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10 results on '"Vijgen, Sara"'

1. Importance of anti-SARS-CoV-2 assay antigenic composition as revealed by the results of the Belgian external quality assessment (EQA) scheme

Author

Moerman, Alena, Vernelen, Kris, China, Bernard, Capron, Arnaud, Bossche, Dorien Van Den, Mariën, Joachim, Ariën, Kevin K., Van Acker, Jos, Delforge, Marie-Luce, Reynders, Marijke, Boel, An, Depypere, Melissa, Van Gasse, Natasja, Vijgen, Sara, Brauner, Jonathan, Dujardin, Barbara, and Padalko, Elizaveta

Published
2022
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2. Risk Factors for Mortality, Intensive Care Unit Admission, and Bacteremia in Patients Suspected of Sepsis at the Emergency Department: A Prospective Cohort Study

Author

D'Onofrio, Valentino, Meersman, Agnes, Vijgen, Sara, Cartuyvels, Reinoud, Messiaen, Peter, and Gyssens, Inge C.

Subjects
sepsis, ICU admission, All institutes and research themes of the Radboud University Medical Center, emergency department, Medicine and Health Sciences, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], risk factors, bacteremia
Abstract

Background. There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department. Methods. A prospective observational cohort study including 1690 patients was performed. Two multivariable logistic regression models were used to identify independent risk factors. Results. Sequential organ failure assessment (SOFA) score of >= 2 and serum lactate of >= 2mmol/L were associated with all outcomes. Other independent risk factors were individual SOFA variables and systemic inflammatory response syndrome variables but varied per outcome. Mean arterial pressure

Published
2021

4. Pitfalls of rubella serology while on the brink of elimination: Evaluation of national data, Belgium, 2017

Author

Colman, Sofie, Vernelen, Kris, China, Bernard, van den Bossche, Dorien, Cornelissen, L., Delforge, Marie-Luce, Reynders, Marijke, Berth, Mario, Depypere, Melissa, van Gasse, Natasja, Vijgen, Sara, Van Acker, Jos, Boel, An, Padalko, Elizaveta, Colman, Sofie, Vernelen, Kris, China, Bernard, van den Bossche, Dorien, Cornelissen, L., Delforge, Marie-Luce, Reynders, Marijke, Berth, Mario, Depypere, Melissa, van Gasse, Natasja, Vijgen, Sara, Van Acker, Jos, Boel, An, and Padalko, Elizaveta

Abstract

Background: In Belgium, rubella serology is frequently requested in women of childbearing age, despite high vaccination coverage and a near-absence of congenital rubella cases. Different test kits are available and should be standardised by an international standard preparation. Aim: To analyse and compare rubella serology practices in Belgian laboratories. Methods: As part of the mandatory External Quality Assessment programme for rubella serology in Belgium, the national public health institute, Sciensano, sent a voluntary questionnaire concerning anti-rubella IgM/IgG analyses in women aged 15 to 45 years in 2017 to 130 laboratories. Results: The questionnaire response rate was 83.8% (109/130). The majority of 169,494 IgG analyses were performed on Roche (55%), Abbott (17%) and Diasorin (13%) analysers. Not all laboratories used the proposed international cut-off of 10 IU/mL. Assumed median seroprevalence ranged from 76.3% with Liaison (Diasorin) to 96.3% with Modular (Roche). Despite very low rubella incidence in Belgium, 93 laboratories performed 85,957 IgM analyses, with 748 positive and 394 grey zone results. The National Reference Centre for Measles, Mumps and Rubella virus and the National Reference Centre for Congenital infections did not confirm any positive rubella cases in 2017. Conclusion: This retrospective analysis shows that rubella serology results may differ considerably according to the assay used. It is therefore important to use the same test when comparing results or performing follow-up testing. The number of anti-rubella IgM analyses was very high. Incorrect use of IgM for screening women of childbearing age can lead to unwarranted anxiety and overuse of confirmation tests., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

5. Pitfalls of rubella serology while on the brink of elimination: evaluation of national data, Belgium, 2017

Author

Colman, Sofie, primary, Vernelen, Kris, additional, China, Bernard, additional, Van den Bossche, Dorien, additional, Cornelissen, Laura, additional, Delforge, Marie-Luce, additional, Reynders, Marijke, additional, Berth, Mario, additional, Depypere, Melissa, additional, Van Gasse, Natasja, additional, Vijgen, Sara, additional, Van Acker, Jos, additional, Boel, An, additional, and Padalko, Elizaveta, additional

Published
2021
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6. Synthesis and conformational analysis of a ribo-type cyclohexenyl nucleoside

Author

Vijgen, Sara, Nauwelaerts, Koen, Jing Wang, Aerschot, Arthur Van, Lagoja, Irene, and Herdewijn, Piet

Subjects
Nucleosides -- Chemical properties, Cyclohexane -- Chemical properties, Conformational analysis -- Research, Biological sciences, Chemistry
Abstract

A 'ribo'-type cylohexenyl nucleoside with an adenine base moiety is synthesized and its solution-state conformation is studied using NMR. It is concluded that introduction of OH in the ribo position shifts the conformation in a way that is opposite to what is observed in natural ribo-nucleosides.

Published
2005

10. Risk Factors for Mortality, Intensive Care Unit Admission, and Bacteremia in Patients Suspected of Sepsis at the Emergency Department: A Prospective Cohort Study.

Author

D'Onofrio V, Meersman A, Vijgen S, Cartuyvels R, Messiaen P, and Gyssens IC

Abstract

Background: There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department., Methods: A prospective observational cohort study including 1690 patients was performed. Two multivariable logistic regression models were used to identify independent risk factors., Results: Sequential organ failure assessment (SOFA) score of ≥2 and serum lactate of ≥2mmol/L were associated with all outcomes. Other independent risk factors were individual SOFA variables and systemic inflammatory response syndrome variables but varied per outcome. Mean arterial pressure <70 mmHg negatively impacted all outcomes., Conclusions: These readily available measurements can help with early risk stratification and prediction of prognosis., (© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

Published
2020
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