1. Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes
- Author
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Torben Hansen, Thea Skaaby, Daniel R. Witte, Henrik Vestergaard, Allan Linneberg, Oluf Pedersen, Marit E. Jørgensen, Louise Lundby-Christensen, Thomas Drivsholm, Niels Grarup, Theresia M. Schnurr, Line Engelbrechtsen, and Vincent E Appel
- Subjects
Carotid Artery Diseases ,Male ,Endocrinology, Diabetes and Metabolism ,Blood Pressure ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,0302 clinical medicine ,Risk Factors ,carotid thickening ,risk factors ,Randomized Controlled Trials as Topic ,Cardiometabolic risk ,Middle Aged ,Plaque, Atherosclerotic ,Phenotype ,Hypertension ,Hypertension/diagnosis ,Cardiology ,Female ,Thickening ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Blood Pressure/genetics ,Quantitative Trait Loci ,030209 endocrinology & metabolism ,Risk Assessment ,genetic risk score ,03 medical and health sciences ,Quantitative Trait, Heritable ,Diabetes Mellitus, Type 2/diagnosis ,Predictive Value of Tests ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,In patient ,Carotid Artery Diseases/diagnostic imaging ,Genetic Association Studies ,Aged ,business.industry ,medicine.disease ,Blood pressure ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,atherosclerosis ,business - Abstract
OBJECTIVES: The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes.METHODS: In total, 12 genetic risk scores for blood pressure, blood lipids and glycaemic traits were constructed. The genetic risk scores were tested for association with carotid intima-media thickness and plaques in patients with type 2 diabetes ( n = 401) and in non-diabetic individuals ( n = 648) and for association with glucose levels in two population-based cohorts ( n = 1328 and n = 6161).RESULTS: In patients with type 2 diabetes, the genetic risk scores for pulse pressure were positively associated with plaque formation ( β = 0.036 ± 0.01 standard deviation/allele, p = 0.003). The genetic risk score for diastolic blood pressure was negatively associated with carotid intima-media thickness ( β = -0.037 ± 0.01 standard deviation/allele, p = 0.005), although not significant after correction for multiple testing ( p CONCLUSION: Genetic loci for pulse pressure are associated with plaque formation among patients with type 2 diabetes, suggesting an underlying genetic contribution to arterial stiffening and atherosclerosis.
- Published
- 2019
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