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1. Transfemoral TAVR in Nonagenarians: From the CENTER Collaboration

Author

Vlastra, Wieneke, Chandrasekhar, Jaya, Vendrik, Jeroen, Gutierrez-Ibanes, Enrique, Tchétché, Didier, de Brito, Fabio S., Jr., Barbanti, Marco, Kornowski, Ran, Latib, Azeem, D’Onofrio, Augusto, Ribichini, Flavio, Baan, Jan, Tijssen, Jan G.P., Pan, Manuel, Dumonteil, Nicolas, Mangione, José A., Sartori, Samantha, D’Errigo, Paola, Tarantini, Giuseppe, Lunardi, Mattia, Orvin, Katia, Pagnesi, Matteo, Sanchez Gila, Joaquin, Modine, Thomas, Dangas, George, Mehran, Roxana, Piek, Jan J., and Delewi, Ronak

Published
2019
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3. Aortic valve calcification volumes and chronic brain infarctions in patients undergoing transcatheter aortic valve implantation

Author

Vlastra, Wieneke, van den Boogert, Thomas P. W., Krommenhoek, Thomas, Bronzwaer, Anne-Sophie G. T., Mutsaerts, Henk J. M. M., Achterberg, Hakim C., Bron, Esther E., Niessen, Wiro J., Majoie, Charles B. L. M., Nederveen, Aart J., Baan, Jan, van Lieshout, Johannes J., Piek, Jan J., Planken, R. Nils, Henriques, José P. S., and Delewi, Ronak

Published
2019
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6. Cerebral Blood Flow in Patients with Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation

Author

Researchgr. Neuroradiologie, Neurologen, Brain, Circulatory Health, Zorglijn AN/AAN Medisch, Vlastra, Wieneke, van Nieuwkerk, Astrid C, Bronzwaer, Anne-Sophie G T, Versteeg, Adriaan, Bron, Esther E, Niessen, Wiro J, Mutsaerts, Henk J M M, van der Ster, Björn J P, Majoie, Charles B L M, Biessels, Geert J, Nederveen, Aart J, Daemen, Mat J A P, van Osch, Matthias J P, Baan, Jan, Piek, Jan J, Van Lieshout, Johannes J, Delewi, Ronak, Researchgr. Neuroradiologie, Neurologen, Brain, Circulatory Health, Zorglijn AN/AAN Medisch, Vlastra, Wieneke, van Nieuwkerk, Astrid C, Bronzwaer, Anne-Sophie G T, Versteeg, Adriaan, Bron, Esther E, Niessen, Wiro J, Mutsaerts, Henk J M M, van der Ster, Björn J P, Majoie, Charles B L M, Biessels, Geert J, Nederveen, Aart J, Daemen, Mat J A P, van Osch, Matthias J P, Baan, Jan, Piek, Jan J, Van Lieshout, Johannes J, and Delewi, Ronak

Published
2021

7. Cerebral Blood Flow in Patients with Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation

Author

Vlastra, Wieneke, primary, van Nieuwkerk, Astrid C., additional, Bronzwaer, Anne‐Sophie G.T., additional, Versteeg, Adriaan, additional, Bron, Esther E., additional, Niessen, Wiro J., additional, Mutsaerts, Henk J.M.M., additional, van der Ster, Björn J.P., additional, Majoie, Charles B.L.M., additional, Biessels, Geert J., additional, Nederveen, Aart J., additional, Daemen, Mat J.A.P., additional, van Osch, Matthias J.P., additional, Baan, Jan, additional, Piek, Jan J., additional, Van Lieshout, Johannes J., additional, and Delewi, Ronak, additional

Published
2020
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10. Predictors, Incidence, and Outcomes of Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation Complicated by Stroke

Author

Vlastra, Wieneke, Jimenez-Quevedo, Pilar, Tchétché, Didier, Chandrasekhar, Jaya, de Brito, Fabio S, Barbanti, Marco, Kornowski, Ran, Latib, Azeem, D'Onofrio, Augusto, Ribichini, Flavio, Baan, Jan, Tijssen, Jan G P, De la Torre Hernandez, Jose M, Dumonteil, Nicolas, Sarmento-Leite, Rogério, Sartori, Samantha, Rosato, S, Tarantini, Giuseppe, Lunardi, Mattia, Orvin, Katia, Pagnesi, Matteo, Hernandez-Antolin, Rosana, Modine, Thomas, Dangas, George, Mehran, Roxana, Piek, Jan J, Delewi, Ronak, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Cardiology, ACS - Amsterdam Cardiovascular Sciences, APH - Aging & Later Life, and ACS - Heart failure & arrhythmias

Subjects
Aged, 80 and over, Male, Clinical Trials as Topic, Time Factors, Incidence, Aortic Valve Stenosis, Punctures, Risk Assessment, follow-up studies, Femoral Artery, Stroke, Transcatheter Aortic Valve Replacement, Treatment Outcome, Risk Factors, humans, incidence, stroke, transcatheter aortic valve replacement, Aortic Valve, Catheterization, Peripheral, Humans, Female, Registries, Aged
Abstract

BACKGROUND: Stroke remains one of the most devastating complications of transcatheter aortic valve implantation (TAVI). The aim of this study was to identify the incidence, timing, temporal trends, and predictors of stroke after TAVI and evaluate the outcomes of patients with stroke. METHODS AND RESULTS: The CENTER-Collaboration is an international collaboration consisting of 3 national registries and 7 local registries or prospective clinical trials, selected through a systematic review. Accordingly, a total of 10 982 patients undergoing transfemoral TAVI between 2007 and 2018 were included in the current patient-level pooled analyses. A total of 261 patients (2.4%) experienced stroke during the first month after TAVI. The median time between TAVI and stroke was 1 day (interquartile range, 0-6 days). The stroke rate was comparable in procedures performed in the early years of TAVI (2007-2012) to those in the more recent years of TAVI (2013-2018; both 2.4%; P=1.0). Independent predictors of stroke at 30 days were a history of cerebrovascular events (odds ratio, 2.2; 95% CI, 1.4-3.6; P=0.0012) and a glomerular filtration rate of

Published
2019

11. Reply

Author

Vlastra, Wieneke, primary, van Nieuwkerk, Astrid C., additional, Santos, Raquel B., additional, Chandrasekhar, Jaya, additional, and Delewi, Ronak, additional

Published
2020
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12. Transfemoral TAVR in Nonagenarians: From the CENTER Collaboration

Author

Vlastra, Wieneke, Chandrasekhar, Jaya, Vendrik, Jeroen, Gutierrez-Ibanes, Enrique, Tchétché, Didier, de Brito, Fabio S, Barbanti, Marco, Kornowski, Ran, Latib, Azeem, D'Onofrio, Augusto, Ribichini, Flavio, Baan, Jan, Tijssen, Jan G P, Pan, Manuel, Dumonteil, Nicolas, Mangione, José A, Sartori, Samantha, D'Errigo, Paola, Tarantini, Giuseppe, Lunardi, Mattia, Orvin, Katia, Pagnesi, Matteo, Sanchez Gila, Joaquin, Modine, Thomas, Dangas, George, Mehran, Roxana, Piek, Jan J, and Delewi, Ronak

Subjects
Male, Time Factors, Punctures, Risk Assessment, Transcatheter Aortic Valve Replacement, Postoperative Complications, Risk Factors, Catheterization, Peripheral, Humans, Registries, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Trauma Severity Indices, Age Factors, Hemodynamics, Aortic Valve Stenosis, Recovery of Function, stroke, centenarians, nonagenarians, transcatheter aortic valve replacement, Femoral Artery, Treatment Outcome, Aortic Valve, Female
Abstract

This study aimed to compare differences in patient characteristics and clinical outcomes of nonagenarians undergoing transcatheter aortic valve replacement (TAVR) versus patients younger than 90 years of age and to test the predictive accuracy of the logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation), the EuroSCORE II, and the STS-PROM (Society of Thoracic Surgeons Predicted Risk of Mortality) for mortality after TAVR in nonagenarians. The prevalence of severe aortic valve stenosis is increasing due to the rising life expectancy. However, there are limited data evaluating outcomes in patients older than 90 years of age. Moreover, the predictive accuracy of risk scores for mortality has not been evaluated in nonagenarian patients undergoing transfemoral TAVR. The CENTER (Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation) collaboration (N = 12,381) is an international collaboration consisting of 3 national registries, 6 local or multicenter registries, and 1 prospective clinical study, selected through a systematic online search. The primary endpoint of this study was the difference in 30-day all-cause mortality and stroke after TAVR in nonagenarians versus patients younger than 90 years of age. Secondary endpoints included differences in baseline characteristics, in-hospital outcomes, and the differences in predictive accuracy of the logistic EuroSCORE, the EuroSCORE II, and STS-PROM. A total of 882 nonagenarians and 11,499 patients younger than 90 years of age undergoing transfemoral TAVR between 2007 and 2018 were included. Nonagenarians had considerably fewer comorbidities than their counterparts. Nevertheless, rates of 30-day mortality (9.9% vs. 5.4%; relative risk [RR]: 1.8; 95% confidence interval [CI]: 1.4 to 2.3; p = 0.001), in-hospital stroke (3.0% vs. 1.9%; RR: 1.5; 95% CI: 1.0 to 2.3; p = 0.04), major or life-threatening bleeding (8.1% vs. 5.5%; RR: 1.6; 95% CI: 1.1 to 2.2; p = 0.004), and new-onset atrial fibrillation (7.9% vs. 5.2%; RR: 1.6; 95% CI: 1.1 to 2.2; p = 0.01) were higher in nonagenarians. The STS-PROM adequately estimated mortality in nonagenarians, with an observed-expected mortality ratio of 1.0. In this large, global, patient-level analysis, mortality after transfemoral TAVR was 2-fold higher in nonagenarians compared with patients younger than 90 years of age, despite the lower prevalence of baseline comorbidities. Moreover, nonagenarians had a higher risk of in-hospital stroke, major or life-threatening bleeding, and new-onset atrial fibrillation. The STS-PROM was the only surgical risk score that accurately predicted the risk of mortality in nonagenarians.

Published
2018

13. Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

Author

Vlastra, Wieneke, primary, Chandrasekhar, Jaya, additional, García Del Blanco, Bruno, additional, Tchétché, Didier, additional, de Brito, Fabio S., additional, Barbanti, Marco, additional, Kornowski, Ran, additional, Latib, Azeem, additional, D’Onofrio, Augusto, additional, Ribichini, Flavio, additional, Baan, Jan, additional, Tijssen, Jan G.P., additional, Moreno, Raul, additional, Dumonteil, Nicolas, additional, Tarasoutchi, Flavio, additional, Sartori, Samantha, additional, D’Errigo, Paola, additional, Tarantini, Giuseppe, additional, Lunardi, Mattia, additional, Orvin, Katia, additional, Pagnesi, Matteo, additional, Berenguer, Alberto, additional, Modine, Thomas, additional, Dangas, George, additional, Mehran, Roxana, additional, Piek, Jan J., additional, and Delewi, Ronak, additional

Published
2019
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14. TCT-693 Aortic Valve Calcification Volumes and Chronic Brain Infarctions in Patients Undergoing Transcatheter Aortic Valve Implantation

Author

Vlastra, Wieneke, primary, van den Boogert, Thomas, additional, Krommenhoek, Thomas, additional, Bronzwaer, Anne-Sophie, additional, Achterberg, Hakim, additional, Bron, Esther, additional, Majoie, Charles, additional, Baan, Jan, additional, Piek, Jan, additional, Planken, Nils, additional, Henriques, Jose P.S., additional, and Delewi, Ronak, additional

Published
2019
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15. TCT-745 Insights Into Sex Differences in Transfemoral Transcatheter Aortic Valve Implantation From 2007–2018: From the CENTER Collaboration, A Global Patient-Level Analysis of 12,381 Patients

Author

Chandrasekhar, Jaya, primary, Vlastra, Wieneke, additional, Tchetche, Didier, additional, Brito, Fabio, additional, Barbanti, Marco, additional, Kornowski, Ran, additional, Latib, Azeem, additional, D’Onofrio, Augusto, additional, Ribichini, Flavio, additional, Baan, Jan, additional, Tijssen, Jan, additional, Moreno, Raul, additional, Dumonteil, Nicolas, additional, Tarasoutchi, Flávio, additional, Sartori, Samantha, additional, D’Errigo, Paola, additional, Tarantini, Giuseppe, additional, Lunardi, Mattia, additional, Orvin, Katia, additional, Pagnesi, Matteo, additional, Berenguer, Alberto, additional, Modine, Thomas, additional, Dangas, George, additional, Mehran, Roxana, additional, Piek, Jan, additional, and Delewi, Ronak, additional

Published
2019
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17. Cerebral Blood Flow in Patients with Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation.

Author

Vlastra, Wieneke, Nieuwkerk, Astrid C., Bronzwaer, Anne‐Sophie G.T., Versteeg, Adriaan, Bron, Esther E., Niessen, Wiro J., Mutsaerts, Henk J.M.M., Ster, Björn J.P., Majoie, Charles B.L.M., Biessels, Geert J., Nederveen, Aart J., Daemen, Mat J.A.P., Osch, Matthias J.P., Baan, Jan, Piek, Jan J., Van Lieshout, Johannes J., and Delewi, Ronak

Subjects
*AORTIC stenosis treatment, *CEREBRAL circulation, *CARDIAC output, *HEART valve prosthesis implantation, *PATIENT aftercare
Abstract

BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a minimally invasive, life‐saving treatment for patients with severe aortic valve stenosis that improves quality of life. We examined cardiac output and cerebral blood flow in patients undergoing TAVI to test the hypothesis that improved cardiac output after TAVI is associated with an increase in cerebral blood flow. DESIGN: Prospective cohort study. SETTING: European high‐volume tertiary multidisciplinary cardiac care. PARTICIPANTS: Thirty‐one patients (78.3 ± 4.6 years; 61% female) with severe symptomatic aortic valve stenosis. MEASUREMENTS: Noninvasive prospective assessment of cardiac output (L/min) by inert gas rebreathing and cerebral blood flow of the total gray matter (mL/100 g per min) using arterial spin labeling magnetic resonance imaging in resting state less than 24 hours before TAVI and at 3‐month follow‐up. Cerebral blood flow change was defined as the difference relative to baseline. RESULTS: On average, cardiac output in patients with severe aortic valve stenosis increased from 4.0 ± 1.1 to 5.4 ± 2.4 L/min after TAVI (P =.003). The increase in cerebral blood flow after TAVI strongly varied between patients (7% ± 24%; P =.41) and related to the increase in cardiac output, with an 8.2% (standard error = 2.3%; P =.003) increase in cerebral blood flow per every additional liter of cardiac output following the TAVI procedure. CONCLUSION: Following TAVI, there was an association of increase in cardiac output with increase in cerebral blood flow. These findings encourage future larger studies to determine the influence of TAVI on cerebral blood flow and cognitive function. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Comparison of balloon-expandable vs. self-expandable valves in patients undergoing transfemoral transcatheter aortic valve implantation: from the CENTER-collaboration

Author

Vlastra, Wieneke, primary, Chandrasekhar, Jaya, additional, Muñoz-Garcia, Antonio J, additional, Tchétché, Didier, additional, de Brito, Fabio S, additional, Barbanti, Marco, additional, Kornowski, Ran, additional, Latib, Azeem, additional, D’Onofrio, Augusto, additional, Ribichini, Flavio, additional, Baan, Jan, additional, Tijssen, Jan G P, additional, Trillo-Nouche, Ramiro, additional, Dumonteil, Nicolas, additional, Abizaid, Alexandre, additional, Sartori, Samantha, additional, D’Errigo, Paola, additional, Tarantini, Giuseppe, additional, Lunardi, Mattia, additional, Orvin, Katia, additional, Pagnesi, Matteo, additional, del Valle, Raquel, additional, Modine, Thomas, additional, Dangas, George, additional, Mehran, Roxana, additional, Piek, Jan J, additional, and Delewi, Ronak, additional

Published
2018
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19. CT determined psoas muscle area predicts mortality in women undergoing transcatheter aortic valve implantation

Author

van Mourik, Martijn S., primary, Janmaat, Yvonne C., additional, van Kesteren, Floortje, additional, Vendrik, Jeroen, additional, Planken, R. Nils, additional, Henstra, Marieke J., additional, Velu, Juliëtte F., additional, Vlastra, Wieneke, additional, Zwinderman, Aeilko H., additional, Koch, Karel T., additional, de Winter, Robbert J., additional, Wykrzykowska, Joanna J., additional, Piek, Jan J., additional, Henriques, José P. S., additional, Lanting, Vincent R., additional, Baan, Jan, additional, Latour, Corine, additional, Lindeboom, Robert, additional, and Vis, M. Marije, additional

Published
2018
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20. TCT-71 Predictors, incidence and outcomes of patients undergoing transcatheter aortic valve implantation complicated by stroke – From the CENTER-Collaboration

Author

Vlastra, Wieneke, primary, Jimenez-Quevedo, Pilar, additional, Tchetche, Didier, additional, Chandrasekhar, Jaya, additional, Brito, Fabio, additional, Barbanti, Marco, additional, Kornowski, Ran, additional, Latib, Azeem, additional, D'Onofrio, Augusto, additional, Ribichini, Flavio, additional, Baan, Jan, additional, Tijssen, Jan, additional, Hernandez, Jose de la Torre, additional, Dumonteil, Nicolas, additional, Leite, Rogério, additional, Sartori, Samantha, additional, D'Errigo, Paola, additional, Fraccaro, Chiara, additional, Lunardi, Mattia, additional, Orvin, Katia, additional, Pagnesi, Matteo, additional, Hernandez, Rosana, additional, Modine, Thomas, additional, Mehran, Roxana, additional, Piek, Jan, additional, and Delewi, Ronak, additional

Published
2018
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22. TCT-6 The CENTER-Collaboration: Outcomes in patients undergoing transfemoral transcatheter aortic valve implantation with balloon-expandable valves versus self-expandable valves.

Author

Vlastra, Wieneke, primary, Chandrasekhar, Jaya, additional, Munoz-Garcia, Antonio, additional, Tchetche, Didier, additional, Brito, Fabio, additional, Barbanti, Marco, additional, Kornowski, Ran, additional, Latib, Azeem, additional, D'Onofrio, Augusto, additional, Ribichini, Flavio, additional, Baan, Jan, additional, Tijssen, Jan, additional, Trillo, Ramiro, additional, Dumonteil, Nicolas, additional, Abizaid, Alexandre, additional, Sartori, Samantha, additional, D'Errigo, Paola, additional, Fraccaro, Chiara, additional, Lunardi, Mattia, additional, Orvin, Katia, additional, Pagnesi, Matteo, additional, Del Valle, Raquel, additional, Modine, Thomas, additional, Mehran, Roxana, additional, Piek, Jan, additional, and Delewi, Ronak, additional

Published
2018
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27. Premedication to reduce anxiety in patients undergoing coronary angiography and percutaneous coronary intervention

Author

Vlastra, Wieneke, primary, Delewi, Ronak, additional, Rohling, Wim J, additional, Wagenaar, Tineke C, additional, Hirsch, Alexander, additional, Meesterman, Martin G, additional, Vis, Marije M, additional, Wykrzykowska, Joanna J, additional, Koch, Karel T, additional, de Winter, Robbert J, additional, Baan Jr, Jan, additional, Piek, Jan J, additional, Sprangers, Mirjam A G, additional, and Henriques, José P S, additional

Published
2018
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29. Long-term left ventricular remodelling after revascularisation for ST-segment elevation myocardial infarction as assessed by cardiac magnetic resonance imaging

Author

Hassell, Mariella ECJ, primary, Vlastra, Wieneke, additional, Robbers, Lourens, additional, Hirsch, Alexander, additional, Nijveldt, Robin, additional, Tijssen, Jan GP, additional, van Rossum, Albert C, additional, Zijlstra, Felix, additional, Piek, Jan J, additional, and Delewi, Ronak, additional

Published
2017
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30. CT determined psoas muscle area predicts mortality in women undergoing transcatheter aortic valve implantation.

Author

van Mourik, Martijn S., Janmaat, Yvonne C., van Kesteren, Floortje, Vendrik, Jeroen, Planken, R. Nils, Henstra, Marieke J., Velu, Juliëtte F., Vlastra, Wieneke, Zwinderman, Aeilko H., Koch, Karel T., de Winter, Robbert J., Wykrzykowska, Joanna J., Piek, Jan J., Henriques, José P. S., Lanting, Vincent R., Baan, Jan, Latour, Corine, Lindeboom, Robert, and Vis, M. Marije

Published
2019
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31. Comparison of balloon-expandable vs. self-expandable valves in patients undergoing transfemoral transcatheter aortic valve implantation: from the CENTER-collaboration.

Author

Vlastra, Wieneke, Chandrasekhar, Jaya, Muñoz-Garcia, Antonio J, Tchétché, Didier, Brito, Fabio S de, Barbanti, Marco, Kornowski, Ran, Latib, Azeem, D'Onofrio, Augusto, Ribichini, Flavio, Baan, Jan, Tijssen, Jan G P, Trillo-Nouche, Ramiro, Dumonteil, Nicolas, Abizaid, Alexandre, Sartori, Samantha, D'Errigo, Paola, Tarantini, Giuseppe, Lunardi, Mattia, and Orvin, Katia

Abstract

Aims The aim of this study was to compare clinical outcomes of patients undergoing transfemoral transcatheter aortic valve implantation (TAVI) with balloon-expandable (BE) valves vs. self-expandable (SE) valves. Transcatheter aortic valve implantation is a minimally invasive and lifesaving treatment in patients with aortic valve stenosis. Even though BE-valves and SE-valves are both commonly used on a large scale, adequately sized trials comparing clinical outcomes in patients with severe aortic valve stenosis treated with BE-valves compared with SE-valves are lacking. Methods and results In this CENTER-collaboration, data from 10 registries or clinical trials, selected through a systematic search, were pooled and analysed. Propensity score methodology was used to reduce treatment selection bias and potential confounding. The primary endpoints were mortality and stroke at 30 days follow-up in patients treated with BE-valves compared with SE-valves. Secondary endpoints included clinical outcomes, e.g. bleeding during hospital admission. All outcomes were split for early-generation BE-valves compared with early-generation SE-valves and new-generation BE-valves with new-generation SE-valves. The overall patient population (N  = 12 381) included 6239 patients undergoing TAVI with BE-valves and 6142 patients with SE-valves. The propensity matched population had a mean age of 81 ± 7 years and a median STS-PROM score or 6.5% [interquartile range (IQR) 4.0–13.0%]. At 30-day follow-up, the mortality rate was not statistically different in patients undergoing TAVI with BE-valves compared with SE-valves [BE: 5.3% vs. SE: 6.2%, relative risk (RR) 0.9; 95% confidence interval (CI) 0.7–1.0, P  = 0.10]. Stroke occurred less frequently in patients treated with BE-valves (BE: 1.9% vs. SE: 2.6%, RR 0.7; 95% CI 0.5–1.0, P  = 0.03). Also, patients treated with BE-valves had a three-fold lower risk of requiring pacemaker implantation (BE: 7.8% vs. SE: 20.3%, RR 0.4; 95% CI 0.3–0.4, P  < 0.001). In contrast, patients treated with new-generation BE-valves more frequently experienced major and life-threatening bleedings compared with new-generation SE-valves (BE: 4.8% vs. SE: 2.1%, RR 2.3; 95% CI 1.6–3.3, P  < 0.001). Conclusion In this study, which is the largest study to compare valve types in TAVI, we demonstrated that the incidence of stroke and pacemaker implantation was lower in patients undergoing transfemoral TAVI with BE-valves compared with SE-valves. In contrast, patients treated with new-generation BE-valves more often suffered from major or life-threatening bleedings than patients with new-generation SE-valves. Mortality at 30-days was not statistically different in patients treated with BE-valves compared with SE-valves. This study was a propensity-matched analysis generated from observational data, accordingly current outcomes will have to be confirmed in a large scale randomized controlled trial. [ABSTRACT FROM AUTHOR]

Published
2019
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