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1. The Near Infrared Imager and Slitless Spectrograph for the James Webb Space Telescope -- III. Single Object Slitless Spectroscopy

Author

Albert, Loic, Lafreniere, David, Doyon, Rene, Artigau, Etienne, Volk, Kevin, Goudfrooij, Paul, Martel, Andre R., Radica, Michael, Rowe, Jason, Espinoza, Nestor, Roy, Arpita, Filippazzo, Joseph C., Darveau-Bernier, Antoine, Talens, Geert Jan, Sivaramakrishnan, Anand, Willott, Chris J., Fullerton, Alexander W., LaMassa, Stephanie, Hutchings, John B., Rowlands, Neil, Vila, M. Begona, Zhou, Julia, Aldridge, David, Maszkiewicz, Michael, Beaulieu, Mathilde, Cook, Neil J., Piaulet, Caroline, Roy, Pierre-Alexis, Lamontagne, Pierrot, Morel, Kim, Frost, William, Salhi, Salma, Coulombe, Louis-Philippe, Benneke, Bjorn, MacDonald, Ryan J., Johnstone, Doug, Turner, Jake D., Fournier-Tondreau, Marylou, Allart, Romain, and Kaltenegger, Lisa

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The Near Infrared Imager and Slitless Spectrograph instrument (NIRISS) is the Canadian Space Agency (CSA) contribution to the suite of four science instruments of JWST. As one of the three NIRISS observing modes, the Single Object Slitless Spectroscopy (SOSS) mode is tailor-made to undertake time-series observations of exoplanets to perform transit spectroscopy. The SOSS permits observing point sources between 0.6 and 2.8 um at a resolving power of 650 at 1.25 um using a slit-less cross-dispersing grism while its defocussing cylindrical lens enables observing targets as bright as J=6.7 by spreading light across 23 pixels along the cross-dispersion axis. This paper officially presents the design of the SOSS mode, its operation, characterization, and its performance, from ground-based testing and flight-based Commissioning. On-sky measurements demonstrate a peak photon conversion efficiency of 55% at 1.2 um. The first time-series on the A-type star BD+60o1753 achieves a flux stability close to the photon-noise limit, so far tested to a level of 20 parts per million on 40-minute time-scales after simply subtracting a long-term trend. Uncorrected 1/f noise residuals underneath the spectral traces add an extra source of noise equivalent to doubling the readout noise. Preliminary analysis of a HAT-P-14b transit time-series indicates that it is difficult to remove all the noise in pixels with partially saturated ramps. Overall, the SOSS delivers performance at the level required to tackle key exoplanet science programs such as detecting secondary atmospheres on terrestrial planets and measuring abundances of several chemical species in gas giants., Comment: 41 pages, 28 figures, accepted for publication in PASP

Published
2023
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2. The Near Infrared Imager and Slitless Spectrograph for the James Webb Space Telescope -- I. Instrument Overview and in-Flight Performance

Author

Doyon, Rene, Willott, C. J, Hutchings, John B., Sivaramakrishnan, Anand, Albert, Loic, Lafreniere, David, Rowlands, Neil, Vila, M. Begona, Martel, Andre R., LaMassa, Stephanie, Aldridge, David, Artigau, Etienne, Cameron, Peter, Chayer, Pierre, Cook, Neil J., Cooper, Rachel A., Darveau-Bernier, Antoine, Dupuis, Jean, Earnshaw, Colin, Espinoza, Nestor, Filippazzo, Joseph C., Fullerton, Alexander W., Gaudreau, Daniel, Gawlik, Roman, Goudfrooij, Paul, Haley, Craig, Kammerer, Jens, Kendall, David, Lambros, Scott D., Ignat, Luminita Ilinca, Maszkiewicz, Michael, McColgan, Ashley, Morishita, Takahiro, Ouellette, Nathalie N. -Q., Pacifici, Camilla, Philippi, Natasha, Radica, Michael, Ravindranath, Swara, Rowe, Jason, Roy, Arpita, Saad, Karl, Sohn, Sangmo Tony, Talens, Geert Jan, Thatte, Deepashri, Taylor, Joanna M., Vandal, Thomas, Volk, Kevin, Wander, Michel, Warner, Gerald, Zheng, Sheng-Hai, Zhou, Julia, Abraham, Roberto, Beaulieu, Mathilde, Benneke, Bjorn, Ferrarese, Laura, Johnstone, Doug, Kaltenegger, Lisa, Meyer, Michael R., Pipher, Judy L., Rameau, Julien, Rieke, Marcia, Salhi, Salma, and Sawicki, Marcin

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Near-Infrared Imager and Slitless Spectrograph (NIRISS) is the science module of the Canadian-built Fine Guidance Sensor (FGS) onboard the James Webb Space Telescope (JWST). NIRISS has four observing modes: 1) broadband imaging featuring seven of the eight NIRCam broadband filters, 2) wide-field slitless spectroscopy (WFSS) at a resolving power of $\sim$150 between 0.8 and 2.2 $\mu$m, 3) single-object cross-dispersed slitless spectroscopy (SOSS) enabling simultaneous wavelength coverage between 0.6 and 2.8 $\mu$m at R$\sim$700, a mode optimized for exoplanet spectroscopy of relatively bright ($J<6.3$) stars and 4) aperture masking interferometry (AMI) between 2.8 and 4.8 $\mu$m enabling high-contrast ($\sim10^{-3}-10^{-4}$) imaging at angular separations between 70 and 400 milliarcsec for relatively bright ($M<8$) sources. This paper presents an overview of the NIRISS instrument, its design, its scientific capabilities, and a summary of in-flight performance. NIRISS shows significantly better response shortward of $\sim2.5\,\mu$m resulting in 10-40% sensitivity improvement for broadband and low-resolution spectroscopy compared to pre-flight predictions. Two time-series observations performed during instrument commissioning in the SOSS mode yield very stable spectro-photometry performance within $\sim$10% of the expected noise. The first space-based companion detection of the tight binary star AB Dor AC through AMI was demonstrated.

Published
2023

3. The Near Infrared Imager and Slitless Spectrograph for the James Webb Space Telescope -- IV. Aperture Masking Interferometry

Author

Sivaramakrishnan, Anand, Tuthill, Peter, Lloyd, James P., Greenbaum, Alexandra Z., Thatte, Deepashri, Cooper, Rachel A., Vandal, Thomas, Kammerer, Jens, Sanchez-Bermudez, Joel, Pope, Benjamin J. S., Blakely, Dori, Albert, Loïc, Cook, Neil J., Johnstone, Doug, Martel, André R., Volk, Kevin, Soulain, Anthony, Artigau, Étienne, Lafrenière, David, Willott, Chris J., Parmentier, Sébastien, Ford, K. E. Saavik, McKernan, Barry, Vila, M. Begoña, Rowlands, Neil, Doyon, René, Desdoigts, Louis, Fullerton, Alexander W., De Furio, Matthew, Goudfrooij, Paul, Holfeltz, Sherie T., LaMassa, Stephanie, Maszkiewicz, Michael, Meyer, Michael R., Perrin, Marshall D., Pueyo, Laurent, Sahlmann, Johannes, Sohn, Sangmo Tony, and Teixeira, Paula S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The James Webb Space Telescope's Near Infrared Imager and Slitless Spectrograph (JWST-NIRISS) flies a 7-hole non-redundant mask (NRM), the first such interferometer in space, operating at 3-5 \micron~wavelengths, and a bright limit of $\simeq 4$ magnitudes in W2. We describe the NIRISS Aperture Masking Interferometry (AMI) mode to help potential observers understand its underlying principles, present some sample science cases, explain its operational observing strategies, indicate how AMI proposals can be developed with data simulations, and how AMI data can be analyzed. We also present key results from commissioning AMI. Since the allied Kernel Phase Imaging (KPI) technique benefits from AMI operational strategies, we also cover NIRISS KPI methods and analysis techniques, including a new user-friendly KPI pipeline. The NIRISS KPI bright limit is $\simeq 8$ W2 magnitudes. AMI (and KPI) achieve an inner working angle of $\sim 70$ mas that is well inside the $\sim 400$ mas NIRCam inner working angle for its circular occulter coronagraphs at comparable wavelengths., Comment: 30 pages, 10 figures

Published
2022
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7. Carbon nanotube synthesis and spinning as macroscopic fibers assisted by the ceramic reactor tube

Author

Rodiles, X., Reguero, V., Vila, M., Alemán, B., Arévalo, L., Fresno, F., Shea, V. A. de la Peña O, and Vilatela, J. J.

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

Macroscopic fibers of carbon nanotubes (CNT) have emerged as an ideal architecture to exploit the exceptional properties of CNT building blocks in applications ranging from energy storage to reinforcement in structural composites. Controlled synthesis and scalability are amongst the most pressing challenges to further materialize the potential of CNT fibers. This workshows that under floating catalyst chemical vapor conditions in the direct spinning method, used both in research and industry,the ceramic reactor tube plays an unsuspected active role in CNT growth, leading for example to doubling of reaction yield when mullite (Al4+2xSi2-2xO10-x(x = 0.4)) is used instead of alumina (Al2O3), but without affecting CNT morphology in terms of number of layers, purity or degree of graphitization. This behaviour has been confirmed for different carbon sources andwhen growing either predominantly single-walled or multi-walled CNTs by adjusting promotor concentration. Analysis of large Si-based impurities occasionally found in CNT fiber fabric samples, attributed to reactor tube fragments that end up trapped inthe porous fibers, indicate that the role of the reactor tube is in catalyzing the thermal decomposition of hydrocarbons, which subsequently react with floating Fe catalyst nanoparticles and produce extrusion of the CNTs and formation of an aerogel. Reactor gas analysis confirms that extensive thermal decomposition of the carbon source occurs in the absence of Fe catalystparticles, and that the concentration of different carbon species (e.g. carbon dioxide and ethylene) is sensitive to the reactor tube type. These finding open new avenues for controlled synthesis of CNT fibers by decoupling precursor decomposition from CNT extrusion at the catalyst particle., Comment: 12 pages, Figure 6

Published
2020

10. Patritumab deruxtecan in untreated hormone receptor-positive/HER2-negative early breast cancer: final results from part A of the window-of-opportunity SOLTI TOT-HER3 pre-operative study

Author

Oliveira, M., Falato, C., Cejalvo, J.M., Vila, M. Margelí, Tolosa, P., Salvador-Bofill, F.J., Cruz, J., Arumi, M., Luna, A.M., Guerra, J.A., Vidal, M., Martínez-Sáez, O., Paré, L., González-Farré, B., Sanfeliu, E., Ciruelos, E., Espinosa-Bravo, M., Pernas, S., Izarzugaza, Y., Esker, S., Fan, P.-D., Parul, P., Santhanagopal, A., Sellami, D., Villacampa, G., Ferrero-Cafiero, J.M., Pascual, T., and Prat, A.

Published
2023
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11. The Internationalization in the Learning of the Accounting Profession: Use of the Kahoot as a Teaching Tool for Learning

Author

Curós Vilá, M. Pilar, Cano Montero, Elisa Isabel, Chamizo González, Julián, Martí Pidelaserra, Jordi, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Gil-Lafuente, Anna Maria, editor, Boria, Josefa, editor, Torres, Agustín, editor, and Merigó, José M., editor

Published
2022
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18. A scenario-guided strategy for the future management of biological invasions

Author

Roura-Pascual, N, Saul, WC, Pérez-Granados, C, Rutting, L, Peterson, GD, Latombe, G, Essl, F, Adriaens, T, Aldridge, DC, Bacher, S, Bernardo-Madrid, R, Brotons, L, Diaz, F, Gallardo, B, Genovesi, P, Golivets, M, González-Moreno, P, Hall, M, Kutlesa, P, Lenzner, B, Liu, CL, Pagitz, K, Pastor, T, Rabitsch, W, Robertson, P, Roy, HE, Seebens, H, Solarz, W, Starfinger, U, Tanner, R, Vilà, M, Leung, B, Garcia-Lozano, C, Jeschke, JM, Roura-Pascual, N, Saul, WC, Pérez-Granados, C, Rutting, L, Peterson, GD, Latombe, G, Essl, F, Adriaens, T, Aldridge, DC, Bacher, S, Bernardo-Madrid, R, Brotons, L, Diaz, F, Gallardo, B, Genovesi, P, Golivets, M, González-Moreno, P, Hall, M, Kutlesa, P, Lenzner, B, Liu, CL, Pagitz, K, Pastor, T, Rabitsch, W, Robertson, P, Roy, HE, Seebens, H, Solarz, W, Starfinger, U, Tanner, R, Vilà, M, Leung, B, Garcia-Lozano, C, and Jeschke, JM

Abstract

Future dynamics of biological invasions are highly uncertain because they depend on multiple social–ecological drivers. We used a scenario-based approach to explore potential management options for invasive species in Europe. During two workshops involving a multidisciplinary team of experts, we developed a management strategy arranged into 19 goals relating to policy, research, public awareness, and biosecurity. We conceived solutions for achieving these goals under different plausible future scenarios, and identified four interrelated recommendations around which any long-term strategy for managing invasive species can be structured: (1) a European biosecurity regime, (2) a dedicated communication strategy, (3) data standardization and management tools, and (4) a monitoring and assessment system. Finally, we assessed the feasibility of the management strategy and found substantial differences among scenarios. Collectively, our results indicate that it is time for a new strategy for managing biological invasions in Europe, one that is based on a more integrative approach across socioeconomic sectors and countries.

Published
2024

19. A scenario-guided strategy for the future management of biological invasions

Author

Roura-Pascual, N., Saul, W.-C., Pérez-Granados, C., Rutting, L., Peterson, G.D., Latombe, G., Essl, F., Adriaens, T., Aldridge, D.C., Bacher, S., Bernardo-Madrid, R., Brotons, L., Diaz, F., Gallardo, B., Genovesi, P., Golivets, Maryna, González-Moreno, P., Hall, M., Kutlesa, P., Lenzner, B., Liu, C., Pagitz, K., Pastor, T., Rabitsch, W., Robertson, P., Roy, H.E., Seebens, H., Solarz, W., Starfinger, U., Tanner, R., Vilà, M., Leung, B., Garcia-Lozano, C., Jeschke, J.M., Roura-Pascual, N., Saul, W.-C., Pérez-Granados, C., Rutting, L., Peterson, G.D., Latombe, G., Essl, F., Adriaens, T., Aldridge, D.C., Bacher, S., Bernardo-Madrid, R., Brotons, L., Diaz, F., Gallardo, B., Genovesi, P., Golivets, Maryna, González-Moreno, P., Hall, M., Kutlesa, P., Lenzner, B., Liu, C., Pagitz, K., Pastor, T., Rabitsch, W., Robertson, P., Roy, H.E., Seebens, H., Solarz, W., Starfinger, U., Tanner, R., Vilà, M., Leung, B., Garcia-Lozano, C., and Jeschke, J.M.

Abstract

Future dynamics of biological invasions are highly uncertain because they depend on multiple social–ecological drivers. We used a scenario-based approach to explore potential management options for invasive species in Europe. During two workshops involving a multidisciplinary team of experts, we developed a management strategy arranged into 19 goals relating to policy, research, public awareness, and biosecurity. We conceived solutions for achieving these goals under different plausible future scenarios, and identified four interrelated recommendations around which any long-term strategy for managing invasive species can be structured: (1) a European biosecurity regime, (2) a dedicated communication strategy, (3) data standardization and management tools, and (4) a monitoring and assessment system. Finally, we assessed the feasibility of the management strategy and found substantial differences among scenarios. Collectively, our results indicate that it is time for a new strategy for managing biological invasions in Europe, one that is based on a more integrative approach across socioeconomic sectors and countries.

Published
2024

20. Early-season mass-flowering crop cover dilutes wild bee abundance and species richness in temperate regions : A quantitative synthesis

Author

Riggi, L.G.A., Raderschall, C.A., Fijen, T.P.M., Scheper, J., Smith, H.G., Kleijn, D., Holzschuh, A., Aguilera, G., Badenhausser, I., Bänsch, S., Beyer, N., Blitzer, E.J., Bommarco, R., Danforth, B., González-Varo, J.P., Grab, H., Le Provost, G., Poveda, K., Potts, S.G., Rundlöf, M., Steffan-Dewenter, I., Tscharntke, T., Vilà, M., Westphal, C., Berggren, Lundin, O., Riggi, L.G.A., Raderschall, C.A., Fijen, T.P.M., Scheper, J., Smith, H.G., Kleijn, D., Holzschuh, A., Aguilera, G., Badenhausser, I., Bänsch, S., Beyer, N., Blitzer, E.J., Bommarco, R., Danforth, B., González-Varo, J.P., Grab, H., Le Provost, G., Poveda, K., Potts, S.G., Rundlöf, M., Steffan-Dewenter, I., Tscharntke, T., Vilà, M., Westphal, C., Berggren, and Lundin, O.

Abstract

Pollinators benefit from increasing floral resources in agricultural landscapes, which could be an underexplored co-benefit of mass-flowering crop cultivation. However, the impacts of mass-flowering crops on pollinator communities are complex and appear to be context-dependent, mediated by factors such as crop flowering time and the availability of other flower resources in the landscape. A synthesis of research is needed to develop management recommendations for effective pollinator conservation in agroecosystems. By combining 22 datasets from 13 publications conducted in nine temperate countries (20 European, 2 North American), we investigated if mass-flowering crop flowering time (early or late season), bloom state (during or after crop flowering) and extent of non-crop habitat cover in the landscape moderated the effect of mass-flowering crop cover on wild pollinator abundance and species richness in mass-flowering crop and non-crop habitats. During bloom, wild bee abundance and richness are negatively related to mass-flowering crop cover. Dilution effects were predominant in crop habitats and early in the season, except for bumblebees, which declined with mass-flowering crop cover irrespective of habitat or season. Late in the season and in non-crop habitats, several of these negative relationships were either absent or reversed. Late-season mass-flowering crop cover is positively related to honeybee abundance in crop habitats and to other bee abundance in non-crop habitats. These results indicate that crop-adapted species, like honeybees, move to forage and concentrate on late-season mass-flowering crops at a time when flower availability in the landscape is limited, potentially alleviating competition for flower resources in non-crop habitats. We found no evidence of pollinators moving from mass-flowering crop to non-crop habitats after crop bloom. Synthesis and applications: Our results confirm that increasing early-season mass-flowering crop cover dilutes w

Published
2024

21. A scenario-guided strategy for the future management of biological invasions

Author

Environmental Governance, Roura-Pascual, N, Saul, WC, Pérez-Granados, C, Rutting, L, Peterson, GD, Latombe, G, Essl, F, Adriaens, T, Aldridge, DC, Bacher, S, Bernardo-Madrid, R, Brotons, L, Diaz, F, Gallardo, B, Genovesi, P, Golivets, M, González-Moreno, P, Hall, M, Kutlesa, P, Lenzner, B, Liu, CL, Pagitz, K, Pastor, T, Rabitsch, W, Robertson, P, Roy, HE, Seebens, H, Solarz, W, Starfinger, U, Tanner, R, Vilà, M, Leung, B, Garcia-Lozano, C, Jeschke, JM, Environmental Governance, Roura-Pascual, N, Saul, WC, Pérez-Granados, C, Rutting, L, Peterson, GD, Latombe, G, Essl, F, Adriaens, T, Aldridge, DC, Bacher, S, Bernardo-Madrid, R, Brotons, L, Diaz, F, Gallardo, B, Genovesi, P, Golivets, M, González-Moreno, P, Hall, M, Kutlesa, P, Lenzner, B, Liu, CL, Pagitz, K, Pastor, T, Rabitsch, W, Robertson, P, Roy, HE, Seebens, H, Solarz, W, Starfinger, U, Tanner, R, Vilà, M, Leung, B, Garcia-Lozano, C, and Jeschke, JM

Published
2024

27. Early‐season mass‐flowering crop cover dilutes wild bee abundance and species richness in temperate regions: A quantitative synthesis

Author

Riggi, L. G. A., primary, Raderschall, C. A., additional, Fijen, T. P. M., additional, Scheper, J., additional, Smith, H. G., additional, Kleijn, D., additional, Holzschuh, A., additional, Aguilera, G., additional, Badenhausser, I., additional, Bänsch, S., additional, Beyer, N., additional, Blitzer, E. J., additional, Bommarco, R., additional, Danforth, B., additional, González‐Varo, J. P., additional, Grab, H., additional, Le Provost, G., additional, Poveda, K., additional, Potts, S. G., additional, Rundlöf, M., additional, Steffan‐Dewenter, I., additional, Tscharntke, T., additional, Vilà, M., additional, Westphal, C., additional, Berggren, Å., additional, and Lundin, O., additional

Published
2023
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28. Association between PD1 mRNA and response to anti-PD1 monotherapy across multiple cancer types

Author

Paré, L., Pascual, T., Seguí, E., Teixidó, C., Gonzalez-Cao, M., Galván, P., Rodríguez, A., González, B., Cuatrecasas, M., Pineda, E., Torné, A., Crespo, G., Martin-Algarra, S., Pérez-Ruiz, E., Reig, Ò, Viladot, M., Font, C., Adamo, B., Vidal, M., Gaba, L., Muñoz, M., Victoria, I., Ruiz, G., Viñolas, N., Mellado, B., Maurel, J., Garcia-Corbacho, J., Molina-Vila, M Á, Juan, M., Llovet, J.M., Reguart, N., Arance, A., and Prat, A.

Published
2018
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29. Study of the Convergence in Automatic Generation of Instance Level Constraints

Author

Diaz-Valenzuela, Irene, Campaña, Jesús R., Senatore, Sabrina, Loia, Vincenzo, Vila, M. Amparo, Martin-Bautista, Maria J., Kacprzyk, Janusz, Series editor, Andreasen, Troels, editor, Christiansen, Henning, editor, Larsen, Henrik, editor, Pasi, Gabriella, editor, Pivert, Olivier, editor, De Tré, Guy, editor, Vila, Maria Amparo, editor, Yazici, Adnan, editor, and Zadrożny, Sławomir, editor

Published
2016
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32. A review of the combination among global change factors in forests, shrublands and pastures of the Mediterranean Region: Beyond drought effects

Author

Doblas-Miranda, E., Alonso, R., Arnan, X., Bermejo, V., Brotons, L., de las Heras, J., Estiarte, M., Hódar, J.A., Llorens, P., Lloret, F., López-Serrano, F.R., Martínez-Vilalta, J., Moya, D., Peñuelas, J., Pino, J., Rodrigo, A., Roura-Pascual, N., Valladares, F., Vilà, M., Zamora, R., and Retana, J.

Published
2017
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37. European scenarios for future biological invasions

Author

Pérez-Granados, C., Lenzner, B., Golivets, Maryna, Saul, W.-C., Jeschke, J.M., Essl, F., Peterson, G.D., Rutting, L., Latombe, G., Adriaens, T., Aldridge, D.C., Bacher, S., Bernardo-Madrid, R., Brotons, L., Díaz, F., Gallardo, B., Genovesi, P., González-Moreno, P., Kühn, Ingolf, Kutleša, P., Leung, B., Liu, C., Pagitz, K., Pastor, T., Pauchard, A., Rabitsch, W., Robertson, P., Roy, H.E., Seebens, H., Solarz, W., Starfinger, U., Tanner, R., Vilà, M., Roura-Pascual, N., Pérez-Granados, C., Lenzner, B., Golivets, Maryna, Saul, W.-C., Jeschke, J.M., Essl, F., Peterson, G.D., Rutting, L., Latombe, G., Adriaens, T., Aldridge, D.C., Bacher, S., Bernardo-Madrid, R., Brotons, L., Díaz, F., Gallardo, B., Genovesi, P., González-Moreno, P., Kühn, Ingolf, Kutleša, P., Leung, B., Liu, C., Pagitz, K., Pastor, T., Pauchard, A., Rabitsch, W., Robertson, P., Roy, H.E., Seebens, H., Solarz, W., Starfinger, U., Tanner, R., Vilà, M., and Roura-Pascual, N.

Abstract

Invasive alien species are one of the major threats to global biodiversity, ecosystem integrity, nature's contributions to people and human health. While scenarios about potential future developments have been available for other global change drivers for quite some time, we largely lack an understanding of how biological invasions might unfold in the future across spatial scales.Based on previous work on global invasion scenarios, we developed a workflow to downscale global scenarios to a regional and policy-relevant context. We applied this workflow at the European scale to create four European scenarios of biological invasions until 2050 that consider different environmental, socio-economic and socio-cultural trajectories, namely the European Alien Species Narratives (Eur-ASNs).We compared the Eur-ASNs with their previously published global counterparts (Global-ASNs), assessing changes in 26 scenario variables. This assessment showed a high consistency between global and European scenarios in the logic and assumptions of the scenario variables. However, several discrepancies in scenario variable trends were detected that could be attributed to scale differences. This suggests that the workflow is able to capture scale-dependent differences across scenarios.We also compared the Global- and Eur-ASNs with the widely used Global and European Shared Socioeconomic Pathways (SSPs), a set of scenarios developed in the context of climate change to capture different future socio-economic trends. Our comparison showed considerable divergences in the scenario space occupied by the different scenarios, with overall larger differences between the ASNs and SSPs than across scales (global vs. European) within the scenario initiatives.Given the differences between the ASNs and SSPs, it seems that the SSPs do not adequately capture the scenario space relevant to understanding the complex future of biological invasions. This underlines the importance of developing independent but c

Published
2023

46. 155TiP A randomised phase II trial of neoadjuvant multi-agent chemotherapy (CHT) OR patritumab deruxtecan (HER3-DXd; U3-1402) +/- endocrine therapy (ET) for high-risk hormone receptor-positive (HR+/HER2-) early breast cancer (EBC): SOLTI-2103 VALENTINE trial

Author

Oliveira, M., Pascual, T., Villacampa, G., Munoz, M., Martorell, A. Perello, Lopez, M.E. Perez, Parraga, K. Amillano, Farre, X. González, Vila, C. Martinez, Ortega, P. Tolosa, Puy, M. Borrell, Vila, M. Margeli, Cejalvo, J.M., Zheteyava, Y., Sternberg, D.W., Fan, P.D., Santhanagopal, A., Bayona, R. Sanchez, Ferrero-Cafiero, J.M., and Prat, A.

Published
2023
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47. 124O Patritumab deruxtecan (HER3-DXd) in hormonal receptor-positive/HER2-negative (HR+/HER2-) and triple-negative breast cancer (TNBC): Results of part B of SOLTI TOT-HER3 window of opportunity trial

Author

Oliveira, M., Pascual, T., Ortega, P. Tolosa, Vila, M. Margeli, Cejalvo, J.M., Jurado, J. Cruz, Bofill, F.J. Salvador, Arumi de Dios, M.A., Losada, M.J. Vidal, Simon, S. Pernas, Esker, S., Fan, P-D., Santhanagopal, A., Martínez-Sáez, O., Brasó-Maristany, F., Villacampa, G., Bayona, R. Sanchez, Ferrero-Cafiero, J.M., Falato, C., and Prat, A.

Published
2023
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48. 240P Effect of dose intensity (DI) of palbociclib (PAB) and initial body weight dosage (BWD) on progression free survival (PFS): A real-world data analysis in patients with hormone-receptor (HR) positive HER2 negative metastatic breast cancer (MBC)

Author

Penabad, S. Recalde, Fort, E., Otero, S., Lezcano, C., Gil, V.L. Obadia, Sabaté, N., Juher, H. Pla, Falgas, E. Felip, Vila, M. Margeli, Villaro, G. Vinas, Gomez, A.M. Esteve, Rey, M., Simon, S. Pernas, and Fontanals, S.

Published
2023
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50. 3MO HER2 expression and early response to patritumab deruxtecan (HER3-DXd) in early-stage hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer (BC): A correlative analysis from SOLTI-TOT-HER3 trial

Author

Brasó-Maristany, F., Oliveira, M., Ortega, P. Tolosa, Vila, M. Margeli, Jurado, J. Cruz, Bofill, F.J. Salvador, Cejalvo, J.M., Arumi de Dios, M.A., Losada, M.J. Vidal, Simon, S. Pernas, Esker, S., Fan, P-D., Santhanagopal, A., Saez, O. Martinez, Villacampa, G., Bayona, R. Sanchez, Ferrero-Cafiero, J.M., Falato, C., Pascual, T., and Prat, A.

Published
2023
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