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Your search keyword '"Villatoro, Tatiana M"' showing total 13 results
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13 results on '"Villatoro, Tatiana M"'

1. Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?

Author

Yu, Jing, da Silva, Edaise M., La, Hae-Sun, Clark, Beth Z., Fine, Jeffrey L., Carter, Gloria J., Villatoro, Tatiana M., Soong, T. Rinda, Lee, Adrian V., Oesterreich, Steffi, Basili, Thais, Blanco-Heredia, Juan, Selenica, Pier, Ye, Qiqi, Da Cruz Paula, Arnaud, Dopeso, Higinio, Gazzo, Andrea, Marra, Antonio, Pareja, Fresia, Reis-Filho, Jorge S., and Bhargava, Rohit

Published
2023
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6. Upgrade rates of variant lobular carcinoma in-situ (LCIS) compared to classic LCIS diagnosed in core needle biopsies: A ten-year single institution retrospective study

Author

Harinath, Lakshmi, primary, Villatoro, Tatiana M., additional, Clark, Beth Z., additional, Fine, Jeffrey L., additional, Yu, Jing, additional, Carter, Gloria J., additional, Diego, Emilia, additional, McAuliffe, Priscilla F., additional, Mai, Phuong, additional, Lu, Amy, additional, Zuley, Margarita, additional, Berg, Wendie A., additional, and Bhargava, Rohit, additional

Published
2024
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7. Implementation of Digital Image Analysis in Assessment of Ki67 Index in Breast Cancer

Author

Vanderschelden, Rachel K., primary, Jerome, Jacob A., additional, Gonzalez, Daniel, additional, Seigh, Lindsey, additional, Carter, Gloria J., additional, Clark, Beth Z., additional, Elishaev, Esther, additional, Louis Fine, Jeffrey, additional, Harinath, Lakshmi, additional, Jones, Mirka W., additional, Villatoro, Tatiana M., additional, Soong, Thing Rinda, additional, Yu, Jing, additional, Zhao, Chengquan, additional, Hartman, Doug, additional, and Bhargava, Rohit, additional

Published
2023
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8. Utility of TRPS1 immunohistochemistry in confirming breast carcinoma: Emphasis on staining in triple-negative breast cancers and gynecologic tumors.

Author

Rammal, Rayan, Goel, Kanika, Elishaev, Esther, Soong, T Rinda, Jones, Mirka W, Zhao, Chengquan, Clark, Beth Z, Carter, Gloria J, Yu, Jing, Fine, Jeffrey L, Villatoro, Tatiana M, Skvarca, Lauren, Harinath, Lakshmi, and Bhargava, Rohit

Subjects
BREAST, TRIPLE-negative breast cancer, GYNECOLOGIC cancer, SQUAMOUS cell carcinoma, TUMORS, HORMONE receptors
Abstract

Objectives Our aim was to explore the performance of TRPS1 as an immunohistochemical diagnostic marker; find the optimal conditions for its use in breast carcinomas, especially triple-negative breast cancers (TNBCs); and compare its results in carcinomas of a select few organ sites, with an emphasis on gynecologic tumors. Methods Tissue microarrays from breast carcinomas (n = 197), endometrial adenocarcinomas (n = 69), ovarian tumors (n = 250), vulvar squamous cell carcinomas (n = 97), pancreatic ductal adenocarcinomas (n = 20), and gastric adenocarcinomas (n = 12) were stained with TRPS1 using 2 different conditions (protocol 1: high pH; protocol 2: low pH). Breast carcinomas consisted of hormone receptor (HR)–positive/ERBB2 (formerly HER2 or HER2/neu)–negative (n = 53) samples, HR-positive/ERBB2-positive (n = 6) samples, and TNBCs (n = 138). Results Comparing TRPS1 results in breast carcinomas vs tumors from other organ sites, the sensitivity of TRPS1 was 91% and 87%, respectively, while the specificity was 66% and 74% for protocol 1 and 2, respectively. For TNBCs vs gynecologic tumors, the sensitivity of TRPS1 was 89% and 85%, respectively, while the specificity was 65% and 73%, respectively. Conclusions TRPS1 stains approximately 90% of breast carcinomas but also up to 71% of endometrial carcinomas, albeit with a weaker median expression. Our data show that although TRPS1 is a highly sensitive marker for TNBCs, it is not as highly specific as previously reported. [ABSTRACT FROM AUTHOR]

Published
2023
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9. The Utility of SOX10 Immunohistochemical Staining in Breast Pathology

Author

Rammal, Rayan, primary, Goel, Kanika, additional, Elishaev, Esther, additional, Rinda Soong, T, additional, Jones, Mirka W, additional, Zhao, Chengquan, additional, Clark, Beth Z, additional, Carter, Gloria J, additional, Yu, Jing, additional, Fine, Jeffrey L, additional, Villatoro, Tatiana M, additional, Harinath, Lakshmi, additional, and Bhargava, Rohit, additional

Published
2022
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13. Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis

Author

Villatoro, Tatiana M. and Mardekian, Stacey K.

Subjects
Article Subject
Abstract

Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin. This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.

Published
2018
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