Search

Twitter is a free, open access social media platform that is widely used in medicine by physicians, scientists, and patients. It provides an opportunity for advocacy, education, and collaboration. However, it is likely not utilized to its full advantage by many disciplines in medicine, and pitfalls exist in its use. In particular, there has not been a review of Twitter use and its applications in the field of neurology. This review seeks to provide an understanding of the current use of Twitter in the field of neurology to assist neurologists in engaging with this potentially powerful application to support their work.

Byline: Archita. Makharia, Ayush. Agarwal, Divyani. Garg, Venugopalan. Vishnu, M. Padma Srivastava Stroke is the second leading cause of death and a major cause of disability worldwide. Stroke severity scales [...]

Byline: Ayush. Agarwal, Ayush. Makkar, Ajay. Garg, Madhavi. Tripathi, Venugopalan. Vishnu, Roopa. Rajan, Mamta. Singh, Rohit. Bhatia, M. P. Srivastava, Anu. Gupta Dear Editor, Mixed transcortical aphasia (MTA) results from [...]

Byline: Venugopalan. Vishnu, Rohit. Bhatia, Dheeraj. Khurana, Sucharita. Ray, Sudhir. Sharma, Girish. Kulkarni, Girish. Rao, Pooja. Mailankody, Butchi. Garuda, Amit. Bharadwaj, Monika. Angra, Teresa. Ferriera, Ashish. Sharma, Vinny. Wilson, Neha. [...]

We wanted to evaluate if optical coherence tomography angiography OCTA findings could predict the functional outcome in extracranial carotid artery atherosclerotic disease (ECAD) associated stroke. This exploratory study was performed on adults with acute ischaemic stroke due to ECAD at 3–6 weeks following stroke onset with risk factor matched controls without carotid artery stenosis. Twenty-three stroke patients (cases) and 23 controls were enrolled. There was significant difference between cases and controls in deep vessel density at the macula (p =.0007) and in radial peripapillary capillary perfusion density (RPCPD) at the optic nerve head (ONH) (p =.0007). Statistically significant difference was noted in the total superficial vessel density (SVD) at the macula (SVD within 1 standard deviation [SD] versus SVD beyond 1 SD of control data) in the ipsilateral eye and functional outcome at 3 months (poor versus very good outcome, modified Rankin scale [mRS] 0–1 versus mRS 2–6, respectively; p =.0361). There was statistically insignificant correlation between the RPCPD at the ONH and the National Institutes of Health Stroke Scale score at admission, mRS at discharge, and mRS at 3 months following stroke onset (r =.33, r =.35, r =.39; p =.11, p =.09, p =.06, respectively). The findings of this exploratory study suggested that OCTA findings may predict 3 month outcomes in cases of ECAD-related stroke and could be useful in decision making in future intervention studies as to whether intervene or not in patients having critical or non-critical ECAD for preventing stroke. [ABSTRACT FROM AUTHOR]

Byline: Garima. Saini, Simran. Malhotra, Roopa. Rajan, Venugopalan. Vishnu, Kalaivani. Mani, Rohit. Bhatia, Mamta. Bhushan, M. Padma Srivastava, Anu. Gupta Objective: To determine the feasibility, reliability, and acceptability of video [...]

Byline: Biswamohan. Mishra, Pachipala. Sudheer, Ayush. Agarwal, M. Padma Srivastava, Nilima, Venugopalan. Vishnu The concept of the minimal clinically important difference (MCID) emerged from the recognition that statistical significance alone [...]

Byline: Ayush. Agarwal, M. Padma Srivastava, Venugopalan. Vishnu Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy, which causes acute flaccid paralysis. Most cases of GBS report either a gastrointestinal or respiratory [...]

Byline: Divyani. Garg, Ayush. Agarwal, M. Padma Srivastava, Venugopalan. Vishnu Background: Stroke is a leading cause of death and disability globally. Over the last decade, digital health and related technology [...]

Byline: Ayush. Agarwal, Suhas. Murali, Anand. Warrier, Aneesha. Thomas, Yamini. Antil, Aanchal. Chadha, Venugopalan. Vishnu, Ajay. Garg, M. Padma Srivastava Sir, Cerebral malaria is the most severe complication associated with [...]

Byline: Alisha. Reyaz, Ayush. Agarwal, M. Padma Srivastava, Rohit. Bhatia, A. Sharif, Roopa. Rajan, Anu. Gupta, M. Singh, Venugopalan. Vishnu Dear Editor, Worldwide, healthcare systems are dealing with unforeseen challenges [...]

Byline: Archana. Sharma, Ayush. Agarwal, Venugopalan. Vishnu, M. Padma Srivastava Cerebral collateral circulation refers to the auxiliary vascular structures which compensate cerebral blood flow when it has been compromised due [...]

Byline: Maneesh. Shakywar, Ayush. Agarwal, M. Padma Srivastava, Rohit. Bhatia, Mamta. Singh, Roopa. Rajan, Anu. Gupta, Awadh. Pandit, Ajay. Garg, Jyoti. Sharma, Aakash. Gupta, Ashish. Upadhyay, Venugopalan. Vishnu Background and [...]

Background and Aims: Tenecteplase is used as the standard of care treatment for thrombolysis in acute ischemic stroke (AIS) patients within 4.5 h of symptom onset. Documented reports were less certain to claim the benefits of it in an extended window period. EAST-AIS (CTRI/2022/03/040718) trial is designed to determine the success rate of thrombolysis in an extended window period for good clinical outcomes. Study Design: It is a randomized, placebo-controlled trial of tenecteplase administered within 4.5-24 h of stroke onset (with or without large vessel occlusion) based on evidence of salvageable tissue through baseline computed tomography perfusion (CTP) or magnetic resonance imaging (MRI) scan. Criteria of patient inclusion are as follows: patients of both genders (male and female), age >18 years, pre-stroke modified Ranking Scale (mRS) <2, baseline NIHSS >5, CTP showing penumbra--ischemic core ratio >1.8, absolute difference in volume >10 ml, and ischemic core volume <70 ml. The sample size for the study is 100 patients: 50 in the tenecteplase arm (0.25 mg/kg body weight; maximum- 25 mg) and 50 in the placebo arm (controls). Study Outcomes: The study's primary objective is safety endpoints along with the efficacy of tenecteplase assessed using the mRS score at 90 days of stroke onset. Conclusion: The result obtained from EAST-AIS will determine the safety and efficacy of tenecteplase injection administered 4.5-24 h following the symptom onset for AIS patients within the territory of Internal Carotid Artery (ICA), Middle Cerebral Artery (MCA), or Anterior Cerebral Artery (ACA) occlusion. [ABSTRACT FROM AUTHOR]

Background: Acute kidney injury (AKI) is prevalent in patients with acute stroke. Although AKI is linked to poor clinical outcomes, data about its incidence and effect on stroke outcomes is limited. Methods: This was a prospective observational study carried out at a single tertiary care center that analyzed the data of 204 consecutive subjects with acute ischemic stroke and intracerebral hemorrhage. Considering serum creatinine at admission as the baseline, AKI was defined as a rise in serum creatinine value of 0.3 mg/dl over 48 h or a percentage increase of at least 50% from baseline over 7 days during hospitalization. The primary outcome was to measure the prevalence of AKI in patients with acute stroke. Secondary outcome measures were all-cause mortality, duration of hospital stay, need for dialysis, and comparison of outcomes in ischemic and hemorrhagic stroke. For both the stroke subtypes, we employed a multivariate logistic regression model, with AKI and hospital mortality being the outcomes. Covariates included gender, age, ventilatory requirement, duration of hospital stay, and National Institutes of Health Stroke Scale score at admission. Results: There were 144 cases of ischemic stroke with 12 deaths (8.3%) and 60 cases of intracranial hemorrhage (ICH) with 22 deaths (36.7%). The mean age was 55 years, 72.6% were males, and AKI complicated 34% of ischemic stroke and 66.7% of ICH hospitalizations. AKI was linked to increased hospital mortality from ischemic stroke (odds ratio [OR] 27.21, 95% CI 3.39-218.13) and hemorrhagic stroke (OR 5.12, 95% CI 1.29-20.28) in multivariate analysis stratified by stroke type. Conclusions: AKI complicates stroke frequently and increases hospital mortality. Additional studies are required to assess if the association is causal and if remedies to prevent AKI would decrease mortality. [ABSTRACT FROM AUTHOR]

The article focuses on cervical artery dissection (CAD), a condition where blood collects between the arterial wall layers, leading to a false lumen and mural hematoma. Topics include the multifactorial causes and symptoms of CAD, diagnostic imaging features like the crescent sign and double lumen, and the management approach involving antithrombotic therapy, with a particular focus on a study analyzing demographic and outcome data from CAD patients in India.

Byline: Ayush. Agarwal, Priyanka. Sehrawat, Venugopalan. Vishnu, Ajay. Garg, Mamta. Singh, Vinay. Goyal, M. Padma Srivastava Sir, Acute ischemic stroke (AIS) is the fifth leading cause of death and disability [...]

Byline: Ayush. Agarwal, M. Padma Srivastava, Venugopalan. Vishnu Background and Aims: Bruns-Garland syndrome (BGS) continues to be a contentious topic even 100 years after its discovery. Its lifelong incidence is [...]

Byline: Ayush. Agarwal, Jerry. George, Mohit. Anand, Abu. Tahir, Venugopalan. Vishnu, Mamta. Singh, M. Padma Srivastava Sir, An 83-year-old gentleman with non-valvular atrial fibrillation, diabetes, and hypertension on 5 mg [...]

Byline: M. Padma Srivastava, Venugopalan. Vishnu How do you define the quality of life? As a measure of how easily and successfully one can accomplish activities of daily living? Eating, [...]

Byline: M. Padma Srivastava, Venugopalan. Vishnu Stroke continues to scourge society in terms of death and disability. In the developing world, the statistics from India narrate an alarming trend of [...]

Byline: Pachipala. Sudheer, Ayush. Agarwal, Ajay. Garg, M. Padma Srivastava, Venugopalan. Vishnu Dear Editor, A 27-year-old man born out of nonconsanguineous parentage [[Figure 1]: Pedigree chart] with normal developmental history [...]