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1. Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology

Author

Frédérique Truffault, Ludivine Auger, Nadine Dragin, Jean-Thomas Vilquin, Elie Fadel, Vincent Thomas de Montpreville, Audrey Mansuet-Lupo, Jean-François Regnard, Marco Alifano, Tarek Sharshar, Anthony Behin, Bruno Eymard, Francis Bolgert, Sophie Demeret, Sonia Berrih-Aknin, and Rozen Le Panse

Subjects
Autoimmunity, Thymus, Follicular hyperplasia, Thymectomy, Puberty, Age, Medicine, Science
Abstract

Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle fatigability due to acetylcholine receptor (AChR) autoantibodies. To better characterize juvenile MG (JMG), we analyzed 85 pre- and 132 post-pubescent JMG (with a cutoff age of 13) compared to 721 adult MG patients under 40 years old using a French database. Clinical data, anti-AChR antibody titers, thymectomy, and thymic histology were analyzed. The proportion of females was higher in each subgroup. No significant difference in the anti-AChR titers was observed. Interestingly, the proportion of AChR+ MG patients was notably lower among adult MG patients aged between 30 and 40 years, at 69.7%, compared to over 82.4% in the other subgroups. Thymic histological data were examined in patients who underwent thymectomy during the year of MG onset. Notably, in pre-JMG, the percentage of thymectomized patients was significantly lower (32.9% compared to more than 42.5% in other subgroups), and the delay to thymectomy was twice as long. We found a positive correlation between anti-AChR antibodies and germinal center grade across patient categories. Additionally, only females, particularly post-JMG patients, exhibited the highest rates of lymphofollicular hyperplasia (95% of cases) and germinal center grade. These findings reveal distinct patterns in JMG patients, particularly regarding thymic follicular hyperplasia, which appears to be exacerbated in females after puberty.

Published
2024
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3. Chameleon Screening in Cosmic Voids

Author

Tamosiunas, Andrius, Briddon, Chad, Burrage, Clare, Cutforth, Alan, Moss, Adam, and Vincent, Thomas

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

A key goal in cosmology in the upcoming decade will be to form a better understanding of the accelerated expansion of the Universe. Upcoming surveys, such as the Vera C. Rubin Observatory's 10-year Legacy Survey of Space and Time (LSST), Euclid and the Square Killometer Array (SKA) will deliver key datasets required to tackle this and other puzzles in contemporary cosmology. With this data, constraints of unprecedented power will be put on different models of dark energy and modified gravity. In this context it is crucial to understand how screening mechanisms, which hide the deviations of these theories from the predictions of general relativity in local experiments, affect structure formation. In this work we approach this problem by using a combination of analytic and numerical methods to describe chameleon screening in the context of cosmic voids. We apply a finite element method (FEM) code, SELCIE, to solve the chameleon equation of motion for a number of void profiles derived from observational data and simulations. The obtained results indicate a complex relationship between the properties of cosmic voids and the size of the chameleon acceleration of a test particle. We find that the fifth force on a test particle in a void is primarily related to the depth and the inner density gradient of the void. For realistic void profiles, the obtained chameleon-to-Newtonian acceleration ratios range between $a_{\phi}/a_{\rm Newt} \approx 10^{-6} - 10^{-5}$. However, it should be noted that in unusually deep voids with large inner density gradients, the acceleration ratios can be significantly higher. Similarly, other chameleon models, such as $f(R)$ Hu-Sawicki theory allow for significantly higher acceleration ratios. Given these results, we also discuss the optimal density profiles for detecting the fifth force in the upcoming observational surveys., Comment: 19 pages, 9 figures. The SELCIE code is available at: https://github.com/C-Briddon/SELCIE. Submitted to JCAP

Published
2022
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4. Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

Author

Edman, Natasha I., Phal, Ashish, Redler, Rachel L., Schlichthaerle, Thomas, Srivatsan, Sanjay R., Ehnes, Devon Duron, Etemadi, Ali, An, Seong J., Favor, Andrew, Li, Zhe, Praetorius, Florian, Gordon, Max, Vincent, Thomas, Marchiano, Silvia, Blakely, Leslie, Lin, Chuwei, Yang, Wei, Coventry, Brian, Hicks, Derrick R., Cao, Longxing, Bethel, Neville, Heine, Piper, Murray, Analisa, Gerben, Stacey, Carter, Lauren, Miranda, Marcos, Negahdari, Babak, Lee, Sangwon, Trapnell, Cole, Zheng, Ying, Murry, Charles E., Schweppe, Devin K., Freedman, Benjamin S., Stewart, Lance, Ekiert, Damian C., Schlessinger, Joseph, Shendure, Jay, Bhabha, Gira, Ruohola-Baker, Hannele, and Baker, David

Published
2024
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5. Listeria monocytogenes-associated spontaneous bacterial peritonitis in France: a nationwide observational study of 208 cases

Author

Abdou, Mohamed, Abdulhai, Ayman, Abdulhal, Ayman, Abel, Samy, Abergel, Armand, Aberrane, Saïd, Abraham, Bruno, Adler, Maxime, Agard, Christian, Agha-Mir, Ilhem, Aguilar, Claire, Agulles, Baptiste, Aldallal, Hamza, Alric, Laurent, Amiot, Xavier, Andrau, Pierre, Andrieux, Vladimir, Ansart, Séverine, Anty, Rodolphe, Archambeaud, Isabelle, Arem, Samir, Armand, Laurence, Aubailly, Lucie, Audibert, Juliette, Auguereau, Olivier, Auvray, Christelle, Aziz, Karime, Bachelier, Marie-Nadège, Bacquaert-Dufour, Karine, Badet, Françoise, Bahallah, Mohamed-Larbi, Balanant, Hélène, Baraduc, Régine, Bardis, Alexandre, Barraud, Olivier, Barrier, Jocelyn, Baudet, Antoine, Baumert, Thomas, Beaugerie, Laurent, Bébéar, Cécile, Becheur, Hakim, Bemer, Pascale, Benard, Caroline, Benezet, Marie-Pierre, Benmahammed, Mohammed, Bennouna, Jaafar, Benseddik, Zehaira, Bensimon, Pierre-Yves, Bental, Abdeslam, Berete, Aliou, Bergier, Jean-Michel, Berkani, Wacila, Bernardi, Franck, Bert, Frederic, Bertrou, Anne, Beuret, Pascal, Beurton-Chataigner, Isabelle, Beuscart, Claude, Beusnel, Christine, Bevilacqua, Sibylle, Beze, François, Bideau, Karine, Bidegain, Frédéric, Billon, Laura, Blaison, Gilles, Blanc, Michèle, Blanc, Pierre, Blanchi, Sophie, Blancho, Gilles, Bland, Stephane, Blondeau, Vincent, Boldron, Amale, Bon, Djemah, Bonacorsi, Stéphane, Bonzon, Lucas, Borderon, Anaïs, Botelho-Nevers, Elisabeth, Bottlaender, Jacques, Bouc-Boucher, Mathilde, Bouchaud, Olivier, Bougon, David, Boukelikha, Khaled, Bourlet, Thomas, Boussoukaya, Samy, Boutaleb, Hamza, Bouziges, Nicole, Bray, Philippe, Bréchet, Caroline, Bret, Laurent, Brieu, Nathalie, Briffaut, David, Brochet, Christine, Brulez-Des-Varannes, Stanislas, Brunel, Valéry, Brung-Lefebvre, Maud, Bureau, Christophe, Burucoa, Christophe, Buscail, Louis, Buzele, Rodolphe, Cadot, Catherine, Cadranel, Jean-Francois, Cady, Anne, Caillon, Jocelyne, Camiade, Sabine, Campillo, Bernard, Carbonnel, Franck, Carbonnelle, Etienne, Cardot-Martin, Émilie, Cariou, Marie-Estelle, Carles, Michel, Caron, Francois, Carrara-Delarue, Lucrecia, Carrier, Paul, Castang, Céline, Castellano, Inès, Cattoir, Vincent, Caubet, Olivier, Causse, Xavier, Chabrol, Amélie, Chanard, Emmanuel, Chatagnon, Thomas, Chazouilleres, Olivier, Chedanni, Halima, Chevrel, Pauline, Chirol, Catherine, Chirouze, Catherine, Chouquer, Renaud, Clavière, Christophe, Codreuil, Sylvain, Colardelle, Philippe, Combarnous, François, Commeau, Grégory, Cornillet, Anne, Corvec, Stephane, Costa, Yannick, Couderc, Philippe, Couffon, Caroline, Courivaud, Cécile, Courtade, Henri, Cruchant, Etienne, Cuen, David, Culard, Jean-François, Cung, Hong Ahn, Dahyot, Sandrine, D'Altéroche, Louis, Dao, Manh Thông, Darfeuil, Fabien, Darnaud, Céline, Daure, Sophie, De Grossouvre-Taillefer, Ludivine, Debriel, Dominique, Debrueres, Jacques, Decaens, Thomas, Decambron, Audrey, Decre-Grapinet, Dominique, Degand, Nicolas, Dehaye, Bruno, Delacour, Thierry, Delarbe, Jean-Marie, Delobel, Pierre, Delpierre, Éric, Delrez, René, Delvert, Didier, Demartino, Sylvie, Deniel, Marie-Clémence, Denis, Bernard, Derumeaux, Guy, Desroches, Marine, Dessein, Rodrigue, Devillez, Simon, Deweerdt, Didier, Diamantis, Sylvain, Diaz, Emmanuel, Didier, Raffenot, Dimartino, Vincent, Dion, Ludivine, Djemai, Mohand, Doche, Christophe, Donascimento, Maud, Dorval, Ian, Douala, Carol, Doucet-Populaire, Florence, Drouillat, Valérie, Dubée, Vincent, Dudermel, Anne-France, Dumont, Betty, Dupin, Clarisse, Dupont, Mathieu, Dupont, Philippe, Dupuy, Marion, Dupuychaffray, Jean-Pierre, Durand, Francois, Dusser, Pascale, Duval, Valérie, Duveau, Nicolas, El-Azouzi, Abdelghani, El-Gharras, Hynd, Elsendoorn, Antoine, Emile, Loïc, Epaulard, Olivier, Etchepare, Nicolas, Etienne, Jean-Pierre, Eveillard, Mathieu, Evers, Annie, Fach, Joelle, Faizoun, Claudia, Fangous, Marie-Sarah, Farmachidi, Jean Pierre, Fatome, Armelle, Faulques, Bernard, Faure, Karine, Felix, Charlotte, Ferec, Marc, Ferey, Janine, Ferracci, Serge, Feryn, Jean-Marc, Fesler, Pierre, Fiette, Hélène, Flevin, Emilie, Floch, Pauline, Fort, Eric, Fortineau, Nicolas, Fourcade, Jacques, Fraissinet, François, Franck, Patricia, Françoise, Thiebaut, Fratte, Serge, Galempoix, Jean-Marc, Garcera, Yves, Garcia, Anne, Garcon, Pierre, Garret, Charlotte, Gayet, Clement, Gazeau, Pierre, Gerber, Florence, Gilles, Raclot, Gillot, Jean-Michel, Goarant, Eric, Godreuil, Sylvain, Goret, Julien, Gorret, Julie, Goujard, Cecile, Goulenok, Thiphaine, Gournay, Jérôme, Gousseff, Marie, Goux, Alain, Graf, Emmanuelle, Grange, Jean-Didier, Gravet, Alain, Greder-Belan, Alix, Gronier, Olivier, Grosset, Marine, Guellouz, Sabra, Guenenna, Dalida, Guerbaa, Mohammed, Guerin, Meggie, Guerrot, Dominique, Guery, Benoit, Gugenheim, Jean, Guidet, Bertrand, Guiheneuf, Raphael, Guillet-Caruba, Christelle, Guimard, Yves, Guinard, Jérome, Guindre, Laure, Hagege, Albert, Hagege, Hervé, Haineaux, Paul-Arthur, Hamon, Rémy, Hassan, Firas, Hassine, Mélanie, Helie, Ludovic, Herber-Mayne, Anne, Hervio, Pascale, Héry-Arnaud, Geneviève, Hitoto, Hikombo, Hubsch, Théophile, Hunaut, Nicolas, Hurtova, Monika, Husson-Wetzel, Stéphanie, Hutin, Pascal, Izopet, Théo, Jacob, Jean-Louis, Jacomet, Christine, Jaffar-Bandjee, Marie-Christine, Janvier, Fréderic, Jaulhac, Benoît, Jaureguiberry, Stephane, Javaud, Nicolas, Jeannot, Katty, Joundy, Noureddine, Kacem, Moez, Karama, Rouis, Karsenti, David, Kempf, Marie, Khatibi, Sarah, Kikolski, Florence, Kittirath, Christine, Koch, Stephane, Kouatchet-Achille, Tchamba, Krummel, Yves, La Combe, Karine, Labarriere, Damien, Laberenne, Jean-Eric, Lacroix, Hervé, Ladrat, Laure, Lagarde, Stéphanie, Lagasse, Jean-Paul, Laggoune, Ahmed-Saïd, Lambare, Benedicte, Landgraf, Nathalie, Landraud, Luce, Laude, Jean-Francois, Laurent, François, Lavigne, Jean-Philippe, Lavoue, Vincent, Le Berre, Rozenn, Le Goff, Vallérie, Lebars, Hervé, Lebrun, Armandine, Lecapitaine, Anne-Lise, Lechat, Sylvie, Lecoustumier, Alain, Ledreau, Gérard, Lefevre, Benjamin, Leflon, Véronique, Lefort, Agnès, Legall, Florence, Legoff, Isabelle, Legrand, Eric, Lehello, Simon, Le-Henaff-Bourhis, Catherine, Leleu, Olivier, Lelievre, Lucie, Lemaignen, Adrien, Lemaire, Xavier, Le-Maout, Charles, Lemblé, Chantal, Lemeille, Yolande, Lemenand, Olivier, Lemeunier, Violaine, Lemeur, Yannick, Lemierre, Sylvia, Leotard, Sophie, Lepileur, Lucie, Letellier-Demonchy, Claire, Levecq, Hervé, Levy, Marc, Limal, Nicolas, Locher, Christophe, Lopez, Benjamin, Loron, Marie-Charlotte, Loulergue, Joelle, Loury-Larivière, Isabelle, Loustaud-Ratti, Véronique, Macchi, Valèrie, Machado, Moise, Madaule, Serge, Mainardi, Jean-Luc, Males, Silvija, Malherbe, Philippe, Maneglier, Benjamin, Marceau, Maryline, Marcel, Kévin, Marmonier, Alain, Martha, Benoît, Martin, Xavier, Martin-Blondel, Guillaume, Martinez, Camille, Marty, Fabrice, Marty, Patrick, Matray, Olivier, Maurin, Arnaud, Mazerand, Sandie, Mazouz, Nadia, Medevielle, Muriel, Mercat, Alain, Méreghetti, Laurent, Merzoug, Noureddine, Meziane, Ilham, Michaud, Anthony, Michel, Marc, Michel, Pierre, Mignard, Sophie, Milesi-Lecat, Anne-Marie, Mion, Mathieu, Mnasri, Nabil, Mohareb, Abdo, Mohib, Samir, Moindrot, Henri, Monlun, Eric, Montewis, Audrey, Morin, Thierry, Moussata, Driffa, Muller, Sandrine, Muzellec, Valérie, Nancey, Stéphane, Nassereddine, Ahmad, Naude, Sebastien, Neau, Didier, Ovidiu, Negru Calin, Ngo, Thuy, Ngwhotue, Marthe-Andree, Nivet, Patrick, Nordmann, Patrice, Nousbaum, Jean-Baptiste, Nouvel, Bernadette, Obled, Stephane, Oswald, Eric, Otto, Marie-Pierre, Pageaux, Georges-Philippe, Papin, Gregory, Parant, Fabrice, Patenotte, Arnaud, Paupard, Thierry, Pauwels, Arnaud, Pawlotsky, Jean Michel, Pelloux, Hervé, Perlemuter, Gabriel, Peron, Jean-Marie, Pestel-Caron, Martine, Peter, Natasha, Petillon, Sophie, Petit, Richard, Petitprez, Helene, Pettinelli, Francois, Phelip, Jean Marc, Philit, Jean-Baptiste, Phoutthasang, Valérie, Pialoux, Gilles, Piau-Couapel, Caroline, Pichard, Benoit, Pichon, Maxime, Picon-Coste, Magali, Picque, Marie, Pierson, Henri, Piques, Jean Francois, Piton, Béatrice, Planade, Orianne, Plassart, Claire, Plésiat, Patrick, Ploy, Marie-Cécile, Poubeau, Patrice, Pouderoux, Philippe, Pouedras, Pascal, Pourbaix, Annabelle, Poynard, Thierry, Preau, Florence, Pricope, Dumitrita, Queffelec, Gwenaëlle, Queneherve, Lucille, Quentin, Thomas, Raffenot, Didier, Rakotoniaina, Daniella, Ramanantsoa, Celine, Ramarijaona, Solofoniaina, Rami-Arab, Lila, Raulin, Olivia, Rebibou, Jean Michel, Renault, David, Rey, Philippe, Riche, Agnès, Rigaud, Jean Philippe, Rivière, Antoine, Rivière, Brigitte, Robert, Jérôme, Roblot, Pascal, Roger, Helene, Rolland, Christophe, Rondinaud, Emilie, Rosa-Hezode, Isabelle, Roubille, Martine, Rouquette, Olivier, Roux, Juliette, Ruimy, Raymond, Sachot-Ollivier, Sonia, Sailler, Laurent, Salamant, Sarah, Sarbu-Pop, Silvia, Sartre, Jacques, Schmitt, François, Scribe-Outtas, Myriam, Sefrioui, David, Sehouane, Rachid, Sekhri, Hacène, Serfaty, Lawrence, Sevin, Odile, Shawali, Cédric, Siladi, Souad, Silvain, Christine, Simon, Mireille, Simonet, Batiste, Sinayoko, Leila, Sirach, Estelle, Smati, Mustafa, Smets, Aurélie, Soltani, Dhaoui, Sommabere, André, Soulier-Guerin, Karine, Soulillou, Jean Paul, Soupison, Alain, Souply, Laurent, Soussy, Claude-James, Stampfli, Claire, Strullu, Bernard, Suatean, Diana, Tadjerouni, Nacer, Talarmin, Jean-Philippe, Tankovic, Jacques, Tarroun, Abdullah, Tchuenbou, Juliette, Teboul, Jean-Louis, Tedlaouti, Husni, Tellini, Charlotte, Thabut, Dominique, Thannberger, Philippe, Thiebault, Henri, Thiebaut, Françoise, Thomazeau, Joséphine, Tielman, Guillaume, Timsit, Jean-Francois, Tognon, Patrick, Tougeron, David, Toure, Fatouma, Tran, Albert, Tranvouez, Jean-Luc, Trésallet, Christophe, Trubert, Lise, Tsakiris, Laurent, Twizeyimana, Eterne, Vachee, Anne, Valade, Hélène, Valat, Isabelle, Vandendriessche, Anne, Vandermee, Nathalie, Vanheste, Marc, Varon, Emmanuelle, Vasse, Marc, Vasseur, Philippe, Vaucel, Elisabeth, Vauthier, Anne, Verdavaine-Loidreau, Delphine, Verdet, Charlotte, Verdon, Renaud, Vergnaud, Michel, Véziris, Nicolas, Vignaud, Guillaume, Viguier, Jérôme, Villemain, Marc, Villeneuve, Laurent, Vimont-Vicary, Alexandre, Vincent, Thomas, Vuillemenot, Jean-Baptiste, Walewski, Violaine, Warmoes, Elodie, Watry, Hélène, Weber, Jean-Christophe, Witz, Marie Thérèse, Woerther, Paul-Louis, Yazdanpanah, Yazdan, Zamfir, Oana, Zarka, Jonathan, Zavadil, Patrick, Zeboudj, Nabil, Zerbib, Franck, Blanchard, Florian, Henry, Benoît, Vijayaratnam, Sofieya, Canouï, Etienne, Moura, Alexandra, Thouvenot, Pierre, Bracq-Dieye, Hélène, Tessaud-Rita, Nathalie, Valès, Guillaume, Diakité, Andrée, Leclercq, Alexandre, Lecuit, Marc, and Charlier, Caroline

Published
2024
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6. Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers

Author

Delphine Bredel, Edi Tihic, Séverine Mouraud, François-Xavier Danlos, Sandrine Susini, Marine Aglave, Alexia Alfaro, Chifaou Mohamed-Djalim, Mathieu Rouanne, Héloise Halse, Amélie Bigorgne, Lambros Tselikas, Stéphane Dalle, Dana M. Hartl, Eric Baudin, Catherine Guettier, Eric Vibert, Olivier Rosmorduc, Caroline Robert, Sophie Ferlicot, Bastien Parier, Laurence Albiges, Vincent Thomas de Montpreville, Benjamin Besse, Olaf Mercier, Caroline Even, Ingrid Breuskin, Marion Classe, Camélia Radulescu, Thierry Lebret, Patricia Pautier, Sébastien Gouy, Jean-Yves Scoazec, Laurence Zitvogel, Aurélien Marabelle, and Mélodie Bonvalet

Subjects
Cancer, Immunology, Immune checkpoints, T-cells, Immunotherapy, Single-cell RNA-Seq, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background In addition to anti-PD(L)1, anti-CTLA-4 and anti-LAG-3, novel immune checkpoint proteins (ICP)-targeted antibodies have recently failed to demonstrate significant efficacy in clinical trials. In these trials, patients were enrolled without screening for drug target expression. Although these novel ICP-targeted antibodies were expected to stimulate anti-tumor CD8 + T-cells, the rationale for their target expression in human tumors relied on pre-clinical IHC stainings and transcriptomic data, which are poorly sensitive and specific techniques for assessing membrane protein expression on immune cell subsets. Our aim was to describe ICP expression on intratumoral T-cells from primary solid tumors to better design upcoming neoadjuvant cancer immunotherapy trials. Methods We prospectively performed multiparameter flow cytometry and single-cell RNA sequencing (scRNA-Seq) paired with TCR sequencing on freshly resected human primary tumors of various histological types to precisely determine ICP expression levels within T-cell subsets. Results Within a given tumor type, we found high inter-individual variability for tumor infiltrating CD45 + cells and for T-cells subsets. The proportions of CD8+ T-cells (~ 40%), CD4+ FoxP3- T-cells (~ 40%) and CD4+ FoxP3+ T-cells (~ 10%) were consistent across patients and indications. Intriguingly, both stimulatory (CD25, CD28, 4-1BB, ICOS, OX40) and inhibitory (PD-1, CTLA-4, PD-L1, CD39 and TIGIT) checkpoint proteins were predominantly co-expressed by intratumoral CD4+FoxP3+ T-cells. ScRNA-Seq paired with TCR sequencing revealed that T-cells with high clonality and high ICP expressions comprised over 80% of FoxP3+ cells among CD4+ T-cells. Unsupervised clustering of flow cytometry and scRNAseq data identified subsets of CD8+ T-cells and of CD4+ FoxP3- T-cells expressing certain checkpoints, though these expressions were generally lower than in CD4+ FoxP3+ T-cell subsets, both in terms of proportions among total T-cells and ICP expression levels. Conclusions Tumor histology alone does not reveal the complete picture of the tumor immune contexture. In clinical trials, assumptions regarding target expression should rely on more sensitive and specific techniques than conventional IHC or transcriptomics. Flow cytometry and scRNAseq accurately characterize ICP expression within immune cell subsets. Much like in hematology, flow cytometry can better describe the immune contexture of solid tumors, offering the opportunity to guide patient treatment according to drug target expression rather than tumor histological type.

Published
2023
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8. New Oldowan locality Sare-Abururu (ca. 1.7 Ma) provides evidence of diverse hominin behaviors on the Homa Peninsula, Kenya

Author

Finestone, Emma M., Plummer, Thomas W., Vincent, Thomas H., Blumenthal, Scott A., Ditchfield, Peter W., Bishop, Laura C., Oliver, James S., Herries, Andy I.R., Palfery, Christopher Vere, Lane, Timothy P., McGuire, Elizabeth, Reeves, Jonathan S., Rodés, Angel, Whitfield, Elizabeth, Braun, David R., Bartilol, Simion K., Rotich, Nelson Kiprono, Parkinson, Jennifer A., Lemorini, Cristina, Caricola, Isabella, Kinyanjui, Rahab N., and Potts, Richard

Published
2024
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10. Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers

Author

Bredel, Delphine, Tihic, Edi, Mouraud, Séverine, Danlos, François-Xavier, Susini, Sandrine, Aglave, Marine, Alfaro, Alexia, Mohamed-Djalim, Chifaou, Rouanne, Mathieu, Halse, Héloise, Bigorgne, Amélie, Tselikas, Lambros, Dalle, Stéphane, Hartl, Dana M., Baudin, Eric, Guettier, Catherine, Vibert, Eric, Rosmorduc, Olivier, Robert, Caroline, Ferlicot, Sophie, Parier, Bastien, Albiges, Laurence, de Montpreville, Vincent Thomas, Besse, Benjamin, Mercier, Olaf, Even, Caroline, Breuskin, Ingrid, Classe, Marion, Radulescu, Camélia, Lebret, Thierry, Pautier, Patricia, Gouy, Sébastien, Scoazec, Jean-Yves, Zitvogel, Laurence, Marabelle, Aurélien, and Bonvalet, Mélodie

Published
2023
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15. Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity

Author

Mangiante, Lise, Alcala, Nicolas, Sexton-Oates, Alexandra, Di Genova, Alex, Gonzalez-Perez, Abel, Khandekar, Azhar, Bergstrom, Erik N., Kim, Jaehee, Liu, Xiran, Blazquez-Encinas, Ricardo, Giacobi, Colin, Le Stang, Nolwenn, Boyault, Sandrine, Cuenin, Cyrille, Tabone-Eglinger, Severine, Damiola, Francesca, Voegele, Catherine, Ardin, Maude, Michallet, Marie-Cecile, Soudade, Lorraine, Delhomme, Tiffany M., Poret, Arnaud, Brevet, Marie, Copin, Marie-Christine, Giusiano-Courcambeck, Sophie, Damotte, Diane, Girard, Cecile, Hofman, Veronique, Hofman, Paul, Mouroux, Jérôme, Cohen, Charlotte, Lacomme, Stephanie, Mazieres, Julien, de Montpreville, Vincent Thomas, Perrin, Corinne, Planchard, Gaetane, Rousseau, Nathalie, Rouquette, Isabelle, Sagan, Christine, Scherpereel, Arnaud, Thivolet, Francoise, Vignaud, Jean-Michel, Jean, Didier, Ilg, Anabelle Gilg Soit, Olaso, Robert, Meyer, Vincent, Boland-Auge, Anne, Deleuze, Jean-Francois, Altmuller, Janine, Nuernberg, Peter, Ibáñez-Costa, Alejandro, Castaño, Justo P., Lantuejoul, Sylvie, Ghantous, Akram, Maussion, Charles, Courtiol, Pierre, Hernandez-Vargas, Hector, Caux, Christophe, Girard, Nicolas, Lopez-Bigas, Nuria, Alexandrov, Ludmil B., Galateau-Salle, Françoise, Foll, Matthieu, and Fernandez-Cuesta, Lynnette

Published
2023
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17. How to induce superconductivity in epitaxial graphene $via$ remote proximity effect through an intercalated gold layer

Author

Mazaleyrat, Estelle, Vlaic, Sergio, Artaud, Alexandre, Magaud, Laurence, Vincent, Thomas, Gómez-Herrero, Ana Cristina, Lisi, Simone, Singh, Priyank, Bendiab, Nedjma, Guisset, Valérie, David, Philippe, Pons, Stéphane, Roditchev, Dimitri, Chapelier, Claude, and Coraux, Johann

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Graphene holds promises for exploring exotic superconductivity with Dirac-like fermions. Making graphene a superconductor at large scales is however a long-lasting challenge. A possible solution relies on epitaxially-grown graphene, using a superconducting substrate. Such substrates are scarce, and usually destroy the Dirac character of the electronic band structure. Using electron diffraction (reflection high-energy, and low-energy), scanning tunneling microscopy and spectroscopy, atomic force microscopy, angle-resolved photoemission spectroscopy, Raman spectroscopy, and density functional theory calculations, we introduce a strategy to induce superconductivity in epitaxial graphene $via$ a remote proximity effect, from the rhenium substrate through an intercalated gold layer. Weak graphene-Au interaction, contrasting with the strong undesired graphene-Re interaction, is demonstrated by a reduced graphene corrugation, an increased distance between graphene and the underlying metal, a linear electronic dispersion and a characteristic vibrational signature, both latter features revealing also a slight $p$ doping of graphene. We also reveal that the main shortcoming of the intercalation approach to proximity superconductivity is the creation of a high density of point defects in graphene (10$^{14}$~cm$^{-2}$). Finally, we demonstrate remote proximity superconductivity in graphene/Au/Re(0001), at low temperature., Comment: 13 pages, 6 figures, to appear in 2D Materials

Published
2020
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18. Single-cell census of human tooth development enables generation of human enamel

Author

Alghadeer, Ammar, Hanson-Drury, Sesha, Patni, Anjali P., Ehnes, Devon D., Zhao, Yan Ting, Li, Zicong, Phal, Ashish, Vincent, Thomas, Lim, Yen C., O’Day, Diana, Spurrell, Cailyn H., Gogate, Aishwarya A., Zhang, Hai, Devi, Arikketh, Wang, Yuliang, Starita, Lea, Doherty, Dan, Glass, Ian A., Shendure, Jay, Freedman, Benjamin S., Baker, David, Regier, Mary C., Mathieu, Julie, and Ruohola-Baker, Hannele

Published
2023
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24. Psychobiotics and the Microbiota–Gut–Brain Axis: Where Do We Go from Here?

Author

Sylvie Binda, Annie Tremblay, Umar Haris Iqbal, Ola Kassem, Mélanie Le Barz, Vincent Thomas, Stéphane Bronner, Tara Perrot, Nafissa Ismail, and J.Alex Parker

Subjects
psychobiotics, microbiota–gut–brain axis, stress, early-life stress, neuropsychiatric disorders, neuroinflammation, Biology (General), QH301-705.5
Abstract

The bidirectional relationship between the gut microbiota and the nervous system is known as the microbiota–gut–brain axis (MGBA). The MGBA controls the complex interactions between the brain, the enteric nervous system, the gut-associated immune system, and the enteric neuroendocrine systems, regulating key physiological functions such as the immune response, sleep, emotions and mood, food intake, and intestinal functions. Psychobiotics are considered tools with the potential to modulate the MGBA through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects of health are yet to be characterized. This narrative review and perspectives article highlights the key paradigms needing attention as the scope of potential probiotics applications in human health increases, with a growing body of evidence supporting their systemic beneficial effects. However, there are many limitations to overcome before establishing the extent to which we can incorporate probiotics in the management of neuropsychiatric disorders. Although this article uses the term probiotics in a general manner, it remains important to study probiotics at the strain level in most cases.

Published
2024
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27. Videoconference version of the Montreal Cognitive Assessment: normative data for Quebec-French people aged 50 years and older

Author

Gagnon, Christine, Olmand, Miloudza, Dupuy, Emma Gabrielle, Besnier, Florent, Vincent, Thomas, Grégoire, Catherine-Alexandra, Lévesque, Marianne, Payer, Marie, Bérubé, Béatrice, Breton, Juliana, Lecchino, Catia, Bouabdallaoui, Nadia, Iglesies-Grau, Josep, Gayda, Mathieu, Vitali, Paolo, Nigam, Anil, Juneau, Martin, Hudon, Carol, and Bherer, Louis

Published
2022
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29. Corrigendum: A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia

Author

Paul Tetteh Asare, Chi-Hsien Lee, Vera Hürlimann, Youzheng Teo, Aline Cuénod, Nermin Akduman, Cordula Gekeler, Afrizal Afrizal, Myriam Corthesy, Claire Kohout, Vincent Thomas, Tomas de Wouters, Gilbert Greub, Thomas Clavel, Eric G. Pamer, Adrian Egli, Lisa Maier, and Pascale Vonaesch

Subjects
human gut microbiota, Clostridia, MALDI-TOF MS, commensal bacteria, anaerobic, bacterial identification, Microbiology, QR1-502
Published
2023
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30. Listeria monocytogenes-associated spontaneous bacterial peritonitis in France: a nationwide observational study of 208 cases

Author

Blanchard, Florian, primary, Henry, Benoît, additional, Vijayaratnam, Sofieya, additional, Canouï, Etienne, additional, Moura, Alexandra, additional, Thouvenot, Pierre, additional, Bracq-Dieye, Hélène, additional, Tessaud-Rita, Nathalie, additional, Valès, Guillaume, additional, Diakité, Andrée, additional, Leclercq, Alexandre, additional, Lecuit, Marc, additional, Charlier, Caroline, additional, Abdou, Mohamed, additional, Abdulhai, Ayman, additional, Abdulhal, Ayman, additional, Abel, Samy, additional, Abergel, Armand, additional, Aberrane, Saïd, additional, Abraham, Bruno, additional, Adler, Maxime, additional, Agard, Christian, additional, Agha-Mir, Ilhem, additional, Aguilar, Claire, additional, Agulles, Baptiste, additional, Aldallal, Hamza, additional, Alric, Laurent, additional, Amiot, Xavier, additional, Andrau, Pierre, additional, Andrieux, Vladimir, additional, Ansart, Séverine, additional, Anty, Rodolphe, additional, Archambeaud, Isabelle, additional, Arem, Samir, additional, Armand, Laurence, additional, Aubailly, Lucie, additional, Audibert, Juliette, additional, Auguereau, Olivier, additional, Auvray, Christelle, additional, Aziz, Karime, additional, Bachelier, Marie-Nadège, additional, Bacquaert-Dufour, Karine, additional, Badet, Françoise, additional, Bahallah, Mohamed-Larbi, additional, Balanant, Hélène, additional, Baraduc, Régine, additional, Bardis, Alexandre, additional, Barraud, Olivier, additional, Barrier, Jocelyn, additional, Baudet, Antoine, additional, Baumert, Thomas, additional, Beaugerie, Laurent, additional, Bébéar, Cécile, additional, Becheur, Hakim, additional, Bemer, Pascale, additional, Benard, Caroline, additional, Benezet, Marie-Pierre, additional, Benmahammed, Mohammed, additional, Bennouna, Jaafar, additional, Benseddik, Zehaira, additional, Bensimon, Pierre-Yves, additional, Bental, Abdeslam, additional, Berete, Aliou, additional, Bergier, Jean-Michel, additional, Berkani, Wacila, additional, Bernardi, Franck, additional, Bert, Frederic, additional, Bertrou, Anne, additional, Beuret, Pascal, additional, Beurton-Chataigner, Isabelle, additional, Beuscart, Claude, additional, Beusnel, Christine, additional, Bevilacqua, Sibylle, additional, Beze, François, additional, Bideau, Karine, additional, Bidegain, Frédéric, additional, Billon, Laura, additional, Blaison, Gilles, additional, Blanc, Michèle, additional, Blanc, Pierre, additional, Blanchi, Sophie, additional, Blancho, Gilles, additional, Bland, Stephane, additional, Blondeau, Vincent, additional, Boldron, Amale, additional, Bon, Djemah, additional, Bonacorsi, Stéphane, additional, Bonzon, Lucas, additional, Borderon, Anaïs, additional, Botelho-Nevers, Elisabeth, additional, Bottlaender, Jacques, additional, Bouc-Boucher, Mathilde, additional, Bouchaud, Olivier, additional, Bougon, David, additional, Boukelikha, Khaled, additional, Bourlet, Thomas, additional, Boussoukaya, Samy, additional, Boutaleb, Hamza, additional, Bouziges, Nicole, additional, Bray, Philippe, additional, Bréchet, Caroline, additional, Bret, Laurent, additional, Brieu, Nathalie, additional, Briffaut, David, additional, Brochet, Christine, additional, Brulez-Des-Varannes, Stanislas, additional, Brunel, Valéry, additional, Brung-Lefebvre, Maud, additional, Bureau, Christophe, additional, Burucoa, Christophe, additional, Buscail, Louis, additional, Buzele, Rodolphe, additional, Cadot, Catherine, additional, Cadranel, Jean-Francois, additional, Cady, Anne, additional, Caillon, Jocelyne, additional, Camiade, Sabine, additional, Campillo, Bernard, additional, Carbonnel, Franck, additional, Carbonnelle, Etienne, additional, Cardot-Martin, Émilie, additional, Cariou, Marie-Estelle, additional, Carles, Michel, additional, Caron, Francois, additional, Carrara-Delarue, Lucrecia, additional, Carrier, Paul, additional, Castang, Céline, additional, Castellano, Inès, additional, Cattoir, Vincent, additional, Caubet, Olivier, additional, Causse, Xavier, additional, Chabrol, Amélie, additional, Chanard, Emmanuel, additional, Chatagnon, Thomas, additional, Chazouilleres, Olivier, additional, Chedanni, Halima, additional, Chevrel, Pauline, additional, Chirol, Catherine, additional, Chirouze, Catherine, additional, Chouquer, Renaud, additional, Clavière, Christophe, additional, Codreuil, Sylvain, additional, Colardelle, Philippe, additional, Combarnous, François, additional, Commeau, Grégory, additional, Cornillet, Anne, additional, Corvec, Stephane, additional, Costa, Yannick, additional, Couderc, Philippe, additional, Couffon, Caroline, additional, Courivaud, Cécile, additional, Courtade, Henri, additional, Cruchant, Etienne, additional, Cuen, David, additional, Culard, Jean-François, additional, Cung, Hong Ahn, additional, Dahyot, Sandrine, additional, D'Altéroche, Louis, additional, Dao, Manh Thông, additional, Darfeuil, Fabien, additional, Darnaud, Céline, additional, Daure, Sophie, additional, De Grossouvre-Taillefer, Ludivine, additional, Debriel, Dominique, additional, Debrueres, Jacques, additional, Decaens, Thomas, additional, Decambron, Audrey, additional, Decre-Grapinet, Dominique, additional, Degand, Nicolas, additional, Dehaye, Bruno, additional, Delacour, Thierry, additional, Delarbe, Jean-Marie, additional, Delobel, Pierre, additional, Delpierre, Éric, additional, Delrez, René, additional, Delvert, Didier, additional, Demartino, Sylvie, additional, Deniel, Marie-Clémence, additional, Denis, Bernard, additional, Derumeaux, Guy, additional, Desroches, Marine, additional, Dessein, Rodrigue, additional, Devillez, Simon, additional, Deweerdt, Didier, additional, Diamantis, Sylvain, additional, Diaz, Emmanuel, additional, Didier, Raffenot, additional, Dimartino, Vincent, additional, Dion, Ludivine, additional, Djemai, Mohand, additional, Doche, Christophe, additional, Donascimento, Maud, additional, Dorval, Ian, additional, Douala, Carol, additional, Doucet-Populaire, Florence, additional, Drouillat, Valérie, additional, Dubée, Vincent, additional, Dudermel, Anne-France, additional, Dumont, Betty, additional, Dupin, Clarisse, additional, Dupont, Mathieu, additional, Dupont, Philippe, additional, Dupuy, Marion, additional, Dupuychaffray, Jean-Pierre, additional, Durand, Francois, additional, Dusser, Pascale, additional, Duval, Valérie, additional, Duveau, Nicolas, additional, El-Azouzi, Abdelghani, additional, El-Gharras, Hynd, additional, Elsendoorn, Antoine, additional, Emile, Loïc, additional, Epaulard, Olivier, additional, Etchepare, Nicolas, additional, Etienne, Jean-Pierre, additional, Eveillard, Mathieu, additional, Evers, Annie, additional, Fach, Joelle, additional, Faizoun, Claudia, additional, Fangous, Marie-Sarah, additional, Farmachidi, Jean Pierre, additional, Fatome, Armelle, additional, Faulques, Bernard, additional, Faure, Karine, additional, Felix, Charlotte, additional, Ferec, Marc, additional, Ferey, Janine, additional, Ferracci, Serge, additional, Feryn, Jean-Marc, additional, Fesler, Pierre, additional, Fiette, Hélène, additional, Flevin, Emilie, additional, Floch, Pauline, additional, Fort, Eric, additional, Fortineau, Nicolas, additional, Fourcade, Jacques, additional, Fraissinet, François, additional, Franck, Patricia, additional, Françoise, Thiebaut, additional, Fratte, Serge, additional, Galempoix, Jean-Marc, additional, Garcera, Yves, additional, Garcia, Anne, additional, Garcon, Pierre, additional, Garret, Charlotte, additional, Gayet, Clement, additional, Gazeau, Pierre, additional, Gerber, Florence, additional, Gilles, Raclot, additional, Gillot, Jean-Michel, additional, Goarant, Eric, additional, Godreuil, Sylvain, additional, Goret, Julien, additional, Gorret, Julie, additional, Goujard, Cecile, additional, Goulenok, Thiphaine, additional, Gournay, Jérôme, additional, Gousseff, Marie, additional, Goux, Alain, additional, Graf, Emmanuelle, additional, Grange, Jean-Didier, additional, Gravet, Alain, additional, Greder-Belan, Alix, additional, Gronier, Olivier, additional, Grosset, Marine, additional, Guellouz, Sabra, additional, Guenenna, Dalida, additional, Guerbaa, Mohammed, additional, Guerin, Meggie, additional, Guerrot, Dominique, additional, Guery, Benoit, additional, Gugenheim, Jean, additional, Guidet, Bertrand, additional, Guiheneuf, Raphael, additional, Guillet-Caruba, Christelle, additional, Guimard, Yves, additional, Guinard, Jérome, additional, Guindre, Laure, additional, Hagege, Albert, additional, Hagege, Hervé, additional, Haineaux, Paul-Arthur, additional, Hamon, Rémy, additional, Hassan, Firas, additional, Hassine, Mélanie, additional, Helie, Ludovic, additional, Herber-Mayne, Anne, additional, Hervio, Pascale, additional, Héry-Arnaud, Geneviève, additional, Hitoto, Hikombo, additional, Hubsch, Théophile, additional, Hunaut, Nicolas, additional, Hurtova, Monika, additional, Husson-Wetzel, Stéphanie, additional, Hutin, Pascal, additional, Izopet, Théo, additional, Jacob, Jean-Louis, additional, Jacomet, Christine, additional, Jaffar-Bandjee, Marie-Christine, additional, Janvier, Fréderic, additional, Jaulhac, Benoît, additional, Jaureguiberry, Stephane, additional, Javaud, Nicolas, additional, Jeannot, Katty, additional, Joundy, Noureddine, additional, Kacem, Moez, additional, Karama, Rouis, additional, Karsenti, David, additional, Kempf, Marie, additional, Khatibi, Sarah, additional, Kikolski, Florence, additional, Kittirath, Christine, additional, Koch, Stephane, additional, Kouatchet-Achille, Tchamba, additional, Krummel, Yves, additional, La Combe, Karine, additional, Labarriere, Damien, additional, Laberenne, Jean-Eric, additional, Lacroix, Hervé, additional, Ladrat, Laure, additional, Lagarde, Stéphanie, additional, Lagasse, Jean-Paul, additional, Laggoune, Ahmed-Saïd, additional, Lambare, Benedicte, additional, Landgraf, Nathalie, additional, Landraud, Luce, additional, Laude, Jean-Francois, additional, Laurent, François, additional, Lavigne, Jean-Philippe, additional, Lavoue, Vincent, additional, Le Berre, Rozenn, additional, Le Goff, Vallérie, additional, Lebars, Hervé, additional, Lebrun, Armandine, additional, Lecapitaine, Anne-Lise, additional, Lechat, Sylvie, additional, Lecoustumier, Alain, additional, Ledreau, Gérard, additional, Lefevre, Benjamin, additional, Leflon, Véronique, additional, Lefort, Agnès, additional, Legall, Florence, additional, Legoff, Isabelle, additional, Legrand, Eric, additional, Lehello, Simon, additional, Le-Henaff-Bourhis, Catherine, additional, Leleu, Olivier, additional, Lelievre, Lucie, additional, Lemaignen, Adrien, additional, Lemaire, Xavier, additional, Le-Maout, Charles, additional, Lemblé, Chantal, additional, Lemeille, Yolande, additional, Lemenand, Olivier, additional, Lemeunier, Violaine, additional, Lemeur, Yannick, additional, Lemierre, Sylvia, additional, Leotard, Sophie, additional, Lepileur, Lucie, additional, Letellier-Demonchy, Claire, additional, Levecq, Hervé, additional, Levy, Marc, additional, Limal, Nicolas, additional, Locher, Christophe, additional, Lopez, Benjamin, additional, Loron, Marie-Charlotte, additional, Loulergue, Joelle, additional, Loury-Larivière, Isabelle, additional, Loustaud-Ratti, Véronique, additional, Macchi, Valèrie, additional, Machado, Moise, additional, Madaule, Serge, additional, Mainardi, Jean-Luc, additional, Males, Silvija, additional, Malherbe, Philippe, additional, Maneglier, Benjamin, additional, Marceau, Maryline, additional, Marcel, Kévin, additional, Marmonier, Alain, additional, Martha, Benoît, additional, Martin, Xavier, additional, Martin-Blondel, Guillaume, additional, Martinez, Camille, additional, Marty, Fabrice, additional, Marty, Patrick, additional, Matray, Olivier, additional, Maurin, Arnaud, additional, Mazerand, Sandie, additional, Mazouz, Nadia, additional, Medevielle, Muriel, additional, Mercat, Alain, additional, Méreghetti, Laurent, additional, Merzoug, Noureddine, additional, Meziane, Ilham, additional, Michaud, Anthony, additional, Michel, Marc, additional, Michel, Pierre, additional, Mignard, Sophie, additional, Milesi-Lecat, Anne-Marie, additional, Mion, Mathieu, additional, Mnasri, Nabil, additional, Mohareb, Abdo, additional, Mohib, Samir, additional, Moindrot, Henri, additional, Monlun, Eric, additional, Montewis, Audrey, additional, Morin, Thierry, additional, Moussata, Driffa, additional, Muller, Sandrine, additional, Muzellec, Valérie, additional, Nancey, Stéphane, additional, Nassereddine, Ahmad, additional, Naude, Sebastien, additional, Neau, Didier, additional, Ovidiu, Negru Calin, additional, Ngo, Thuy, additional, Ngwhotue, Marthe-Andree, additional, Nivet, Patrick, additional, Nordmann, Patrice, additional, Nousbaum, Jean-Baptiste, additional, Nouvel, Bernadette, additional, Obled, Stephane, additional, Oswald, Eric, additional, Otto, Marie-Pierre, additional, Pageaux, Georges-Philippe, additional, Papin, Gregory, additional, Parant, Fabrice, additional, Patenotte, Arnaud, additional, Paupard, Thierry, additional, Pauwels, Arnaud, additional, Pawlotsky, Jean Michel, additional, Pelloux, Hervé, additional, Perlemuter, Gabriel, additional, Peron, Jean-Marie, additional, Pestel-Caron, Martine, additional, Peter, Natasha, additional, Petillon, Sophie, additional, Petit, Richard, additional, Petitprez, Helene, additional, Pettinelli, Francois, additional, Phelip, Jean Marc, additional, Philit, Jean-Baptiste, additional, Phoutthasang, Valérie, additional, Pialoux, Gilles, additional, Piau-Couapel, Caroline, additional, Pichard, Benoit, additional, Pichon, Maxime, additional, Picon-Coste, Magali, additional, Picque, Marie, additional, Pierson, Henri, additional, Piques, Jean Francois, additional, Piton, Béatrice, additional, Planade, Orianne, additional, Plassart, Claire, additional, Plésiat, Patrick, additional, Ploy, Marie-Cécile, additional, Poubeau, Patrice, additional, Pouderoux, Philippe, additional, Pouedras, Pascal, additional, Pourbaix, Annabelle, additional, Poynard, Thierry, additional, Preau, Florence, additional, Pricope, Dumitrita, additional, Queffelec, Gwenaëlle, additional, Queneherve, Lucille, additional, Quentin, Thomas, additional, Raffenot, Didier, additional, Rakotoniaina, Daniella, additional, Ramanantsoa, Celine, additional, Ramarijaona, Solofoniaina, additional, Rami-Arab, Lila, additional, Raulin, Olivia, additional, Rebibou, Jean Michel, additional, Renault, David, additional, Rey, Philippe, additional, Riche, Agnès, additional, Rigaud, Jean Philippe, additional, Rivière, Antoine, additional, Rivière, Brigitte, additional, Robert, Jérôme, additional, Roblot, Pascal, additional, Roger, Helene, additional, Rolland, Christophe, additional, Rondinaud, Emilie, additional, Rosa-Hezode, Isabelle, additional, Roubille, Martine, additional, Rouquette, Olivier, additional, Roux, Juliette, additional, Ruimy, Raymond, additional, Sachot-Ollivier, Sonia, additional, Sailler, Laurent, additional, Salamant, Sarah, additional, Sarbu-Pop, Silvia, additional, Sartre, Jacques, additional, Schmitt, François, additional, Scribe-Outtas, Myriam, additional, Sefrioui, David, additional, Sehouane, Rachid, additional, Sekhri, Hacène, additional, Serfaty, Lawrence, additional, Sevin, Odile, additional, Shawali, Cédric, additional, Siladi, Souad, additional, Silvain, Christine, additional, Simon, Mireille, additional, Simonet, Batiste, additional, Sinayoko, Leila, additional, Sirach, Estelle, additional, Smati, Mustafa, additional, Smets, Aurélie, additional, Soltani, Dhaoui, additional, Sommabere, André, additional, Soulier-Guerin, Karine, additional, Soulillou, Jean Paul, additional, Soupison, Alain, additional, Souply, Laurent, additional, Soussy, Claude-James, additional, Stampfli, Claire, additional, Strullu, Bernard, additional, Suatean, Diana, additional, Tadjerouni, Nacer, additional, Talarmin, Jean-Philippe, additional, Tankovic, Jacques, additional, Tarroun, Abdullah, additional, Tchuenbou, Juliette, additional, Teboul, Jean-Louis, additional, Tedlaouti, Husni, additional, Tellini, Charlotte, additional, Thabut, Dominique, additional, Thannberger, Philippe, additional, Thiebault, Henri, additional, Thiebaut, Françoise, additional, Thomazeau, Joséphine, additional, Tielman, Guillaume, additional, Timsit, Jean-Francois, additional, Tognon, Patrick, additional, Tougeron, David, additional, Toure, Fatouma, additional, Tran, Albert, additional, Tranvouez, Jean-Luc, additional, Trésallet, Christophe, additional, Trubert, Lise, additional, Tsakiris, Laurent, additional, Twizeyimana, Eterne, additional, Vachee, Anne, additional, Valade, Hélène, additional, Valat, Isabelle, additional, Vandendriessche, Anne, additional, Vandermee, Nathalie, additional, Vanheste, Marc, additional, Varon, Emmanuelle, additional, Vasse, Marc, additional, Vasseur, Philippe, additional, Vaucel, Elisabeth, additional, Vauthier, Anne, additional, Verdavaine-Loidreau, Delphine, additional, Verdet, Charlotte, additional, Verdon, Renaud, additional, Vergnaud, Michel, additional, Véziris, Nicolas, additional, Vignaud, Guillaume, additional, Viguier, Jérôme, additional, Villemain, Marc, additional, Villeneuve, Laurent, additional, Vimont-Vicary, Alexandre, additional, Vincent, Thomas, additional, Vuillemenot, Jean-Baptiste, additional, Walewski, Violaine, additional, Warmoes, Elodie, additional, Watry, Hélène, additional, Weber, Jean-Christophe, additional, Witz, Marie Thérèse, additional, Woerther, Paul-Louis, additional, Yazdanpanah, Yazdan, additional, Zamfir, Oana, additional, Zarka, Jonathan, additional, Zavadil, Patrick, additional, Zeboudj, Nabil, additional, and Zerbib, Franck, additional

Published
2024
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31. The Effect of Pollen on Coral Health

Author

Triona Barker, Mark Bulling, Vincent Thomas, and Michael Sweet

Subjects
pollen, coral mortality, immune response, hay fever, nutrient cascades, Biology (General), QH301-705.5
Abstract

Corals are facing a range of threats, including rises in sea surface temperature and ocean acidification. Some now argue that keeping corals ex situ (in aquaria), may be not only important but necessary to prevent local extinction, for example in the Florida Reef Tract. Such collections or are already becoming common place, especially in the Caribbean, and may act as an ark, preserving and growing rare or endangered species in years to come. However, corals housed in aquaria face their own unique set of threats. For example, hobbyists (who have housed corals for decades) have noticed seasonal mortality is commonplace, incidentally following months of peak pollen production. So, could corals suffer from hay fever? If so, what does the future hold? In short, the answer to the first question is simple, and it is no, corals cannot suffer from hay fever, primarily because corals lack an adaptive immune system, which is necessary for the diagnosis of such an allergy. However, the threat from pollen could still be real. In this review, we explore how such seasonal mortality could play out. We explore increases in reactive oxygen species, the role of additional nutrients and how the microbiome of the pollen may introduce disease or cause dysbiosis in the holobiont.

Published
2023
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32. On the Importance of Attention in Meta-Learning for Few-Shot Text Classification

Author

Jiang, Xiang, Havaei, Mohammad, Chartrand, Gabriel, Chouaib, Hassan, Vincent, Thomas, Jesson, Andrew, Chapados, Nicolas, and Matwin, Stan

Subjects
Computer Science - Learning, Computer Science - Artificial Intelligence, Statistics - Machine Learning
Abstract

Current deep learning based text classification methods are limited by their ability to achieve fast learning and generalization when the data is scarce. We address this problem by integrating a meta-learning procedure that uses the knowledge learned across many tasks as an inductive bias towards better natural language understanding. Based on the Model-Agnostic Meta-Learning framework (MAML), we introduce the Attentive Task-Agnostic Meta-Learning (ATAML) algorithm for text classification. The essential difference between MAML and ATAML is in the separation of task-agnostic representation learning and task-specific attentive adaptation. The proposed ATAML is designed to encourage task-agnostic representation learning by way of task-agnostic parameterization and facilitate task-specific adaptation via attention mechanisms. We provide evidence to show that the attention mechanism in ATAML has a synergistic effect on learning performance. In comparisons with models trained from random initialization, pretrained models and meta trained MAML, our proposed ATAML method generalizes better on single-label and multi-label classification tasks in miniRCV1 and miniReuters-21578 datasets., Comment: 13 pages, 4 figures, submitted to NIPS

Published
2018

34. A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia

Author

Paul Tetteh Asare, Chi-Hsien Lee, Vera Hürlimann, Youzheng Teo, Aline Cuénod, Nermin Akduman, Cordula Gekeler, Afrizal Afrizal, Myriam Corthesy, Claire Kohout, Vincent Thomas, Tomas de Wouters, Gilbert Greub, Thomas Clavel, Eric G. Pamer, Adrian Egli, Lisa Maier, and Pascale Vonaesch

Subjects
human gut microbiota, Clostridia, MALDI-TOF MS, commensal bacteria, anaerobic, bacterial identification, Microbiology, QR1-502
Abstract

IntroductionMicrobial isolates from culture can be identified using 16S or whole-genome sequencing which generates substantial costs and requires time and expertise. Protein fingerprinting via Matrix-assisted Laser Desorption Ionization–time of flight mass spectrometry (MALDI-TOF MS) is widely used for rapid bacterial identification in routine diagnostics but shows a poor performance and resolution on commensal bacteria due to currently limited database entries. The aim of this study was to develop a MALDI-TOF MS plugin database (CLOSTRI-TOF) allowing for rapid identification of non-pathogenic human commensal gastrointestinal bacteria.MethodsWe constructed a database containing mass spectral profiles (MSP) from 142 bacterial strains representing 47 species and 21 genera within the class Clostridia. Each strain-specific MSP was constructed using >20 raw spectra measured on a microflex Biotyper system (Bruker-Daltonics) from two independent cultures.ResultsFor validation, we used 58 sequence-confirmed strains and the CLOSTRI-TOF database successfully identified 98 and 93% of the strains, respectively, in two independent laboratories. Next, we applied the database to 326 isolates from stool of healthy Swiss volunteers and identified 264 (82%) of all isolates (compared to 170 (52.1%) with the Bruker-Daltonics library alone), thus classifying 60% of the formerly unknown isolates.DiscussionWe describe a new open-source MSP database for fast and accurate identification of the Clostridia class from the human gut microbiota. CLOSTRI-TOF expands the number of species which can be rapidly identified by MALDI-TOF MS.

Published
2023
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35. Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

Author

Hélène Le Ribeuz, Bastien Masson, Mary Dutheil, Angèle Boët, Antoine Beauvais, Jessica Sabourin, Vincent Thomas De Montpreville, Véronique Capuano, Olaf Mercier, Marc Humbert, David Montani, and Fabrice Antigny

Subjects
ATP, ABCC9, pulmonary arterial tone, migration, proliferation, metabolism, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

AimsWe hypothesized that the ATP-sensitive K+ channels (KATP) regulatory subunit (ABCC9) contributes to PAH pathogenesis. ABCC9 gene encodes for two regulatory subunits of KATP channels: the SUR2A and SUR2B proteins. In the KATP channel, the SUR2 subunits are associated with the K+ channel Kir6.1. We investigated how the SUR2/Kir6.1 channel contributes to PAH pathogenesis and its potential as a therapeutic target in PAH.Methods and resultsUsing in vitro, ex vivo, and in vivo approaches, we analyzed the localization and expression of SUR2A, SUR2B, and Kir6.1 in the pulmonary vasculature of controls and patients with PAH as in experimental pulmonary hypertension (PH) rat models and its contribution to PAH physiopathology. Finally, we deciphered the consequences of in vivo activation of SUR2/Kir6.1 in the monocrotaline (MCT)-induced PH model. We found that SUR2A, SUR2B, and Kir6.1 were expressed in the lungs of controls and patients with PAH and MCT-induced PH rat models. Organ bath studies showed that SUR2 activation by pinacidil induced relaxation of pulmonary arterial in rats and humans. In vitro experiments on human pulmonary arterial smooth muscle cells and endothelial cells (hPASMCs and hPAECs) in controls and PAH patients showed decreased cell proliferation and migration after SUR2 activation. We demonstrated that SUR2 activation in rat right ventricular (RV) cardiomyocytes reduced RV action potential duration by patch-clamp. Chronic pinacidil administration in control rats increased heart rate without changes in hemodynamic parameters. Finally, in vivo pharmacological activation of SUR2 on MCT and Chronic-hypoxia (CH)-induced-PH rats showed improved PH.ConclusionWe showed that SUR2A, SUR2B, and Kir6.1 are presented in hPASMCs and hPAECs of controls and PAH patients. In vivo SUR2 activation reduced the MCT-induced and CH-induced PH phenotype, suggesting that SUR2 activation should be considered for treating PAH.

Published
2023
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40. Species-targeted sorting and cultivation of commensal bacteria from the gut microbiome using flow cytometry under anaerobic conditions

Author

Samuel Bellais, Mélanie Nehlich, Maryne Ania, Aurore Duquenoy, Wilfrid Mazier, Ger van den Engh, Jan Baijer, Nicole Simone Treichel, Thomas Clavel, Ilia Belotserkovsky, and Vincent Thomas

Subjects
Microbiota, Faecalibacterium, Christensenella, Anaerobic, Flow cytometry, Sorting, Microbial ecology, QR100-130
Abstract

Abstract Background There is a growing interest in using gut commensal bacteria as “next generation” probiotics. However, this approach is still hampered by the fact that there are few or no strains available for specific species that are difficult to cultivate. Our objective was to adapt flow cytometry and cell sorting to be able to detect, separate, isolate, and cultivate new strains of commensal species from fecal material. We focused on the extremely oxygen sensitive (EOS) species Faecalibacterium prausnitzii and the under-represented, health-associated keystone species Christensenella minuta as proof-of-concept. Results A BD Influx® cell sorter was equipped with a glovebox that covered the sorting area. This box was flushed with nitrogen to deplete oxygen in the enclosure. Anaerobic conditions were maintained during the whole process, resulting in only minor viability loss during sorting and culture of unstained F. prausnitzii strains ATCC 27766, ATCC 27768, and DSM 17677. We then generated polyclonal antibodies against target species by immunizing rabbits with heat-inactivated bacteria. Two polyclonal antibodies were directed against F. prausnitzii type strains that belong to different phylogroups, whereas one was directed against C. minuta strain DSM 22607. The specificity of the antibodies was demonstrated by sorting and sequencing the stained bacterial fractions from fecal material. In addition, staining solutions including LIVE/DEAD™ BacLight™ Bacterial Viability staining and polyclonal antibodies did not severely impact bacterial viability while allowing discrimination between groups of strains. Finally, we combined these staining strategies as well as additional criteria based on bacterial shape for C. minuta and were able to detect, isolate, and cultivate new F. prausnitzii and C. minuta strains from healthy volunteer’s fecal samples. Conclusions Targeted cell-sorting under anaerobic conditions is a promising tool for the study of fecal microbiota. It gives the opportunity to quickly analyze microbial populations, and can be used to sort EOS and/or under-represented strains of interest using specific antibodies, thus opening new avenues for culture experiments. Video abstract

Published
2022
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42. Fauna and Paleoenvironments of the Homa Peninsula, Western Kenya

Author

Bishop, Laura C., primary, Plummer, Thomas W., additional, Braun, David R., additional, Ditchfield, Peter W., additional, Early, Emily Goble, additional, Hertel, Fritz, additional, Lemorini, Cristina, additional, Oliver, James S., additional, Potts, Richard, additional, Vincent, Thomas, additional, Whitfield, Elizabeth, additional, and Kinyanjui, Rahab N., additional

Published
2022
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43. Unexpected Cardiotoxicity in Patients With HER2-Mutant NSCLC Treated With Trastuzumab Deruxtecan: A Case Report

Author

Mariona Riudavets, MD, PhD, Arshid Azarine, MD, MSc, Sondes Smaali, MD, Young-Wouk Kim, MD, Vincent Thomas de Montpréville, MD, Alina Miruna Grecea, MD, Charles Naltet, MD, Annas Gazzah, MD, and David Planchard, MD, PhD

Subjects
Non–small cell lung cancer, HER2 mutation, Antibody drug conjugates, Trastuzumab deruxtecan, Cardiotoxicity: Case Report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Antibody-drug conjugates targeting receptor tyrosine-protein kinase erbB-2 (ERBB2, HER2) have emerged as promising targeted options for HER2-mutant NSCLC. Among antibody-drug conjugates targeting HER2, trastuzumab deruxtecan was found to have the most impressive efficacy and is a potential new standard of care. Drug-related interstitial lung disease remains a serious unpredictable identified risk for patients treated with trastuzumab deruxtecan, requiring careful monitoring and multidisciplinary management. We report the first two cases of drug-related cardiotoxicity with acute myocarditis that developed after the first trastuzumab deruxtecan cycle. Routine cardiovascular risk screening is advisable, with close collaboration between cardiology specialists and oncologists.

Published
2022
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46. Fine tuning of Nb-incorporated TiO2 thin films by atomic layer deposition and application as efficient electron transport layer in perovskite solar cells

Author

Vincent, Thomas, primary, Coutancier, Damien, additional, Dally, Pia, additional, Al Katrib, Mirella, additional, Frégnaux, Mathieu, additional, Cacovich, Stefania, additional, Donsanti, Frédérique, additional, Yaïche, Armelle, additional, Medjoubi, Karim, additional, Guillemot, Thomas, additional, Provost, Marion, additional, Rousset, Jean, additional, Bouttemy, Muriel, additional, and Schneider, Nathanaelle, additional

Published
2024
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49. Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience

Author

Vallée, Aurélien, primary, Houyel, Lucile, additional, To, Ngoc Tram, additional, Fels, Audrey, additional, Kloeckner, Martin, additional, Blanchard, David, additional, Lemann, Thomas, additional, Gaillard, Maïra, additional, Ramadan, Ramzi, additional, Genty, Thibaut, additional, Montpreville, Vincent Thomas de, additional, Beaussier, Hélène, additional, Chatellier, Gilles, additional, Deleuze, Philippe, additional, Haulon, Stephan, additional, and Guihaire, Julien, additional

Published
2024
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