87 results on '"Visintini, E"'
Search Results
2. Bleeding events after simple dental extraction among patients undergoing anticoagulation therapy: cohort prospective comparative study
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Franco, Anna, Rizzo, Roberto, Costantinides, F., Visintini, E., Maglione, M., Berton, F., Di Lenarda, R., Franco, Anna, Rizzo, Roberto, Costantinides, F., Visintini, E., Maglione, M., Berton, F., and Di Lenarda, R.
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anticoagulation therapy ,Bleeding ,dental extraction - Abstract
Aim: The aim of the study is to evaluate and compare the intra- and post-operative bleeding during asimple dental extraction, among patients undergoing conventional Oral Anticoagulant Therapy (OAT) and patients assuming Direct Oral Anticoagulants (DOACs). Methods: Patients in chronic oral anticoagulant therapy (at least 6 months) with indication of a single dental extraction were enrolled and divided between OAT e DOACs group. All the participants were evaluated at four different time-points: T0 during the first examination, T1 during surgery, T2 thirty minutes after surgery and T3 the day of suture removal (seven days after surgery). At the different time-points anagraphic, medical history, local periodontal and dental variables were collected. The surgical protocol consisted in a simple dental extraction lead by the same surgeon (FB), in the least invasive procedure. Bleeding occurrence and biological complications were registered, according to Iwabuchi classification. Results: 15 patients (mean age 77,27±5,72) and 18 patients (mean age 75,94±12,18) were enrolled respectively in OAT e DOACs group. Overall 33 teeth were extracted within 20 minutes of surgical time (cut off that defined the simple extraction in our research protocol). The results of the present study showed no statistical difference between the two groups regarding the intraoperative bleeding and post-extraction bleeding complications. In detail, no intra-operative bleeding occurred, two patients for each group reported a post-operative bleeding managed with a single gauze compression during the week after the extraction, three patients of OAT group and one subject belonging to DOACs group needed more than two compressions in the week, and finally one patient for each group referred to our dental first aid. In these two cases, the urgency was managed with the local application of tranexamic acid and the complication could be attributable to high blood pressure values. Conclusion: Within the limits of the present study, apparently, patients assuming DOACs can be treated for simple oral surgery like patients undergoing OAT with INR index in therapeutic range. No discontinuation or changes of anticoagulation treatment with novel oral anticoagulants are possibly required. The adoption of local hemostasis techniques represents the most important precaution to prevent bleeding complications and to discriminate between bleeding caused by anticoagulation therapy and surgical technique. The patient education for the post-operative care of surgical site appears also strictly necessary.
- Published
- 2017
3. ElectroBond improves immediate dentin microtensile bond strength of two etch-and-rinse adhesives
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Breschi, L., Roberto Di Lenarda, Dorigo, E., Mazzoni, A., Pasquantonio, G., Ruggeri Jr, A., Saboia, V. P., Visintini, E., Vita, F., Mazzoni A, Visintini E, Vita F, Pasquantonio G, Saboia VP, Ruggeri A Jr, Di Lenarda R, Dorigo E, Breschi L., Mazzoni, A, Visintini, E, Vita, Francesca, Pasquantonio, G, Saboia, Vp, RUGGERI A., Jr, DI LENARDA, Roberto, DE STEFANO, Elettra, and Breschi, Lorenzo
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Silver Staining ,Surface Properties ,dentin bonding systems ,electric current ,TEM ,microtensile ,dentin ,IONTOPHORESIS ,TOOTH ,Composite Resins ,COMPARATIVE SEM ,NANOLEAKAGE ,SINGLE-STEP ADHESIVES ,HYBRID LAYER ,IN-VITRO ,PERMEABILITY ,CONVERSION ,INTERFACE ,Acid Etching, Dental ,Microscopy, Electron, Transmission ,Settore MED/28 - Malattie Odontostomatologiche ,Tensile Strength ,Materials Testing ,Humans ,Single-Blind Method ,Dental Leakage ,Dental Bonding ,Electrochemical Techniques ,Resin Cements ,Dentin-Bonding Agents ,Dentin ,Stress, Mechanical - Abstract
Purpose: The aim of this study was to investigate whether an electrical device for dental adhesive application (ElectroBond) influences bonding of two-step etch-and-rinse adhesives. Materials and Methods: Human teeth were selected and cut perpendicularly to their long axis to expose middle/deep dentin. Specimens were then longitudinally sectioned into halves (experimental and control halves) to create two similar bonding substrates. Experimental halves were bonded using an ElectroBond-assisted application, while control halves were bonded with disposable sponges. The adhesives tested were Adper Scotchbond 1XT and XP-BOND. Bonded specimens were submitted to the microtensile bond strength test. Additional adhesive interfaces were prepared and processed for nanoleakage investigation involving TEM examination. Results: The microtensile bond test revealed higher values (p < 0.05) for both adhesives if ElectroBond was used during layering (55.5 +/- 7.9 IVIPa for Adper Scotchbond 1XT and 54.7 +/- 7.1 IVIPa for XP-BOND) compared to the conventional mechanical adhesive application technique (41.1 +/- 6.1 MPa for Adper Scotchbond 1XT and 38.0 +/- 7.8 MPa for XP-BOND). No difference between the two adhesives was found under the same application conditions. With electricity-assisted application, TEM micrographs revealed a significant decrease in nanoleakage expression compared to the controls. Conclusion: The use of an electric current produced by ElectroBond during the application of two-step etch-and-rinse adhesives may enhance resin impregnation, thus improving dentin hybridization. Further studies should be done to confirm that this device can similarly improve adhesive application in vivo.
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- 2009
4. Clinical and histologic evaluation of fresh frozen human bone grafts for horizontal reconstruction of maxillary alveolar ridges
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Giovanna ORSINI, Stacchi, C., Visintini, E., Di Iorio, D., Putignano, A., Breschi, L., Di Lenarda, R., Orsini G, Stacchi C, Visintini E, Di Iorio D, Putignano A, Breschi L, Di Lenarda R, Orsini, G, Stacchi, C, Visintini, Erika, Di Iorio, D, Putignano, A, Breschi, Lorenzo, and DI LENARDA, Roberto
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Adult ,Male ,Biopsy ,Bone Screws ,implants ,bone ,Surgical Flaps ,Young Adult ,Osseointegration ,Osteogenesis ,Alveolar Process ,Maxilla ,Humans ,Piezosurgery ,Aged ,Cryopreservation ,Bone Transplantation ,Dental Implantation, Endosseous ,Alveolar Ridge Augmentation ,Middle Aged ,Plastic Surgery Procedures ,Treatment Outcome ,Debridement ,Female ,Tomography, X-Ray Computed ,Follow-Up Studies - Abstract
The aims of the present study were to clinically and histologically evaluate human fresh frozen bone (FFB) grafts used to treat severe maxillary horizontal defects prior to dental implant placement. Ten patients were treated with FFB onlay grafts. Measurements using computed tomography scans were recorded preoperatively and at 5 months. Six core biopsies were retrieved and processed for light microscopy. At baseline, thickness of the maxillary alveolar ridge measured 2.3 +/- 0.4 mm; it measured 6.8 +/- 0.5 mm after reconstruction. All implants were successful after 24 months. Histologic results showed that FFB blocks and new bone were integrated perfectly. Histomorphometry revealed a mean percentage of bone of 57.5% +/- 24.7%. (Int J Periodontics Restorative Dent 2011; 31:535-544.)
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- 2011
5. Microtensile bond strength of simplified and un-simplified adesive
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Diolosà, Marina, Navarra, Chiara, Visintini, E., Cadenaro, Milena, DI LENARDA, Roberto, Breschi, Lorenzo, Diolosà, Marina, Navarra, Chiara, Visintini, E., Cadenaro, Milena, DI LENARDA, Roberto, and Breschi, Lorenzo
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Microtensile bond strength ,dental adhesive - Published
- 2010
6. Bonding effectiveness of an experimental CHX-containing adhesive
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Visintini, E., Mazzoni, Annalisa, Navarra, Chiara, Cadenaro, Milena, DI LENARDA, Roberto, Breschi, Lorenzo, Visintini, E., Mazzoni, Annalisa, Navarra, Chiara, Cadenaro, Milena, DI LENARDA, Roberto, and Breschi, Lorenzo
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Bonding ,chlorhexidine ,dental adhesive - Published
- 2010
7. Microtensile bond strength of simplified and un-simplified adesive
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Diolosà M., Navarra C., Visintini E., Cadenaro M., Di Lenarda R, BRESCHI, LORENZO, Diolosà M., Navarra C., Visintini E., Cadenaro M., Di Lenarda R, and Breschi L. .
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dentin bonding systems - Published
- 2010
8. Bonding effectiveness of an experimental CHX-containing adhesive
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Visintini E., MAZZONI, ANNALISA, Navarra C., Cadenaro M., Di Lenarda R., BRESCHI, LORENZO, Visintini E., Mazzoni A., Navarra C., Cadenaro M., Di Lenarda R., and Breschi L.
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dentin - Published
- 2010
9. Effect of two in-office whitening agents on enamel surface in vivo: a morphological and non contact profilometric study
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CADENARO, MILENA, BRESCHI, LORENZO, DI LENARDA, Roberto, NUCCI C, ANTONIOLLI F, VISINTINI E, PRATI C, MATIS BA, Cadenaro, Milena, Breschi, Lorenzo, Nucci, C, Antoniolli, F, Visintini, E, Prati, C, Matis, Ba, and DI LENARDA, Roberto
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- 2008
10. Chlorhexidine improves bond strength of Scotchbond 1XT: a 2-year study
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BRESCHI, LORENZO, Visintini E, MAZZONI, ANNALISA, Cammelli F, Carrilho MR, Di Lenarda R, Tay FR, Pashley DH, Breschi, Lorenzo, Visintini, Erika, Mazzoni, Annalisa, Cammelli, F, Carrilho, Mr, DI LENARDA, Roberto, Tay, Fr, Pashley, Dh, Breschi L, Visintini E, Mazzoni A, Cammelli F, Carrilho MR, Di Lenarda R, Tay FR, and Pashley DH
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dentin bonding systems - Published
- 2008
11. Verruciform xanthoma of the oral mucosa. Report of a case
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Visintini, E., CLARA RIZZARDI, Chiandussi, S., Biasotto, M., Melato, M., Di Lenarda, R., Visintini, E, Rizzardi, Clara, Chiandussi, S, Biasotto, Matteo, Melato, Mauro, and DI LENARDA, Roberto
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Adult ,Male ,Humans ,Mouth Diseases ,Mouth Mucosa ,Xanthomatosis ,Mouth Disease ,Human - Abstract
Verruciform xanthoma is a rare benign lesion of unknown etiology and pathogenesis, although an inflammatory process seems to be implicated in its origin. It usually shows a slow-growing small lesion which can be sessile or pedunculated and has a typical rough and granular surface. A clinical case of an asymptomatic verruciform xanthoma of the ventral surface of the tongue in a 24-year-old male is reported. The lesion was noticed for the first time during a routine dental examination and it appeared as a sessile whitish verrucous lump hard in texture. An incisional biopsy followed by the excision of the whole lesion was performed. The histological and immunohistochemistry examinations were carried out using antibodies CD68-KP1, CD68-PGM1, alpha-1-antitrypsin and vimentin, desmin, cytokeratins, NSE and S-100. Histology showed epithelial degeneration. The connective tissue papillae were entirely occupied by foamy cells that were positive for CD68-KP1, CD68-PGM1, alpha-1-antitrypsin and vimentin and negative for desmin, cytokeratins, NSE and S-100. The foamy cells were characterized by a large granulous cytoplasm and small picnotic nuclei. In accordance with the literature, the immunohistochemistry analysis confirmed that foamy cells are likely to have a macrophagic origin and that epithelial degeneration could be correlated with the pathogenesis of this lesion.
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- 2007
12. Efficacia di differenti sistemi di cementazione intracanalare mediante test di microtensile
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SUPPA, PIETRO, BRESCHI, LORENZO, MAZZONI, ANNALISA, RUGGERI, ALESSANDRA, Biasotto M., Visintini E., Di Lenarda R., Suppa P., Breschi L., Biasotto M., Mazzoni A., Visintini E., Ruggeri A., and Di Lenarda R.
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- 2007
13. Influence of aging on etch-and-rinse adhesives applied with ElectroBond
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Pasquantonio G, MAZZONI, ANNALISA, Cova A, Visintini E, Cadenaro M, Di Lenarda R, BRESCHI, LORENZO, Pasquantonio G, Mazzoni A, Cova A, Visintini E, Cadenaro M, Di Lenarda R, and Breschi L
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dentin bonding systems - Published
- 2007
14. Effetto delle lampade LED sulla microdurezza degli adesivi smalto-dentinali
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Cadenaro, Milena, Breschi, L, Antoniolli, F, Visintini, E, Dorigo, E, DI LENARDA, Roberto, Cadenaro, Milena, Breschi, L, Antoniolli, F, Visintini, E, Dorigo, E, and DI LENARDA, Roberto
- Published
- 2006
15. Bond Strength of Scotchbond 1 Applied with Electric Impulses: Voltage Influence
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Visintini E, MAZZONI, ANNALISA, Suppa P, Pasquantonio G, Cadenaro M, Di Lenarda R., BRESCHI, LORENZO, Visintini E, Mazzoni A, Suppa P, Pasquantonio G, Cadenaro M, Breschi L, and Di Lenarda R
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dentin bonding systems - Published
- 2006
16. I sistemi adesivi nella terapia dell’iperestesia dentinale
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ANGERAME D, GARAFFA S, VISINTINI E, DI LENARDA, Roberto, DE STEFANO, ELETTRA, Angerame, D, Garaffa, S, Visintini, E, DI LENARDA, Roberto, and DE STEFANO, Elettra
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- 2004
17. Peripheral neurological damage following lower third molar removal. A preliminary clinical study
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Visintini, E., DANIELE ANGERAME, Costantinides, F., Maglione, M., Visintini, Erika, Angerame, Daniele, Costantinides, Fulvia, and Maglione, Michele
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tooth extraction ,Male ,Mandibular Nerve ,Peripheral Nervous System Diseases ,Lingual Nerve ,molar ,third ,neurological disorder ,mouth ,surgery ,radiography ,panoramic ,Cranial Nerve Diseases ,Tooth Extraction ,Humans ,Female ,Molar, Third - Abstract
Type of impaction and site of nerve are important risk factors of neurological damage following the lower third molar removal. The purpose of this study was to evaluate the peripheral damage of lingual and lower alveolar nerves in relation to tooth angulation and radiographic proximity to the alveolar canal.Sixty-seven consecutive patients (41 women and 26 men, mean age 29.97+/-14.35 years) underwent lower wisdom teeth extraction and were clinically evaluated over a one year period, checking any evidence of peripheral damage of the lower alveolar or lingual nerves. Tooth angulation and presence or absence of spongy bone between the mandibular canal and the root apex were considered; so, the patients were assigned twice to two groups: G1A (third molar in axis); G2A (third molar angulated); G1B (third molar apex adjacent to the mandibular canal); G2B (spongy bone between root apex and canal). The extraction was carried out according to a standardised technique without raising and retracting of a lingual flap. The follow-up checks were at one week, 1, 3, 6, 12 months and until any problem was solved. Statistical analysis was carried out using chi2 test.A total of two cases of temporary damage to the lingual nerve (1 case in G1A and 1 in G2A; 2 cases in G2B) and 3 cases to the lower alveolar nerve (3 cases in G2A; 1 in G1B and 2 in G2B) were discovered. No statistical differences were found. Symptoms cleared up within a maximum period of 5 months.Tooth angulation and proximity to lower alveolar canal were not related to alveolar or lingual damage; the conservative surgical technique seems to be an important factor in preventing neurological complications.
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- 2007
18. Buccal-masseteric mycotic abscess as a consequence of dental procedures
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Maglione, M., DANIELE ANGERAME, Costantinides, F., Visintini, E., Maglione, Michele, Angerame, Daniele, Costantinides, Fulvia, and Visintini, Erika
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Masseter Muscle ,Candidiasis ,Nerve Block ,anaesthesia ,Middle Aged ,mycotic absce ,Abscess ,trismus ,Muscular Diseases ,Maxillary Nerve ,Humans ,facial oedema ,Female ,mycotic abscess ,alveolar nerve ,Dental Restoration, Permanent ,Mouth Diseases - Abstract
Trismus may represent an external sign of masticatory or lateral pharyngeal abscess that in rare cases is the consequence of pathogen action by micro-organisms introduced in deep tissues after inferior alveolar block. The case presented shows a buccal-masseteric mycotic abscess following restorative procedure involving inferior alveolar anesthesia on the same side. A 49-year-old woman was referred to the Dental Clinic (University of Trieste) complaining of a progressive inability to open her mouth since one week associated to a hemifacial edema in the right parotid region. The symptoms initially started one week before. Infection developed after restorative procedures performed 10 days before on the same side. Based on clinical signs and cultural exam findings, a buccal-masseteric mycotic abscess was found and magnetic resonance (MR) was performed to assess its localization and extension. Initial pharmacological therapy with piperacillin/tazobactam administered intravenously, was replaced by appropriate antimycotic therapy on the basis of sensitivity test to antibiotics. Infection resolution was obtained but complete absence of facial asymmetry occurred after 5 months only. Introduction of micro-organisms during anesthetic alveolar block is a documented source of infection and may occur after dental procedure involving inferior alveolar anesthesia. Complete medical history, cultural exam with sensitivity test to antibiotics and RM or computed tomography (CT) images, are necessary to perform an adequate treatment plan and to administer a correct therapy. Presence of trismus, accompanied by pain or facial edema after dental procedure or during dental or perioral infections has to be carefully considered by clinician to diagnose as soon as possible a deep spaces infection and to avoid serious or life-threatening complications.
- Published
- 2007
19. Extracciones dentarias en pacientes en tratamiento con anticoagulantes: revisión de la literatura
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Visintini, E, Contardo, L, Biasotto, M, and Vignoletti, F
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cicatrización ,Anticoagulant drugs ,extracciones dentarias ,extraction ,healin, dental ,Anticoagulantes - Abstract
Objetivo del trabajo. En pacientes en terapia con anticoagulantes orales, una simple extracción puede provocar hemorragias importantes. En la literatura se describen dos enfoques terapéuticos en casos de intervenciones quirúrgicas en esta categoría de pacientes. Uno propone la reducción de la dosis terapéutica del fármaco, mientras que el segundo sugiere la sustitución con heparina. El objetivo de este trabajo es revisar la literatura que trata este tema con el fin de obtener un protocolo ideal. Conclusiones. En caso de extracciones simples es suficiente usar anestesia con vasoconstrictor (en el caso de que no haya otras contraindicaciones), realizar suturas bien tensadas, aplicar coadyuvantes hemostáticos locales y ácido tranexámico tópico. Solo en casos de intervenciones más complejas, o con valores de INR mayores a 3,5, será necesario reducir la dosis del fármaco y consecuente sustitución con heparina de acuerdo a las instrucciones del hematólogo y del cardiólogo. Aim of the work. In patients treated with oral anticoagulants, even simple tooth extractions can produce large hemorrhages. There are two main therapeutic outlines suggested in literature in case of little oral surgery. The first one is based on the reduction of the therapeutic dose of the drug, and the second one on the substitution with heparin. The aim of this paper was to review the.literature on the management of patients treated with anticoagulants in order to obtain univocal guidelines. Conclusion. In case of simple tooth extractions generally a vasoconstrictive anaesthetic (if there are no other contraindications), tight sutures, the application of hemostats and tronexamic acid are enough. Only in case of more complex surgery or of INR values higher than 3,5 it is necessory to reduce the anticoagulant dose or to change the therapy with heparin, if agreed by the hoemotologist and/ or the cardiologist.
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- 2006
20. La diagnosi endoscopica précoce di ulcere superficiali di tipo acuto e di erosioni dell mucosa, esofago, gastro, duodenale in corso di emorragia
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Visintini, E. and Belsasso, E.
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- 1973
- Full Text
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21. Epidemiology and variables involved in dental abscess: survey of dental emergency unit in Trieste
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Ottaviani, G, primary, Costantinides, F, additional, Perinetti, G, additional, Luzzati, R, additional, Contardo, L, additional, Visintini, E, additional, Tirelli, G, additional, Di Lenarda, R, additional, Gobbo, M, additional, and Biasotto, M, additional
- Published
- 2013
- Full Text
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22. QAM-based primers do not affect immediate bond strength of an etch-and-rinse adhesive
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Visintini, E., primary, Cadenaro, M., additional, di Lenarda, R., additional, Tay, F.R., additional, Pashley, D.H., additional, and Breschi, L., additional
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- 2010
- Full Text
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23. Microtensile bond strength of simplified and un-simplified adhesives
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Diolosá, M., primary, Navarra, C.O., additional, Visintini, E., additional, Cadenaro, M., additional, Di Lenarda, R., additional, and Breschi, L., additional
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- 2010
- Full Text
- View/download PDF
24. Effect of thermocycling on bond strength of fiber posts
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Mazzoni, A., primary, Marchesi, G., additional, Visintini, E., additional, Cadenaro, M., additional, Di Lenarda, R., additional, Ferrari, M., additional, and Breschi, L., additional
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- 2009
- Full Text
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25. Microtensile bond strength before and after aging of self-etch adhesives
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Visintini, E., primary, Martin, P., additional, Gotti, J., additional, Cadenaro, M., additional, Di Lenarda, R., additional, and Breschi, L., additional
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- 2009
- Full Text
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26. Effect of Two In-office Whitening Agents on the Enamel Surface In Vivo: A Morphological and Non-contact Profilometric Study
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Cadenaro, M., primary, Breschi, L., additional, Nucci, C., additional, Antoniolli, F., additional, Visintini, E., additional, Prati, C., additional, Matis, B. A., additional, and Di Lenarda, R., additional
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- 2008
- Full Text
- View/download PDF
27. Extracciones dentarias en pacientes en tratamiento con anticoagulantes: revisión de la literatura
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Visintini, E, primary, Contardo, L, additional, Biasotto, M, additional, and Vignoletti, F, additional
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- 2006
- Full Text
- View/download PDF
28. Dental extractions in anticoagulant treatment patients: Literature review | Extracciones dentarias en pacientes en tratamiento con anticoagulantes: Revisión de la literatura
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Biasotto, M., Luca Contardo, Vignoletti, F., and Visintini, E.
29. Influence of chlorhexidine concentration on the durability of etch-and-rinse dentin bonds: a 12-month in vitro study
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Breschi, Lorenzo, Cammelli, Federica, Visintini, Erika, Mazzoni, Annalisa, Vita, Francesca, Carrilho, Marcela, Cadenaro, Milena, Stephen Foulger, Mazzoti, Giovanni, Tay, Franklin R., Di Lenarda, Roberto, Pashley, David, Breschi, Lorenzo, Cammelli, F, Visintini, E, Mazzoni, A, Vita, Francesca, Carrilho, M, Cadenaro, Milena, Foulger, S, Mazzoti, G, Tay, Fr, DI LENARDA, Roberto, Pashley, D., Breschi L, Cammelli F, Visintini E, Mazzoni A, Vita F, Carrilho M, Cadenaro M, Foulger S, Mazzotti G, Tay FR, Di Lenarda R, and Pashley D.
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Dental Leakage ,Dental Stress Analysis ,Acid Etching, Dental ,Dentin-Bonding Agents ,Tensile Strength ,Chlorhexidine ,Materials Testing ,Dental Bonding ,Humans ,Molar, Third ,Protease Inhibitors ,Article ,DENTIN BONDING SYSTEMS - Abstract
Purpose: To investigate the effect of 0.2% and 2% chlorhexidine (CHX) used as a therapeutic primer on the long-term bond strengths of two etch-and-rinse adhesive systems. Materials and Methods: Adper Scotchbond 1XT (SB1) and XP-Bond (XPB) were evaluated. Etched dentin substrates were assigned to 6 treatment groups: (1) 0.2% CHX + SB1; (2) 2% CHX + SB1; (3) SB1 (control); (4) 0.2% CHX + XPB; (5) 2% CHX + XPB; (6) XPB (control). Composite buildups were made and beams prepared for microtensile bond strength testing. Beams were divided into 3 subgroups and either immediately pulled to failure or stored in artificial saliva for 6 or 12 months prior to testing. Data were evaluated with three-way ANOVA. Additional adhesive interfaces were prepared to investigate nanoleakage expression by TEM. Results: SB1 and XPB showed similar immediate bond strength values with or without CHX pretreatment (p > 0.05). After 12 months, bonds fell from 43.9 +/- 9.5 MPa to 20.1 +/- 5.4 MPa and from 39.6 +/- 9.4 MPa to 14.2 +/- 5.0 MPa in control specimens for SB1 and XPB respectively, while bond fell only from 41.9 +/- 9.6MPa to 33.2 +/- 8.3 MPa and 38.3 +/- 8.9 MPa to 26.5 +/- 10.9 (for SB1 and XPB, respectively) when 0.2% CHX was previously used. CHX concentration did not affect bond strength values (0.2% vs 2%, p > 0.05). Nanoleakage increased during aging in controls, but reduced silver deposits were found in CHX-treated specimens. Conclusion: Chlorhexidine significantly reduced the loss of bond strength seen in control bonds. Since no bacterial growth was present in the aging conditions, the results of this study suggest that endogenous factors thought to degrade the adhesive interface can be inhibited by CHX. Further in vivo trials should confirm the role of CHX in bond durability.
- Published
- 2009
30. Effects of thermocycling and use of ElectroBond on microtensile strength and nanoleakage using commercial one-step self-etch adhesives
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Guido Pasquantonio, Annalisa Mazzoni, Milena Cadenaro, Lorenzo Breschi, Francesca Vita, Roberto Di Lenarda, E Visintini, Visintini, E, Mazzoni, A, Vita, Francesca, Pasquantonio, G, Cadenaro, Milena, DI LENARDA, Roberto, Breschi, Lorenzo, Visintini E, Mazzoni A, Vita F, Pasquantonio G, Cadenaro M, Di Lenarda R, and Breschi L
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Molar ,Dentistry ,One-Step ,Microtensile ,Random Allocation ,Acid Etching, Dental ,Electricity ,Dentin ,dentin bonding agents ,Composite material ,tooth disease ,comparative study ,Dental Leakage ,Bond strength ,Statistics ,article ,Temperature ,methodology ,Iontophoresis ,Self etch adhesive ,medicine.anatomical_structure ,Thermocycling ,Adhesion ,Acid Etching ,dentin bonding agent ,Dental Stress Analysis ,Materials science ,randomization ,Statistics, Nonparametric ,Settore MED/28 - Malattie Odontostomatologiche ,Tensile Strength ,nonparametric test ,medicine ,Humans ,Dental Bonding ,Electric Conductivity ,Molar, Third ,Dentin-Bonding Agents ,Resin Cements ,Dentistry (all) ,Nonparametric ,human ,General Dentistry ,Third ,dental acid etching ,business.industry ,molar tooth ,Xeno III ,resin cement ,dental bonding ,dental care ,electric conductivity ,iontophoresis ,temperature ,tensile strength ,Dental ,Adhesive ,business - Abstract
The aim of this study was to determine the effect of thermocycling and the use of an electronically assisted application technique on the microtensile bond strength and nanoleakage of bonded interfaces created using one-step self-etch adhesives. Composite build-ups were bonded coronally to sectioned human molars using XENO III or Clearfil S(3)Bond. Adhesives were applied following the manufacturers' instructions (control) or with the aid of an electrical application device (ElectroBond). Teeth were sectioned into non-trimmed bonded beams for microtensile testing. Half of the specimens were subjected to 20,000 thermocycles, and the controls were not thermocycled. All specimens were tested to failure and peak stress was calculated. Additional specimens were prepared for nanoleakage analysis using transmission electron microscopy (TEM). The immediate bond strength of both adhesives increased as a result of using the ElectroBond device (XENO III 38.9 +/- 8.1 MPa; Clearfil S(3)Bond 46.2 +/- 9.9 MPa) compared with no use of the device (XENO III 26.7 +/- 7.8 MPa; Clearfil S(3)Bond 38.9 +/- 8.1 MPa). Thermocycling significantly decreased the bond strength of XENO III (27.1 +/- 7.9 MPa with the use of ElectroBond; 20.7 +/- 9.2 MPa without the use of ElectroBond); however, thermocycling did not affect the Clearfil S(3)Bond strength (47.2 +/- 8.6 MPa with the use of ElectroBond; 33.6 +/- 8.3 MPa without the use of ElectroBond). Reduced nanoleakage was found for both resins as a result of the use of the ElectroBond device, with or without thermocycling. Application of one-step, self-etch adhesives with the ElectroBond device significantly increased microtensile bond strength and reduced nanoleakage, but the effect of thermocycling was found to be brand-dependent.
- Published
- 2008
31. QAM-based primers do not affect immediate bond strength of an etch-and-rinse adhesive
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Fr Tay, E Visintini, Milena Cadenaro, Lorenzo Breschi, R. Di Lenarda, D.H. Pashley, Visintini, E., Cadenaro, Milena, DI LENARDA, Roberto, Tay, F. R., Pashley, D. H., and Breschi, Lorenzo
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QAM ,bond strength ,etch-and-rinse adhesives ,Materials science ,Mechanics of Materials ,Bond strength ,QAMs ,General Materials Science ,Etch and rinse ,Composite material ,General Dentistry - Published
- 2010
32. Chlorhexidine stabilizes the adhesive interface: a 2-year in vitro study
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David H. Pashley, Franklin Chi Meng Tay, E Visintini, Marcela Carrilho, E. Dorigo, F Nato, Lorenzo Breschi, Leo Tjäderhane, Annalisa Mazzoni, Alessandra Ruggeri, Breschi L, Mazzoni A, Nato F, Carrilho M, Visintini E, Tjäderhane L, Ruggeri A Jr, Tay FR, Dorigo ED, and Pashley DH.
- Subjects
Dental Stress Analysis ,Materials science ,Dentistry ,Matrix metalloproteinase ,Matrix Metalloproteinase Inhibitors ,Statistics, Nonparametric ,Article ,Collagen fibril ,Chlorhexidine digluconate ,stomatognathic system ,Tensile Strength ,Dentin ,medicine ,In vitro study ,Humans ,General Materials Science ,General Dentistry ,Dental Leakage ,Analysis of Variance ,business.industry ,Chlorhexidine ,Dental Bonding ,Resin Cements ,Dentin Permeability ,Enzyme Activation ,stomatognathic diseases ,medicine.anatomical_structure ,Mechanics of Materials ,Dentin-Bonding Agents ,Biophysics ,Anti-Infective Agents, Local ,Matrix Metalloproteinase 2 ,Adhesive ,business ,medicine.drug - Abstract
Objectives. This study evaluated the role of endogenous dentin MMPs in auto-degradation of collagen fibrils within adhesive-bonded interfaces. The null hypotheses tested were that adhesive blends or chlorhexidine digluconate (CHX) application does not modify dentin MMPs activity and that CHX used as therapeutic primer does not improve the stability of adhesive interfaces over time. Methods. Zymograms of protein extracts from human dentin powder incubated with Adper Scotchbond 1XT (SB1XT) on untreated or 0.2-2% CHX-treated dentin were obtained to assay dentin MMPs activity. Microtensile bond strength and interfacial nanoleakage expression of SB1XT bonded interfaces ( with or without CHX pre-treatment for 30 s on the etched surface) were analyzed immediately and after 2 years of storage in artificial saliva at 37 degrees C. Results. Zymograms showed that application of SB1XT to human dentin powder increases MMP-2 activity, while CHX pre-treatment inhibited all dentin gelatinolytic activity, irrespective from the tested concentration. CHX significantly lowered the loss of bond strength and nanoleakage seen in acid-etched resin-bonded dentin artificially aged for 2 years. Significance. The study demonstrates the active role of SB1XT in dentin MMP-2 activation and the efficacy of CHX inhibition of MMPs even if used at low concentration (0.2%).
- Published
- 2009
33. Microtensile bond strength before and after aging of self-etch adhesives
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Milena Cadenaro, R. Di Lenarda, Lorenzo Breschi, J. Gotti, E Visintini, P. Martin, Visintini, E., Martin, P., Gotti, J., Cadenaro, Milena, DI LENARDA, Roberto, and Breschi, Lorenzo
- Subjects
adhesion ,Materials science ,Mechanics of Materials ,Bond strength ,Microtensile bond strength ,self-etch adhesive ,self-etch adhesives ,General Materials Science ,Adhesion ,Composite material ,General Dentistry ,Self etch adhesive - Published
- 2009
34. Effect of two in-office whitening agents on the enamel surface in vivo: a morphological and non-contact profilometric study
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R. Di Lenarda, Cesare Nucci, Bruce A. Matis, Carlo Prati, Milena Cadenaro, E Visintini, Lorenzo Breschi, Francesca Antoniolli, Cadenaro M, Breschi L, Nucci C, Antoniolli F, Visintini E, Prati C, Matis BA, and Di Lenarda R.
- Subjects
Adult ,Male ,Materials science ,Dentistry ,Carbamide Peroxide ,Dental Materials ,Acid Etching, Dental ,In vivo ,Dentin ,medicine ,Tooth Bleaching ,Humans ,Replica Techniques ,Urea ,Bovine enamel ,Phosphoric Acids ,Dental Enamel ,General Dentistry ,Whitening Agents ,Enamel paint ,business.industry ,Hydrogen Peroxide ,Oxidants ,Peroxides ,Incisor ,Drug Combinations ,medicine.anatomical_structure ,visual_art ,visual_art.visual_art_medium ,Microscopy, Electron, Scanning ,Female ,Molar, Third ,business ,Follow-Up Studies - Abstract
This study evaluated the morphological effects produced in vivo by two in-office bleaching agents on enamel surface roughness using a non-contact profilometric analysis of epoxy replicas. The null hypothesis tested was that there would be no difference in the micromorphology of the enamel surface during or after bleaching with two different bleaching agents. Eighteen subjects were selected and randomly assigned to two treatment groups (n=9). The tooth whitening materials tested were 38% hydrogen peroxide (HP) (Opalescence Xtra Boost) and 35% carbamide peroxide (CP) (Rembrandt Quik Start). The bleaching agents were applied in accordance with manufacturer protocols. The treatments were repeated four times at one-week intervals. High precision impressions of the upper right incisor were taken at baseline as the control (CTRL) and after each bleaching treatment (TO: first application, T(1): second application at one week, T(2): third application at two weeks and T(3): fourth application at three weeks). Epoxy resin replicas were poured from impressions, and the surface roughness was analyzed by means of a non-contact profilometer (Talysurf CLI 1000). Epoxy replicas were then observed using SEM. All data were statistically analyzed using ANOVA and differences were determined with a t-test. No significant differences in surface roughness were found on enamel replicas using either 38% hydrogen peroxide or 35% carbamide peroxide in vivo. This in vivo study supports the null hypothesis that two in-office bleaching agents, with either a high concentration of hydrogen or carbamide peroxide, do not alter enamel surface roughness, even after multiple applications
- Published
- 2008
35. TEM/FEI-SEM immunohistochemical identification of MMP-2 within the hybrid layer
- Author
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MAZZONI, Annalisa, VISINTINI, ERIKA, CADENARO, MILENA, BRESCHI, LORENZO, Vita F, Carrilho MR, Ruggeri AJ, Tay FR, Pashley DH, Mazzoni A, Visintini E, Vita F, Carrilho MR, Ruggeri AJ, Cadenaro M, Tay FR, Pashley DH, Breschi L, Mazzoni, Annalisa, Visintini, Erika, Vita, F, Carrilho, Mr, Ruggeri, Aj, Cadenaro, Milena, Tay, Fr, Pashley, Dh, and Breschi, Lorenzo
- Subjects
dentin bonding systems ,DENTIN BONDING SYSTEMS - Published
- 2008
36. Microtensile Bond Strength of Self-etching Bonding Systems using Electric Impulses
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MAZZONI, Annalisa, VISINTINI, ERIKA, BRESCHI, LORENZO, Pasquantonio G, Suppa P, CONTARDO, LUCA, Mazzoni A, Pasquantonio G, Suppa P, Visintini E, Contardo L, Breschi L, Mazzoni, Annalisa, Pasquantonio, G, Suppa, P, Visintini, Erika, Contardo, Luca, and Breschi, Lorenzo
- Subjects
dentin bonding systems ,dentin bonding agents - Published
- 2005
37. [The use of standardized nursing languages in electronic medical records: an exploratory study on opportunities, limitations, and strategies].
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Visintini E, Chiappinotto S, Palese A, and Saiani L
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- Humans, Vocabulary, Controlled, Language, Italy, Electronic Health Records, Nursing Care
- Abstract
. The use of standardized nursing languages in electronic medical records: an exploratory study on opportunities, limitations, and strategies., Introduction: Standardized nursing languages (SNLs) have found increasing application in electronic medical records in recent years. In Italy their use is still uneven and accompanied by a silent debate between positions 'against' and 'for' their use., Aim: To render visible the debate regarding SNLs in Italy, and the strategies to consider when digitized records are based on a SNL., Method: Data has been collected through audio-recorded semi-structured interviews, selecting three Italian nursing professors, four managers representing Italian healthcare settings that used a SNT and a representative of the Central committee of the National federation of orders of nursing professions. The thematic approach was used to analyze the data., Results: Participants reported having introduced digitized records based on nursing diagnoses, integrated with the Nursing Interventions Classification System and Nursing Outcome Classification, Clinical Care Classification System, Nursing Sensitive Outcomes or mixed models. Divergent aspects emerge regarding: (1) using nursing languages vs a common language to other healthcare professions; (2) planning care vs enhancing clinical reasoning; (3) measuring nursing care vs accepting the variability of the practice, and (4) making documentation efficient vs dedicating more time. Some convergences have emerged and a set of indications for introducing electronic records when based on standardized languages., Conclusions: The introduction of electronic documentation requires the use of homogeneous languages. The debate on the potential and limits of SNL is still open and requires reflection among researchers, trainers, clinicians, and coordinators/managers of nursing care regarding the choices to be made which may have long-term effects on many nurses.
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- 2024
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38. Lessons learnt while designing and conducting a longitudinal study from the first Italian COVID-19 pandemic wave up to 3 years.
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Palese A, Chiappinotto S, Fonda F, Visintini E, Peghin M, Colizzi M, Balestrieri M, De Martino M, Isola M, and Tascini C
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- Humans, Female, Male, Longitudinal Studies, Learning, Data Collection, Pandemics, COVID-19
- Abstract
Background: Several scientific contributions have summarized the "lessons learnt" during the coronavirus disease 2019 (COVID-19) pandemic, but only a few authors have discussed what we have learnt on how to design and conduct research during a pandemic. The main intent of this study was to summarize the lessons learnt by an Italian multidisciplinary research group that developed and conducted a longitudinal study on COVID-19 patients infected during the first wave in March 2020 and followed-up for 3 years., Methods: A qualitative research approach embedded into the primary CORonavirus MOnitoRing study (CORMOR) study was developed, according to the the consolidated criteria for reporting qualitative research. Multiple data collection strategies were performed: each member was invited to report the main lessons learnt according to his/her perspective and experience from the study design throughout its conduction. The narratives collected were summarized and discussed in face-to-face rounds. The narratives were then thematically analysed according to their main topic in a list that was resent to all members to check the content and their organization. The list of the final "lessons learnt" has been agreed by all members, as described in a detailed fashion., Results: Several lessons were learnt while designing and conducting a longitudinal study during the COVID-19 pandemic and summarised into ten main themes: some are methodological, while others concern how to conduct research in pandemics/epidemics/infectious disease emergencies., Conclusions: The multidisciplinary approach, which also included patients' perspective, helped us to protect the consistency and quality of the research provided in pandemic times. The lesson learnt suggest that our research approach may benefit from changes in education, clinical practice and policies., (© 2023. The Author(s).)
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- 2023
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39. Factors triggering the progressive detachment of nurses toward the fundamental needs of patients: findings from a qualitative study.
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Visintini E, Inzerillo M, Savaris M, Paravan G, Serafini M, and Palese A
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- Humans, Qualitative Research, Patients, Nurses
- Abstract
The progressive desensitization of nurses in relation to fundamental needs (FNs) has been documented in anecdotical, scientific, and policy literature with nurses spending limited time at the bedside, thus affecting the quality of care and clinical outcomes. A potential reason that has been recognized is the limited nursing staff available in the units. However, other cultural, social, and psychological factors which have not been investigated to date may have a role in triggering the phenomenon. To investigate nurses' perceptions of the reasons that progressively detach clinical nurses from the FNs of patients, was the main intent of the study. In 2020, a qualitative study based on grounded theory following the Standards for Reporting Qualitative Research guidelines was performed. Purposeful sampling was adopted, by including 22 clinical nurses designated as 'good nurses' according to the perception of nurses working in executive and academic position. All agreed to be interviewed face-to-face. The detachment of nurses from the patients' FNs has been explained by three main factors that are interconnected: namely 'Being personally and professionally convinced regarding the role of FNs', 'Being progressively detached from the FNs', and 'Being forced to be detached from FNs'. Nurses also identified a category including strategies aimed at preventing detachment and 'Rediscovering the FNs as the core of nursing'. Nurses are personally and professionally convinced about the relevance of the FNs. However, they distance themselves from the FNs due to: (a) factors mainly attributable to internal personal and professional forces, such as the emotional fatigue that daily work entails; and (b) external forces related to the work environment where nurses work. To prevent this detrimental process that may result in negative outcomes for patients and their relatives, several strategies at the individual, organizational, and educational levels should be implemented., (© 2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)
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- 2023
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40. Using Metaphors to Understand Suffering in COVID-19 Survivors: A Two Time-Point Observational Follow-Up Study.
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Palese A, Visintini E, Bressan V, Fonda F, Chiappinotto S, Grassetti L, Peghin M, Tascini C, Balestrieri M, and Colizzi M
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- Humans, Female, Middle Aged, Male, Follow-Up Studies, Metaphor, Pandemics, Survivors, COVID-19 epidemiology
- Abstract
Accumulating evidence indicates that the COVID-19 pandemic carries risks to psychological health and represents a collective traumatic experience with consequences at the social, economic, and health levels. The primary aim of this study was to collect ongoing COVID-19 survivors’ pandemic-related experiences as expressed through the use of metaphors; the secondary aim was to explore socio-demographic variables associated with the metaphor orientation as negative, positive or neutral. An observational follow-up survey was conducted and reported according to the STROBE guidelines. Patients ≥ 18 years, who were treated for COVID-19 during the first wave (March/April 2020) and who were willing to participate in a telephone interview were involved and asked to summarize their COVID-19 experience as lived up to 6 and 12 months in a metaphor. A total of 339 patients participated in the first (6 months) and second (12 months) data collection. Patients were mainly female (51.9%), with an average age of 52.9 years (confidence interval, CI 95% 51.2−54.6). At 6 months, most participants (214; 63.1%) used a negative-oriented metaphor, further increasing at 12 months (266; 78.5%), when they used fewer neutral-/positive-oriented metaphors (p < 0.001). At the 6-month follow-up, only three individual variables (female gender, education, and experiencing symptoms at the COVID-19 onset) were significantly different across the possible metaphor orientation; at 12 months, no individual variables were significantly associated. This study suggests increasingly negative lived experiences over time and the need for personalized healthcare pathways to face the long-term traumatic consequences of COVID-19.
- Published
- 2023
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41. Framing the time while designing and conducting reviews: A Focused Mapping Review and Synthesis.
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Palese A, Mansutti I, Visintini E, Caruzzo D, Moreale R, Longhini J, and Danielis M
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- Humans, Checklist
- Abstract
Aims and Objectives: To identify the profile of time restrictions and their justifications as reported on a set of published reviews., Background: There is a body of methodological knowledge addressing how to design and perform reviews in their different designs. However, how the time restrictions should be set and the justifications that should be provided have received limited attention to date., Design: A Focused Mapping Review and Synthesis following three steps (Focus, Mapping and Synthesis) was performed on 2021. The ENTREQ checklist was followed to report methods and findings., Methods: All Journal of Clinical Nursing reviews published in online or printed version on 2020 (n = 85). Time limits imposed in the literature search, and justifications provided were mapped and synthetised with quantitative and a qualitative analysis., Results: Time restrictions in reviews are not always reported and, when available, reflect three different profiles: (a) including all studies, to provide a comprehensive review; (b) selecting a period, to provide reviews for a contemporary practice; and (b) including only recent studies for reviews reflecting current practice. Reasons justifying time restrictions are not always reported; when documented, justifications regard changes in the practice, in the research or in the theory occurred over time, recent or ongoing., Conclusions: In exploring the date restrictions applied in reviews published over the course of a year, it emerged that the time of access to the sources and the justifications are not always indicated. The attributes of the emerging concepts of "comprehensive reviews," "contemporary practice reviews" and "current practice reviews" might be further developed to support researchers in selecting an appropriate time frame., Relevance to Clinical Practice: Reviews require improvements regarding the time restrictions and their justifications. Methodological efforts to standardise the approach ensuring transparency in review protocols and in the following review publication are recommended., (© 2021 John Wiley & Sons Ltd.)
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- 2022
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42. Patient Experiences of Systemic Lupus Erythematosus: Findings From a Systematic Review, Meta-Summary, and Meta-Synthesis.
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Petrocchi V, Visintini E, De Marchi G, Quartuccio L, and Palese A
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- Adult, Humans, Female, Male, Qualitative Research, Fatigue psychology, Emotions, Patient Outcome Assessment, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic psychology
- Abstract
Objective: To explore the experience of patients with systemic lupus erythematosus (SLE)., Methods: A systematic review of qualitative studies published in English in the past 10 years and identified through the PubMed, CINAHL, Scopus, and Web of Science databases was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The methodologic quality of each included study was assessed using the Critical Appraisal Screening Programme tool. Study findings were then subjected to a meta-summary and meta-synthesis., Results: Twenty-six studies with a good overall methodologic quality were included, documenting the experience of 565 adult patients (95% women). A total of 17 codes emerged, summarizing the life experience of SLE patients; the most and least frequent codes in the meta-summary were "feeling not as I usually do" (69.2%) and "having wishes" (7.7%). The codes were then categorized into 5 main themes, summarizing the experience of living with SLE: 1) "experiencing waves of emotions due to the unpredictable nature of the disease," 2) "trying to live an ordinary life," 3) "listening to and obeying the body's limitations," 4) "reviewing my life projects," and 5) "dealing with future uncertainties.", Conclusion: Several qualitative studies have been published to date using good methodologic approaches. According to the findings, SLE negatively impacts patient experiences by affecting multiple dimensions of their daily lives, with fatigue and pain as the most frequent symptoms., (© 2021 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
- Published
- 2022
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43. Italian nurses' experiences of the COVID-19 pandemic through social media: A longitudinal mixed methods study of Internet posts.
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Rossettini G, Peressutti V, Visintini E, Fontanini R, Caruzzo D, Longhini J, and Palese A
- Abstract
Objective: To examine the experience of Italian nurses posted on social media and discover changes, if any, over the waves., Methods: A mixed methods study reported according to the Good Reporting of a Mixed Methods Study criteria. All narratives (texts, letters and interviews) posted by Italian nurses from February 2020 to May 2020 (first wave) and from October 2020 to May 2021 (second/third wave) on the five most famous Italian professional social media platforms. The data were analysed qualitatively (first wave) and then quantitatively (second/third wave)., Results: A total of 380 narratives (202,626 words, 2510 quotes) were posted in the first wave, and 161 (68,388 words, 835 quotes) in the second/third wave. In the first wave, the following five themes emerged: (a) 'sharing what is happening within myself' (891; 35.5%); (b) 'experiencing unprecedented working conditions' (749; 29.8%); (c) 'failing to rehabilitate the image of nurses in society' (376; 15%); (d) 'experiencing a deep change' (253; 10.1%) and (e) 'do not abandon us' (241; 9.6%). The same themes and subthemes also emerged in the second/third wave with some significant differences, indicating changes in the lived experience of nurses. Moreover, in the second/third wave, a new theme emerged: 'experiencing the mixed emotions towards jabs'., Conclusions: By analysing their posts, Italian nurses continue to face challenges during the COVID-19 pandemic, with changes in their lived experiences across the waves. Governments, nursing associations and health care organizations should consider these changes to design policies to prevent the further loss of nurses., Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article., (© The Author(s) 2022.)
- Published
- 2022
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44. Post-COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients.
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Peghin M, De Martino M, Palese A, Gerussi V, Bontempo G, Graziano E, Visintini E, D'Elia D, Dellai F, Marrella F, Fabris M, Curcio F, Sartor A, Isola M, and Tascini C
- Subjects
- Adult, Antibodies, Viral, COVID-19 Vaccines, Female, Humans, Immunoglobulin G, Male, Middle Aged, Prospective Studies, SARS-CoV-2, Post-Acute COVID-19 Syndrome, COVID-19 complications, COVID-19 prevention & control
- Abstract
Objectives: This study aimed to describe the impact of vaccination and the role of humoral responses on post-COVID-19 syndrome 1 year after the onset of SARS coronavirus type 2 (CoV-2)., Methods: This prospective study was conducted through interviews to investigate post-COVID-19 syndrome 6 and 12 months after disease onset in all adult in- and outpatients with COVID-19 at Udine Hospital (March-May 2020). Vaccination status and two different serological assays to distinguish between response to vaccination (receptor-binding domain (RBD) SARS-CoV-2 IgG) and/or natural infection (non-RBD-SARS-CoV-2 IgG) were also assessed., Results: A total of 479 patients (52.6% female; mean age: 53 years) were interviewed 13.5 months (standard deviation: 0.6 months) after acute infection. Post-COVID-19 syndrome was observed in 47.2% of patients (n = 226) after 1 year. There were no significant differences in the worsening of post-COVID-19 symptoms (22.7% vs. 15.8%; p = 0.209) among vaccinated (n = 132) and unvaccinated (n = 347) patients. The presence of non-RBD SARS-CoV-2 IgG induced by natural infection showed a significant association with post-COVID-19 syndrome (OR: 1.35; 95% CI, 1.11-1.64; p = 0.003), and median non-RBD SARS-CoV-2 IgG titres were significantly higher in long haulers than in patients without symptoms (22 kAU/L (interquartile range, 9.7-37.2 kAU/L) vs. 14.1 kAU/L (interquartile range, 5.4-31.3 kAU/L); p = 0.009) after 1 year. In contrast, the presence of RBD SARS-CoV-2 IgG was not associated with the occurrence of post-COVID-19 syndrome (>2500 U/mL vs. 0.9-2500 U/mL; OR: 1.36; 95% CI, 0.62-3.00; p = 0.441), and RBD SARS-CoV-2 IgG titres were similar in long haulers as in patients without symptoms (50% values > 2500 U/mL vs. 55.6% values > 2500 U/mL; p = 0.451)., Discussion: The SARS-CoV-2 vaccination is not associated with the emergence of post-COVID-19 symptoms more than 1 year after acute infection. The persistence of high serological titre response induced by natural infection, but not vaccination, may play a role in long-haul COVID-19., (Copyright © 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2022
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45. One Word to Describe My Experience as a COVID-19 Survivor Six Months after Its Onset: Findings of a Qualitative Study.
- Author
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Palese A, Peghin M, Bressan V, Venturini M, Gerussi V, Bontempo G, Graziano E, Visintini E, and Tascini C
- Subjects
- Adult, Female, Humans, Metaphor, Middle Aged, Pandemics, Qualitative Research, Survivors, COVID-19 epidemiology
- Abstract
The COVID-19 pandemic emotionally affected the lives of patients cared for in different settings. However, a comprehensive view of the whole experience as lived by survived patients, from the onset of the disease and over time, is substantially unknown to date. A descriptive qualitative design was implemented according to the Standards for Reporting Qualitative Research. Adult patients (=1067) cared for during the first wave (March/April 2020) capable of answering an interview and willing to participate were interviewed (=397) by phone with an interview guide including open- and closed-ended questions. In this context, they were asked to summarise with a metaphor their entire COVID-19 experience at six months. Then, the emotional orientation (positive, neutral, or negative) of the metaphors expressed was identified. The participants were mainly female (206; 51.9%), with an average age of 52.6 years (CI 95% 50.4-53.6), reporting a mild severity of COVID-19 disease at the onset (261; 65.7%) and the perception of being completely healed (294; 70%) at six months. The patients summarised their experiences mainly using negative-oriented (248; 62.5%) metaphors; only 54 (13.6%) reported positive-oriented metaphors and a quarter (95; 23.95) neutral-oriented metaphors. Nearly all positive-oriented metaphors were reported by patients with symptoms at the onset (53; 98.1%), a significantly higher proportion compared to those reporting negative- (219; 88.3%) and neutral-oriented (78; 82.1%) metaphors ( p = 0.014). While no other clinical features of the disease were associated, among females, significantly more negative-oriented metaphors emerged. Moreover, neutral-oriented metaphors were reported by younger patients (49.5 years, CI 95% 64.11-52.92) as compared to those negative and positive that were reported by more mature patients (53.9; CI 95% 52.04-55.93 and 54.8; CI 95% 50.53-59.24, respectively) ( p = 0.044). Nurses and healthcare services require data to predict the long-term needs of patients. Our findings suggest that, for many patients, the COVID-19 lived experience was negative over time.
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- 2022
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46. The Fall in Antibody Response to SARS-CoV-2: a Longitudinal Study of Asymptomatic to Critically Ill Patients Up to 10 Months after Recovery.
- Author
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Peghin M, De Martino M, Fabris M, Palese A, Visintini E, Graziano E, Gerussi V, Bontempo G, D'Aurizio F, Biasotto A, Sartor A, Pipan C, Marzinotto S, Curcio F, Bouza E, Isola M, and Tascini C
- Subjects
- Adult, Aged, Antibodies, Viral, Antibody Formation, Critical Illness, Female, Humans, Immunoglobulin M, Longitudinal Studies, Middle Aged, Prospective Studies, COVID-19, SARS-CoV-2
- Abstract
The aim of this study was to assess the long-term dynamics and factors associated with the serological response against the severe acute respiratory syndrome coronavirus 2 after primary infection. A prospective longitudinal study was conducted with monthly serological follow-up during the first 4 months, and then at 6, 8, and 10 months after the disease onset of all recovered adult in- and outpatients with coronavirus disease 2019 (COVID-19) attending Udine Hospital (Italy) during the first wave (from March to May 2020). A total of 546 individuals were included (289 female, mean age 53.1 years), mostly with mild COVID-19 (370, 68.3%). Patients were followed for a median of 302 days (interquartile range, 186 to 311). The overall seroconversion rate within 2 months was 32% for IgM and 90% for IgG. Seroreversion was observed in 90% of patients for IgM at 4 months and in 47% for IgG at 10 months. Older age, number of symptoms at acute onset, and severity of acute COVID-19 were all independent predictors of long-term immunity both for IgM (β, linear regression coefficient, 1.10, P = 0.001; β 5.15 P = 0.014; β 43.84 P = 0.021, respectively) and for IgG (β 1.43 P < 0.001; β 10.46 P < 0.001; β 46.79 P < 0.001, respectively), whereas the initial IgG peak was associated only with IgG duration (β 1.12, P < 0.001). IgM antibodies disappeared at 4 months, and IgG antibodies declined in about half of patients 10 months after acute COVID-19. These effects varied depending on the intensity of the initial antibody response, age, and burden of acute COVID-19.
- Published
- 2021
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47. The experience of individuals placed in quarantine: A systematic review, meta-summary, and meta-synthesis.
- Author
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Basso M, Visintini E, Achil I, Fabris S, Mattiussi E, Danielis M, and Palese A
- Subjects
- Adult, Humans, Qualitative Research, Quarantine
- Abstract
Objective: To summarize the experience of individuals placed in quarantine during an outbreak., Design: A meta-summary and a meta-synthesis based upon a systematic review of qualitative studies., Sample: The Cumulative Index of Nursing and Allied Health Literature, MEDLINE, and Scopus databases were all searched up to April 2020., Measurements: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed; then, the methodological quality of the studies included was assessed with the Critical Appraisal Screening Programme tool for qualitative studies., Results: Five studies have been included documenting the experience of 125 adult individuals. A total of 16 codes emerged: in the meta-summary, the most and least frequent codes were "Thinking about quarantine" (80%) and "Emotional roller coaster," "Being alert for any symptom," "Trusting or not?," "Knowing who brought the infection," and "Living in a surreal world" (20%). The codes which emerged were categorized into three main themes which summarized the whole experience of being placed in quarantine: (a) "Being swamped with a thousand emotions"; (b) "Being restrained"; and (c) "Needing to be considered.", Conclusions: The experience of quarantine for people is a long journey which can feel chaotic due to uncertainty about the consequences on health, work, and the future. The findings of this study can help nurses in caring for quarantined individuals by enabling them to understand people's need for educational and emotional support. Ensuring the supply of consistent information is also important to increase people's compliance., (© 2021 The Authors. Public Health Nursing published by Wiley Periodicals LLC.)
- Published
- 2021
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48. Italian Nurses' experiences during the COVID-19 pandemic: a qualitative analysis of internet posts.
- Author
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Fontanini R, Visintini E, Rossettini G, Caruzzo D, Longhini J, and Palese A
- Subjects
- COVID-19 epidemiology, Female, Humans, Italy epidemiology, Male, Pandemics, Pneumonia, Viral epidemiology, Pneumonia, Viral virology, Qualitative Research, SARS-CoV-2, Attitude of Health Personnel, COVID-19 nursing, Nurses psychology, Pneumonia, Viral nursing, Social Media
- Abstract
Aim: To investigate the experience of Italian nurses during the first wave of the COVID-19 outbreak by analysing professional social media posts., Background: The COVID-19 outbreak has overwhelmed health care institutions; as a consequence, nurses' lives and psycho-physical health have been affected., Introduction: The COVID-19 pandemic forced nurses to work in physically and psychologically stressful conditions impacting on their life., Methods: A qualitative descriptive study. All narratives (texts and videos) posted by nurses from the 23
rd of February 2020 to the 3rd of May (from the start of the outbreak to the end of the first lockdown) were analysed and published on the five most popular Italian professional social media platforms. The Consolidated Criteria for Reporting Qualitative research guidelines were followed., Results: Five themes emerged from the 380 narratives explored: 'Sharing what is happening within myself'; 'Experiencing unprecedented working conditions'; 'Experiencing a deep change'; 'Failing to rehabilitate the image of nurses in society'; and 'Do not abandon us'. Even though nurses appreciated the recognition of their communities, they still felt devalued and not recognized as professionals., Discussion: Several psychological, physical, social and professional implications emerged from nurses working during the COVID-19 pandemic. Despite being highly praised, nurses perceived they had failed in rehabilitating the image of nurses in society., Conclusion: The experience of working during the COVID-19 pandemic represented a traumatic event for nurses but it offered them personal and professional growth opportunities. IMPLICATIONS FOR NURSING PRACTICE, NURSING POLICY AND HEALTH POLICY: Supporting nurses' mental health is highly recommended, together with a cultural investment on nurses' role recognition, and a zero-tolerance policy towards violence and aggression towards nurses., (© 2021 International Council of Nurses.)- Published
- 2021
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49. Patients' experience of haemorrhagic cystitis after Haematopoietic Stem Cell Transplantation: Findings from a phenomenological study.
- Author
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Visintini E, Visintini C, Venturini M, and Palese A
- Subjects
- Adult, Aged, Cystitis etiology, Female, Hemorrhage etiology, Humans, Male, Middle Aged, Patients statistics & numerical data, Qualitative Research, Cystitis psychology, Hematopoietic Stem Cell Transplantation adverse effects, Hemorrhage psychology, Patients psychology
- Abstract
Purpose: Haemorrhagic cystitis (HC) is a severe complication of haematopoietic stem cell transplantation (HSCT), which significantly affects patients' quality of life. However, no qualitative studies have described to date the experience of patients who have developed this complication. Therefore, the aim of this interpretative phenomenological study performed on 2019 was to explore the experience of patients who developed HC after HSCT., Method: A purposeful sample of nine patients who had experienced at least one episode of HC after the HSCT were approached. The audio-recorded interviews were transcribed verbatim and then analysed according to Giorgi's method. Member checking of the findings was also performed., Results: The experience of the participants with HC after HSCT has been summarised around three main themes: "Being alerted", "It has arrived" and "It has been overcome." Patients reported to have been informed regarding the HC; after the first devastating symptoms, they reported fear and in searching for causes and strategies to alleviate the problem, which seemed to be never resolved. Patients' experience with HC is complex and experienced dramatically due to the pain and the discomforting consequences of the treatments received; they develop a sense of exhaustion that can further increase both their physical and emotional burden. The process of recovery from the huge impact, required time over the end of the HC symptoms., Conclusions: Patients' experience of HC is complex, and varies according to the various phases of the complication. HC creates an increased physical and psychological stresses that demand additional coping strategies: therefore, the emotional support of patients is crucial. Moreover, strategies used autonomously by patients to alleviate symptoms are at merit of consideration in future studies., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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50. Vaccine Hesitancy among Italian Patients Recovered from COVID-19 Infection towards Influenza and Sars-Cov-2 Vaccination.
- Author
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Gerussi V, Peghin M, Palese A, Bressan V, Visintini E, Bontempo G, Graziano E, De Martino M, Isola M, and Tascini C
- Abstract
We aimed to assess the attitude towards influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations among coronavirus disease 2019 (COVID-19) recovered patients. We performed a cross-sectional study consisting of a standardized telephone interview carried out between September and November 2020 targeting a cohort of adult in- and out-patients that had recovered from COVID-19 after the first wave (March-May 2020) at Udine Hospital (Italy). Overall, 599 people participated (320 female, median age 53 years) and most had experienced an acute COVID-19 with mild illness (409, 68.3%). The majority were hesitant or undecided towards influenza (327, 54.6%) and SARS-CoV-2 (353, 59.2%) vaccines. Older age, public work exposure, and previous 2019 flu shots were the main factors associated with a positive attitude toward both vaccinations ( p < 0.05). Being hospitalized during the acute COVID-19 phase was associated with the willingness to get a flu shot (94/272, 34.5%) but not SARS-CoV-2 vaccine (70/244, 28.7%). Vaccine hesitancy is diffuse and multifactorial also among COVID-19 recovered.
- Published
- 2021
- Full Text
- View/download PDF
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