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3. Introduction

Author

Bousquet, J., Bourret, R., Camuzat, T., Augé, P., Domy, P., Bringer, J., Best, N., Jonquet, O., de la Coussaye, J.-E., Noguès, M., Robine, J.-M., Avignon, A., Blain, H., Combe, B., Dray, G., Dufour, V., Fouletier, M., Giraudeau, N., Hève, D., Jeandel, C., Laffont, I., Larrey, D., Laune, D., Laurent, C., Mares, P., Marion, C., Pastor, E., Pélissier, J.-Y., Radier-Pontal, F., Reynes, J., Royère, E., Ychou, M., Bedbrook, A., Granier, S., Abecassis, F., Albert, S., Adnet, P.-A., Alomène, B., Amouyal, M., Arnavielhe, S., Asteriou, T., Attalin, V., Aubas, P., Azevedo, C., Badin, M., Bakhti, Baptista, G., Bardy, B., Battesti, M.-P., Bénézet, O., Bernard, P.-L., Berr, C., Berthe, J., Bobia, X., Bockaert, J., Boegner, C., Boichot, S., Bonnin, H.-Y., Boulet, P., Bouly, S., Boubakri, C., Bourdin, A., Bourrain, J.-L., Bourrel, G., Bouix, V., Breuker, C., Bruguière, V., Burille, J., Cade, S., Caimmi, D., Calmels, M.-V., Camu, W., Canovas, G., Carre, V., Cavalli, G., Cayla, G., Chiron, R., Claret, P.-G., Coignard, P., Coroian, F., Costa, D.-J., Costa, P., Cottalorda, Coulet, B., Coupet, A.-L., Courrouy-Michel, M.-C., Courtet, P., Cristol, J.-P., Cros, V., Cuisinier, F., Daien, C., Danko, M., Dauenhauer, P., Dauzat, M., David, M., Davy, J.-M., Delignières, D., Demoly, P., Desplan, J., Dhivert-Donnadieu, H., Dujols, P., Dupeyron, A., Dupeyron, G., Engberink, O., Enjalbert, M., Fattal, C., Fernandes, J., Fesler, P., Fraisse, P., Froger, J., Gabrion, P., Galano, E., Gellerat-Rogier, M., Gellis, A., Goucham, A.-Y., Gouzi, F., Gressard, F., Gris, J.-C., Guillot, B., Guiraud, D., Handweiler, V., Hantkié, H., Hayot, M., Hérisson, C., Heroum, C., Hoa, D., Jacquemin, S., Jaber, S., Jakovenko, D., Jorgensen, C., Journot, L., Kaczorek, M., Kouyoudjian, P., Labauge, P., Landreau, L., Lapierre, M., Leblond, C., Léglise, M.-S., Lemaitre, J.-M., Le Moing, V., Le Quellec, A., Leclercq, F., Lehmann, S., Lognos, B., Lussert, J.-M., Makinson, A., Mandrick, K., Marmelat, V., Martin-Gousset, P., Matheron, A., Mathieu, G., Meissonnier, M., Mercier, G., Messner, P., Meunier, C., Mondain, M., Morales, R., Morel, J., Morquin, D., Mottet, D., Nérin, P., Nicolas, P., Ninot, G., Nouvel, F., Ortiz, J.-P., Paccard, D., Pandraud, G., Pasdelou, M.-P., Pasquié, J.-L., Patte, K., Perrey, S., Pers, Y.-M., Picot, M.-C., Pin, J.-P., Pinto, N., Porte, E., Portejoie, F., Pujol, J.-L., Quantin, X., Quéré, I., Raffort, N., Ramdani, S., Ribstein, J., Rédini-Martinez, I., Richard, S., Ritchie, K., Riso, J.-P., Rivier, F., Rolland, C., Roubille, F., Sablot, D., Savy, J.-L., Schifano, L., Senesse, P., Sicard, R., Soua, B., Stephan, Y., Strubel, D., Sultan, A., Taddei-Ologeanu, Tallon, G., Tanfin, M., Tassery, H., Tavares, I., Torre, K., Touchon, J., Tribout, V., Uziel, A., Van de Perre, P., Vasquez, X., Verdier, J.-M., Vergne-Richard, C., Vergotte, G., Vian, L., Viarouge-Reunier, C., Vialla, F., Viart, F., Villain, M., Villiet, M., Viollet, E., Wojtusciszyn, A., Aoustin, M., Bourquin, C., and Mercier, J.

Published
2015
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5. MACVIA-LR, Reference site of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) in Languedoc Roussillon

Author

Bousquet, J., Bourquin, C., Augé, P., Domy, P., Bringer, J., Aoustin, M., Camuzat, T., Bourret, R., Best, N., Jonquet, O., de la Coussaye, J.E., Robine, J.M., Avignon, A., Blain, H., Giraudeau, N., Hève, D., Jeandel, C., Laffont, I., Larrey, D., Laurent, C., Noguès, M., Pélissier, J.Y., Radier-Pontal, F., Royère, E., Bedbrook, A., Granier, S., Abecassis, F., Albert, S., Adnet, P.A., Alomène, B., Amouyal, M., Arnavieilhe, S., Attalin, V., Aubas, P., Badin, M., Baptista, G., Bardy, B., Battesti, M.P., Bénézet, O., Bernard, P.L., Berr, C., Berthe, J., Bockaert, J., Boubakri, C., Bourdin, A., Bourrain, J.L., Bourrel, G., Bouix, V., Burille, J., Cade, S., Caimmi, D., Calmels, M.V., Camu, W., Cavalli, G., Cayla, G., Chiron, R., Combe, B., Costa, D.J., Costa, P., Courrouy-Michel, M.C., Courtet, P., Cristol, J.P., Cuisinier, F., Daien, C., Danko, M., Dauenhauer, P., Dauzat, M., David, M., Davy, J.M., Delignières, D., Demoly, P., Dhivert-Donnadieu, H., Dray, G., Dujols, P., Dupeyron, A., Dupeyron, G., Engberink, O., Fesler, P., Gellerat-Rogier, M., Gouzi, F., Gressard, F., Hoa, D., Jacquemin, S., Gris, J.C., Guillot, B., Handweiler, V., Hayot, M., Jaber, S., Jakovenko, D., Jorgensen, C., Journot, L., Kaczorek, M., Lapierre, M., Laune, D., Léglise, M.S., Le Quellec, A., Leclerc, F., Lehmann, S., Lognos, B., Lussert, J.M., Mandrick, K., Marmelat, V., Martin-Gousset, P., Matheron, A., Mathieu, G., Mercier, G., Messner, P., Meunier, C., Mondain, M., Morel, J., Morquin, D., Nérin, P., Ninot, G., Nouvel, F., Ortiz, J.P., Pandraud, G., Pasdelou, M.P., Pasquié, J.L., Pastor, E., Perrey, S., Pers, Y.M., Picot, M.C., Pin, J.P., Pinto, N., Portejoie, F., Pujol, J.L., Quantin, X., Quéré, I., Raffort, N., Ramdani, S., Reynes, J., Ribstein, J., Rédini-Martinez, I., Richard, S., Ritchie, K., Rolland, C., Roubille, F., Roux, E., Salvat, A., Savy, J.L., Stephan, Y., Strubel, D., Sultan, A., Tallon, G., Tassery, H., Torre, K., Uziel, A., Van de Perre, P., Vasquez, X., Verdier, J.M., Vergotte, G., Vian, L., Viarouge-Reunier, C., Vialla, F., Viart, F., Villain, M., Viollet, E., Ankri, J., Berrut, G., Crooks, G., Joël, M.E., Michel, J.P., Samolinski, B., Strandberg, T., Vellas, B., and Mercier, J.

Published
2014
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21. Identification of alprazolam in hair in two cases of drug-facilitated incidents.

Author

Kintz, Pascal, Villain, M., Cheze, M., and Pepin, Gilbert

Subjects
Hair -- Analysis -- Usage, Mass spectrometry -- Usage -- Methods -- Analysis, Alprazolam -- Identification and classification -- Methods -- Analysis -- Usage, Liquid chromatography -- Methods -- Usage -- Analysis, Sex crimes -- Evidence -- Usage -- Analysis -- Methods
Abstract

Abstract The use of a drug to modify a person's behaviour for criminal gain is not a recent phenomenon. However, the recent increase in reports of drug-facilitated crimes (sexual assault, [...]

Published
2005

22. Evidence of addiction by anesthesiologists as documented by hair analysis.

Author

Kintz, Pascal, Villain, M., Dumestre, V., and Cirimele, Vincent

Subjects
Anesthesiologists -- Drug use -- Usage -- Analysis -- Research, Hair -- Analysis -- Usage, Mass spectrometry -- Usage -- Research -- Analysis, Fentanyl -- Analysis -- Usage -- Research, Drug abuse -- Research
Abstract

Abstract Chemical dependency is a disease that can affect all professions. Among the health care professionals, anesthesiologists represent a specific group. Numerous factors have been proposed to explain the high [...]

Published
2005

23. Screening and confirmatory method for benzodiazepines and hypnotics in oral fluid by LC-MS/MS.

Author

Kintz, Pascal, Villain, M., Concheiro, Marta, and Cirimele, Vincent

Subjects
Salivary glands -- secretions, Extraction (Chemistry) -- Usage -- Analysis -- Methods, Benzodiazepines -- Analysis -- Usage, Hypnotics -- Analysis -- Usage, Mass spectrometry -- Methods -- Usage -- Analysis, Liquid chromatography -- Methods -- Usage -- Analysis, Sedatives -- Analysis -- Usage, Saliva -- Analysis -- Methods -- Usage
Abstract

Abstract A procedure is presented for the screening of 17 benzodiazepines and hypnotics in oral fluid after collection with the Intercept@ device by LC-MS/MS (alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, bromazepam, clobazam, diazepare, [...]

Published
2005

24. Evaluation of the One-Step™ ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens.

Author

Cirimele, Vincent, Etienne, S., Villain, M., Ludes, B., and Kintz, Pascal

Subjects
Hair -- Analysis -- Research, Blood -- Analysis -- Research, Buprenorphine -- Analysis -- Research, High performance liquid chromatography -- Research -- Analysis, Urine -- Analysis -- Research
Abstract

Abstract A solid-phase enzyme immunoassay involving microtiter plates was recently proposed by International Diagnostic Systems corporation (IDS) to screen for buprenorphine in human serum. The performance of the kit led [...]

Published
2004

25. GHB in postmortem toxicology discrimination between endogenous production from exposure using multiple specimens.

Author

Kintz, Pascal, Villain, M., Cirimele, Vincent, and Ludes, B.

Subjects
Forensic toxicology -- Research -- Usage -- Analysis, Blood -- Analysis -- Usage -- Research, Gamma-hydroxybutyrate -- Analysis -- Research, Discriminant analysis -- Usage -- Research -- Analysis, Factor analysis -- Usage -- Research -- Analysis, Death -- Causes of -- Usage -- Analysis -- Research
Abstract

Abstract Since gamma-hydroxybutyrate (GHB) is present in both blood and urine of the general population as an endogenous compound, toxicologists must be able to discriminate between these endogenous levels and [...]

Published
2004

26. Windows of detection of zolpidem in urine and hair: application to two drug facilitated sexual assaults.

Author

Villain, M., Cheze, M., Tracqui, A., Ludes, B., and Kintz, Pascal

Subjects
Zolpidem -- Influence -- Research -- Usage, Hair -- Analysis -- Usage, Mass spectrometry -- Usage -- Research -- Analysis, Liquid chromatography -- Usage -- Research -- Analysis, Urine -- Analysis -- Usage -- Research, Sex crimes -- Research -- Usage -- Analysis
Abstract

Abstract A LC--MS/MS method for the detection of zolpidem in hair was developed to detect this drug after a single dose in possible drug facilitated sexual assaults. To determine the [...]

Published
2004

38. Synthetic Complementary Peptides Inhibit a Neutrophil Chemoattractant Found in the Alkali-injured Cornea

Author

Villain M, Blalock Je, Jeffrey L. Haddox, Roswell R. Pfister, Coplan L, and Charnell I. Sommers

Subjects
Proline, Neutrophils, Leukotriene B4, Dimer, Peptide, Tripeptide, Cornea, chemistry.chemical_compound, Tetramer, Burns, Chemical, Fluorescence Polarization Immunoassay, Animals, Humans, Sodium Hydroxide, Potency, chemistry.chemical_classification, Chemotactic Factors, Antagonist, Chemotaxis, Chemotaxis, Leukocyte, Eye Burns, Ophthalmology, Antisense Elements (Genetics), chemistry, Biochemistry, Immunology, Rabbits, Oligopeptides, Corneal Injuries
Abstract

PURPOSE We have previously presented evidence that the neutrophil chemoattractant, N-acetyl-proline-glycine-proline (N-acetyl-PGP), triggers the initial polymorphonuclear leukocyte (PMN) invasion into the alkali-injured eye. In this study, sense-antisense methodology was used to develop novel complementary peptides to be potential inhibitors of N-acetyl-PGP. METHODS The polarization assay was used to measure the potential chemotactic response of PMNs to synthetic N-acetyl-PGP, the ultrafiltered tripeptide chemoattractants obtained from alkali-degraded rabbit corneas, or leukotriene B4 (LTB4). Inhibition was expressed as the peptide concentration producing 50% inhibition (ID50) of polarization. Five complementary peptides were tested as potential inhibitors of N-acetyl-PGP: arginine-threonine-arginine (RTR), RTR-glycine-glycine (RTRGG), RTR dimer, RTR tetramer, and alanine-serine-alanine (ASA) tetramer. In addition, the RTR tetramer and both monomeric peptides (RTR and RTRGG) were separately tested for inhibition of the ultrafiltered tripeptide chemoattractants or LTB4. RESULTS The complementary RTR tetrameric peptide was a powerful antagonist of N-acetyl-PGP-induced PMN polarization (ID50 of 200 nM). The RTR dimer was much less potent (ID50 of 105 microM). Both monomeric peptides, RTR and RTRGG, were only antagonistic at millimolar concentrations. The ASA tetramer showed no capacity to inhibit N-acetyl-PGP. The RTR tetramer also inhibited PMN activation by the ultrafiltered tripeptide chemoattractants (ID50 of 30 microM) but had no effect on LTB4. CONCLUSIONS A complementary peptide (RTR) was designed which is an effective inhibitor of the neutrophil chemoattractant, N-acetyl-PGP. The potency of the RTR complementary peptide is dramatically enhanced by tetramerization. Inhibition of N-acetyl-PGP by complementary peptides offers great promise for control of the inflammatory response in the alkali-injured eye.

Published
2000
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41. Impact de la nature de l’effluent (synthétique ou réel) sur les performances d’un bioréacteur à membranes en conditions stationnaires

Author

Villain, M., Bourven, I., Guibaud, G., Marrot, B., Constant, Eddy, Lavoisier Technique et Documentation, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience; no abstract

Published
2013

43. Influence de la nature de l'effluent sur les performances d'un bioréacteur à membranes en conditions stationnaires et non stationnaires

Author

Villain, M., Guibaud, G., Marrot, B., Constant, Eddy, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience; no abstract

Published
2012

45. Evaluation du risque d’apparition de comorbidités psychiatriques chez le consommateur de cannabis par la détermination du rapport des concentrations capillaires en THC et en CBD

Author

Barguil, Y., Charlot, J.-Y., Southwell, G., Kintz, P., Baumann, F., Guégan, A., Cirimele, V., Villain, M., Choblet, E., Hnawia, E., Nour, M., Laboratoire Insulaire du Vivant et de l'Environnement (LIVE), Université de la Nouvelle-Calédonie (UNC), and BUNC, Pole ID

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

48. Profils cannabinoïdes et multiélémentaires : intérét judiciaire

Author

Barguil, Y., Kintz, P., Villain, M., Bruno FOGLIANI, Cirimele, V., Choblet, E., Hnawia, E., Nour, M., Laboratoire Insulaire du Vivant et de l'Environnement (LIVE), Université de la Nouvelle-Calédonie (UNC), and BUNC, Pole ID

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2009

49. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages

Author

ten Broeke, R., Leusink-Muis, A., Hilberdink, R., van Ark, I., van den Worm, E., Villain, M., de Clerck, F., Blalock, J.E., Nijkamp, F.P., Folkerts, G., Immunofarmacologie van het respiratoire en gastrointestinale systemen, Universiteit Utrecht, and Dep Farmaceutische wetenschappen

Subjects
Farmacie/Biofarmaceutische wetenschappen (FARM), Pharmacology, Immunology, Farmacie(FARM), Biomedische technologie en medicijnen, Overig medisch onderzoek
Published
2004

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