-positive extrathoracic tumors. The diagnostic performance of the two UFGFAs and standard procedures was compared. Results: The accuracy was 92.3% and 93.1% for Idylla and Genexus, respectively. Both systems improved the sensitivity for detection by including a 5′-3′ imbalance analysis. Although detection of ROS1, MET exon 14 skipping, and RET was excellent with both systems, ALK fusion detection was reduced with sensitivities of 87% and 88%, respectively. Idylla had a limited sensitivity of 67% for NTRK fusions, in which only an imbalance assessment was used. Conclusions: UFGFA using NGS and reverse-transcriptase polymerase chain reaction approaches had an equal level of detection of gene fusion but with some technique-specific limitations. Nevertheless, UFGFA detection in routine clinical care is feasible with both systems allowing faster initiation of therapy and a broad degree of screening.

Non-conventional stable isotopes have received increasing attention in the past decade to investigate multi-level ecological connections from individuals to ecosystems. More recently, isotopes from trace and non-nutrient elements, potentially toxic (i.e., Hg), have also been recognized of great significance to discriminate sources, transports, and bioaccumulation, as well as trophic transfers. In contrast, lithium (Li) concentrations and its isotope compositions (δ7Li) remain poorly documented in aquatic ecosystems, despite its possible accumulation in marine organisms, its increasing industrial production, and its demonstrated hazardous effects on biota. Here, we present the first Li isotope investigation of various soft tissues, organs or whole organisms, from marine plankton, bivalves, cephalopods, crustaceans, and fish of different biogeographical regions [North Mediterranean Sea, North Atlantic Ocean (Bay of Biscay), South East Pacific Ocean (New Caledonia), and Southern Indian Ocean (Kerguelen Islands)]. Independently of the considered organisms, δ7Li values range widely, from 4.6‰ (digestive gland of bivalves) to 32.0‰ (zooplankton). Compared to homogeneous seawater (δ7Li ∼ 31.2‰ ± .3‰), marine organisms mostly fractionate Li isotopes in favor of the light isotope (6Li). Within the same taxonomic group, significant differences are observed among organs, indicating a key role of physiology on Li concentrations and on the distribution of Li isotopes. Statistically, the trophic position is only slightly related to the average Li isotope composition of soft tissues of marine organisms, but this aspect deserves further investigation at the organ level. Other potential influences are the Li uptake by ingestion or gill ventilation. Overall, this work constitutes the first δ7Li extensive baseline in soft tissues of coastal organisms from different large geographic areas mostly preserved from significant anthropogenic Li contamination.

Forty-eight spring barley genotypes were evaluated for deoxynivalenol (DON) concentration under natural infection across 5 years at Harrington, Prince Edward Island. These genotypes were also evaluated for Fusarium head blight (FHB) severity and DON concentration under field nurseries with artificial inoculation of Fusarium graminearum by the grain spawn method across 2 years at Ottawa, Ontario, and one year at Hangzhou, China. Additionally, these genotypes were also evaluated for FHB severity under greenhouse conditions with artificial inoculation of F. graminearum by conidial suspension spray method across 3 years at Ottawa, Ontario. The objective of the study was to investigate if reactions of barley genotypes to artificial FHB inoculation correlate with reactions to natural FHB infection. DON concentration under natural infection was positively correlated with DON concentration (r = 0.47, P < 0.01) and FHB incidence (r = 0.56, P < 0.01) in the artificially inoculated nursery with grain spawn method. Therefore, the grain spawn method can be used to effectively screen for low DON. FHB severity, generated from greenhouse spray, however, was not correlated with DON concentration (r = 0.12, P > 0.05) under natural infection and it was not correlated with DON concentration (r = −0.23, P > 0.05) and FHB incidence (r = 0.19, P > 0.05) in the artificially inoculated nursery with grain spawn method. FHB severity, DON concentration, and yield were affected by year, genotype, and the genotype × year interaction. The effectiveness of greenhouse spray inoculation for indirect selection for low DON concentration requires further studies. Nine of the 48 genotypes were found to contain low DON under natural infection. Island barley had low DON and also had high yield.

The European Space Agency is funding the research and development of 241Am-bearing oxide-fuelled radioisotope power systems (RPSs) including radioisotope thermoelectric generators (RTGs) and European Large Heat Sources (ELHSs). The RPSs’ requirements include that the fuel’s maximum temperature, Tmax, must remain below its melting temperature. The current prospected fuel is (Am0.80U0.12Np0.06Pu0.02)O1.8. The fuel’s experimental heat capacity, Cp, is determined between 20 K and 1786 K based on direct low temperature heat capacity measurements and high temperature drop calorimetry measurements. The recommended high temperature equation is Cp(T/K) = 55.1189 + 3.46216 × 102 T − 4.58312 × 105 T−2 (valid up to 1786 K). The RTG/ELHS Tmax is estimated as a function of the fuel thermal conductivity, k, and the clad’s inner surface temperature, Ti cl, using a new analytical thermal model. Estimated bounds, based on conduction-only and radiation-only conditions between the fuel and clad, are established. Estimates for k (80–100% T.D.) are made using Cp, and estimates of thermal diffusivity and thermal expansion estimates of americium/uranium oxides. The lowest melting temperature of americium/uranium oxides is assumed. The lowest k estimates are assumed (80% T.D.). The highest estimated Tmax for a ‘standard operating’ RTG is 1120 K. A hypothetical scenario is investigated: an ELHS Ti cl = 1973K-the RPSs’ requirements’ maximum permitted temperature. Fuel melting will not occur.

El uso de servicios financieros mejora las posibilidades de ahorro, de acceso a bienes y servicios, para la salud, educación o vivienda, mejora el acceso al crédito, y por ende, aumenta los niveles de inversión y productividad de los hogares, de emprendimientos y empresas. En base a la Encuesta Nacional sobre la Estructura Social (ENES), realizada en 339 aglomerados urbanos de Argentina durante el año 2015, se analizan los determinantes de la inclusión financiera de los hogares. Se consideran variables vinculadas con el empleo y perfil del principal sostén del hogar, los ingresos familiares y otros aspectos relevantes. A través de métodos estadísticos se analiza si estas últimas variables influyen en la probabilidad de inclusión financiera de los hogares (medida a través de la tenencia de cuenta bancaria, tarjeta de crédito y el haber obtenido un crédito en los últimos 5 años). Los test estadísticos demuestran que la formalidad del empleo, el nivel de ingresos y educación del principal sostén del hogar son variables significativas sobre la probabilidad de encontrarse incluido en términos financieros, no así el género, a excepción de la tenencia de tarjetas de crédito. La edad es una variable significativa pero en términos no lineales. A su vez, se corrobora la probabilidad marginal de tres perfiles de hogares, según las principales variables determinantes, para cuantificar las brechas existentes.

Lithium (Li) has two stable isotopes, 6Li and 7Li, whose large relative mass difference is responsible for significant isotopic fractionation during physico-chemical processes, allowing Li isotopes to be a good tracer of continental chemical weathering. Although physical erosion is dominant in the Polar regions due to glaciers, increasing global surface temperature may enhance chemical weathering, with possible consequences on carbon biogeochemical cycle and nutriment flux to the ocean. Here, we examined elemental and Li isotope geochemistry of meltwaters, suspended sediments, soils, and bedrocks in the Barton Peninsula, King George Island, Antarctica. Li concentrations range from 8.7 nM to 23.3 μM in waters, from 0.01 to 1.43 ppm in suspended sediments, from 9.56 to 36.9 ppm in soils, and from 0.42 to 28.3 ppm in bedrocks. δ7Li values are also variable, ranging from +16.4 to +41.1‰ in waters, from −0.4 to +13.4‰ in suspended sediments, from −2.5 to +6.9‰ in soils, and from −1.8 to +11.7‰ in bedrocks. Elemental and Li isotope geochemistry reveals that secondary phase formation during chemical weathering mainly control dissolved δ7Li values, rather than a mixing with sea salt inputs from atmosphere or ice melting. Likewise, δ7Li values of suspended sediments and soils lower than those of bedrocks indicate modern chemical weathering with mineral neoformation. This study suggests that increasing global surface temperature enhances modern chemical weathering in Antarctica, continuing to lower δ7Li values in meltwater with intense water-rock interactions.