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ObjectiveMost young autistic children display emotional and behavioral problems (EBPs). There is evidence that behavioral parenting interventions (BPIs) reduce these. The COVID-19 pandemic and associated lockdowns can be seen as a natural experiment to test the longer-term effect of BPIs under conditions of increased uncertainty.MethodOpportunistic follow-up (n = 49) of a pilot randomized controlled trial (RCT) cohort (n = 62 autistic children aged 6-11 years; originally randomized to a 12-week group BPI [Predictive Parenting; n = 31] or an attention control [Psychoeducation; n = 31]) was conducted during COVID-19−related lockdowns. Measures of parent-reported child irritability and parenting stress were collected at 3 time points (baseline: mean age = 6.7 years; primary endpoint: mean age = 7.1 years, ∼5 months after randomization; and COVID-19 follow-up: mean age = 8.8 years, ∼2 years after randomization). We tested the magnitude of intervention effects using point estimates of differences in child irritability and parenting stress between arms at primary endpoint and COVID-19 follow-up, covarying for baseline scores. We used area under the curve (AUC) analyses to obtain overall estimates of the average intervention effect across all 3 timepoints. Semi-structured qualitative interviews were conducted with a subsample of parents (n = 18).ResultsA small but significant intervention effect was found from baseline to COVID-19 follow-up in favor of Predictive Parenting on parent-reported child irritability (d = −0.33, 95% CI = −0.65, −0.01) and parenting stress (d = −0.31, 95% CI = −0.59, −0.03). No overall mean intervention effect for these measures as estimated by the AUC analyses (which takes into account the nonsignificant effect at primary endpoint) was found. Interview feedback on the both interventions was positive, and parents reported using strategies from Predictive Parenting during COVID-19−related restrictions.ConclusionThis opportunistic follow-up study at a time of stress indicates the need for careful consideration of how and when to measure the effects of BPIs in autistic child populations. Future trials should consider both the most appropriate endpoint and in what context effects may be more likely to be seen.Clinical trial registration informationAutism Spectrum Treatment and Resilience (ASTAR); https://www.isrctn.com; 91411078.

In the general population, irritability is associated with later depression. Despite irritability being more prevalent in autistic children, the long-term sequelae are not well explored. We tested whether irritability in early childhood predicted depression symptoms in autistic adolescents, and whether associations could be explained by difficulties in peer relationships and lower educational engagement. Analyses tested the longitudinal associations between early childhood irritability (ages 3–5) and adolescent depression symptoms (age 14) in a prospective inception cohort of autistic children (N = 390), followed from early in development shortly after they received a clinical diagnosis. Mediators were measured in mid-childhood (age 10) by a combination of measures, from which latent factors for peer relationships and educational engagement were estimated. Results showed early childhood irritability was positively associated with adolescent depression symptoms, and this association remained when adjusting for baseline depression. A significant indirect pathway through peer relationships was found, which accounted for around 13% of the association between early childhood irritability and adolescent depression, suggesting peer problems may partially mediate the association between irritability and later depression. No mediation effects were found for education engagement. Results highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children.

BackgroundAlthough autism and callous-unemotional (CU) traits are distinct conditions, both are associated with difficulties in emotion recognition. However, it is unknown whether the emotion recognition difficulties characteristic of autism and CU traits are driven by comparable underpinning mechanisms.MethodsWe tested whether cueing to the eyes improved emotion recognition in relation to autistic and CU traits in a heterogeneous sample of children enhanced for social, emotional and behavioural difficulties. Participants were 171 (n = 75 male) children aged 10–16 years with and without a diagnosis of autism (n = 99 autistic), who completed assessments of emotion recognition with and without cueing to the eyes. Parents completed the assessment of autistic and CU traits.ResultsAssociations between autistic and CU traits and emotion recognition accuracy were dependent upon gaze cueing. CU traits were associated with an overall decrease in emotion recognition in the uncued condition, but better fear recognition when cued to the eyes. Conversely, autistic traits were associated with decreased emotion recognition in the cued condition only, and no interactions between autistic traits and emotion were found.ConclusionsThe differential effect of cueing to the eyes in autistic and CU traits suggests different mechanisms underpin emotion recognition abilities. Results suggest interventions designed to promote looking to the eyes may be beneficial for children with CU traits, but not for children with autistic characteristics. Future developmental studies of autism and CU characteristics are required to better understand how different pathways lead to overlapping socio-cognitive profiles.

Despite the high prevalence of mental health difficulties in autistic youth, little is known about the patterns of developmental continuity and change in psychiatric symptoms between childhood and adolescence. Using a stratified community-derived sample of autistic youth (n = 101; 57 males, 44 females), within (homotypic) and between (heterotypic) domain associations between psychiatric symptoms in childhood to adolescence were tested as well as whether any continuities were moderated by sex, IQ, autism symptom severity, social economic status, or parental mental health.Autistic youth were assessed for emotional, behavioral, and attention-deficit/hyperactivity disorder (ADHD) symptoms in childhood (age 4-9 years) and adolescence (age 13-17 years) using parental diagnostic interview. Unadjusted and adjusted (accounting for the co-occurrence of psychiatric symptoms in childhood) weighted models tested homotypic and heterotypic associations between symptoms in childhood and adolescence. Moderation of significant pathways was tested using multigroup analysis.Adolescent psychiatric symptoms all were predicted by symptoms of their childhood counterparts (emotional symptoms incidence rate ratio [IRR] = 1.06, 95% CI = 1.02-1.10, p .01; behavioral symptoms IRR = 1.38, 95% CI = 1.21-1.59, p .01; ADHD symptoms IRR = 1.11, 95% CI = 1.05-1.19, p .01); the only heterotypic pathway that remained significant in adjusted analyses was from childhood emotional symptoms to adolescent ADHD symptoms (IRR = 1.04, 95% CI = 1.01-1.07, p = .02). Sex moderated the homotypic ADHD symptoms pathway; associations were significant in female participants only. Child IQ moderated the homotypic behavioral symptoms pathway; the association was stronger in youth with IQ 70.Results from this community-based sample suggest that psychiatric symptoms in autistic youth exhibit substantial developmental continuity and thus highlight the importance of early screening and intervention. Sex and IQ may be important factors to consider when predicting likelihood of stability of ADHD and behavioral symptoms.

Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. This study examines longitudinal and contemporaneous associations of adaptive functioning in autistic youth across a wide ability range. Parent-reported autism symptoms, co-occurring emotional, behavioral and attention deficit hyperactivity disorder (ADHD) symptoms, and IQ were assessed in early childhood (M age 7 years; T1) and 6 years later in adolescence (M age 13 years; T2) in 179 autistic youth. Adaptive functioning was assessed at T2. Structural equation modeling estimated pathways to adaptive functioning from autism, and psychiatric symptoms at T1 and T2, testing whether associations were driven by continuity of behaviors from T1 to T2 or their contemporaneous effect at T2, or both, controlling for T1 IQ. Lower adaptive functioning at T2 was associated with higher T1 and T2 ADHD symptoms (β = −0.14, and β = −0.21) but not behavioral nor emotional symptoms at either timepoint. Lower adaptive functioning at T2 was also associated with lower T1 IQ (β = 0.43) and higher social communication symptoms (β = −0.37) at T2 but not T1, but the relationship with ADHD symptoms remained. Paths were not moderated by sex or IQ. Increased symptoms of ADHD, both in early childhood and contemporaneously, were associated with reduced adaptive functioning in adolescence. Co-occurring ADHD may be a modifiable risk factor for adaptive function impairments and should be routinely assessed and when present evidence-based treatments initiated which may benefit adaptive functioning outcomes. Lay Summary: Adaptive functioning is lower in many autistic individuals to a greater extent than would be expected based on IQ. However, the clinical features associated with these difficulties are less well understood. In a community sample higher attention deficit/hyperactivity disorder (ADHD) symptoms, but not emotional or behavioral symptoms, in both early childhood and contemporaneously were associated with lower adaptive functioning in autistic adolescents. Co-occurring ADHD may be a modifiable risk factor for adaptive function difficulties in autism.

OBJECTIVE: Previous literature shows an increased risk for eating disorders in autistic individuals. This study tested whether fussy eating contributes to the association between childhood autistic traits and adolescent eating disorder behaviours.METHOD: Using data from the Avon Longitudinal Study of Parents and Children, we estimated the intercept and slope of parent-rated autistic traits and fussy eating between 7 and 14 years (N = 8982) and their association with self-reported eating disorder behaviours at age 14 years, including the indirect path from autistic traits to eating disorder behaviours via fussy eating. Analyses were adjusted for child sex, maternal age at delivery, maternal body mass index and maternal education.RESULTS: Analyses found a small indirect pathway from autistic traits intercept to eating disorder behaviours via fussy eating slope (b = 0.017, 95% CI = 0.002-0.032, p = 0.026), with higher levels of autistic traits at age 7 years being associated with a shallower decline in fussy eating, which in turn was associated with greater eating disorder behaviours.CONCLUSION: Findings point towards fussy eating as a potential link between childhood autistic traits and later disordered eating. Addressing fussy eating patterns before they become entrenched may decrease risk for eating disorders later in development.

Emotional and behavioral problems (EBPs) frequently occur in young autistic children. Discrepancies between parents and other informants are common but can lead to uncertainty in formulation, diagnosis and care planning. This study aimed to explore child and informant characteristics are associated with reported child EBPs across settings. Participants were 83 4–8-year-old autistic children and their parents and teachers in the Autism Spectrum Treatment and Resilience (ASTAR) study. Questionnaires of child EBPs were completed by parents and teachers, and self-reported parenting stress and wellbeing measures were obtained. An observation of parent–child/researcher-child interaction was also completed. Parents reported more EBPs than teachers and parent-teacher agreement was low, particularly for emotional problems. Greater parenting stress and being verbal was associated with more parent- but not teacher-reported EBPs. More observed behaviors that challenge were displayed by minimally verbal children. More parenting stress could be associated with the presence of more EBPs in the home; alternatively, parenting stress may confound reports. It is essential for assessments of EBPs in autistic children to take a multi-informant approach. Better understanding of the associations between informant characteristics and informant discrepancies of EBPs is needed.

Item does not contain fulltext Neurodevelopmental disorders - including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disability, motor disorders, specific learning disorders, and tic disorders - manifest themselves early in development. Valid, reliable and broadly usable biomarkers supporting a timely diagnosis of these disorders would be highly relevant from a clinical and public health standpoint. We conducted the first systematic review of studies on candidate diagnostic biomarkers for these disorders in children and adolescents. We searched Medline and Embase + Embase Classic with terms relating to biomarkers until April 6, 2022, and conducted additional targeted searches for genome-wide association studies (GWAS) and neuroimaging or neurophysiological studies carried out by international consortia. We considered a candidate biomarker as promising if it was reported in at least two independent studies providing evidence of sensitivity and specificity of at least 80%. After screening 10,625 references, we retained 780 studies (374 biochemical, 203 neuroimaging, 133 neurophysiological and 65 neuropsychological studies, and five GWAS), including a total of approximately 120,000 cases and 176,000 controls. While the majority of the studies focused simply on associations, we could not find any biomarker for which there was evidence - from two or more studies from independent research groups, with results going into the same direction - of specificity and sensitivity of at least 80%. Other important metrics to assess the validity of a candidate biomarker, such as positive predictive value and negative predictive value, were infrequently reported. Limitations of the currently available studies include mostly small sample size, heterogeneous approaches and candidate biomarker targets, undue focus on single instead of joint biomarker signatures, and incomplete accounting for potential confounding factors. Future multivariable and multi-level approaches may be best suited to find valid candidate biomarkers, which will then need to be validated in external, independent samples and then, importantly, tested in terms of feasibility and cost-effectiveness, before they can be implemented in daily clinical practice. 01 februari 2023

Background Irritability is a common and impairing occurrence in autistic youth, yet the underlying mechanisms are not well-known. In typically developing populations, differences in frustration response have been suggested as important driver of the behavioural symptoms of irritability. Research exploring the role of frustration response as a risk factor for irritability in autistic populations is limited and often uses parent report or observer ratings; objective measures of frustration response appropriate for use in autistic populations are required to advance the field. Methods In the current study, fifty-two autistic adolescents aged 13–17 years from a population-based longitudinal study completed an experimental task designed to induce frustration through exposure to periods of unexpected delay. Behavioural (number of button presses) and physiological (heart rate; HR) metrics were collected during delay periods. Irritability was measured using the parent-rated Affective Reactivity Index (ARI). Analyses used mixed-level models to test whether irritability was associated with different slopes of behavioural and physiological response to experimentally induced frustration during the task. Age and baseline HR (for the physiological data only) were included as covariates. Results Analyses showed a marginal association between irritability and the slope of behavioural response (incident rate ratio (IRR) =.98, p=.06), and a significant association with the slope of physiological response (b=−.10, p=.04); higher levels of irritability were associated with a dampened behavioural and physiological response, as indicated by flatter slopes of change over the course of the task. The pattern of results largely remained in sensitivity analyses, although the association with physiological response became non-significant when adjusting for IQ, autism symptom severity, and medication use (b=−.10, p=.10). Conclusions Results suggest that the current experimental task may be a useful objective measure of frustration response for use with autistic populations, and that a non-adaptive response to frustration may be one biological mechanism underpinning irritability in autistic youth. This may represent an important target for future intervention studies.

Mental health problems are prevalent in autistic youth, but the underpinning mechanisms are not well explored. In neurotypical youth, stressful life events are an established risk factor for mental health problems. This study tested longitudinal bidirectional associations between family-level stressful life events and mental health problems and whether these were moderated by cognitive flexibility, in a cohort of autistic children ( N = 247). Family-stressful life events, assessed using the parent-reported Family Inventory of Life Events and Changes, and mental health problems, assessed using the teacher-reported Child Behavior Checklist Internalizing and Externalizing Symptoms subscales, were measured at multiple points between 7 and 11 years. Analyses showed no significant pathways from internalizing or externalizing symptoms to family-stressful life events or from family-stressful life events to internalizing or externalizing symptoms. There was some evidence of moderation by cognitive flexibility; the family-stressful life events to internalizing symptoms pathway was non-significant in the group with typical shifting ability but significant in the group with clinically significant shifting problems. Information about family-level stressful life event exposure and cognitive flexibility may be helpful in identifying autistic youth who may be at higher risk of developing mental health problems. Established risk factors for mental health problems in neurotypical populations are relevant for understanding mental health in autistic youth. Lay abstract Experiencing stressful life events, such as a parent having had serious illness, parental divorce, bullying and victimization, is known to increase risk for mental health difficulties in neurotypical children. However, few studies have looked at whether stressful life events have a similar impact in autistic youth and if any individual characteristics may moderate the impact of said life events. In this study, we tested whether in autistic children aged 7–11 years, exposure to family-level stressful life events predicted later mental health symptoms (and vice versa). We also tested whether associations between stressful life events and mental health symptoms differed depending on the child’s level of cognitive flexibility. We found stressful life events only predicted internalizing symptoms (such as anxiety and depression) in children with clinically significant difficulties in cognitive flexibility (as rated by their parents). Mental health symptoms did not predict future exposure to stressful life events. Results suggest that information about exposure to stressful life events and cognitive inflexibility may be helpful in identifying autistic children who may be at risk of developing anxiety and depression symptoms.

The current study explored the role of pre-existing and pandemic-time child, family or environmental factors in the presentation of mental health symptoms of autistic youth and their parents during the pandemic. Participants were parents/carers of autistic children (Autism Spectrum Treatment and Resilience Cohort, N = 67, Mage = 9 years) and adolescents (QUEST cohort, N = 112, Mage = 17 years). Parents completed an online survey that asked about child and parental mental health, infection experience, and changes to education arrangements, family life, housing and finances during the pandemic. Pre-existing measures of mental health, autism and adaptive functioning were also utilised. More engagement and enjoyment in education provision and going outside was associated with better child and parental mental health. In multivariate multiple linear regression models, more pre-existing attention deficit hyperactivity disorder symptoms were associated with more behavioural/attention deficit hyperactivity disorder symptoms during the pandemic in the pre-adolescent cohort, and with greater emotional symptoms in the adolescent cohort. More pre-existing parental mental health problems were associated with more parental mental health symptoms during the pandemic in both cohorts. Knowledge of pre-existing mental health and pandemic-related stressors may help care planning. Encouraging engagement and enjoyment in education and promoting physical exercise are key intervention targets. Ensuring access to attention deficit hyperactivity disorder medication and support is important, especially if this is managed jointly across school and home. Lay abstract What is already known about the topic: The COVID-19 pandemic and the associated restrictions impacted all of society. There is emerging evidence showing a range of impacts on autistic children and young people and their families. Further research that looks at how individuals coped during the pandemic while considering how they were doing before the pandemic is needed. What this paper adds: This article explores whether how well autistic youth were doing before the pandemic influenced how they coped during the pandemic. It also looked at how well their parents were doing during the pandemic and whether any pre-pandemic factors influenced how they coped. Samples of both primary-school-aged autistic children and autistic teenagers and their parents were surveyed to answer these questions. More engagement and enjoyment in education provision during the pandemic and getting outside more were linked with better child and parental mental health during the pandemic. More attention deficit hyperactivity disorder before the pandemic was linked with more attention deficit hyperactivity disorder and behavioural problems during the pandemic in primary-school-aged autistic children, and more emotional problems during the pandemic in autistic teenagers. Parents with more mental health problems during the pandemic had more mental health problems before the pandemic. Implications for practice, research or policy: Encouraging engagement and enjoyment in education and promoting physical exercise are key intervention targets. Ensuring access to attention deficit hyperactivity disorder medication and support is important, especially if this is managed jointly across school and home.

Autistic people experience high rates of co-occurring psychiatric diagnoses. Current prevalence estimates vary considerably due to an over-reliance on clinical cohorts and the longitudinal stability of diagnoses from childhood into adolescence is poorly understood. This study aims to provide prevalence rates of co-occurring DSM-5 psychiatric diagnosis for autistic adolescence and investigate, for the first time, the stability of diagnoses from childhood. Using a longitudinal stratified sample of autistic youth (N = 77; 13–17 years; 60% male), selected from a larger community-derived sample of those with pre-existing autism diagnoses (N = 277) weighted prevalence estimates of emotional (anxiety, depression), behavioural (oppositional and conduct disorders) and ADHD diagnoses were calculated based on semi-structured psychiatric interview. Prediction of adolescent psychiatric diagnosis based on childhood diagnostic status, sex, childhood IQ (both assessed at age 4–10 years) was tested. Emotional and behavioural disorders in adolescence were particularly prevalent, and significantly predicted by childhood disorder status. Attention-deficit/hyperactivity-disorder (ADHD) was prevalent but not predicted by childhood ADHD diagnosis. Neither sex nor childhood IQ predicted diagnostic outcomes. Autistic youth have high levels of co-occurring psychiatric conditions, which are broadly persistent across childhood and adolescence. Emotional disorders are particularly prevalent and remain persistent from childhood to adolescence. Greater diagnostic variability was found for ADHD with more adolescents moving across diagnostic thresholds.

Autism spectrum disorder (ASD) has its origins in the atypical development of brain networks. Infants who are at high familial risk for, and later diagnosed with ASD, show atypical activity in multiple electroencephalography (EEG) oscillatory measures. However, infant‐sibling studies are often constrained by small sample sizes. We used the International Infant EEG Data Integration Platform, a multi‐site dataset with 432 participants, including 222 at high‐risk for ASD, from whom repeated measurements of EEG were collected between the ages of 3–36 months. We applied a latent growth curve model to test whether familial risk status predicts developmental trajectories of spectral power across the first 3 years of life, and whether these trajectories predict ASD outcome. Change in spectral EEG power in all frequency bands occurred during the first 3 years of life. Familial risk, but not a later diagnosis of ASD, was associated with reduced power at 3 months, and a steeper developmental change between 3 and 36 months in nearly all absolute power bands. ASD outcome was not associated with absolute power intercept or slope. No associations were found between risk or outcome and relative power. This study applied an analytic approach not used in previous prospective biomarker studies of ASD, which was modeled to reflect the temporal relationship between genetic susceptibility, brain development, and ASD diagnosis. Trajectories of spectral power appear to be predicted by familial risk; however, spectral power does not predict diagnostic outcome above and beyond familial risk status. Discrepancies between current results and previous studies are discussed. Lay Summary Infants with an older sibling who is diagnosed with ASD are at increased risk of developing ASD themselves. This article tested whether EEG spectral power in the first year of life can predict whether these infants did or did not develop ASD.

Research suggests an increased prevalence of callous-unemotional (CU) traits in children with autism spectrum disorder (ASD), and a similar impairment in fear recognition to that reported in non-ASD populations. However, past work has used measures not specifically designed to measure CU traits and has not examined whether decreased attention to the eyes reported in non-ASD populations is also present in individuals with ASD. The current paper uses a measure specifically designed to measure CU traits to estimate prevalence in a large community-based ASD sample. Parents of 189 adolescents with ASD completed questionnaires assessing CU traits, and emotional and behavioral problems. A subset of participants completed a novel emotion recognition task (n = 46). Accuracy, reaction time, total looking time, and number of fixations to the eyes and mouth were measured. Twenty-two percent of youth with ASD scored above a cut-off expected to identify the top 6% of CU scores. CU traits were associated with longer reaction times to identify fear and fewer fixations to the eyes relative to the mouth during the viewing of fearful faces. No associations were found with accuracy or total looking time. Results suggest the mechanisms that underpin CU traits may be similar between ASD and non-ASD populations.

This review analyzes literature regarding urban heating and urban heat islands (UHIs) in dryland cities. This topic is of widespread importance in the era of climate change since many global cities are in arid, semiarid, or Mediterranean regions. We first analyze the literature on dryland UHIs, finding major differences with those for temperate cities. We then review research on cooling strategies involving vegetation, built form, and materials. Finally, we consider planning dimensions. Overall, we find that the most sustainable cooling approach for dryland cities is likely to combine low-water tree species with dense, shade-producing built form and high-albedo materials.

Highlights • Peak alpha frequency (PAF) is thought to be a more sensitive and reliable measure of alpha band oscillatory activity. • Higher PAF has been associated with better performance on a range of cognitive tasks. • This study examines associations between PAF and non-verbal and verbal cognitive development in young infants aged 12–36 months., Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD

One of the goals promoted by the ‘2030 Agenda for Sustainable Development’ is to make cities more inclusive, safe, resilient, and sustainable, responding to the challenges that cities face today, including the increase of urban temperature because of climate change effects, and the deficit of urban green spaces. Within this context, green urbanism aims to create more sustainable cities in terms of greenness, compactness, energy efficiency, zero emissions, and waste production, having as a result sustainable places, communities, and lifestyles. The approach arises to address some of the challenges mentioned above, through seven features expressed in emerging archetypal cities, where the ‘biophilic city’ is one of them. Biophilic cities are the materialization of the biophilic urbanism approach, which pursues the strategic integration of nature in cities through planning and design to achieve more livable cities in terms of the well-being and health of their inhabitants, as well as the creation of resilient urban environments. Firstly, this research compiled initiatives performed under the biophilic urbanism, defined here as biophilic urbanism initiatives (BUIs), where the main differences in its implementation can be traced back to income differences between countries. Secondly, it presents opportunities, as well as challenges for greening emerging and developing cities, based on one of the five categories of indicators associated with biophilic cities, ‘biophilic institutions and governance.’ The indicators comprising this group aim to describe the extent to which local governments are involved in encouraging green features and biophilic design. Finally, this research draws contributions already implemented by a group of Latin American cities located in Argentina, Chile, Colombia, and Peru. One of our main findings is that these initiatives have not yet been widely implemented in emerging and developing countries, compared with advanced economies, such as the USA, Germany, and Singapore, among others.

© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Objective: Atypical emotion recognition (ER) is characteristic of children with high callous unemotional (CU) traits. The current study aims to 1) replicate studies showing ER difficulties for static faces in relation to high CU-traits; 2) test whether ER difficulties remain when more naturalistic dynamic stimuli are used; 3) test whether ER performance for dynamic stimuli is moderated by eye-gaze direction and 4) assess the impact of co-occurring autistic traits on the association between CU and ER. Methods: Participants were 292 (152 male) 7-year-olds from the Wirral Child Health and Development Study (WCHADS). Children completed a static and dynamic ER eye-tracking task, and accuracy, reaction time and attention to the eyes were recorded. Results: Higher parent-reported CU-traits were significantly associated with reduced ER for static expressions, with lower accuracy for angry and happy faces. No association was found for dynamic expressions. However, parent-reported autistic traits were associated with ER difficulties for both static and dynamic expressions, and after controlling for autistic traits, the association between CU-traits and ER for static expressions became non-significant. CU-traits and looking to the eyes were not associated in either paradigm. Conclusion: The finding that CU-traits and ER are associated for static but not naturalistic dynamic expressions may be because motion cues in the dynamic stimuli draw attention to emotion-relevant features such as eyes and mouth. Further, results suggest that ER difficulties in CU-traits may be due, in part, to co-occurring autistic traits. Future developmental studies are required to tease apart pathways toward the apparently overlapping cognitive phenotype.

There is strong evidence to suggest that individuals with autism spectrum disorder (ASD) are at heightened risk for developing co-occurring psychiatric conditions. However, the reasons behind this increased risk remain unclear. This chapter describes multiple conceptual models of the reasons for comorbidity and appraises the strength for each in relation to currently available evidence. The first section considers the evidence to suggest the reported increase in prevalence can be explained by purely artefactual factors (e.g., issues in sample acquisition or symptom measurement) and concludes this is unlikely as a complete explanation. The second section discusses more theoretical models, and how these could manifest in autistic individuals (e.g., increased prevalence or potency of established risk factors, and the role of ASD-specific risk factors). There is evidence to support multiple mechanisms playing a role in explaining the increased prevalence of psychiatric conditions, and these mechanisms are unlikely to be mutually exclusive. As the current literature is limited, priority areas for future research are suggested, including the need for accurate measurement of predictors and outcomes, more sensitive research designs, and the inclusion of underrepresented groups.

This dissertation examines the evolution of a Soviet fashion industry and the primary state institutions for fashion, the houses of design, especially the All-Union House of Design (ODMO). Using heretofore untapped materials on the Soviet fashion industry, I consider how, during the height of the Cold War, fashion became a vital arena for Soviet self-identity and rivalry with the West. We can learn a great deal about the Soviet system and society from this institution and its employees, including the role of centralization and the bureaucratization of the state and the economy and the impact of Cold War rhetoric on art and culture. Soviet designers developed their own system, which both drew from and resisted Western design, incorporating ethnic motifs and preexisting cultural and gender norms to create a Soviet and socialist national style. The ODMO and Soviet clothing production underwent profound transformations between 1948 and 1982, but not quickly enough to keep pace with international fashion, which changed seasonally. Unlike their Western counterparts, Soviet designers could influence every level of production, as they not only designed clothing, but also advised factory managers, provided patterns for independent clothing production (carried out by tailors and seamstresses), and bore responsibility for marketing. Designers believed that fashion could unify the Soviet Union on two fronts: at home, with citizens wearing Soviet-designed and manufactured clothing, and abroad, at international competitions, as a symbol of the USSR’s artistic and cultural uniqueness. However, the command administrative economy’s centralization generated problems that beleaguered an industry that had to respond to changing tastes. Designers succeeded in dressing much of the population and in impressing international audiences, but they did so in a way that failed to appease consumers or uphold the uniqueness of the Soviet project. My study underlines the constraints and opportunities of a command economy and the linkages among popular, elite, and national culture through an institutional and cultural study of the All-Union House of Design.

Many young people with autism spectrum disorder display 'challenging behaviours', characterised by externalising behaviour and self-injurious behaviours. These behaviours can have a negative impact on a young person's well-being, family environment and educational achievement. However, the development of effective interventions requires greater knowledge of autism spectrum disorder-specific models of challenging behaviours. Autism spectrum disorder populations are found to demonstrate impairments in different cognitive domains, namely social domains, such as theory of mind and emotion recognition, but also non-social domains such as executive functioning and sensory or perceptual processing. Parent-rated self-injurious behaviour and externalising behaviours, and neurocognitive performance were assessed in a population-derived sample of 100 adolescents with autism spectrum disorder. Structural equation modelling was used to estimate associations between cognitive domains (theory of mind, emotion recognition, executive functioning and perceptual processing) and self-injurious behaviour and externalising behaviours. Poorer theory of mind was associated with increased self-injurious behaviour, whereas poorer perceptual processing was associated with increased externalising behaviours. These associations remained when controlling for language ability. This is the first analysis to examine how a wide range of neurocognitive domains relate to challenging behaviours and suggests specific domains that may be important targets in the development of interventions in adolescents with autism spectrum disorder.

Los Sistemas de Evaluación de Impacto Ambiental son instrumentos de gestión ambiental de carácter preventivo, cuyo principal objetivo es incorporar consideraciones ambientales en los procesos y actividades que acompañan el crecimiento económico de un país. Su influencia en la conservación de la biodiversidad es fundamental, ya que, dentro del proceso de evaluación, permiten identificar y evaluar impactos ambientales potenciales asociados a estas actividades, y definir reparaciones, compensaciones, o mitigaciones. Detener la pérdida de biodiversidad, provocada por actividades humanas y el cambio climático, es un objetivo de carácter mundial. Chile no está ajeno a este desafío, considerando su condición de Hotspot de biodiversidad, las proyecciones asociadas al cambio climático que afectarán el territorio, y los pendientes que el Sistema de Evaluación de Impacto Ambiental (SEIA) presenta respecto de conservación de la biodiversidad desde una mirada más estratégica al considerar cuestiones como el alcance territorial de los impactos ambientales generados por los proyectos, bajo una mirada sistémica y transversal con otras materias. Al respecto, la investigación presenta un análisis de las principales modificaciones experimentadas desde de su creación, comparándolo con otros sistemas de evaluación en Latinoamérica; junto a estadísticas nacionales del comportamiento de los proyectos de inversión que afectan potencialmente la conservación de la biodiversidad. Se abordan dos cuestionamientos que guían la discusión de funcionamiento y cambios que debiese impulsar el Estado chileno: 1) influencia sobre titulares de proyectos para que internalicen la importancia de proteger la biodiversidad más allá de lo normativo, y; 2) introducción de otras mejoras en la ley ambiental que podrían propiciar de manera indirecta mejoras en el SEIA. Finalmente, se concluye sobre la importancia de potenciar la Evaluación Ambiental Estratégica (EAE) y su integración con el SEIA, impulsando una mejora en los diseños de proyectos mediante la incorporación de la sustentabilidad desde su formulación. Environmental impact assessment systems are preventive management instruments whose main objective is to include environmental considerations in the processes and activities accompanying economic growth in a nation. The influence of these systems in the conservation of biodiversity is fundamental, since within the evaluation process, they enable identifying and evaluating potential environmental impacts, as well as defining reparations, compensations, or mitigations. Halting the loss of biodiversity caused by human activities and climate change is a global objective. Chile is also facing this challenge, considering its status of Biodiversity Hotspot, projections associated with climate change, and the outstanding issues that the Environmental Impact Assessment System (SEIA) shows regarding biodiversity conservation. The latest, based on the lack of strategic view when considering issues such as the territorial scope of the environmental impacts generated by the projects, under a systemic and transversal approach. This research analyses the main changes experienced since the creation of SEIA, and compares this system with other evaluation systems used in Latin America. National statistics on investment projects potentially affecting the conservation of biodiversity are given. Two issues are addressed to guide discussion of the operational changes that should be encouraged by the Chilean government, namely: 1) internalising the importance of protecting biodiversity beyond current regulations, and; 2) introducing improvements in environmental legislation that could indirectly lead to improvements in SEIA. The research concludes on the importance of strengthening the Strategic Environmental Assessment (SEA) and its integration with the SEIA, in order to encourage better project designs by including sustainability from the beginning. Este trabajo contó con el apoyo del proyecto “Sistema de Evaluación Ambiental bajo los Principios de la Encíclica Laudato Si’. ¿Avances o Retrocesos en la Evaluación de Proyectos e Instrumentos de Planificación Territorial en Chile?” de la Vicerrectoría de Investigación - Dirección de Pastoral y Cultura Cristiana, de la Pontificia Universidad Católica de Chile y del proyecto FONDECYT Regular Nº 1180268.

Biophilic urbanism seeks to integrate nature into the planning and design of urban spaces to pursue two main goals: making cities greener and improving the health and well-being of its inhabitants. Based on ordinal data gathered through a national survey, this paper analyses the perceptions of local governments on the potential implementation of this approach in Chile. Using Latent Class Analysis (LCA), heterogeneous groups of responses are identified as ‘Latent Classes.’ We implement two LCAs, one assessing the importance of the criteria driving biophilic urbanism and one evaluating the perceived barriers inhibiting this approach. We also examine local governments’ perceptions regarding the most and the least feasible Biophilic Urbanism Initiatives (BUIs) by considering a set of driving criteria as a base scenario. The first LCA reveals two groups of respondents in which both the current administration and financial resources are perceived to be driving biophilic urbanism. The second LCA reveals three groups of respondents: two groups perceiving the barriers as neutral and barely inhibiting the approach, respectively; and a third group pointing to the lack of economic resources and the lack of support from national and regional governments. Despite the differences in the perception of the criteria driving and the barriers inhibiting biophilic urbanism, the latent classes suggest the most and the least viable initiatives for implementation to be similar. Results are discussed in the context of the wider literature on biophilic urbanism.

Previous research suggests that variation in at-rest neural activity correlates with specific domains of the ASD phenotype; however, few studies have linked patterns of brain activity with autistic trait expression in typically developing populations. The purpose of this study was to examine associations between resting-state electroencephalography (EEG) and three domains of the broader autism phenotype (social interest, rigidity, and pragmatic language) in typically developing individuals. High-density scalp EEG was recorded in thirty-seven typically developing adult participants (13 male, aged 18–52 years). The Broad Autism Phenotype Questionnaire (BAP-Q) was used to measure autistic trait expression. Absolute alpha power (8–13 Hz) was extracted from eyes-closed epochs using spectral decomposition techniques. Analyses revealed a specific positive association between scores on the BAP-Q Rigidity subscale and alpha power in the parietal scalp region. No significant associations were found between alpha power and the BAP-Q Aloofness or Pragmatic Language subscales. Furthermore, the association between EEG power and behavioral rigidity was specific to the alpha frequency band. This study demonstrates that specific traits within the broader autism phenotype are associated with dissociable patterns of at-rest neural activity.

Background Many young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypicalities are also often reported in individuals with ASD, but how these relate to co-occurring emotional and behavioural problems remains unclear, and few studies have used objective measurement of perceptual processing. Methods Event-related potentials (ERPs) were recorded in response to both standard and deviant stimuli (which varied in pitch) in an auditory oddball paradigm in adolescents (mean age of 13.56 years, SD = 1.12, range = 11.40–15.70) with ASD (n = 43) with a wide range of IQ (mean IQ of 84.14, SD = 24.24, range 27–129). Response to deviant as compared to standard stimuli (as indexed by the mismatch negativity (MMN)) and response to repeated presentations of standard stimuli (habituation) were measured. Multivariate regression tested the association between neural indices of perceptual processing and co-occurring emotional and behavioural problems. Results Greater sensitivity to changes in pitch in incoming auditory information (discrimination), as indexed by increased MMN amplitude, was associated with higher levels of parent-rated behaviour problems. MMN amplitude also showed a trend positive correlation with parent-rated sensory hyper-sensitivity. Conversely, greater habituation at the later N2 component was associated with higher levels of emotional problems. Upon more detailed analyses, this appeared to be driven by a selectively greater ERP response to the first (but not the second or third) standard stimuli that followed deviant stimuli. A similar pattern of association was found with other measures of anxiety. All results remained in covariation analyses controlling for age, sex and IQ, although the association between MMN amplitude and behaviour problems became non-significant when controlling for ASD severity. Conclusions Findings suggest that alterations in mechanisms of perceptual processing and discrimination may be important for understanding co-occurring emotional and behavioural problems in young people with ASD. Electronic supplementary material The online version of this article (10.1186/s13229-018-0236-2) contains supplementary material, which is available to authorized users.

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