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49 results on '"Vogel, Wolfgang F."'

1. Analgesic, anti-inflammatory, and anti-pyretic activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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2. Respiratory activity

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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3. Effects on peripheral nerve function

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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4. Psychotropic and neurotropic activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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5. Drug effects on learning and memory1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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6. Activity on urinary tract1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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7. Activity on blood constituents1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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8. Guidelines for the care and use of laboratory animals

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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9. Endocrinology1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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10. Pharmacological models in dermatology

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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11. Antidiabetic activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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12. Anti-atherosclerotic activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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13. Introduction Strategies in drug discovery and evaluation1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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14. Activity on the gastrointestinal tract1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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15. Cardiovascular activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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16. Anti-obesity activity1

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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17. Ophthalmologic activity

Author

Vogel, H. Gerhard, Vogel, Wolfgang H., Schölkens, Bernward A., Sandow, Jürgen, Müller, Günter, Vogel, Wolfgang F., Vogel, H. Gerhard, editor, Vogel, Wolfgang H., editor, Schölkens, Bernward A., editor, Sandow, Jürgen, editor, Müller, Günter, editor, and Vogel, Wolfgang F., editor

Published
2002
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26. Flat-Panel Detector-Based Volume Computed Tomography: A Novel 3D Imaging Technique to Monitor Osteolytic Bone Lesions in a Mouse Tumor Metastasis Model1

Author

Missbach-Guentner, Jeannine, Dullin, Christian, Zientkowska, Marta, Domeyer-Missbach, Melanie, Kimmina, Sarah, Obenauer, Silvia, Kauer, Fritz, Stühmer, Walter, Grabbe, Eckhardt, Vogel, Wolfgang F, and Alves, Frauke

Subjects
Tibia, Femoral Neoplasms, Skull Neoplasms, Bone Neoplasms, Breast Neoplasms, Mice, SCID, Osteolysis, Adenocarcinoma, Humerus, Specific Pathogen-Free Organisms, Tumor Burden, Mice, Imaging, Three-Dimensional, Models, Animal, Disease Progression, Animals, Female, Tomography, X-Ray Computed, Research Article
Abstract

Skeletal metastasis is an important cause of mortality in patients with breast cancer. Hence, animal models, in combination with various imaging techniques, are in high demand for preclinical assessment of novel therapies. We evaluated the applicability of flat-panel volume computed tomography (fpVCT) to noninvasive detection of osteolytic bone metastases that develop in severe immunodeficient mice after intracardial injection of MDA-MB-231 breast cancer cells. A single fpVCT scan at 200-microm isotropic resolution was employed to detect osteolysis within the entire skeleton. Osteolytic lesions identified by fpVCT correlated with Faxitron X-ray analysis and were subsequently confirmed by histopathological examination. Isotropic three-dimensional image data sets obtained by fpVCT were the basis for the precise visualization of the extent of the lesion within the cortical bone and for the measurement of bone loss. Furthermore, fpVCT imaging allows continuous monitoring of growth kinetics for each metastatic site and visualization of lesions in more complex regions of the skeleton, such as the skull. Our findings suggest that fpVCT is a powerful tool that can be used to monitor the occurrence and progression of osteolytic lesions in vivo and can be further developed to monitor responses to antimetastatic therapies over the course of the disease.

Published
2007

27. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease

Author

Gross, Oliver, primary, Girgert, Rainer, additional, Beirowski, Bogdan, additional, Kretzler, Matthias, additional, Kang, Hee Gyung, additional, Kruegel, Jenny, additional, Miosge, Nicolai, additional, Busse, Ann-Christin, additional, Segerer, Stephan, additional, Vogel, Wolfgang F., additional, Müller, Gerhard-Anton, additional, and Weber, Manfred, additional

Published
2010
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33. Flat-Panel Detector—Based Volume Computed Tomography: A Novel 3D Imaging Technique to Monitor Osteolytic Bone Lesions in a Mouse Tumor Metastasis Model

Author

Missbach-Guentner, Jeannine, primary, Dullin, Christian, additional, Zientkowska, Marta, additional, Domeyer-Missbach, Melanie, additional, Kimmina, Sarah, additional, Obenauer, Silvia, additional, Kauer, Fritz, additional, Stühmer, Walter, additional, Grabbe, Eckhardt, additional, Vogel, Wolfgang F., additional, and Alves, Frauke, additional

Published
2007
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49. DDR1 signaling is essential to sustain Stat5 function during lactogenesis.

Author

Faraci-Orf E, McFadden C, and Vogel WF

Subjects
Animals, Base Sequence, Blotting, Western, DNA Primers, Discoidin Domain Receptor 1, Electrophoretic Mobility Shift Assay, Immunoprecipitation, Mice, Lactation, Mammary Glands, Animal metabolism, Membrane Proteins metabolism, Receptor Protein-Tyrosine Kinases metabolism, STAT5 Transcription Factor physiology
Abstract

Postnatal development of the mammary gland is achieved by an interplay of endocrine and extracellular matrix-derived signals. Despite intense research, a comprehensive understanding of the temporal and spatial coordination of these hormonal and basement membrane stimuli is still lacking. Here, we address the role of the collagen-receptor DDR1 in integrating extracellular matrix-derived signaling with the lactogenic pathway initiated by the prolactin receptor. We found that stimulation of DDR1-overexpressing mammary epithelial HC11 cells with collagen and prolactin resulted in stronger and more sustained induction of Stat5 phosphorylation as compared to control cells. Enhanced Stat5 activity in HC11-DDR1 cells correlated with increased beta-casein gene expression. In contrast, cells derived from DDR1-null mice showed reduced Stat5 activation upon lactogenic stimulation and completely failed to induce beta-casein expression. The cell-autonomous role of DDR1 in controlling ductal branching and alveologenesis prior to the onset of lactogenesis was corroborated by mammary tissue transplantation experiments. Our results show that aside from hormone- and cytokine receptors, DDR1 signaling establishes a third matrix-derived pathway vital to maintain mammary gland function., ((c) 2005 Wiley-Liss, Inc.)

Published
2006
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