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10 results on '"Villalón-Letelier, Fernando"'

1. The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection

Author

Fernández, Jose Javier, Marín, Arturo, Rosales, Romel, Penrice-Randal, Rebekah, Mlcochova, Petra, Alvarez, Yolanda, Villalón-Letelier, Fernando, Yildiz, Soner, Pérez, Enrique, Rathnasinghe, Raveen, Cupic, Anastasija, Kehrer, Thomas, Uccellini, Melissa B., Alonso, Sara, Martínez, Fernando, McGovern, Briana Lynn, Clark, Jordan J., Sharma, Parul, Bayón, Yolanda, Alonso, Andrés, Albrecht, Randy A., White, Kris M., Schotsaert, Michael, Miorin, Lisa, Stewart, James P., Hiscox, Julian A., Gupta, Ravindra K., Irigoyen, Nerea, García-Sastre, Adolfo, Crespo, Mariano Sánchez, and Fernández, Nieves

Published
2024
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4. Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

Author

Schwab, Lara S. U., primary, Villalón-Letelier, Fernando, additional, Tessema, Melkamu B., additional, Londrigan, Sarah L., additional, Brooks, Andrew G., additional, Hurt, Aeron, additional, Coch, Christoph, additional, Zillinger, Thomas, additional, Hartmann, Gunther, additional, and Reading, Patrick C., additional

Published
2022
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6. Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Author

Watterson, Daniel, Wijesundara, Danushka K, Modhiran, Naphak, Mordant, Francesca L, Li, Zheyi, Avumegah, Michael S, McMillan, Christopher Ld, Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey Tm, Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L, Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam, Zhou, Qi, Brockman, David A, Morgan, Sherry J, Lau, Cora, Tran, Mai H, Tapley, Peter, Villalón-Letelier, Fernando, Barnes, James, Young, Andrew, Jaberolansar, Noushin, Scott, Connor Ap, Isaacs, Ariel, Amarilla, Alberto A, Khromykh, Alexander A, van den Brand, Judith Ma, Reading, Patrick C, Ranasinghe, Charani, Subbarao, Kanta, Munro, Trent P, Young, Paul R, Chappell, Keith J, VPDC pathologie, dPB CR, dPB I&I, VPDC pathologie, dPB CR, and dPB I&I

Subjects
0301 basic medicine, medicine.medical_treatment, Immunology, Nursing(all), Hamster, SARS‐CoV‐2, Molecular Clamp, 03 medical and health sciences, polyfunctional T cells, 0302 clinical medicine, Antigen, Immunity, Medicine, rapid response, Immunology and Allergy, 030212 general & internal medicine, Viral shedding, General Nursing, neutralising antibodies, business.industry, SARS-CoV-2, Immunogenicity, Original Articles, RC581-607, Vaccine efficacy, Vaccination, 030104 developmental biology, Original Article, subunit vaccine, Immunologic diseases. Allergy, business, Adjuvant
Abstract

Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion‐stabilised spike (S) protein, Sclamp, in combination with the licensed adjuvant MF59 ‘MF59C.1’ (Seqirus, Parkville, Australia). Methods A panel recombinant Sclamp proteins were produced in Chinese hamster ovary and screened in vitro to select a lead vaccine candidate. The structure of this antigen was determined by cryo‐electron microscopy and assessed in mouse immunogenicity studies, hamster challenge studies and safety and toxicology studies in rat. Results In mice, the Sclamp vaccine elicits high levels of neutralising antibodies, as well as broadly reactive and polyfunctional S‐specific CD4+ and cytotoxic CD8+ T cells in vivo. In the Syrian hamster challenge model (n = 70), vaccination results in reduced viral load within the lung, protection from pulmonary disease and decreased viral shedding in daily throat swabs which correlated strongly with the neutralising antibody level. Conclusion The SARS‐CoV‐2 Sclamp vaccine candidate is compatible with large‐scale commercial manufacture, stable at 2–8°C. When formulated with MF59 adjuvant, it elicits neutralising antibodies and T‐cell responses and provides protection in animal challenge models., We describe preclinical development of a prefusion stabilized spike protein subunit vaccine for SARS‐CoV‐2. Results include structural resolution by cryo‐electron microscopy, mouse immunogenicity and a hamster protection study.

Published
2021

7. Rapid Application of the Molecular Clamp Platform for SARS-CoV-2

Author

Watterson, Daniel, primary, Wijesundara, Danushka K., additional, Modhiran, Naphak, additional, Mordant, Francesca L., additional, Li, Zheyi, additional, Avumegah, Michael S., additional, McMillan, Christopher, additional, Lackenby, Julia, additional, Guilfoyle, Kate, additional, van Amerongen, Geert, additional, Stittelaar, Koert, additional, Cheung, Stacey, additional, Bibby, Summa, additional, Daleris, Mallory, additional, Hoger, Kym, additional, Gillard, Marianne, additional, Radunz, Eve, additional, Jones, Martina L., additional, Hughes, Karen, additional, Hughes, Benjamin, additional, Goh, Justin, additional, Edwards, David, additional, Scoble, Judith, additional, Pearce, Lesley, additional, Kowalczyk, Lukasz, additional, Phan, Tram, additional, La, Mylinh, additional, Lu, Louis, additional, Pham, Tam, additional, Zhou, Qi, additional, Brockman, David A., additional, Morgan, Sherry J., additional, Lau, Cora, additional, Tran, Mai H., additional, Tapley, Peter, additional, Villalón-Letelier, Fernando, additional, Barnes, James, additional, Young, Andrew, additional, Jaberolansar, Noushin, additional, Scott, Connor A.P., additional, Isaacs, Ariel, additional, Amarilla, Alberto A., additional, Khromykh, Alexander A., additional, van den Brand, Judith M.A., additional, Reading, Patrick, additional, Ranasinghe, Charani, additional, Subbarao, Kanta, additional, Munro, Trent P., additional, Young, Paul, additional, and Chappell, Keith Joseph, additional

Published
2020
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