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1. Lateralization of uric acid stones on the left side

Author

Letavernier, Emmanuel, Flamant, Martin, Marsault, Claude, Haymann, Jean-Philippe, Müller, Guillaume, Villa, Luca, Cloutier, Jonathan, Traxer, Olivier, and Daudon, Michel

Subjects
Uric acid, Nephrolithiasis, Lateralization, Renal cyst, Polycystic kidney disease, Biochemistry, QD415-436, Physical and theoretical chemistry, QD450-801, Mathematics, QA1-939
Abstract

The analysis of 35,087 kidney stones revealed that 60% of uric acid stones originate from the left kidney whereas other stones are homogeneously distributed ($p

Published
2021
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3. Temperature profile during endourological laser activation: introducing the thermal safety distance concept

Author

Ventimiglia, Eugenio, Robesti, Daniele, Keller, Etienne Xavier, Corsini, Christian, Folcia, Andrea, Fantin, Margherita, Candela, Luigi, Pozzi, Edoardo, Sierra, Alba, Pietropaolo, Amelia, Somani, Bhaskar K., Panthier, Frederic, Pauchard, Felipe, Goumas, Ioannis Kartalas, Villa, Luca, Montorsi, Francesco, Traxer, Olivier, Salonia, Andrea, and Saccomandi, Paola

Published
2024
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6. Trends in the use of radiation protection and radiation exposure of European endourologists: a prospective trial from the EULIS-YAU Endourology Group

Author

Fontanet Soler, Sofia, Bravo-Balado, Alejandra, Skolarikos, Andreas, Seitz, Christian, Traxer, Olivier, Talso, Michele, Ventimiglia, Eugenio, Villa, Luca, Pietropaolo, Amelia, Keller, Etienne Xavier, Kallidonis, Panagiotis, Sener, Tarik Emre, Nagele, Udo, De Coninck, Vincent, Hameed, Zeeshan, Tsaturyan, Arman, Juliebø-Jones, Patrick, Mikoniatis, Ioannis, Wiseman, Oliver, Tzelves, Lazaros, and Emiliani, Esteban

Published
2024
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8. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project

Author

Beunders, Alexandra JM, Klaus, Federica, Kok, Almar AL, Schouws, Sigfried NTM, Kupka, Ralph W, Blumberg, Hilary P, Briggs, Farren, Eyler, Lisa T, Forester, Brent P, Forlenza, Orestes V, Gildengers, Ariel, Jimenez, Esther, Mulsant, Benoit H, Patrick, Regan E, Rej, Soham, Sajatovic, Martha, Sarna, Kaylee, Sutherland, Ashley, Yala, Joy, Vieta, Eduard, Villa, Luca M, Korten, Nicole CM, and Dols, Annemieke

Subjects
Bipolar Disorder, Serious Mental Illness, Depression, Clinical Research, Mental Health, Aging, Brain Disorders, 2.4 Surveillance and distribution, Aetiology, Mental health, Humans, Aged, Cross-Sectional Studies, Cognition, Cognitive Dysfunction, bipolar disorder, cognition, comorbidities, diagnostic subtypes, elderly, functioning, geriatrics, impairment, older-age bipolar disorder, psychiatry, Clinical Sciences, Neurosciences, Psychiatry
Abstract

ObjectivesThe distinction between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) has been a topic of long-lasting debate. This study examined differences between BD-I and BD-II in a large, global sample of OABD, focusing on general functioning, cognition and somatic burden as these domains are often affected in OABD.MethodsCross-sectional analyses were conducted with data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) database. The sample included 963 participants aged ≥50 years (714 BD-I, 249 BD-II). Sociodemographic and clinical factors were compared between BD subtypes including adjustment for study cohort. Multivariable analyses were conducted with generalized linear mixed models (GLMMs) and estimated associations between BD subtype and (1) general functioning (GAF), (2) cognitive performance (g-score) and (3) somatic burden, with study cohort as random intercept.ResultsAfter adjustment for study cohort, BD-II patients more often had a late onset ≥50 years (p = 0.008) and more current severe depression (p = 0.041). BD-I patients were more likely to have a history of psychiatric hospitalization (p

Published
2023

9. Experts’ recommendations in laser use for the treatment of upper tract urothelial carcinoma: a comprehensive guide by the European Section of Uro-Technology (ESUT) and Training Research in Urological Surgery and Technology (T.R.U.S.T.) group

Author

Ortner, Gernot, Somani, Bhaskar Kumar, Güven, Selcuk, Kitzbichler, Gerhard, Traxer, Olivier, Giusti, Guido, Proietti, Silvia, Liatsikos, Evangelos, Kallidonis, Panagiotis, Ulvik, Øyvind, Goumas, Ioannis Kartalas, Duvdevani, Mordechai, Baard, Joyce, Kamphuis, Guido M., Ferretti, Stefania, Dragos, Laurian, Villa, Luca, Miernik, Arkadiusz, Tailly, Thomas, Pietropaolo, Amelia, Hamri, Saeed Bin, Papatsoris, Athanasios, Gözen, Ali Serdar, Herrmann, Thomas R. W., Nagele, Udo, and Tokas, Theodoros

Published
2023
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11. What to expect from the novel pulsed thulium:YAG laser? A systematic review of endourological applications

Author

Ventimiglia, Eugenio, Robesti, Daniele, Bevilacqua, Luigi, Tondelli, Elena, Oliva, Isabella, Orecchia, Luca, Juliebø-Jones, Patrick, Pietropaolo, Amelia, De Coninck, Vincent, Esperto, Francesco, Tailly, Thomas, Ferretti, Stefania, Gauhar, Vineet, Somani, Bhaskar, Villa, Luca, Keller, Etienne Xavier, Salonia, Andrea, Traxer, Olivier, and Kartalas Goumas, Ioannis

Published
2023
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15. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).

Author

Chen, Peijun, Eyler, Lisa T, Gildengers, Ariel, Beunders, Alexandra Jm, Blumberg, Hilary P, Briggs, Farren Bs, Dols, Annemiek, Rej, Soham, Forlenza, Orestes V, Jimenez, Esther, Mulsant, Benoit, Schouws, Sigfried, Orhan, Melis, Sarna, Kaylee, Sutherland, Ashley N, Vieta, Eduard, Tsai, Shangying, Yala, Joy, Villa, Luca M, and Sajatovic, Martha

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Bipolar Disorder, Aging, Serious Mental Illness, Clinical Research, Brain Disorders, Aetiology, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 2.4 Surveillance and distribution, Mental health, Adult, Aged, Antipsychotic Agents, Cross-Sectional Studies, Demography, Female, Humans, Male, Middle Aged, aging, antipsychotic medication, bipolar disorder, geriatric, manic-depressive disorder, Psychiatry
Abstract

ObjectivesAntipsychotic drugs (APS) are widely used to treat patients with bipolar disorder (BD), but there is limited information in older-age bipolar disorder (OABD). This analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated characteristics of OABD patients prescribed APS vs. those not prescribed APS.Experimental designThe observational analysis used baseline, cross-sectional data from 16 international studies for adults aged ≥ 50 years with BD comprising 1,007 individuals with mean age 63.2 years (SD = 9.0), 57.4% women, and mean age of onset 31.6 years (SD = 15.0). The dependent variable was current APS treatment status. The independent variables included demographic and clinical variables, and a random effect for study, that were included in generalized mixed models.Principal observations46.6% of individuals (n = 469) were using APS. The multivariate model results suggest that those treated with APS were younger (p = 0.01), less likely to be employed (p < 0.001), had more psychiatric hospitalizations (p = 0.009) and were less likely to be on lithium (p < 0.001). Of individuals on APS, only 6.6% of those (n = 27) were on first-generation antipsychotics (FGAs) and experienced a greater burden of psychiatric hospitalizations (p = 0.012).ConclusionsAPS are widely prescribed in OABD, observed in nearly half of this sample with great variation across sites. Individuals with OABD on APS have more severe illness, more frequent hospitalizations and are more often unemployed vs. those not on APS. Future studies need to examine longitudinal outcomes in OABD prescribed APS to characterize underlying causal relationships.

Published
2022

17. A neuroimaging study to characterise adolescent major depressive disorder, the effects of cognitive behavioural therapy, and potential subtypes based on familial loading

Author

Villa, Luca and Suckling, John

Subjects
Major Depressive Disorder, MRI, Cortical Thickness, Resting state functional connectivity, Neuroimaging, Grey Matter Volume, Adolescent Depression
Abstract

Adolescent major depressive disorder (MDD) can have devastating consequences that remain into adulthood. Although the severe effects on those that suffer from MDD are well understood, the neural mechanisms underpinning the illness are still unclear, as the past literature exploring adolescent MDD has suffered greatly from a lack of consistency. In particular, it is still unclear as to what deviations of brain structure and function actually occur in adolescent MDD. Furthermore, though much of the past literature has claimed that cognitive behavioural therapy (CBT) has a normalising effect on disrupted brain function in adolescent MDD, this has not been directly tested. Additionally, past literature has found that adult MDD patients with a high familial loading for MDD, defined as having at least one first degree relative with MDD, show different symptom profiles to MDD patients with a low familial loading for the illness. However, it is not yet clear whether these symptom differences also occur in adolescent MDD patients with differing familial loadings, nor is it clear whether these two patient groups also differ with respect to brain structure and function. If so, familial loading for MDD could potentially be used to subtype adolescent MDD patients. This thesis aimed to further elucidate the neural processes that may be unfolding within the depressed adolescent brain by investigating pre-treatment differences in cortical thickness, white matter volume, and resting-state functional connectivity, using the largest studied sample of adolescent MDD patients under the age of 18 years. This thesis further aimed to investigate CBT's effects on brain function, and whether adolescent MDD patients could be subtyped based on familial loading for MDD. Before receiving treatment, adolescent MDD patients showed structural deviations in the form of greater cortical thickness and white matter volume within frontal and limbic regions of the brain. Furthermore, adolescent MDD patients also showed extensive pre-treatment overconnectivity within multiple functional brain networks, being the fronto-limbic, default mode, central executive, and salience networks. Moreover, when investigating the CBT-related changes to resting-state functional connectivity, in adolescent MDD patients, and how they relate to regions showing pre-treatment functional disruption, it was found that regions showing the greatest pre-treatment functional disruption actually showed the weakest CBT-related changes in resting-state functional connectivity. This suggests that CBT does not have a normalising effect on brain function in adolescent MDD but instead may have a rehabilitative effect on resting-state functional connectivity. Finally, when separating adolescent MDD patients into those with a high or low familial loading for MDD, the two patient groups differed with respect to the structure and function of the default mode network, as well as differing in rumination symptoms. Together, this work demonstrates the need for larger sample sizes to be used when investigating an illness as heterogenous as adolescent MDD, as well as direct investigations into the potential mechanisms of CBT. Moreover, it appears that some of this heterogeneity found in adolescent MDD may be partly addressed by subtyping patients, which may have implications for how the illness is viewed and treated in the future.

Published
2020
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19. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author

van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Zhu, Alyssa H., Bright, Joanna K., Campos, Adrián I., Salminen, Lauren E., Ambrogi, Sonia, Ayesa-Arriola, Rosa, Banaj, Nerisa, Başgöze, Zeynep, Bauer, Jochen, Blair, Karina, Blair, Robert James, Brosch, Katharina, Cheng, Yuqi, Colle, Romain, Connolly, Colm G., Corruble, Emmanuelle, Couvy-Duchesne, Baptiste, Crespo-Facorro, Benedicto, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dohm, Katharina, Fullerton, Janice M., Gonul, Ali Saffet, Gotlib, Ian H., Grotegerd, Dominik, Hahn, Tim, Harrison, Ben J., He, Mengxin, Hickie, Ian B., Ho, Tiffany C., Iorfino, Frank, Jansen, Andreas, Jollant, Fabrice, Kircher, Tilo, Klimes-Dougan, Bonnie, Klug, Melissa, Leehr, Elisabeth J., Lippard, Elizabeth T. C., McLaughlin, Katie A., Meinert, Susanne, Miller, Adam Bryant, Mitchell, Philip B., Mwangi, Benson, Nenadić, Igor, Ojha, Amar, Overs, Bronwyn J., Pfarr, Julia-Katharina, Piras, Fabrizio, Ringwald, Kai G., Roberts, Gloria, Romer, Georg, Sanches, Marsal, Sheridan, Margaret A., Soares, Jair C., Spalletta, Gianfranco, Stein, Frederike, Teresi, Giana I., Tordesillas-Gutiérrez, Diana, Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J., Vermeiren, Robert R. J. M., Winter, Alexandra, Wu, Mon-Ju, Yang, Tony T., Thompson, Paul M., Rentería, Miguel E., Jahanshad, Neda, Blumberg, Hilary P., van Harmelen, Anne-Laura, and Schmaal, Lianne

Published
2022
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24. Looking for the best strategy to treat children with new onset juvenile idiopathic arthritis: presentation of the “comparison of STep-up and step-down therapeutic strategies in childhood ARthritiS” (STARS) trial

Author

Burrone, Marco, Mazzoni, Marta, Naddei, Roberta, Pistorio, Angela, Spelta, Maddalena, Scala, Silvia, Patrone, Elisa, Garrone, Marco, Lombardi, Maria, Villa, Luca, Pascale, Giulia, Cavanna, Roberto, Ruperto, Nicolino, Ravelli, Angelo, and Consolaro, Alessandro

Published
2022
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26. Reducing Flakiness in End-to-End Test Suites: An Experience Report

Author

Olianas, Dario, Leotta, Maurizio, Ricca, Filippo, Villa, Luca, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Paiva, Ana C. R., editor, Cavalli, Ana Rosa, editor, Ventura Martins, Paula, editor, and Pérez-Castillo, Ricardo, editor

Published
2021
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27. Initial Experience and Evaluation of a Nomogram for Outcome Prediction in Management of Medium-sized (1–2 cm) Kidney Stones

Author

Micali, Salvatore, Sighinolfi, Maria Chiara, Iseppi, Andrea, Morini, Elena, Calcagnile, Tommaso, Benedetti, Mattia, Ticonosco, Marco, Kaleci, Shaniko, Bevilacqua, Luigi, Puliatti, Stefano, De Nunzio, Cosimo, Arada, Raphael, Chiancone, Francesco, Campobasso, Davide, Eissa, Ahmed, Bonfante, Giulia, Simonetti, Elisa, Cotugno, Michele, Galli, Riccardo, Curti, Pierpaolo, Schips, Luigi, Ditonno, Pasquale, Villa, Luca, Ferretti, Stefania, Bergamaschi, Franco, Bozzini, Giorgio, Zoeir, Ahmed, Sherbiny, Ahmed El, Frattini, Antonio, Fedelini, Paolo, Okhunov, Zhamshid, Tubaro, Andrea, Landman, Jaime, Bianchi, Giampaolo, and Rocco, Bernardo

Published
2022
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33. A Constructionist and Corpus-Based Approach to Formulas in Old English Poetry.

Author

Ginevra, Riccardo, Biagetti, Erica, Brigada Villa, Luca, and Giarda, Martina

Subjects
OLD English poetry, OLD English language, ENGLISH grammar, CONSTRUCTION grammar, SPEECH
Abstract

This paper explores a constructionist and corpus-based approach to Old English formulaic language through an analysis of the "maþelode system" of speech introductions. The analysis is performed on a section of the York-Helsinki Parsed Corpus of Old English Poetry, comprising the poems Beowulf, Battle of Brunanburh, and Exodus. The results show that most instances of the maþelode system belong to a well-attested construction continuum, structured by the widespread Old English (and ultimately Germanic) poetic devices of variation and kenning. This continuum ranges from more fixed repetitions that exclusively involve the verb maþelian to more schematic patterns that are also attested by other speech verbs, by verbs of giving, as well as by a number of further verbs of various semantic types. The particularly high frequency of this pattern with speech verbs and verbs of giving matches the prominent role, highlighted by previous studies, of both word-exchange and gift-exchange within Old English heroic ideology, and suggests that these formulaic patterns served the purpose to characterize the protagonists of speech or giving events as heroic and/or lordly figures. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Staphylococcus Aureus and Methicillin-Resistant Staphylococci and Mammaliicocci in the Bulk Tank Milk of a High Livestock Density Area in Northern Italy

Author

Fusar Poli, Sara, primary, Locatelli, Clara, additional, Monistero, Valentina, additional, Freu, Gustavo, additional, Cremonesi, Paola, additional, Castiglioni, Bianca, additional, Lecchi, Cristina, additional, Longheu, Carla Maria, additional, Tola, Sebastiana, additional, Guaraglia, Alessandro, additional, Allievi, Carolina, additional, Villa, Luca, additional, Manfredi, Maria Teresa, additional, and Addis, M. Filippa, additional

Published
2024
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39. Gastrointestinal nematodes of goats: host–parasite relationship differences in breeds at summer mountain pasture in northern Italy

Author

Zanzani Sergio Aurelio, Gazzonis Alessia Libera, Olivieri Emanuela, Villa Luca, Fraquelli Cristina, and Manfredi Maria Teresa

Subjects
goat, breed, gastrointestinal nematodes, resistance, italy, Veterinary medicine, SF600-1100
Abstract

The Orobic goat is a hardy breed native to the Orobic Alps (Lombardy, northern Italy). The aim of the study was the assessment of gastrointestinal nematode (GIN) egg excretion in Alpine and Saanen (cosmopolite breeds) and Orobic grazing goats, after a strategic treatment with eprinomectin in late June.

Published
2019
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