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Age-related differences in twist may be mitigated with exercise training, although this remains inconclusive. Moreover, temporal left ventricular (LV) systolic twist mechanics, including early-systolic (twistearly), and beyond peak twist (twistpeak) alone, have not been considered. Therefore, further insights are required to ascertain the influence of age and training status on twist mechanics across systole. Forty males were included and allocated into 1 of 4 groups based on age and training status: young recreationally active (YRA, n = 9; 28 ± 5 years), old recreationally active (ORA, n = 10; 68 ± 6 years), young trained (YT, n = 10; 27 ± 6 years), and old trained (OT, n = 11, 64 ± 4 years) groups. Two-dimensional speckle-tracking echocardiography was performed to determine LV twist mechanics, including twistearly, twistpeak, and total twist (twisttotal), by considering the nadir on the twist time-curve during early systole. Twisttotal was calculated by subtracting twistearly from their peak values. LV twistpeak was higher in older than younger men (p = 0.036), while twistpeak was lower in the trained than recreationally-active (p = 0.004). Twistpeak is underestimated compared with twisttotal (p < 0.001), and when early-systolic mechanics were considered, to calculate twisttotal, the age effect (p = 0.186) was dampened. LV twist was higher in older than younger age, with lower twist in exercise-trained than recreationally-active males. Twistpeak is underestimated when twistearly is not considered, with novel observations demonstrating that the age effect was dampened when considering twistearly. These findings elucidated a smaller age effect when early phases of systole are considered, while lower LV systolic mechanics were observed in older aged trained than recreationally-active males.

There is an increase in the prevalence of elite youth sports academies, whose sole aim is to develop future elite athletes. This involves the exposure of the child and adolescent athlete to high-volume training during a period of volatile growth. The large amount of data in this area has been garnered from the resting echocardiographic left ventricular (LV) evaluation of the youth athlete; while this can provide some insight on the functional adaptations to training, it is unable to elucidate a comprehensive overview of the function of the youth athletes’ LV during exercise. Consequently, there is a need to interrogate the LV responses in-exercise. This review outlines the feasibility and functional insight of capturing global indices of LV function (Stroke Index-SVIndex and Cardiac Index-QIndex), systolic and diastolic markers, and cardiac strain during submaximal and maximal exercise. Larger SVI and QI were noted in these highly trained young athletes compared to recreationally active peers during submaximal and maximal exercise. The mechanistic insights suggest that there are minimal functional systolic adaptions during exercise compared to their recreationally active peers. Diastolic function was superior during exercise in these young athletes, and this appears to be underpinned by enhanced determinants of pre-load.

Considering the perceived benefit of early recruitment and the time and resources spent developing youth players, individuals released from talent development programmes are often re-recruited by rival academies. However, due to the contractual nature of many talent development programmes, limited empirical data exists on players deselected from (or reselected to) youth soccer academies. Adopting a novel case study approach, differences in skill, psychological, and physical attributes associated with reselection following closure of a junior-elite soccer academy were explored. Overall subjective coach ratings for skill, psychological, and physical abilities; subjective coach ratings for skill and psychological attributes; and physical fitness test performance of 79 junior-elite soccer players (U11–U17) were assessed as part of regular scheduled testing and monitoring practices prior to the academy closure. Reselection status was monitored and recorded for all players in the 6 months following the academy closure and was classified as a persistence/progression (“Reselected”) or attrition (“Deselected”) in playing level. Of the 79 released players, a total of 60 players (76%) were re-signed to a junior-elite academy within 6 months. Differences were observed for overall ratings of skill, psychological, and physical abilities in favor of the “Reselected” player group. “Reselected” players were also rated higher by coaches for all attributes categorized as skill and psychological, as well as performing better at all physical fitness tests. However, “Reselected” players were lesser in stature and body mass and less mature than “Deselected” players. Our findings suggest that reselection is not a product of anthropometric criteria and, therefore, a pathway for selection remains open for later maturing players. We also inform upon desirable qualities associated with player reselection and provide a case study approach of a unique, yet highly relevant, scenario for talent identification and development in youth soccer.

Significant structural, developmental, and financial constraints exist in Scottish soccer that may predicate a different approach to talent identification and development. To our knowledge, no published reports exist evaluating the prevalence of the relative age effect (RAE) in Scottish soccer players. Consequently, the aim of this study was to investigate the prevalence of the RAE among varied playing levels and ages of male Scottish youth soccer players. Birthdates of male youth players (n = 1,230) from U10 to U17 age groups and from playing levels: “Amateur” (n = 482), “Development” (n = 214), and “Performance” (n = 534), alongside a group of male Scottish senior professional players (n = 261) were recorded and categorized into quartiles (Q1 = January–March; Q2 = April–June; Q3 = July–September; and Q4 = October–December) and semesters (S1 = January–June and S2 = July–December) from the start of the selection year. Birthdates were analyzed for: (a) each playing level and (b) each age group irrespective of playing level. For the varied playing levels examined, an RAE was evident in “Development” and “Performance” playing levels only at youth level. When examining each age group, an RAE was observed in U12–U17 players only. While there was a slight asymmetry favoring Q1 born senior professional players, the RAE was not present within this group of our sample. Results from our study suggest that a bias in selecting individuals born earlier in the selection year may exist within male soccer academy structures, but not at amateur level. The asymmetry favoring chronologically older players at youth but not professional level questions the efficacy of this (un)conscious bias within male Scottish soccer players.

Prakash Thangavel,1 Buddolla Viswanath,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules. In addition, Ru complexes have favorable adsorption properties, along with excellent photochemical and photophysical properties, which make them promising tools for photodynamic therapy. At present, nanostructured materials functionalized with Ru complexes have become an efficient way to administer Ru-based anticancer drugs for cancer treatment. In this review, the recent developments in the nanostructured materials functionalized with Ru complexes for targeted drug delivery to tumors are discussed. In addition, information on “traditional” (ie, non-nanostructured) Ru-based cancer therapies is included in a precise manner. Keywords: metallodrugs, nanotechnology, cancer treatment, cell apoptosis, DNA damage, toxicity

Buddolla Viswanath,1 Sanghyo Kim,1 Kiyoung Lee2 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, 2Division of Endocrinology and Metabolism, Gachon University Gil Hospital, Incheon, Republic of Korea Abstract: The global incidence of colorectal cancer (CRC) is 1.3 million cases. It is the third most frequent cancer in males and females. Most CRCs are adenocarcinomas and often begin as a polyp on the inner wall of the rectum or colon. Some of these polyps become malignant, eventually. Detecting and removing these polyps in time can prevent CRC. Therefore, early diagnosis of CRC is advantageous for preventive and instant action interventions to decrease the mortality rates. Nanotechnology has been enhancing different methods for the detection and treatment of CRCs, and the research has provided hope within the scientific community for the development of new therapeutic strategies. This review presents the recent development of nanotechnology for the detection and treatment of CRC. Keywords: colorectal cancer, nanotechnology, detection, treatment, targeted therapy

Purpose: To gain knowledge on the beliefs and practices of football practitioners applying high-speed and sprint running exposure programming strategies. Methods: One hundred two football practitioners from 22 different countries participated in a study consisting of a survey including 5 domains: demographic and professional characteristics (Who); importance of high-speed and sprint running exposure for physical-capability development, preparation for competition, and injury-prevention strategies (Why); exposure timing (When); methodological procedures for exposure monitoring and training scheduling (What); and effectiveness of common training practices (How). Data were analyzed using a combination of descriptive statistics, generalized mixed effects, and multinomial logistic regression models. Results: Data revealed 5 main findings: (1) overall agreement on the importance of exposure for physical-capability development, preparation for competition, and injury-prevention strategies; (2) different exposure timing and selective training scheduling for starting and nonstarting players across typical and congested weeks; (3) lack of consensus on the conceptual constructs defining high-speed and sprint running metrics and the methodological procedures used for monitoring; (4) a probable association between match-related outcomes and exposure strategies used in training; and (5) a broad range of training methods considered effective to elicit exposure. Conclusions: This study provides actionable insights into the planning, implementing, and monitoring strategies for high-speed and sprint running exposure in football. While some conform with the evidence on high-speed and sprint running training in football, further research and professional debate are warranted to develop empirical knowledge and provide pragmatic recommendations to help practitioners in adopting evidence-informed decisions. [ABSTRACT FROM AUTHOR]

Purpose: This study examined the interday reliability of a predetermined and a self-determined isometric-squat test among youth soccer players. Familiarization effects were evaluated to determine the minimum number of trials necessary to obtain consistent outputs. Finally, differences between protocols were evaluated. Methods: Thirty-one youth soccer players (mean [SD] age: 13.2 [1.0] y; body mass: 54.1 [3.4] kg; stature: 166.3 [11.2] cm; percentage of estimated adult height: 92.6% [3.6%]) from a top-tier professional academy completed 4 experimental sessions for each protocol: familiarization 1, familiarization 2, test, and retest sessions. Peak force; relative peak force; impulse from 0 to 50 milliseconds, 0 to 100 milliseconds, 0 to 150 milliseconds, and 0 to 200 milliseconds; and rate of force development from 0 to 50 milliseconds, 0 to 100 milliseconds, 0 to 150 milliseconds, and 0 to 200 milliseconds were measured. Results: Both protocols displayed acceptable (intraclass correlation coefficient ≥.75 and coefficient of variation ≤10%) reliability statistics for all metrics apart from rate of force development of any time epoch. Differences were found between familiarization 2 and both test and retest sessions for peak force (P =.034 and.021, respectively) and relative peak force (P =.035 and.005, respectively) across both protocols. Conclusions: The isometric-squat test is a reliable test among youth soccer players. Two familiarization sessions seem to be sufficient to ensure data stabilization. Outputs between the self-determined and predetermined are comparable; however, the latter seems preferable due to improved testing time efficiency. [ABSTRACT FROM AUTHOR]

It has recently been identified that the assessment of peak periods of activity better considers the stochastic nature of match-play and the influence that contextual factors have on these peak periods. Limited research exists attempting to link the tactical and physical aspects of performance, especially in female players. Therefore, the current study aimed to assess post-goal locomotor patterns and positional differences on peak match demands in elite female soccer players. Using 10 Hz global positioning system units, a total of 133 player match observations were recorded from 14 matches played by an elite Scottish women's professional soccer team. The total distance (TD), high-speed running distance (>18 km/h) (HSRD) and PlayerLoad™ (PL) were assessed for 1, 3 and 5-minute peak periods using a rolling epoch approach. Playing position and post-goal activity were used as modulating factors. Linear mixed models established a main effect for playing position for the HSRD at peak 1-minute (p <.001), 3-minute (p <.001) and 5-minute (p <.001) epochs. There were also main effects for the playing position for TD at peak 1-minute (p =.001) and PL at peak-3minute (p =.002). Team-level data showed a main effect for condition (score vs. concede) for 3-minute TD data and main effects for time (pre vs. post) for 1,3 and 5-minute epochs for PL data. The average and peak values were shown to differ across playing positions for all variables. Likewise, potentially indicative of tactical adjustments significant differences were observed at both a team and player level following scoring or conceding a goal. [ABSTRACT FROM AUTHOR]

The transition of elite youth footballers through academy systems towards the first team is highly complex, competitive, and often unsuccessful. A myriad of factors including technical competence, physical prowess, and the development environment combine to determine youth player progression. Current research has focused on broad investigations of multiple clubs and stakeholders, providing a valuable overview of the key aspects associated with elite youth player transition. This study aimed to provide an in-depth, context-specific investigation of key stakeholders within an elite level club in the United Kingdom (UK). Seven key stakeholders including the head of the academy (n = 1), the head of sports science (n = 1), coaches (n = 3), and lead sports scientists (n = 2) were recruited. Framework analysis led to the development of a practical framework outlining the key facilitators and barriers of youth-to-first-team transition. Facilitators of transition included overcoming adversity, high-level physical prowess, exceptional technical competence, and possessing at least one elite-level attribute. Barriers to transition included a lack of opportunity, lucrative youth player contracts and a lack of development-specific coaching. In addition, the developmental environment and developing individuals within a team environment were key influences on youth-to-first-team transition. This study complements recent broad investigations of the UK and global stakeholders by corroborating many of their findings while providing transferable, context-specific accounts of applied issues related to successful transition to first-team football. [ABSTRACT FROM AUTHOR]

CONTEXT: Diabetic eyes suffer from variety of complications including macular edema. Cataract surgery is the most commonly done procedure throughout the world and majority would be diabetics. As pseudophakic-cystoid macular edema (CME) is a known complication following cataract surgery, our study concentrated on finding the role of prophylactic topical nonsteroidal anti-inflammatory drugs (NSAIDs) on change in total macular volume (TMV) postcataract surgery in diabetic eyes. AIMS: To evaluate the role of NSAIDs on change in TMV postcataract surgery in diabetic eyes. SETTINGS AND DESIGN: Retrospective comparative study. SUBJECTS AND METHODS: Data were collected from the medical records department of our institute constituting diabetics undergoing cataract surgery from June-2021 to February-2022. Eighty diabetic eyes were divided into two groups: one group were given topical nepafenac drops and another who were not given. Demographic details, diabetic retinopathy stage, preoperative optical coherence tomography (OCT), and postoperative day (POD) 7, day 28, and 3 months OCT were collected. Statistical analysis was done to compare the change in TMV between both the groups. STATISTICAL ANALYSIS USED: Student's t-test and Chi-squared/Fisher's exact test were employed to find statistically significant differences between the two groups using SPSS-22.0 software. RESULTS: In our study, the mean age in the group with nepafenac was 60.93 ± 5.86 years and 31 (77.5%) had moderate nonproliferative diabetic retinopathy (NPDR), and in the group without nepafenac, the mean age was 58.53 ± 7.41 years and 30 (75%) had moderate NPDR. Majority of the individuals in the study group were known diabetic for 2-5 years. Change in TMV at POD 3 months among two groups was not statistically significant; P = 0.758 (P < 0.05-significant). CONCLUSIONS: Our study concluded that topical-NSAIDs played no role in postoperative period following cataract surgery with respect to change in TMV in diabetic eyes. Thus, prophylactic usage of topical-NSAIDs can be a burden on patient as it has no role in prevention of pseudophakic-CME in those with the duration of diabetes mellitus <5 years and with mild-to-moderate NPDR. [ABSTRACT FROM AUTHOR]

Aims: Cardiac adaptations in elite, male adolescent youth soccer players have been demonstrated in relation to training status. The time course of these adaptations and the delineation of the influence of volatile growth phases from the training effect on these adaptations remain unclear. Consequently, the aims of the study were to evaluate the impact of 3 years of elite‐level soccer training on changes in left ventricular (LV) structure and function in a group of highly trained elite youth male soccer players (SP) as they transitioned through the pre‐to‐adolescent phase of their growth. Methods: Twenty‐two male youth SP from the highest Level of English Premier League Academy U‐12 teams were evaluated once a year for three soccer seasons as the players progressed from the U‐12 to U‐14 teams. Fifteen recreationally active control participants (CON) were also evaluated over the same 3‐year period. Two‐dimensional transthoracic echocardiography was used to quantify LV structure and function. Results: After adjusting for the influence of growth and maturation, training‐induced increases in Years 2 and 3 were noted for: LV end diastolic volume (LVEDV; p = 0.02) and LV end systolic volume (LVESV; p = 0.02) in the SP compared to CON. Training‐induced decrements were noted for LV ejection fraction (LVEF; p = 0.006) and TDI‐S′ (p < 0.001). Conclusions: An increase in training volume (Years 2 and 3) were aligned with LV volumetric adaptations and decrements in systolic function in the SP that were independent from the influence of rapid somatic growth. Decrements in systolic function were suggestive of a functional reserve for exercise. [ABSTRACT FROM AUTHOR]

This study sought to: (1) document the multifaceted training practices of soccer officials in relation to their role and officiating category; and (2) explore the association between the officials' training practices and perceptions of the attributes pertinent to optimal performance. Field referees and assistant referees at officiating categories 1–3 (n = 173) with the Scottish Football Association were invited to participate in this national cross-sectional study. Using the Referee Training Activity Questionnaire (RTAQ), officials reported the volume and type of training engaged in during a 2-week in-season period. Respondents' perceptions of the skills pertinent to performance were also explored using a 7-point Likert scale (1 = not at all important; 7 = extremely important), with the frequency in which they trained these skills assessed using a 5-point Likert Scale (1 = less than once a month; 5 = more than once a week). Ninety-one responses were received, representing a 52.6% response rate. Irrespective of their role or level of professional attainment, the officials' training was focused mostly on physical conditioning, with significantly less time apportioned to decision-making (P < 0.001; ES = 1.28), psychological (P < 0.001; ES = 1.47), and technical (P < 0.001; ES = 1.23) skills training. Meanwhile, although decision-making and psychological skills were rated as " very important " to " extremely important " amongst both field referees and assistant referees, officials purposefully trained these skills " less than once a month. " The present study provides important new insights into the training practices engaged in by soccer officials. As accurate decision-making is at the forefront of soccer officiating, enhancing the exposure of match officials to match-related decision-making during training should be considered a priority for future research. [ABSTRACT FROM AUTHOR]