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1. A narrative review for radiation oncologists to implement preoperative partial breast irradiation

Author

Zerella, Maria Alessia, Zaffaroni, Mattia, Ronci, Giuseppe, Dicuonzo, Samantha, Rojas, Damaris Patricia, Morra, Anna, Gerardi, Marianna Alessandra, Fodor, Cristiana, Rondi, Elena, Vigorito, Sabrina, Penco, Silvia, Sargenti, Manuela, Baratella, Paola, Vicini, Elisa, Morigi, Consuelo, Kahler-Ribeiro-Fontana, Sabrina, Galimberti, Viviana Enrica, Gandini, Sara, De Camilli, Elisa, Renne, Giuseppe, Cattani, Federica, Veronesi, Paolo, Orecchia, Roberto, Jereczek-Fossa, Barbara Alicja, and Leonardi, Maria Cristina

Published
2023
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2. Single fraction ablative preoperative radiation treatment for early-stage breast cancer: the CRYSTAL study – a phase I/II clinical trial protocol

Author

Zerella, Maria Alessia, Zaffaroni, Mattia, Ronci, Giuseppe, Dicuonzo, Samantha, Rojas, Damaris Patricia, Morra, Anna, Fodor, Cristiana, Rondi, Elena, Vigorito, Sabrina, Botta, Francesca, Cremonesi, Marta, Garibaldi, Cristina, Penco, Silvia, Galimberti, Viviana Enrica, Intra, Mattia, Gandini, Sara, Barberis, Massimo, Renne, Giuseppe, Cattani, Federica, Veronesi, Paolo, Orecchia, Roberto, Jereczek-Fossa, Barbara Alicja, and Leonardi, Maria Cristina

Published
2022
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3. The dosimetric impact of axillary nodes contouring variability in breast cancer radiotherapy: An AIRO multi-institutional study

Author

Leonardi, Maria Cristina, Pepa, Matteo, Gugliandolo, Simone Giovanni, Luraschi, Rosa, Vigorito, Sabrina, Morra, Anna, Dicuonzo, Samantha, Gerardi, Marianna Alessandra, Isaksson, Lars Johannes, Zerella, Maria Alessia, Rosa La Porta, Maria, Cante, Domenico, Petrucci, Edoardo, Marino, Lorenza, Borzì, Giuseppina, Ippolito, Edy, Marrocco, Maristella, Huscher, Alessandra, Chieregato, Matteo, Argenone, Angela, Iadanza, Luciano, De Rose, Fiorenza, Lobefalo, Francesca, Cucciarelli, Francesca, Valenti, Marco, Carmen De Santis, Maria, Cavallo, Anna, Rossi, Francesca, Russo, Serenella, Prisco, Agnese, Guernieri, Marika, Guarnaccia, Roberta, Malatesta, Tiziana, Meaglia, Ilaria, Liotta, Marco, Tabarelli de Fatis, Paola, Palumbo, Isabella, Marcantonini, Marta, Pia Colangione, Sarah, Mezzenga, Emilio, Falivene, Sara, Mormile, Maria, Ravo, Vincenzo, Arrichiello, Cecilia, Fozza, Alessandra, Barbero, Maria Paola, Ivaldi, Giovanni Battista, Catalano, Gianpiero, Vidali, Cristiana, Aristei, Cynthia, Giannitto, Caterina, Ciardo, Delia, Ciabattoni, Antonella, Meattini, Icro, Orecchia, Roberto, Cattani, Federica, Jereczek-Fossa, Barbara Alicja, La Porta, Maria Rosa, De Santis, Maria Carmen, and Colangione, Sarah Pia

Published
2022
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4. Stereotactic radioablation for the treatment of ventricular tachycardia: preliminary data and insights from the STRA-MI-VT phase Ib/II study

Author

Carbucicchio, Corrado, Andreini, Daniele, Piperno, Gaia, Catto, Valentina, Conte, Edoardo, Cattani, Federica, Bonomi, Alice, Rondi, Elena, Piccolo, Consiglia, Vigorito, Sabrina, Ferrari, Annamaria, Pepa, Matteo, Giuliani, Mattia, Mushtaq, Saima, Scarà, Antonio, Calò, Leonardo, Gorini, Alessandra, Veglia, Fabrizio, Pontone, Gianluca, Pepi, Mauro, Tremoli, Elena, Orecchia, Roberto, Pompilio, Giulio, Tondo, Claudio, and Jereczek-Fossa, Barbara Alicja

Published
2021
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6. Impact of inter-observer variability on first axillary level dosimetry in breast cancer radiotherapy: An AIRO multi-institutional study

Author

Leonardi, Maria Cristina, primary, Pepa, Matteo, additional, Zaffaroni, Mattia, additional, Vincini, Maria Giulia, additional, Luraschi, Rosa, additional, Vigorito, Sabrina, additional, Morra, Anna, additional, Dicuonzo, Samantha, additional, Mazzola, Giovanni Carlo, additional, Gerardi, Marianna Alessandra, additional, Zerella, Maria Alessia, additional, Cante, Domenico, additional, Petrucci, Edoardo, additional, Borzì, Giuseppina, additional, Marrocco, Maristella, additional, Chieregato, Matteo, additional, Iadanza, Luciano, additional, Lobefalo, Francesca, additional, Valenti, Marco, additional, Cavallo, Anna, additional, Russo, Serenella, additional, Guernieri, Marika, additional, Malatesta, Tiziana, additional, Meaglia, Ilaria, additional, Liotta, Marco, additional, Palumbo, Isabella, additional, Marcantonini, Marta, additional, Mezzenga, Emilio, additional, Falivene, Sara, additional, Arrichiello, Cecilia, additional, Barbero, Maria Paola, additional, Ivaldi, Giovanni Battista, additional, Catalano, Gianpiero, additional, Vidali, Cristiana, additional, Giannitto, Caterina, additional, Ciabattoni, Antonella, additional, Meattini, Icro, additional, Aristei, Cynthia, additional, Orecchia, Roberto, additional, Cattani, Federica, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2023
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7. Cyberknife Radiosurgery for Prostate Cancer after Abdominoperineal Resection (CYRANO): The Combined Computer Tomography and Electromagnetic Navigation Guided Transperineal Fiducial Markers Implantation Technique

Author

Vavassori, Andrea, primary, Mauri, Giovanni, additional, Mazzola, Giovanni Carlo, additional, Mastroleo, Federico, additional, Bonomo, Guido, additional, Durante, Stefano, additional, Zerini, Dario, additional, Marvaso, Giulia, additional, Corrao, Giulia, additional, Ferrari, Elettra Dorotea, additional, Rondi, Elena, additional, Vigorito, Sabrina, additional, Cattani, Federica, additional, Orsi, Franco, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2023
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8. 1831: CyberKnife UH-SBRT for localized PCa: a preliminary report from the PRO-Speed prospective Trial

Author

Mazzola, Giovanni Carlo, Marvaso, Giulia, Corrao, Giulia, Amin, Karl, Zerini, Dario, Durante, Stefano, Vavassori, Andrea, Vincini, Maria Giulia, Zaffaroni, Mattia, Rondi, Elena, Vigorito, Sabrina, Ronci, Giuseppe, Cattani, Federica, Mistretta, Francesco Alessandro, Luzzago, Stefano, Musi, Gennaro, De Cobelli, Ottavio, and Jereczek-Fossa, Barbara Alicja

Published
2024
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9. CyberKnife Ultra-Hypofractionated SBRT for Localized Prostate Cancer with Dose Escalation to the Dominant Intraprostatic Lesion: In Silico Planning Study

Author

Mazzola, Giovanni Carlo, primary, Vincini, Maria Giulia, additional, Rondi, Elena, additional, Ronci, Giuseppe, additional, Vigorito, Sabrina, additional, Zaffaroni, Mattia, additional, Corrao, Giulia, additional, Gallo, Salvatore, additional, Zerini, Dario, additional, Durante, Stefano, additional, Mistretta, Francesco Alessandro, additional, Luzzago, Stefano, additional, Ferro, Matteo, additional, Vavassori, Andrea, additional, Cattani, Federica, additional, Musi, Gennaro, additional, De Cobelli, Ottavio, additional, Petralia, Giuseppe, additional, Orecchia, Roberto, additional, Marvaso, Giulia, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2023
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11. Brain metastases from NSCLC treated with stereotactic radiotherapy: prediction mismatch between two different radiomic platforms

Author

Carloni, Gianluca, primary, Garibaldi, Cristina, additional, Marvaso, Giulia, additional, Volpe, Stefania, additional, Zaffaroni, Mattia, additional, Pepa, Matteo, additional, Isaksson, Lars Johannes, additional, Colombo, Francesca, additional, Durante, Stefano, additional, Lo Presti, Giuliana, additional, Raimondi, Sara, additional, Spaggiari, Lorenzo, additional, de Marinis, Filippo, additional, Piperno, Gaia, additional, Vigorito, Sabrina, additional, Gandini, Sara, additional, Cremonesi, Marta, additional, Positano, Vincenzo, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2023
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12. Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes

Author

Alterio, Daniela, primary, Marani, Simona, additional, Zurlo, Valeria, additional, Zorzi, Stefano Filippo, additional, Ferrari, Annamaria, additional, Volpe, Stefania, additional, Bandi, Francesco, additional, Vigorito, Sabrina, additional, Vincini, Maria Giulia, additional, Gandini, Sara, additional, Gaeta, Aurora, additional, Fodor, Cristiana Iuliana, additional, Casbarra, Alessia, additional, Zaffaroni, Mattia, additional, Starzyńska, Anna, additional, Belgioia, Liliana, additional, Ansarin, Mohssen, additional, Aristei, Cynthia, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2022
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15. Neobladder and ablative pelvic radiotherapy: still a taboo?

Author

Bergamaschi, Luca, primary, Gerardi, Marianna Alessandra, additional, Zaffaroni, Mattia, additional, Augugliaro, Matteo, additional, Vigorito, Sabrina, additional, Rondi, Elena, additional, Della Vigna, Paolo, additional, Varano, Gianluca, additional, Fumagalli Romario, Uberto, additional, Biffi, Roberto, additional, Picardi, Edgardo Enrico Edoardo, additional, Ferrari, Annamaria, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2021
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16. Geometric contour variation in clinical target volume of axillary lymph nodes in breast cancer radiotherapy: an AIRO multi-institutional study

Author

Leonardi, Maria Cristina, primary, Pepa, Matteo, additional, Gugliandolo, Simone Giovanni, additional, Luraschi, Rosa, additional, Vigorito, Sabrina, additional, Rojas, Damaris Patricia, additional, La Porta, Maria Rosa, additional, Cante, Domenico, additional, Petrucci, Edoardo, additional, Marino, Lorenza, additional, Borzì, Giuseppina, additional, Ippolito, Edy, additional, Marrocco, Maristella, additional, Huscher, Alessandra, additional, Chieregato, Matteo, additional, Argenone, Angela, additional, Iadanza, Luciano, additional, De Rose, Fiorenza, additional, Lobefalo, Francesca, additional, Cucciarelli, Francesca, additional, Valenti, Marco, additional, De Santis, Maria Carmen, additional, Cavallo, Anna, additional, Rossi, Francesca, additional, Russo, Serenella, additional, Prisco, Agnese, additional, Guernieri, Marika, additional, Guarnaccia, Roberta, additional, Malatesta, Tiziana, additional, Meaglia, Ilaria, additional, Liotta, Marco, additional, Tabarelli de Fatis, Paola, additional, Palumbo, Isabella, additional, Marcantonini, Marta, additional, Colangione, Sarah Pia, additional, Mezzenga, Emilio, additional, Falivene, Sara, additional, Mormile, Maria, additional, Ravo, Vincenzo, additional, Arrichiello, Cecilia, additional, Fozza, Alessandra, additional, Barbero, Maria Paola, additional, Ivaldi, Giovanni Battista, additional, Catalano, Gianpiero, additional, Vidali, Cristiana, additional, Aristei, Cynthia, additional, Giannitto, Caterina, additional, Miglietta, Eleonora, additional, Ciabattoni, Antonella, additional, Meattini, Icro, additional, Orecchia, Roberto, additional, Cattani, Federica, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2021
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18. Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results

Author

Alterio, Daniela, primary, Tagliabue, Marta, additional, Muto, Matteo, additional, Zorzi, Stefano, additional, Volpe, Stefania, additional, Gandini, Sara, additional, Sibio, Daniela, additional, Bayır, Ömer, additional, Marvaso, Giulia, additional, Ferrari, Annamaria, additional, Bruschini, Roberto, additional, Cossu Rocca, Maria, additional, Preda, Lorenzo, additional, Marangoni, Roberta, additional, Starzynska, Anna, additional, Vigorito, Sabrina, additional, Ansarin, Mohssen, additional, and Jereczek-Fossa, Barbara Alicja, additional

Published
2020
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21. Evaluation of target coverage and margins adequacy during CyberKnife Lung Optimized Treatment

Author

Ricotti, Rosalinda, primary, Seregni, Matteo, additional, Ciardo, Delia, additional, Vigorito, Sabrina, additional, Rondi, Elena, additional, Piperno, Gaia, additional, Ferrari, Annamaria, additional, Zerella, Maria Alessia, additional, Arculeo, Simona, additional, Francia, Claudia Maria, additional, Sibio, Daniela, additional, Cattani, Federica, additional, De Marinis, Filippo, additional, Spaggiari, Lorenzo, additional, Orecchia, Roberto, additional, Riboldi, Marco, additional, Baroni, Guido, additional, and Jereczek‐Fossa, Barbara Alicja, additional

Published
2018
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22. CyberKnife beam output factor measurements: A multi-site and multi-detector study

Author

Masi, Laura, primary, Russo, Serenella, additional, Francescon, Paolo, additional, Doro, Raffaela, additional, Frassanito, Maria Cristina, additional, Fumagalli, Maria Luisa, additional, Reggiori, Giacomo, additional, Marinelli, Marco, additional, Redaelli, Irene, additional, Pimpinella, Maria, additional, Verona Rinati, Gianluca, additional, Siragusa, Carmelo, additional, Vigorito, Sabrina, additional, and Mancosu, Pietro, additional

Published
2016
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24. Multicenter evaluation of a synthetic single-crystal diamond detector for CyberKnife small field size output factors

Author

Russo, Serenella, primary, Masi, Laura, additional, Francescon, Paolo, additional, Frassanito, Maria Cristina, additional, Fumagalli, Maria Luisa, additional, Marinelli, Marco, additional, Falco, Maria Daniela, additional, Martinotti, Anna Stefania, additional, Pimpinella, Maria, additional, Reggiori, Giacomo, additional, Verona Rinati, Gianluca, additional, Vigorito, Sabrina, additional, and Mancosu, Pietro, additional

Published
2016
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27. HYPOFRACTIONATED RAPIDARC (TM) INTENSITY-MODULATED RADIOTHERAPY FOR POSTOPERATIVE OR SALVAGE TREATMENT OF PROSTATE CARCINOMA

Author

Zerini, Dario, Jereczek-Fossa, Barbara Alicja, Mauro, Roberta, Fodor, Cristiana, Bonora, Maria, Fanti, Paola, Bossi-Zanetti, Isa, federica gherardi, Vavassori, Andrea, Vigorito, Sabrina, Luraschi, Rosa, Comi, Stefania, Cattani, Federica, Cambria, Raffaella, Cobelli, Ottavio, Mazzoleni, Federica, Verweij, Fabrizio, Matei, Deliu-Victor, Musi, Gennaro, Scardino, Epifanio, and Orecchia, Roberto

28. 2613: Preoperative single-fraction RT for earlystage BC: preliminary results from CRYSTAL phase I/II study.

Author

Zerella, Maria Alessia, Zaffaroni, Mattia, Mazzola, Giovanni Carlo, Ronci, Giuseppe, Dicuonzo, Samantha, Rojas, Damaris Patricia, Morra, Anna, Gerardi, Marianna Alessandra, Fodor, Cristiana, Rondi, Elena, Vigorito, Sabrina, Penco, Silvia, Sargenti, Manuela, Vicini, Elisa, Galimberti, Viviana Enrica, Gandini, Sara, Cursano, Giulia, De Camilli, Elisa, Cattani, Federica, and Veronesi, Paolo

Subjects
*CRYSTALS
Published
2024
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30. Stereotactic radiotherapy for managing ovarian cancer oligoprogression under poly (ADP-ribose) polymerase inhibitors (PARPi).

Author

Durante S, Cuccia F, Rigo M, Caminiti G, Mastroleo F, Lazzari R, Corrao G, Caruso G, Vigorito S, Cattani F, Ferrera G, Chiantera V, Alongi F, Colombo N, and Jereczek-Fossa BA

Subjects
Humans, Female, Retrospective Studies, Middle Aged, Aged, Adult, Disease Progression, Aged, 80 and over, Carcinoma, Ovarian Epithelial drug therapy, Carcinoma, Ovarian Epithelial radiotherapy, Carcinoma, Ovarian Epithelial therapy, Progression-Free Survival, Poly(ADP-ribose) Polymerase Inhibitors administration & dosage, Ovarian Neoplasms drug therapy, Ovarian Neoplasms pathology, Ovarian Neoplasms therapy, Ovarian Neoplasms radiotherapy, Radiosurgery methods, Radiosurgery adverse effects
Abstract

Objective: Poly (ADP-ribose) polymerase inhibitors (PARPi) have become a new standard of care for the maintenance treatment of advanced epithelial ovarian cancer. This study aims to evaluate the efficacy and safety of combining stereotactic body radiotherapy with PARPi continuation as a strategy to treat ovarian cancer oligoprogression on PARPi., Methods: This is a multicenter retrospective study including ovarian cancer patients treated with stereotactic body radiotherapy and PARPi continuation for oligoprogression under PARPi maintenance therapy between June 2012 and May 2023 in three Italian centers. PARPi treatment was continued until further disease progression or unacceptable toxicity. The primary endpoint was the next-line systemic therapy-free interval. The Kaplan-Meier method was used to assess local control, progression-free survival, and overall survival. Univariate and multivariate Cox regression analyses were performed to evaluate potential clinical outcomes predictors., Results: 46 patients were included, with a total of 89 lesions treated over 63 radiotherapy treatments. Lymph nodes were the most frequently treated lesions (80, 89.9%), followed by visceral lesions (8, 9%) and one case with a bone lesion (1.1%). Median follow-up was 25.9 months (range 2.8-122). The median next-line systemic therapy-free interval was 12.4 months (95% CI 8.3 to 19.5). A number of prior chemotherapy lines greater than five was significantly associated with a reduced next-line systemic therapy-free interval (HR 3.21, 95% CI 1.11 to 9.32, p=0.032). At the time of analysis, 32 (69.6%) patients started a new systemic therapy regimen, while 14 (30.4%) remained on the PARPi regimen. The 2-year progression-free survival, local failure-free survival, and overall survival rates were 10.7%, 78.1%, and 76.5%, respectively. Four patients (8.7%) experienced acute toxicity with G1 gastrointestinal events., Conclusion: Stereotactic body radiotherapy combined with PARPi continuation may be an effective and safe strategy for managing ovarian cancer patients with oligoprogression on PARPi maintenance therapy. Prospective research is warranted to shed more light on this approach., Competing Interests: Competing interests: BAJ-F has received speakers fees from Roche, Bayer, Janssen, Carl Zeiss, Ipsen, Accuray, Astellas, Elekta, and IBA Astra Zeneca, all outside the current project., (© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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31. Post-operative intensity-modulated vs 3D conformal radiotherapy after conservative surgery for laryngeal tumours of the supraglottic region: a dosimetric analysis on 20 patients.

Author

Alterio D, Marani S, Vigorito S, Zurlo V, Zorzi SF, Ferrari A, Volpe S, Bandi F, Vincini MG, Gandini S, Gaeta A, Fodor CI, Casbarra A, Zaffaroni M, Starzynska A, Belgioia L, Ansarin M, Aristei C, and Jereczek-Fossa BA

Subjects
Humans, Male, Retrospective Studies, Female, Middle Aged, Aged, Radiotherapy Dosage, Adult, Postoperative Care methods, Laryngeal Neoplasms radiotherapy, Laryngeal Neoplasms surgery, Radiotherapy, Conformal methods, Radiotherapy, Intensity-Modulated methods
Abstract

Objective: To perform a dosimetric comparison between intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy in patients with locally advanced (stage III and IV) tumours of the supraglottic region treated with conservative surgery and post-operative radiotherapy., Methods: An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered., Results: IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05)., Conclusions: IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings., (Copyright © 2024 Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy.)

Published
2024
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32. Second pelvic recurrence of rectal cancer successfully treated with a re-reirradiation (3rd radiation course).

Author

Dell'Acqua V, Ferrari A, Ciardo D, Piperno G, Vigorito S, Leonardi M, Dicuonzo S, Orecchia R, and Jereczek-Fossa BA

Subjects
Combined Modality Therapy methods, Female, Humans, Middle Aged, Pelvis radiation effects, Radiotherapy Dosage, Re-Irradiation methods, Salvage Therapy methods, Neoplasm Recurrence, Local radiotherapy, Rectal Neoplasms radiotherapy
Abstract

Introduction: In case of pelvic recurrence of colorectal cancer, reirradiation of previously irradiated patients may increase the rate of salvage radical resection. Due to the high cumulative dose, one of the main concerns is radiation-induced lumbosacral plexopathy. This report describes multiple irradiations of a lesion adjacent to the lumbosacral plexus, using a highly selective technique, which allows optimal sparing of such a critical structure., Case Description: A 53-year-old woman treated in 2008 for a locally advanced rectal adenocarcinoma with preoperative pelvic irradiation and concomitant chemotherapy followed by surgery had disease recurrence in 2011 and underwent a second course of pelvic radiotherapy. In December 2015, magnetic resonance imaging showed a single local recurrence infiltrating the muscle next to the right lumbosacral plexus and close to the cauda equina. Repeat reirradiation was planned. The total dose deriving from the previous treatment plans was assessed by nonrigid image registration using the dedicated tool implemented in MIM 6.1.7 (MIMvista Corp., Cleveland, OH). The treatment was performed with Cyberknife (Accuray, Sunnyvale, CA) with a schedule of 20 Gy in 5 fractions (4 Gy per fraction). The dose was prescribed to 70% isodose and target coverage was 97%. Two months after the treatment, magnetic resonance imaging showed a decreased signal and stable disease with no change in tumor size., Conclusions: This case report suggests that pelvic re-reirradiation might be a possibility in very carefully selected cases of rectal cancer, using high-precision radiation modalities.

Published
2018
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33. Hypofractionated stereotactic radiotherapy and radiosurgery for the treatment of patients with radioresistant brain metastases.

Author

Scorsetti M, Facoetti A, Navarria P, Bignardi M, De Santis M, Ninone SA, Lattuada P, Urso G, Vigorito S, Mancosu P, and Del Vecchio M

Subjects
Adult, Aged, Aged, 80 and over, Brain Neoplasms radiotherapy, Brain Neoplasms surgery, Carcinoma, Renal Cell radiotherapy, Carcinoma, Renal Cell secondary, Carcinoma, Renal Cell surgery, Carcinoma, Renal Cell therapy, Combined Modality Therapy, Dose Fractionation, Radiation, Female, Humans, Kidney Neoplasms pathology, Kidney Neoplasms radiotherapy, Kidney Neoplasms surgery, Kidney Neoplasms therapy, Male, Melanoma radiotherapy, Melanoma secondary, Melanoma surgery, Melanoma therapy, Middle Aged, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Retrospective Studies, Sarcoma radiotherapy, Sarcoma secondary, Sarcoma surgery, Sarcoma therapy, Young Adult, Brain Neoplasms secondary, Brain Neoplasms therapy
Abstract

Aim: To evaluate the efficacy of different radiotherapy treatment modalities in radioresistant brain metastasis., Patients and Methods: A retrospective analysis was conducted on 78 patients with brain metastases from melanoma, sarcoma, or renal cell carcinoma primary tumours who underwent radiosurgery (20 Gy) and/or hypofractionated stereotactic radiotherapy (6x4 Gy or 7x4 Gy) with or without whole-brain radiotherapy at our Center., Results: The actuarial median survival times for melanoma, renal cell carcinoma and sarcoma were 23, 22 and 7 months respectively, with a significant correlation to recursive partitioning analysis class., Discussion: Our results show that these treatments were effective both in symptom palliation and in improving survival, suggesting that although outcomes generally remained poor in this study population, it is possible and important to control intracranial brain metastases.

Published
2009

34. Digital mammography: quality and dose control.

Author

Di Maggio C, Gambaccini M, Gennaro G, Baldelli P, Taibi A, Chersevani R, Aimonetto S, Rossetti V, Origgi D, Vigorito S, Contento G, Angelini L, and Maggi S

Subjects
Humans, Phantoms, Imaging, Radiation Dosage, Reproducibility of Results, Time Factors, Mammography standards, Radiographic Image Enhancement
Abstract

Purpose: For almost 3 years, Radiologists and Physicists from Padova and Ferrara Universities have collaborated together, with the aim of collecting and comparing experimental data useful to define the most significant parameters for quality controls in digital mammography. Successively, radiologists and physicists working in other sites where a digital mammography unit was installed joined the work-group., Materials and Methods: In this study we report the results obtained from measurements of linearity, uniformity, short- and long-term reproducibility, AEC stability performed on 5 digital equipment by using a simple test object. X-ray beam quality and tube yield were preliminarily checked in such a way that possible uncertainties of digital system responses could be separated from those due to differences among X-ray tubes., Results: Results showed that the equipment considered, comparable in terms of both beam quality (HVL) and tube yield, always displayed linear response and reproducibility errors lower than 5%. Uniformity was very good and the grey level compensation as a function of exposure parameters remained within 5%. Differences in choice of parameters by exposure control system (AOP) were emphasised, especially for crossing between track/filter combinations (from Mo/Mo to Mo/Rh and from Mo/Rh to Rh/Rh); those differences were attributed to the +/-2 mm tolerance of breast thickness measurement (mechanically obtained) greater than the AOP tolerance (+/-1 mm)., Discussion and Conclusions: Obtained results can be useful, as comparison and reference values, for users employing a digital mammography unit of the same kind reported in this paper. Moreover, the same results could be used as "orientation" also by other users having different digital mammography technologies, whose operation should be nevertheless specifically studied and understood in order to find the most useful parameters for quality controls. The acquired experience clearly showed us that years of investigations will be necessary in order to be able to write reliable protocols. This should induce people to contemplate the necessity of not improvising "theoretical" protocols, that are unreliable and dangerous for their negative clinical implications.

Published
2004

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