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3. Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study.

Author

Visonà, S D, Bertoglio, B, Capella, S, Belluso, E, Austoni, B, Colosio, C, Kurzhunbaeva, Z, Ivic-Pavlicic, T, and Taioli, E

Subjects
*PULMONARY fibrosis, *ASBESTOS, *MESOTHELIOMA, *AUTOPSY, *PLEURA cancer, *LUNGS, *PLEURA diseases
Abstract

The causal attribution of asbestos-related diseases to past asbestos exposures is of crucial importance in clinical and legal contexts. Often this evaluation is made based on the history of exposure, but this method presents important limitations. To assess past asbestos exposure, pleural plaques (PP), lung fibrosis and histological evidence of ferruginous bodies (FB) can be used in combination with anamnestic data. However, such markers have never been associated with a threshold value of inhaled asbestos. With this study we attempted to shed light on the dose–response relationship of PP, lung fibrosis and FBs, investigating if their prevalence in exposed individuals who died from malignant mesothelioma (MM) is related to the concentration of asbestos in lungs assessed using scanning electron microscopy equipped with energy dispersive spectroscopy. Moreover, we estimated the values of asbestos concentration in lungs associated with PP, lung fibrosis and FB. Lung fibrosis showed a significant positive relationship with asbestos lung content, whereas PP and FB did not. We identified, for the first time, critical lung concentrations of asbestos related to the presence of PP, lung fibrosis and FB at histology (respectively, 19 800, 26 400 and 27 400 fibers per gram of dry weight), that were all well-below the background levels of asbestos identified in our laboratory. Such data suggest that PP, lung fibrosis and FB at histology should be used with caution in the causal attribution of MM to past asbestos exposures, while evaluation of amphibole lung content using analytical electron microscopy should be preferred. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Reconstructing historical exposure to asbestos: the validation of 'educated guesses'

Author

Visonà, S. D., Crespi, E., Belluso, E., Capella, S., De Matteis, S., Filippi, F., Lai, M., Loscerbo, R., Meloni, F., Pilia, I., Cocco, P., and Colosio, C.

Subjects
Public Health, Environmental and Occupational Health, Humans, Retrospective Studies
Abstract

Background In both the epidemiological and legal context, the causal attribution of asbestos-related lung diseases requires retrospective exposure assessment (REA). Aims To assess the correlation between the retrospective assessment of occupational and anthropogenic environmental exposure to asbestos and its content in the lung tissue. Methods Based on the available exposure information, a team of occupational physicians retrospectively assessed cumulative exposure to asbestos in 24 subjects who died of asbestos-related diseases. The asbestos lung content was analysed using analytical scanning electron microscope (SEM-EDS). The Log10 asbestos fibre count in the autoptic samples was predicted as a function of the Log10 estimated cumulative exposure using univariate regression analysis. Results The median count of asbestos fibres by grams of dry weight (ff/gdw) in the lung tissue was 81 339 (range 0–2 135 849.06); it was 287 144 (range 0–2 135 849.06) among the occupationally exposed, and 29 671 (range 0–116 891) among the subjects who only had anthropogenic environmental and/or household exposure. Amphiboles, and particularly amosite (52%) and crocidolite (43%), were detected in all the study subjects. Chrysotile was not detected in any of the samples. Overall, the retrospective estimate of lifetime cumulative exposure to asbestos showed a moderate correlation with the total asbestos fibre count in the autoptic lung, with the regression model explaining 38–55% of the total variance. Conclusions Detailed information on occupational, environmental and household exposure circumstances would be indispensable for experienced industrial hygienists and/or occupational physicians to reliably assess past exposure to amphiboles or mixed types of asbestos.

Published
2022

6. Parità di trattamento in materia di occupazione (D.Lgs. 9 luglio 2003, n. 216)

Author

Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, Zicchittu, P, Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, and Zicchittu, P

Published
2020

7. D.Lgs. 9 luglio 2003, n. 215 (parità di trattamento tra le persone)

Author

Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, Zicchittu, P, Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, and Zicchittu, P

Published
2020

8. L. 20 maggio 1970, n. 300 art. 1

Author

Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, Zicchittu, P, Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, and Zicchittu, P

Published
2020

15. A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Author

Ruggeri, Mirella, Bonetto, Chiara, Lasalvia, Antonio, Girolamo, De, G, Fioritti, A, Rucci, P, Santonastaso, P, Neri, G, Pileggi, F, Ghigi, D, Miceli, M, Scarone, S, Cocchi, A, Torresani, S, Faravelli, C, Zimmermann, Christa, Meneghelli, A, Cremonese, C, Scocco, P, Leuci, E, Mazzi, F, Gennarelli, M, Brambilla, P, Bissoli, S, Bertani, Me, Tosato, Sarah, DE SANTI, Katia, Poli, Sara, Cristofalo, Doriana, Tansella, Michele, Get, Up, Group, Ruggeri, M, Mirella, Me, Bonetto, C, Cristofalo, D, De Santi, K, Lasalvia, A, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, Mg, Ballarin, M, Bocchio, Chiavetto, L, Scasselatti, C, Zanardini, R, Bellani, Marcella, Bertoldo, A, Marinelli, Veronica, Perlini, Cinzia, Rambaldelli, Gianluca, Bertani, M, Lazzarotto, L, Bardella, S, Gardellin, F, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosì, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefan, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, Claudia, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Ald, F, Bianchi, B, Cappellari, P, Conti, R, Battisti, De, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visonà, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Veronese, A, Anderle, P, Angelozz, A, Amalric, I, Baron, G, Candeago, Eb, Castelli, F, Chieco, M, Costanzo, Di, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanz, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, Risio, De, A, Gatto, A, Granà, S, Favero, E, Franceschin, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Bortolo, Di, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, Dominoni, A, Andreose, L, Boemio, M, Bressan, L, Cabbia, A, Canesso, E, Cian, R, Dal, Piccol, Dalla, C, Pasqua, Mm, Prisco, Di, Mantellato, L, Luison, M, Morgante, S, Santi, M, Sacillotto, M, Scabbio, M, Sponga, P, Sguotto, Ml, Stach, F, Vettorato, Mg, Martinello, G, Dassiè, F, Marino, S, Cibiniel, L, Masetto, I, Cabianca, O, Valente, A, Caberlotto, L, Passoni, A, Flumian, P, Daniel, L, Gion, M, Stanziale, S, Alborino, F, Bortolozzo, V, Bacelle, L, Bicciato, L, Basso, D, Navaglia, F, Manoni, F, Ercolin, M, Giubilini, F, Imbesi, M, Semrov, E, Giovanni, Cs, Taro, E, Ceno, V, Ovest, P, Anelli, S, Amore, M, Bigi, L, Britta, W, Anna, Gb, Bonatti, U, Borziani, M, Crosato, I, Galluccio, R, Galeotti, M, Gozzi, M, Greco, V, Guagnini, E, Pagani, S, Maccherozzi, M, Marchi, F, Melato, E, Mazzucchi, E, Marzullo, F, Pellegrini, P, Petrolini, N, Volta, P, Bonara, F, Brusamonti, E, Croci, R, Flamia, I, Fontana, F, Losi, R, Marchioro, R, Raffaini, L, Ruju, L, Saginario, A, Tondelli, Mg, Marrama, D, Bernardelli, L, Bonacini, F, Florindo, A, Merli, M, Nappo, P, Sola, L, Tondelli, O, Tonna, M, Torre, Mt, Tosatti, M, Venturelli, G, Zampolla, D, Bernardi, A, Cavalli, C, Cigala, L, Ciraudo, C, Bari, Di, Ferri, L, Gombi, F, Leurini, S, Mandatelli, E, Maccaferri, S, Oroboncoide, M, Pisa, B, Ricci, C, Poggi, E, Zurlini, C, Malpeli, M, Colla, R, Teodori, E, Vecchia, L, D'Andrea, R, Trenti, T, Paolini, P, Carpeggiani, P, Gagliostro, M, Pratelli, M, Lazzaro, S, Antonelli, A, Battistini, L, Bellini, F, Bonini, E, Capelli, Cb, Didomizio, C, Drei, C, Fucci, G, Gualandi, A, Grazia, Mr, Losi, Am, Mazzoni, Fm, Marangoni, D, Monna, G, Morselli, M, Oggioni, A, Oprandi, S, Paganelli, W, Passerini, M, Piscitelli, M, Reggiani, G, Rossi, G, Salvatori, F, Trasforini, S, Uslenghi, C, Veggetti, S, Bartolucci, G, Baruffa, R, Bertelli, R, Borghi, L, Ciavarella, P, Paltrinieri, E, Rizzardi, F, Serra, P, Suzzi, D, Carlo, U, Arienti, P, Aureli, F, Avanzi, R, Callegari, V, Corsino, A, Host, P, Michetti, R, Rizzo, F, Simoncelli, P, Soldati, E, Succi, E, Bertozzi, M, Canetti, E, Cavicchioli, L, Ceccarelli, E, Cenni, S, Marzola, G, Gallina, V, Leoni, C, Olivieri, A, Piccolo, E, Ravagli, S, Russo, R, Tedeschini, D, Verenini, M, Abram, W, Granata, V, Curcio, A, Guerra, G, Granini, S, Natali, L, Montanari, E, Pasi, F, Ventura, U, Valenti, S, Francesca, M, Farneti, R, Ravagli, P, Floris, R, Maroncelli, O, Volpones, G, Casali, D, Bencini, A, Cellini, M, Biase, De, Barbara, L, Charles, L, Pratesi, C, Tanini, A, Loparrino, R, Ulivelli, C, Cussoto, C, Dei, N, Fumanti, E, Pantani, M, Zeloni, G, Bellini, R, Cellesi, R, Dorigo, N, Gullì, P, Ialeggio, L, Pisanu, M, Rinaldi, G, Konze, A, Modignani, L, Frova, M, Monzani, E, Zanobio, A, Malagoli, M, Pagani, R, Barbera, S, Morganti, C, Amadè, Es, Brambilla, V, Montanari, A, Caterina, G, Lopez, C, Marocchi, A, Moletta, A, Sberna, M, Cascio, Mt, Manzone, Ml, Barbara, B, Mari, L, Razzini, E, Bianchi, Y, Pellizzer, Mr, Verdecchia, A, Sferrazza, Mg, Pismataro, R, D'Eril, Gv, Barassi, A, Pacciolla, R, Faraci, G, Rosmini, B, Carpi, F, Soelva, M, Anderlan, M, Francesco, De, M, Duregger, E, Vettori, C, Doimo, S, Kompatscher, E, Forer, M, Kerschbaumer, H, Gampe, A, Nicoletti, M, Acerbi, C, Aquilino, D, Azzali, S, Bensi, L, Cappellari, D, Casana, E, Campagnola, N, Dal, Corso, Di, E, Micco, E, Gobbi, E, Mairaghi, L, Malak, S, Mesiano, L, Paterlini, F, Perini, M, Puliti, Em, Rispoli, R, Rizzo, E, Sergenti, C, Soave, M, Alpi, A, Bislenghi, L, Bolis, T, Colnaghi, F, Fascendini, S, Grignani, S, Patelli, G, Casale, S, Zimmermann, C, Deledda, G, Goss, C, Mazzi, Maria Angela, Rimondini, Michela, Scassellati, C, Bonvicini, C, Longo, S, Ventriglia, M, Squitti, R, Frisoni, G, Pievani, M, Balestrieri, M, Perlini, C, Marinelli, V, Bellani, M, Rambaldelli, G, Atzori, M, Beltramello, A, Alessandrini, F, Pizzini, Francesca, Zoccatelli, G, Politi, P, Emanuele, E, Brondino, N, Martino, G, Bergami, A, Zarbo, R, Riva, Ma, Fumagalli, F, Molteni, R, Calabrese, F, Guidotti, G, Luoni, A, Macchi, F, Artioli, S, Baldetti, M, Bizzocchi, M, Bolzon, D, Bonello, E, Cacciari, G, Carraresi, C, Caselli, G, Furlato, K, Garlassi, S, Gavarini, A, Macchetti, F, Marteddu, V, Plebiscita, G, Totaro, S, Bebbington, P, Birchwood, M, Dazzan, P, Kuipers, E, Thornicroft, G, Pariante, C, Lawrie, S, Soares, J. C., Ruggeri, M., Bonetto, C., Lasalvia, A., De Girolamo, G., Bertani, M., Rucci, P., Santonastaso, P., Neri, G., Pileggi, F., Ghigi, D., Miceli, M., Scarone, S., Cocchi, A., Torresani, S., Faravelli, C., Zimmermann, C., Meneghelli, A., Cremonese, C., Scocco, P., Leuci, E., Mazzi, F., Gennarelli, Massimo, Brambilla, P., Bissoli, S., Lazzarotto, L., Bardella, S., Gardellin, F., Lamonaca, D., Lunardon, M., Magnabosco, R., Martucci, M., Nicolau, S., Nifosì, F., Bertani, M. E., Tosato, S., De Santi, K., Poli, S., Cristofalo, D., Tansella, Michele, Lunardi, S., Negretto, V., Zamboni, M. G., Ballarin, M., Chiavetto, Luisella Bocchio, Scasselatti, C., Zanardini, R., Bellani, M., Bertoldo, A., Marinelli, Valentina, Perlini, C., Rambaldelli, G., Pasqualini, A., Pavanati, M., Rossi, M., Piazza, C., Piccione, G., Sala, A., Roccato, S., Rossi-, A., Sale, A., Stefan, B., Strizzolo, S., Zotos, S., Balbo, M., Boggian, I., Ceccato, E., Dall’Agnola, R., Girotto, B., Leoni, R., Mai, A., Urbani, Alessandro, Ald, F., Bianchi, Benedetta, Cappellari, P., Conti, R., De Battisti, L., Lazzarin, E., Merlin, S., Migliorini, G., Pozzan, T., Sarto, L., Visonà, S., Brazzoli, A., Campi, A., Carmagnani, R., Giambelli, S., Gianella, A., Lunardi-, L., Madaghiele, D., Maestrelli, P., Paiola, L., Posteri, E., Viola, L., Zamberlan, V., Zenari, M., Zanoni, M., Bonadonna, G., Bonomo, M., Veronese, A., Anderle, P., Angelozz, A., Amalric, I., Baron, G., Candeago, E. B., Castelli, F., Chieco, M., Di Costanzo, E., Derossi, M., Doriguzzi, M., Galvano, O., Lattanz, M., Lezzi, R., Marcato, M., Marcolin, A., Marini, F., Matranga, M., Scalabrin, D., Zucchetto, M., Zadro, F., Austoni, G., Bianco, M., Bordino, F., Dario, F., DE RISIO, Alfredo, Gatto, A., Granà, S., Favero, E., Franceschin, A., Friederici, S., Marangon, V., Pascolo, M., Ramon, L., Zambolin, S., Riolo, R., Buffon, A., Di Bortolo, E., Fortin, S., Matarrese, F., Mogni, S., Codemo, N., Russi, A., Silvestro, Antonina, Turella, E., Viel, P., Dominoni, A., Andreose, L., Boemio, M., Bressan, L., Cabbia, A., Canesso, E., Cian, R., Dal Piccol, C., Dalla Pasqua, M. M., Di Prisco, A., Mantellato, L., Luison, M., Morgante, S., Santi, M., Sacillotto, M., Scabbio, M., Sponga, P., Sguotto, M. L., Stach, F., Vettorato, M. G., Martinello, G., Dassiè, F., DI MARINO, Simone, Cibiniel, L., Masetto, I., Cabianca, O., Valente, MADDALENA AGNESE, Caberlotto, L., Passoni, A., Flumian, P., Daniel, L., Gion, M., Stanziale, S., Alborino, F., Bortolozzo, V., Bacelle, L., Bicciato, L., Basso, D., Navaglia, F., Manoni, F., Ercolin, M., Giubilini, F., Imbesi, M., Semrov, E., Giovanni, C. S., Taro e Ceno, V., Ovest, P., Anelli, S., Amore, M., Bigi, L., Britta, W., Anna, G. B., Bonatti, U., Borziani, M., Crosato, I., Galluccio, R., Galeotti, M., Gozzi, M., Greco, V., Guagnini, E., Pagani, S., Maccherozzi, M., Marchi, F., Melato, E., Mazzucchi, E., Marzullo, F., Pellegrini, Pietro Carlo, Petrolini, N., Volta, P., Bonara, F., Brusamonti, E., Croci, R., Flamia, I., Fontana, F., Losi, R., Marchioro, R., Raffaini, L., Ruju, L., Saginario, A., Tondelli, M. G., Marrama, D., Bernardelli, L., Bonacini, F., Florindo, A., Merli, M., Nappo, P., Sola, L., Tondelli-, O., Tonna, M., Torre, M. T., Tosatti, M., Venturelli, G., Zampolla, D., Bernardi, A., Cavalli, Chiara, Cigala, L., Ciraudo, C., Di Bari, A., Ferri, L., Gombi, F., Leurini, S., Mandatelli, E., Maccaferri, S., Oroboncoide, M., Pisa, B., Ricci, Carmine, Poggi, E., Zurlini, C., Malpeli, M., Colla, R., Teodori, E., Vecchia, L., D’Andrea, R., Trenti, T., Paolini, P., Carpeggiani, P., Gagliostro, M., Pratelli, M., Lazzaro, S., Antonelli, A., Battistini, Luca, Bellini, Fiorella, Bonini, E., Capelli, C. B., Didomizio, C., Drei, C., Fucci, G., Gualandi, A., Grazia, M. R., Losi-, A. M., Mazzoni, F. M., Marangoni, D., Monna, G., Morselli, M., Oggioni, A., Oprandi, S., Paganelli, W., Passerini, M., Piscitelli, M., Reggiani, G., Rossi-, G., Salvatori, Franco, Trasforini, S., Uslenghi, C., Veggetti, S., Bartolucci, Giuliana, Baruffa, R., Bertelli, R., Borghi, L., Ciavarella, P., Paltrinieri, E., Rizzardi, F., Serra, P., Suzzi, D., Carlo, U., Arienti, P., Aureli, F., Avanzi, R., Callegari, V., Corsino, A., Host, P., Michetti, R., Rizzo, F., Simoncelli, P., Soldati, E., Succi, E., Bertozzi, M., Canetti, E., Cavicchioli, L., Ceccarelli, E., Cenni, S., Marzola, G., Gallina, V., Leoni, C., Olivieri, A., Piccolo, Elisa, Ravagli, S., Russo, R., Tedeschini, D., Verenini, M., Abram, W., Granata, V., Curcio, A., Guerra, G., Granini, S., Natali, L., Montanari, Eleonora, Pasi, F., Ventura, U., Valenti, S., Francesca, M., Farneti, R., Ravagli-, P., Floris, R., Maroncelli, O., Volpones, G., Casali, D., Bencini, A., Cellini, M., De Biase, L., Barbara, L., Charles, L., Pratesi, C., Tanini, A., Loparrino, R., Ulivelli, C., Cussoto, C., Dei, N., Fumanti, E., Pantani, M., Zeloni, G., Bellini-, R., Cellesi, R., Dorigo, N., Gullì, P., Ialeggio, L., Pisanu, M., Rinaldi, G., Konze, A., Modignani, L., Frova, M., Monzani, E., Amadè, E. S., Zanobio, A., Malagoli, M., Pagani-, R., Barbera, S., Morganti, C., Brambilla-, V., Montanari-, A., Caterina, G., LOPEZ CORTES, Carlo, Marocchi, A., Moletta, A., Sberna, M., Cascio, M. T., Manzone, M. L., Barbara-, B., Mari, L., Razzini, E., Bianchi-, Y., Pellizzer, M. R., Verdecchia, A., Sferrazza, M. G., Pismataro, R., D’Eril, G. V., Barassi, A., Pacciolla, R., Faraci, G., Rosmini, B., Carpi, F., Soelva, M., Anderlan, M., De Francesco, M., Duregger, E., Vettori, C., Doimo, S., Kompatscher, E., Forer, M., Kerschbaumer, H., Gampe, A., Nicoletti, M., Acerbi, C., Aquilino, D., Azzali, S., Bensi, L., Cappellari-, D., Casana, E., Campagnola, N., Dal Corso, E., Di Micco, E., Gobbi, E., Mairaghi, L., Malak, S., Mesiano, L., Paterlini, F., Perini, Matteo, Puliti, E. M., Rispoli, R., Rizzo-, E., Sergenti, C., Soave, M., Alpi, A., Bislenghi, L., Bolis, T., Colnaghi, F., Fascendini, S., Grignani, S., Patelli, G., Casale, S., Deledda, G., Goss, C., Mazzi-, M., Rimondini, M., Scassellati, C., Bonvicini, C., Longo, Salvatore, Bocchio Chiavetto, L., Ventriglia, M., Squitti, R., Frisoni, G., Pievani, M., Balestrieri, M., Atzori, M., Beltramello, A., Alessandrini, F., Pizzini, F., Zoccatelli, G., Politi, P., Emanuele, E., Brondino, N., Martino, G., Bergami, A., Zarbo, R., Riva, M. A., Fumagalli, F., Molteni, R., Calabrese, F., Guidotti, Giovanni, Luoni, Alessia, Macchi, F., Artioli, S., Baldetti, M., Bizzocchi, M., Bolzon, D., Bonello, E., Cacciari, G., Carraresi, C., Caselli, G., Furlato, K., Garlassi, S., Gavarini, A., Macchetti, F., Marteddu, V., Plebiscita, G., Totaro, S., Bebbington, P., Birchwood, M., Dazzan, P., Kuipers, E., Thornicroft, G., Pariante, C., Lawrie, S., Soares, J. C., Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella, and and THE GET UP GROUP

Subjects
Research design, Time Factors, early psychosis, psychosocial interventions, cluster randomized triales, medicine.medical_treatment, Psychological intervention, Medicine (miscellaneous), Assertive community treatment, Severity of Illness Index, law.invention, Study Protocol, Randomized controlled trial, law, Recurrence, Early psychosi, Cluster Analysis, Pharmacology (medical), lcsh:R5-920, Family Relation, Community Mental Health Service, First-episode psychosis, Community Mental Health Center, Community Mental Health Services, Cognitive behavioral therapy, Treatment Outcome, Cognitive Therapy, Italy, Research Design, First-episode psychosisEarly psychosisCognitive behavioral therapyPsychosocial interventionAssertive community treatment, Family Relations, lcsh:Medicine (General), Psychosocial, Human, pragmatic trial, Early psychosis, Family intervention, Psychosocial intervention, Community Mental Health Centers, Humans, Patient Selection, Psychotic Disorders, Sample Size, Case Management, Cognitive Behavioral Therapy, medicine.medical_specialty, psychosocial interventions, Time Factor, cluster randomized triales, Psychotic Disorder, First-episode psychosi, medicine, Psychiatry, Cluster Analysi, business.industry, Mental health, Cognitive therapy, business
Abstract

Background Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in ‘real-world’ services. Methods/Design The Psychosis early Intervention and Assessment of Needs and Outcome (PIANO) trial is part of a larger research program (Genetics, Endophenotypes and Treatment: Understanding early Psychosis - GET UP) which aims to compare, at 9 months, the effectiveness of a multi-component psychosocial intervention versus treatment as usual (TAU) in a large epidemiologically based cohort of patients with FEP and their family members recruited from all public community mental health centers (CMHCs) located in two entire regions of Italy (Veneto and Emilia Romagna), and in the cities of Florence, Milan and Bolzano. The GET UP PIANO trial has a pragmatic cluster randomized controlled design. The randomized units (clusters) are the CMHCs, and the units of observation are the centers’ patients and their family members. Patients in the experimental group will receive TAU plus: 1) cognitive behavioral therapy sessions, 2) psycho-educational sessions for family members, and 3) case management. Patient enrolment will take place over a 1-year period. Several psychopathological, psychological, functioning, and service use variables will be assessed at baseline and follow-up. The primary outcomes are: 1) change from baseline to follow-up in positive and negative symptoms’ severity and subjective appraisal; 2) relapse occurrences between baseline and follow-up, that is, episodes resulting in admission and/or any case-note records of re-emergence of positive psychotic symptoms. The expected number of recruited patients is about 400, and that of relatives about 300. Owing to the implementation of the intervention at the CMHC level, the blinding of patients, clinicians, and raters is not possible, but every effort will be made to preserve the independency of the raters. We expect that this study will generate evidence on the best treatments for FEP, and will identify barriers that may hinder its feasibility in ‘real-world’ clinical settings, patient/family conditions that may render this intervention ineffective or inappropriate, and clinical, psychological, environmental, and service organization predictors of treatment effectiveness, compliance, and service satisfaction. Trial registration ClinicalTrials.gov Identifier NCT01436331

Published
2012

16. A case of sudden death after ultrasound-guided percutaneous alcohol injection of a paraganglioma mis-diagnosed as a peri-renal cyst.

Author

Andrello, L., Visonà, S. D., and Osculati, A.

Subjects
*SUDDEN death, *ULTRASONIC imaging, *DIAGNOSTIC errors, *IMMUNOHISTOCHEMISTRY, *PARAGANGLIOMA, *GANGLIA, *NEURAL crest
Abstract

Paragangliomas are cromaffin tumors arising from the neural crest cells of parasympathetic or sympathetic ganglia. They are known to be rare causes of sudden death. Here we present the autopsy findings, as well as microscopical and immunohistochemistry study, of a 48-years-old woman who died suddenly after a percutaneous alcohol injection of a peri-renal cyst previously diagnosed as a common complex cyst. She manifested a multiorgan failure, with acute heart failure, systemic and pulmonary vasoconstriction with hypoxia, metabolic acidosis (pH 6.974). It was therefore enacted resuscitation that was ineffective. The autopsy pointed out, close to the upper right renal pole, a cyst characterized by very friable walls and septa, with a thickness of approximately 0.5 cm and containing about 75 cm³ of hemoserous fluid. Microscopically, through immunohistochemical examinations, the cyst showed the presence of chromaffin cells, containing enzymes involved in the synthesis of catecholamines, in particular noradrenalin. So, the cause of the death was ascertained in an multi-organ failure caused by a massive release of catecholamines (noradrenaline) from the cyst, identified post-mortem (on the basis of histologic and immunohistochemical examinations) in a noradrenalin-secreting paraganglioma, that remained silent until the cyst ablation. [ABSTRACT FROM AUTHOR]

Published
2015
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17. L. 20 maggio 1970, n. 300 art. 1

Author

Covelli, R, Del Punta, R, Scarpelli, F, Marrucci, M, Rausei, P, Alessi, C, Alvino, I, Amoriello, L, Andreani, A, Angelini, L, Avio, A, Battistelli, S, Borzaga, M, Buoso, S, Carmerlengo, Q, Casale, D, Chiaromonte, W, Colosimo, C, Coraza, L, Corso, S, Corti, M, Covelli, R, Delogu, A, Diamanti, R, Donini, A, Failla, A, Faleri, C, Falsone, M, Forlivesi, M, Frigo, P, Furlan, F, Gadaleta, F, Gaetani, M, Ghitti, C, Giaconi, M, Giasanti, L, Giustiniani, M, Guadagno, S, Imberti, L, Imbriaci, S, Ingrao, A, Lanfranchi, E, Lazzari, C, Lazzeroni, L, Leccese, V, Lozito, M, Magi, E, Mainardi, S, Malzani, F, Marazza, M, Marino, D, Mocella, M, Monaco, M, Moro, G, Mortillaro, G, Natullo, G, Navilli, M, Negri, A, Negri, G, Novella, M, Occhino, A, Pallini, M, Pascucci, P, Pino, G, Pinto, V, Putaturo Donati, F, Ravelli, Renga, S, Renzi, S, Rescigno, S, Riccio, A, Rota, A, Rovere, V, Salazar, P, Sartori, A, Schiavone, R, Schiuma, D, Scorcelli, R, Sileoni, S, Sonnati, S, Stolfa, A, Tarquini, E, Toffoletto, F, Tomassetti, P, Tullini, P, Vallauri, M, Varva, S, Vernia, A, Villa, E, Visonà, S, Volpe, D, and Zicchittu, P

Subjects
Statuto dei lavoratori, Libertà di opinione, Dignità, Diritto del lavoro, IUS/07 - DIRITTO DEL LAVORO
Published
2020

18. The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age.

Author

Scambi I, Peroni D, Nodari A, Merigo F, Benati D, Boschi F, Mannucci S, Frontini A, Visonà S, Sbarbati A, Krampera M, and Galiè M

Subjects
Animals, Mice, Adipose Tissue, Stromal Cells
Abstract

Multipotent stem cells persist within the stromal vascular fraction (SVF) of adipose tissue during adulthood. These cells, commonly referred to as adipose-derived stromal cells (ASC), have been extensively investigated over the past years as a promising therapeutic tool based on their regenerative and immunomodulatory properties. However, how ASC might mirror the age-related alteration of the fat they reside in remains unclear. Herein, we show that inguinal adipose tissue in mice turns from brown/beige- to white-like with age and resident ASC readily mirror these changes both at mRNA and microRNA transcriptional level. Mechanistically, our data suggest that these brown/age-related changes in ASC transcription rely on changes in the activity of E2F1 and NFkB transcription factors., (Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.)

Published
2022
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19. Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells.

Author

Nodari A, Scambi I, Peroni D, Calabria E, Benati D, Mannucci S, Manfredi M, Frontini A, Visonà S, Bozzato A, Sbarbati A, Schena F, Marengo E, Krampera M, and Galiè M

Subjects
Adipose Tissue metabolism, Aging genetics, Animals, Mice, Stromal Cells metabolism, Amino Acids, Branched-Chain, Interferon Regulatory Factor-7 metabolism
Abstract

Dysregulated immunity and widespread metabolic dysfunctions are the most relevant hallmarks of the passing of time over the course of adult life, and their combination at midlife is strongly related to increased vulnerability to diseases; however, the causal connection between them remains largely unclear. By combining multi-omics and functional analyses of adipose-derived stromal cells established from young (1 month) and midlife (12 months) mice, we show that an increase in expression of interferon regulatory factor 7 (IRF7) during adult life drives major metabolic changes, which include impaired mitochondrial function, altered amino acid biogenesis and reduced expression of genes involved in branched-chain amino acid (BCAA) degradation. Our results draw a new paradigm of aging as the 'sterile' activation of a cell-autonomous pathway of self-defense and identify a crucial mediator of this pathway, IRF7, as driver of metabolic dysfunction with age., Competing Interests: Competing interests The authors declare no competing or financial interests., (© 2021. Published by The Company of Biologists Ltd.)

Published
2021
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20. Neuropathological Alzheimer's Disease Lesions in Nasu-Hakola Disease with TREM2 Mutation: Atypical Distribution of Neurofibrillary Changes.

Author

Maderna E, Visonà S, Bolcato V, Redaelli V, Caroppo P, Montalbetti L, Giaccone G, and Osculati A

Subjects
Alzheimer Disease pathology, Brain diagnostic imaging, Entorhinal Cortex diagnostic imaging, Entorhinal Cortex pathology, Female, Frontal Lobe diagnostic imaging, Frontal Lobe pathology, Humans, Lipodystrophy diagnostic imaging, Lipodystrophy genetics, Membrane Glycoproteins genetics, Middle Aged, Neocortex diagnostic imaging, Neocortex pathology, Osteochondrodysplasias diagnostic imaging, Osteochondrodysplasias genetics, Receptors, Immunologic genetics, Subacute Sclerosing Panencephalitis diagnostic imaging, Subacute Sclerosing Panencephalitis genetics, Temporal Lobe diagnostic imaging, Temporal Lobe pathology, Brain pathology, Lipodystrophy pathology, Neurofibrillary Tangles pathology, Osteochondrodysplasias pathology, Plaque, Amyloid pathology, Subacute Sclerosing Panencephalitis pathology
Abstract

Nasu-Hakola disease is a rare autosomal recessive disorder associated to mutations in TREM2 and DAP12 genes, neuropathologically characterized by leukoencephalopathy with axonal spheroids. We report the neuropathologic findings of a 51-year-old female with a homozygous mutation (Q33X) of TREM2 gene. Beside severe cerebral atrophy and hallmarks of Nasu-Hakola disease, significant Alzheimer's disease lesions were present. Neurofibrillary changes showed an atypical topographic distribution being severe at spots in the neocortex while sparing the mesial temporal structures. Our finding suggests that TREM2 genetic defects may favor Alzheimer's disease pathology with neurofibrillary changes not following the hierarchical staging of cortical involvement identified by Braak.

Published
2021
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22. Second opinion system for sudden cardiac death cases in forensic practice.

Author

Sabatasso S, Banz Y, Ringger R, Visonà S, Schyma C, Bolliger S, and Michaud K

Subjects
Documentation, Guidelines as Topic, Humans, Specialization, Specimen Handling, Autopsy, Coronary Artery Disease diagnosis, Death, Sudden, Cardiac etiology, Forensic Pathology, Referral and Consultation
Abstract

Sudden cardiac death (SCD) represents a considerable percentage of cardiovascular deaths worldwide. The most frequent pathological substrate of SCD is atherosclerotic coronary artery disease (CAD). The other, less common, pathologies which can cause SCD include cardiomyopathies, congenital diseases (including abnormal anatomy), and arrhythmias such as channelopathies, many of which are genetically determined. Autopsies of SCD victims are generally performed by forensic pathologists. In some cases, a third person responsibility could be invoked. While CAD diagnosis at post-mortem examination is not a major challenge for the forensic pathologist, the other rarer diseases may be. In such instances, referral of the hearts to specialized centers with recognized expertise is recommended, and this is particularly important in cases of SCDs of young people. Moreover, in order to avoid the frequent overdiagnosis of a pathological heart, an expert opinion should be sought for even in the presence of a morphologically normal heart. In cases where retention of the heart is not feasible, it is essential to provide an extensive photographic documentation, with the indication of the sampling sites for histological examination. However, some practical aspects, as the criteria for case selection in routine forensic practice are missing. In this paper, we present the recommendations for heart retention for a second expert opinion and the alternative of documentation and sampling for cases where retention is not possible.

Published
2020
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23. Evaluation of benzodiazepines and zolpidem in nails and their stability after prolonged exposure to chlorinated water.

Author

Moretti M, Andrello L, Visonà S, Vignali C, Groppi A, Freni F, Osculati A, Tajana L, and Morini L

Subjects
Bromazepam chemistry, Chromatography, Liquid methods, Diazepam chemistry, Female, Forensic Toxicology methods, Humans, Limit of Detection, Male, Tandem Mass Spectrometry methods, Zolpidem, Benzodiazepines chemistry, Chlorine adverse effects, Nails chemistry, Pyridines chemistry, Water adverse effects
Abstract

The study aims the development and validation of a LC-MS/MS method for the identification and quantification of benzodiazepines and zolpidem in nails as alternative keratinized matrix to hair in long-term monitoring of anxiolytic and hypnotic drugs. Both fingernail and toenail samples (1-2 mm) were collected by clipping the excess overhang of the nail from volunteers and from postmortem cases. They were washed twice with organic solvents, dried under nitrogen stream, pulverized, immersed in a methanol solution (internal standard: diazepam-D5) and sonicated up to two hours. The solution was then direct injected in the LC-MS/MS system. Mass spectrometry was set in MRM mode, selecting two transitions for each substance. 32 analytes among benzodiazepines, metabolites and hypnotics were included in the list. The method fulfilled the internationally required criteria for validation. Limits of detection ranged from 0.03 pg/mg (zolpidem) to 13.1 pg/mg (bromazepam). 9 subjects under therapy were positive at 7 different benzodiazepines and/or metabolites (lorazepam, desalkylflurazepam, bromazepam, diazepam, alprazolam, lormetazepam and prazepam), while 5 molecules were measured in 4 postmortem cases (diazepam, desmethyldiazepam, delorazepam, 7-aminoclonazepam and zolpidem). In vitro experiments on eight authentic samples suggested that benzodiazepines in nails are influenced by the prolonged exposure to chlorinated water., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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24. Diagnosis of electrocution: The application of scanning electron microscope and energy-dispersive X-ray spectroscopy in five cases.

Author

Visonà SD, Chen Y, Bernardi P, Andrello L, and Osculati A

Subjects
Adult, Aged, Carbon analysis, Humans, Iron analysis, Male, Middle Aged, Skin chemistry, Staining and Labeling, Titanium analysis, Young Adult, Electric Injuries diagnosis, Microscopy, Electron, Scanning, Skin injuries, Skin ultrastructure, Spectrometry, X-Ray Emission
Abstract

Introduction: Deaths from electricity, generally, do not have specific findings at the autopsy. The diagnosis is commonly based on the circumstances of the death and the morphologic findings, above all the current mark. Yet, the skin injury due to an electrocution and other kinds of thermal injuries often cannot be differentiated with certainty. Therefore, there is a great interest in finding specific markers of electrocution. The search for the metallization of the skin through Scanning Electron Microscope equipped with Energy Dispersive X-Ray Spectroscopy (EDS) probe is of special importance in order to achieve a definite diagnosis in case of suspected electrocution., Materials and Methods: We selected five cases in which the electrocution was extremely likely considering the circumstances of the death. In each case a forensic autopsy was performed. Then, the skin specimens were stained with Hematoxylin Eosin and Perls. On the other hand, the skin lesions were examined with a scanning electron microscope equipped with EDS probe in order to evaluate the morphological ultrastructural features and the presence of deposits on the surface of the skin., Results: The typical skin injury of the electrocution (current mark) were macroscopically detected in all of the cases. The microscopic examination of the skin lesions revealed the typical spherical vacuoles in the horny layer and, in the epidermis, the elongation of the cell nuclei as well as necrosis. Perls staining was negative in 4 out 6 cases. Ultrastructural morphology revealed the evident vacuolization of the horny layer, elongation of epidermic cells, coagulation of the elastic fibers., Eds-Microanalysis: In the specimens collected from the site of contact with the conductor of case 1 and 2, the presence of the Kα peaks of iron was detected. In the corresponding specimens taken from cases 2, 4, 5 the microanalysis showed the Kα peaks of titanium. In case 3, titanium and carbon were found., Conclusions: In the suspicion of electrocution, the integrated use of different tools is recommended, including macroscopic observation, H&E staining, iron-specific staining, scanning electron microscopy and EDS microanalysis. Only the careful interpretation of the results provided by all these methods can allow the pathologist to correctly identify the cause of the death. Particularly, the present study suggests that the microanalysis (SEM-EDS) represents a very useful tool for the diagnosis of electrocution, allowing the detection and the identification of the metals embedded in the skin and their evaluation in the context of the ultrastructural morphology., (Copyright © 2018. Published by Elsevier B.V.)

Published
2018
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