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6. Corrigendum to “Beyond Sedlis—A novel histology-specific nomogram for predicting cervical cancer recurrence risk: An NRG/GOG ancillary analysis” [Gynecologic Oncology 162 (2021) 532–538]

Author

Levinson, Kimberly, Beavis, Anna L, Purdy, Christopher, Rositch, Anne F, Viswanathan, Akila, Wolfson, Aaron H, Kelly, Michael G, Tewari, Krishnansu S, McNally, Leah, Guntupalli, Saketh R, Ragab, Omar, Lee, Yi-Chun, Miller, David S, Huh, Warner K, Wilkinson, Kelly J, Spirtos, Nicola M, Le, Linda Van, Casablanca, Yovanni, Holman, Laura L, Waggoner, Steven E, and Fader, Amanda N

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Reproductive medicine
Abstract

The authors regret that the version of Table 3 originally published in this article was incorrect. The online version has now been updated and the correct table can be found below. The authors would like to apologise for any inconvenience caused. Table 3. Comparison of 3 yr RFS, nomogram recurrence risk, and Sedlis criteria for predictor variable combinations. [Table Presented]

Published
2021

7. Beyond Sedlis—A novel histology-specific nomogram for predicting cervical cancer recurrence risk: An NRG/GOG ancillary analysis

Author

Levinson, Kimberly, Beavis, Anna L, Purdy, Christopher, Rositch, Anne F, Viswanathan, Akila, Wolfson, Aaron H, Kelly, Michael G, Tewari, Krishnansu S, McNally, Leah, Guntupalli, Saketh R, Ragab, Omar, Lee, Yi-Chun, Miller, David S, Huh, Warner K, Wilkinson, Kelly J, Spirtos, Nicola M, Van Le, Linda, Casablanca, Yovanni, Holman, Laura L, Waggoner, Steven E, and Fader, Amanda N

Subjects
Cancer, Adenocarcinoma, Adult, Carcinoma, Squamous Cell, Female, Humans, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Nomograms, Proportional Hazards Models, Randomized Controlled Trials as Topic, Risk Factors, Uterine Cervical Neoplasms, Cervical cancer, Stage I, Adjuvant radiation, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis
Abstract

PurposeThe Sedlis criteria define risk factors for recurrence warranting post-hysterectomy radiation for early-stage cervical cancer; however, these factors were defined for squamous cell carcinoma (SCC) at an estimated recurrence risk of ≥30%. Our study evaluates and compares risk factors for recurrence for cervical SCC compared with adenocarcinoma (AC) and develops histology-specific nomograms to estimate risk of recurrence and guide adjuvant treatment.MethodsWe performed an ancillary analysis of GOG 49, 92, and 141, and included stage I patients who were surgically managed and received no neoadjuvant/adjuvant therapy. Multivariable Cox proportional hazards models were used to evaluate independent risk factors for recurrence by histology and to generate prognostic histology-specific nomograms for 3-year recurrence risk.ResultsWe identified 715 patients with SCC and 105 with AC; 20% with SCC and 17% with AC recurred. For SCC, lymphvascular space invasion (LVSI: HR 1.58, CI 1.12-2.22), tumor size (TS ≥4 cm: HR 2.67, CI 1.67-4.29), and depth of invasion (DOI; middle 1/3, HR 4.31, CI 1.81-10.26; deep 1/3, HR 7.05, CI 2.99-16.64) were associated with recurrence. For AC, only TS ≥4 cm, was associated with recurrence (HR 4.69, CI 1.25-17.63). For both histologies, there was an interaction effect between TS and LVSI. For those with SCC, DOI was most associated with recurrence (16% risk); for AC, TS conferred a 15% risk with negative LVSI versus a 25% risk with positive LVSI.ConclusionsCurrent treatment standards are based on the Sedlis criteria, specifically derived from data on SCC. However, risk factors for recurrence differ for squamous cell and adenocarcinoma of the cervix. Histology-specific nomograms accurately and linearly represent risk of recurrence for both SCC and AC tumors and may provide a more contemporary and tailored tool for clinicians to base adjuvant treatment recommendations to their patients with cervical cancer.

Published
2021

9. Consensus Guidelines for Delineation of Clinical Target Volumes for Intensity-Modulated Radiotherapy for Intact Cervical Cancer: An Update

Author

Fields, Emma C., Bosch, Walter R., Albuquerque, Kevin V., Bhatia, Rohini, Chino, Junzo, Dyer, Brandon, Erickson, Beth, Fabian, Denise, Gaffney, David, Glaser, Scott, Han, Kathy, Hathout, Lara, Hsu, I-Chow, Jegadeesh, Naresh, Kahn, Jenna, Kidd, Elizabeth, Klopp, Ann, Leung, Eric, Lin, Lilie, Ludwig, Michelle, Ma, Tianjun, Mell, Loren, Mayadev, Jyoti, Petersen, Ivy, Portelance, Lorraine, Rash, Dominique, Taunk, Neil, Viswanathan, Akila, Wolfson, Aaron, Yashar, Catheryn, Yeung, Anamaria, Yoshida, Emi, and Fisher, Christine M

Published
2024
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14. Investigating the Use of a Liquid Immunogenic Fiducial Eluter Biomaterial in Cervical Cancer Treatment

Author

Moreau, Michele, primary, Keno, Lensa S., additional, China, Debarghya, additional, Mao, Serena, additional, Acter, Shahinur, additional, Sy, Gnagna, additional, Hooshangnejad, Hamed, additional, Chow, Kwok Fan, additional, Sajo, Erno, additional, Walker, Jacques, additional, Oh, Philmo, additional, Broyles, Eric, additional, Ding, Kai, additional, Viswanathan, Akila, additional, and Ngwa, Wilfred, additional

Published
2024
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16. NRG Oncology/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update

Author

Small, William, Jr., Bosch, Walter R., Harkenrider, Mathew M., Strauss, Jonathan B., Abu-Rustum, Nadeem, Albuquerque, Kevin V., Beriwal, Sushil, Creutzberg, Carien L., Eifel, Patricia J., Erickson, Beth A., Fyles, Anthony W., Hentz, Courtney L., Jhingran, Anuja, Klopp, Ann H., Kunos, Charles A., Mell, Loren K., Portelance, Lorraine, Powell, Melanie E., Viswanathan, Akila N., Yacoub, Joseph H., Yashar, Catheryn M., Winter, Kathryn A., and Gaffney, David K.

Published
2021
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18. The ABS brachytherapy schools

Author

Erickson, Beth, Crook, Juanita, Vicini, Frank, Arthur, Douglas, Ouhib, Zoubir, Thomadsen, Bruce, Bice, William, Butler, Wayne M., Petereit, Daniel G., and Viswanathan, Akila N.

Published
2020
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22. Adjuvant therapy for early stage, endometrial cancer with lymphovascular space invasion: Is there a role for chemotherapy?

Author

Beavis, Anna L., Yen, Ting-Tai, Stone, Rebecca L., Wethington, Stephanie L., Carr, Caitlin, Son, Ji, Chambers, Laura, Michener, Chad M., Ricci, Stephanie, Burkett, Wesley C., Richardson, Debra L., Staley, Allison-Stuart, Ahn, Susie, Gehrig, Paola A., Torres, Diogo, Dowdy, Sean C., Sullivan, Mackenzie W., Modesitt, Susan C., Watson, Catherine, Veade, Ashely, Ehrisman, Jessie, Havrilesky, Laura, Secord, Angeles Alvarez, Loreen, Amy, Griffin, Kaitlyn, Jackson, Amanda, Viswanathan, Akila N., Jager, Leah R., and Fader, Amanda N.

Published
2020
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24. Multi-Institutional Implementation and Evaluation of a Curriculum for the Medical Student Clerkship in Radiation Oncology

Author

Group, Radiation Oncology Education Collaborative Study Group Writing Committee Radiation Oncology Education Collaborative Study, Golden, Daniel W, Braunstein, Steve, Jimenez, Rachel B, Mohindra, Pranshu, Spektor, Alexander, Ye, Jason C, Members, Radiation Oncology Education Collaborative Study Group, Bradley, Kristin A, Chmura, Steven J, Currey, Adam, Das, Prajnan, Du, Kevin, Haas-Kogan, Daphne, Howard, Andrew R, Higgins, Susan A, Hung, Arthur Y, Kharofa, Jordan, Krishnan, Monica S, MacDonald, Shannon M, Mancini, Brandon R, Parashar, Bhupesh, Thaker, Nikhil G, Thomas, Charles R, Viswanathan, Akila N, and Wheatley, Matt

Subjects
Cancer, Academic Medical Centers, Clinical Clerkship, Curriculum, Education, Medical, Undergraduate, Educational Measurement, Humans, Program Development, Program Evaluation, Radiation Oncology, Surveys and Questionnaires, Radiation oncology, undergraduate medical education, curriculum, medical students, Radiation Oncology Education Collaborative Study Group, Radiation Oncology Education Collaborative Study Group Writing Committee, Radiation Oncology Education Collaborative Study Group Members, Clinical Sciences, Public Health and Health Services, Nuclear Medicine & Medical Imaging
Abstract

PurposeRadiation oncology curriculum development is challenging because of limited numbers of trainees at any single institution. The goal of this project is to implement and evaluate a standardized medical student clerkship curriculum following the multi-institutional cooperative group research model.MethodsDuring the 2013 academic year, a standardized curriculum was implemented at 11 academic medical centers consisting of three 1-hour lectures and a hands-on radiation treatment planning workshop. After the curriculum, students completed anonymous evaluations using Likert-type scales (1 = "not at all" to 5 = "extremely") and free responses. Evaluations asked students to rate their comfort, before and after the curriculum, with radiation oncology as a specialty, knowledge of radiotherapy planning methods, and ability to function as a radiation oncology resident. Nonparametric statistical tests were used in the analysis.ResultsEighty-eight students at 11 academic medical centers completed the curriculum de novo, with a 72.7% (64 of 88) survey response rate. Fifty-seven students (89.1%) reported intent to pursue radiation oncology as their specialty. Median (interquartile range) student ratings of the importance of curricular content were as follows: overview, 4 (4-5); radiation biology/physics, 5 (4-5); practical aspects/emergencies, 5 (4-5); and planning workshop, 4 (4-5). Students reported that the curriculum helped them better understand radiation oncology as a specialty (5 [4-5]), increased specialty decision comfort (4 [3-5]), and would help the transition to radiation oncology residency (4 [4-5]). Students rated their specialty decision comfort significantly higher after completing the curriculum (4 [4-5] versus 5 [5-5]; P < .001).ConclusionsA national standardized curriculum was successfully implemented at 11 academic medical centers, providing proof of principle that curriculum development can follow the multi-institutional cooperative group research model.

Published
2016

27. 3T MR-Guided Brachytherapy for Gynecologic Malignancies

Author

Kapur, Tina, Egger, Jan, Damato, Antonio, Schmidt, Ehud J., and Viswanathan, Akila N.

Subjects
Physics - Medical Physics, Computer Science - Graphics
Abstract

Gynecologic malignancies are a leading cause of death in women worldwide. Standard treatment for many primary and recurrent gynecologic cancer cases includes a combination of external beam radiation, followed by brachytherapy. Magnetic Resonance Imaging (MRI) is benefitial in diagnostic evaluation, in mapping the tumor location to tailor radiation dose, and in monitoring the tumor response to treatment. Initial studies of MR-guidance in gynecologic brachtherapy demonstrate the ability to optimize tumor coverage and reduce radiation dose to normal tissues, resulting in improved outcomes for patients. In this article we describe a methodology to aid applicator placement and treatment planning for 3 Tesla (3T) MR-guided brachytherapy that was developed specifically for gynecologic cancers. This has been used in 18 cases to date in the Advanced Multimodality Image Guided Operating suite at Brigham and Women's Hospital. It is comprised of state of the art methods for MR imaging, image analysis, and treatment planning. An MR sequence using 3D-balanced steady state free precession in a 3T MR scan was identified as the best sequence for catheter identification with ballooning artifact at the tip. 3D treatment planning was performed using MR images. Item in development include a software module designed to support virtual needle trajectory planning that includes probabilistic bias correction, graph based segmentation, and image registration algorithms. The results demonstrate that 3T MR has a role in gynecologic brachytherapy. These novel developments improve targeted treatment to the tumor while sparing the normal tissues., Comment: 22 pages, 9 figures, 41 references. Epub 2012 Aug 13

Published
2013
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28. Fractionation Regimens for Gynecologic Malignancies

Author

Jang, Joanne, Guerrieri, Patrizia, Viswanathan, Akila N., Brady, Luther W., Series Editor, Lu, Jiade J., Series Editor, Heilmann, Hans-Peter, Honorary Editor, Molls, Michael, Honorary Editor, Trombetta, Mark, editor, Pignol, Jean-Philippe, editor, and Montemaggi, Paolo, editor

Published
2018
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29. Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients

Author

Gay, Hiram A., Santiago, Roberto, Gil, Betty, Remedios, Carlos, Montes, Pedro J., López-Araujo, Javier, Chévere, Carlos M., Imbert, Winston S., White, Julia, Arthur, Douglas W., Horton, Janet K., Jagsi, Reshma, Rabinovich, Rachel, Beriwal, Sushil, Viswanathan, Akila, Erickson, Beth A., Rengan, Ramesh, Palma, David, Loo, Billy W., Jr., Kavanaugh, James A., Bradley, Jeff, Yom, Sue S., Harari, Paul M., and Lee Burnett, Omer, III

Published
2019
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34. En bloc Kidney Transplant – A Surgical Illustration and Clinical Experience from a Tertiary Care Hospital in South India.

Author

Reddy, Govardhan Krishan, Shetty, Shashank, Panchangam, Vidyashankar, Viswanathan, Akila, and Patil, Vinay

Subjects
KIDNEY transplantation, POSTOPERATIVE care, ORGAN donation, CHRONIC kidney failure, LIVER transplantation, KIDNEYS, IMMUNOSUPPRESSION, PATIENT aftercare
Abstract

There is a global shortage of transplantable organs, especially in a resource‑limited country like India. Deceased pediatric donors provide an excellent opportunity to expand the donor pool. Herein, we report a rare case of multi‑organ harvesting from a 3‑year‑old brain‑dead donor, where both the kidneys were transplanted en bloc to an adult male recipient and the liver to a 4‑year‑old male child. This case report provides the surgical steps and our experience. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Stereotactic Body Radiation Therapy for Gynecologic Malignancies: A Case-Based Radiosurgery Society Practice Review

Author

Ladbury, Colton, primary, Sueyoshi, Mark H., additional, Brovold, Nellie M., additional, Kumar, Ritesh, additional, Andraos, Therese Y., additional, Gogineni, Emile, additional, Kim, Minsun, additional, Klopp, Ann, additional, Albuquerque, Kevin, additional, Kunos, Charles, additional, Leung, Eric, additional, Mantz, Constantine, additional, Biswas, Tithi, additional, Beriwal, Sushil, additional, Small, William, additional, Erickson, Beth, additional, Gaffney, David, additional, Lo, Simon S., additional, and Viswanathan, Akila N., additional

Published
2023
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40. Interventional Radiation Oncology (IRO): Transition of a magnetic resonance simulator to a brachytherapy suite

Author

Anderson, Roberta, Armour, Elwood, Beeckler, Courtney, Briner, Valerie, Choflet, Amanda, Cox, Andrea, Fader, Amanda N., Hannah, Marie N., Hobbs, Robert, Huang, Ellen, Kiely, Marilyn, Lee, Junghoon, Morcos, Marc, McMillan, Paige E., Miller, Dave, Ng, Sook Kien, Prasad, Rashmi, Souranis, Annette, Thomsen, Robert, DeWeese, Theodore L., and Viswanathan, Akila N.

Published
2018
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41. Impact of Human Immunodeficiency Virus Infection on Survival and Acute Toxicities From Chemoradiation Therapy for Cervical Cancer Patients in a Limited-Resource Setting

Author

Grover, Surbhi, Bvochora-Nsingo, Memory, Yeager, Alyssa, Chiyapo, Sebathu, Bhatia, Rohini, MacDuffie, Emily, Puri, Priya, Balang, Dawn, Ratcliffe, Sarah, Narasimhamurthy, Mohan, Gwangwava, Elliphine, Tsietso, Sylvia, Kayembe, Mukendi K.A., Ramogola-Masire, Doreen, Dryden-Peterson, Scott, Mahantshetty, Umesh, Viswanathan, Akila N., Zetola, Nicola M., and Lin, Lilie L.

Published
2018
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43. Gynecologic Brachytherapy: Cervical Cancer

Author

Vargo, John A., Viswanathan, Akila N., Erickson, Beth A., Beriwal, Sushil, Kauczor, Hans-Ulrich, Series editor, Hricak, Hedvig, Series editor, Knauth, Michael, Series editor, Brady, Luther W., Series editor, Combs, Stephanie E., Series editor, Lu, Jiade J., Series editor, Reiser, Maximilian F., Series editor, Montemaggi, Paolo, editor, and Trombetta, Mark, editor

Published
2016
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44. Gynecologic Brachytherapy: Vaginal Cancer

Author

Vargo, John A., Viswanathan, Akila N., Erickson, Beth A., Beriwal, Sushil, Kauczor, Hans-Ulrich, Series editor, Hricak, Hedvig, Series editor, Knauth, Michael, Series editor, Brady, Luther W., Series editor, Combs, Stephanie E., Series editor, Lu, Jiade J., Series editor, Reiser, Maximilian F., Series editor, Montemaggi, Paolo, editor, and Trombetta, Mark, editor

Published
2016
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45. Gynecologic Brachytherapy: Endometrial Cancer

Author

Vargo, John A., Viswanathan, Akila N., Erickson, Beth A., Beriwal, Sushil, Kauczor, Hans-Ulrich, Series editor, Hricak, Hedvig, Series editor, Knauth, Michael, Series editor, Brady, Luther W., Series editor, Combs, Stephanie E., Series editor, Lu, Jiade J., Series editor, Reiser, Maximilian F., Series editor, Montemaggi, Paolo, editor, and Trombetta, Mark, editor

Published
2016
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