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2. Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses.

Author

Jarrosson L, Kolopp-Sarda MN, Aguilar P, Béné MC, Lepori ML, Vignaud MC, Faure GC, and Kohler C

Subjects
Adult, Antibody Formation genetics, CD4-CD8 Ratio, Cell Division physiology, Cytokines biosynthesis, Cytokines genetics, Female, Genotype, Health Personnel, Hepatitis B Surface Antigens immunology, Humans, Immunity, Cellular genetics, Immunization, Secondary, Lymphocytes physiology, Male, Middle Aged, Occupational Exposure, Phenotype, Polymorphism, Genetic, T-Lymphocytes immunology, Th1 Cells immunology, Th1 Cells metabolism, Th2 Cells immunology, Th2 Cells metabolism, Antibody Formation immunology, Hepatitis B Vaccines immunology, Immunity, Cellular immunology
Abstract

About 10% of health care professionals vaccinated against hepatitis B virus (HBV) fail to develop protective antibodies. We tested the capacity of peripheral blood lymphocytes from 121 health care professionals, including 76 non-responders, to proliferate to four HBV vaccines, examined the proliferating cells' subset, production of IFN-gamma, IL-4 and IL-10, and for 22 subjects, the cytokine production genotype. Specific proliferative responses to at least one HBV antigen were noted in 75% humoral non-responders. These cells differed from the CD4+ strongly proliferating cells of responders. Non-responders frequently displayed a genotype of high TGF-beta and intermediate IL-10 secretion. Most humoral non-responders to HBV thus develop specific cellular immune responses, eventually liable to protect them against viral infection.

Published
2004
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