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22 results on '"Vivilecchia, Richard"'

5. The use of ACQUITY UPLC in pharmaceutical development

Author

Jerkovich, Anton D., LoBrutto, Rosario, and Vivilecchia, Richard V.

Abstract

Now more than ever, the demands of the pharmaceutical industry require companies to look for new ways to cut costs and shorten timelines in the development of drugs, while at [...]

Published
2005

22. The Use of Microparticulates in Gel Permeation Chromatography

Author

Vivilecchia, Richard V., Lightbody, Brian G., Thimot, Norma Z., and Quinn, Hubert M.

Abstract

High performance gel permeation chromatography, GPC, was performed by using packed columns of μStyragel™, a porous polymer of styrene and divinylbenzene and μBondagel™E, a new silica-based chromatographic packing. The latter is compatible with aqueous and nonaqueous mobile phases. By using particle sizes of about 10 micron, packed columns yield 4,000–10,000 plates/30 cm for total permeating samples depending upon mobile phase velocity and viscosity. Analysis times are typically 5–20 minutes, μBondagel E Linear, columns with linear calibration curves from 2 million to several thousand molecular weight were prepared and are shown to be valuable general purpose columns for the separation of aqueous and nonaqueous soluble polymers. The value of high performance GPC for the rapid characterization of aqueous and nonaqueous soluble polymers, as a simple preparative tool and as a useful sample clean-up method for subsequent analysis is demonstrated.

Published
1977
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