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This paper discusses the role of the public library in ensuring access to the broadband communication that is so critical in today's knowledge-based society. It examines the culture of information in 2010, and then asks what it means if individuals are online or not. The paper also explores current issues surrounding telecommunications and policy, and finally seeks to understand the role of the library in this highly technological, perpetually connected world. [ABSTRACT FROM AUTHOR]

How should the information on the Internet be organized? This question and the possible solutions spark debates among people concerned with how we identify, classify, and retrieve Internet content. This paper discusses the benefits and the controversies of using a tagging system to organize Internet resources. Tagging refers to a classification system where individual Internet users apply labels, or tags, to digital resources. Tagging increased in popularity with the advent of Web 2.0 applications that encourage interaction among users. As more information is available digitally, the challenge to find an organizational system scalable to the Internet will continue to require forward thinking. Trained to ensure access to a range of informational resources, librarians need to be concerned with access to Internet content. Librarians can play a pivotal role by advocating for a system that supports the user at the moment of need. Tagging may just be the necessary system. [ABSTRACT FROM AUTHOR]

The authors discuss their experiences in facilitating rich learning programs for youth, service diverse populations, and linking youth interests to library programs. They describe the collaboration between U.S. technology company Google and the Office for Information Technology Policy (OITP) of the American Library Association (ALA) to launch the Libraries Ready to Code (RtC) partnership. They also cite the benefits of connecting with OITP for Google.

The article discusses the advent of e-books. According to the author, the e-book market is a challenge as it is uncharted waters for all of the players with publishers reinventing publishing for the digital world while distributors and authors are creating different niches. Hachette, HarperCollins and Simon & Schuster are those included in the so-called "Big 6," which are companies that control about two-thirds of the U.S. consumer book publishing market. A significant growth in young adult circulation of e-books was discovered by the Library Journal's 2012 "E-book Usage in U.S. Public Libraries.

The article offers information on how the Libraries ready to Code initiative is increasing opportunities for youth. Topics discussed include information on the role of the library staff in youth development; discussions on the collaboration of American Library Association with the Young Adult Library Services Association; and the information on the computational thinking activities for problem solving in the public libraries.

Myeloid antigen-presenting cells (APCs) tailor immune responses to the pathogen involved through the production of specific pro- and anti-inflammatory cytokines. It is becoming increasingly clear that the ultimate cytokine profile produced by myeloid APCs crucially depends on interaction between multiple pathogen recognizing receptors. In this respect, we recently identified an important role for cross-talk between Fc gamma receptor IIa (FcγRIIa) and Toll-like receptors (TLRs) in human dendritic cells (DCs), which induces anti-bacterial immunity through the selective induction of TNFα and Th17-promoting cytokines. Here, we show that FcγRIIa-TLR cross-talk is not restricted to DCs, but is a common feature of various human myeloid APC subsets including monocytes and macrophages. Interestingly, FcγRIIa-TLR cross-talk in monocytes resulted in the induction of a cytokine profile distinct from that in DCs and macrophages, indicating that FcγRIIa stimulation induces cell-type and tissue specific responses. Surprisingly, we show that the FCGR2A H131R single nucleotide polymorphism (SNP), which is known to greatly affect FcγRIIa-mediated uptake of IgG2-opsonized bacteria, did not affect FcγRIIa-dependent cytokine production, indicating that these processes are differently regulated. In addition, we demonstrate that FcγRIIa selectively synergized with TLRs, IL-1R, and IFNγR, but did not affect cytokine production induced by other receptors such as C-type lectin receptor Dectin-1. Taken together, these data demonstrate that FcγRIIa-dependent modulation of cytokine production is more widespread than previously considered, and indicate that cross-talk of FcγRIIa with various receptors and in multiple cell types contributes to the induction of pathogen and tissue-specific immunity. [ABSTRACT FROM AUTHOR]