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204 results on '"Vojnovic, Sandra"'

15. Silver(I) complexes containing antifungal azoles: Significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(I) ion

Author

Stanković, Mia, primary, Kljun, Jakob, additional, Stevanović, Nevena, additional, Lazic, Jelena, additional, Bogojevic, Sanja Skaro, additional, Vojnovic, Sandra, additional, Zlatar, Matija, additional, Nikodinovic-Runic, Jasmina, additional, Turel, Iztok, additional, Djuran, Miloš, additional, and Glisic, Biljana, additional

Published
2024
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26. Copper(ii) and silver(i) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex

Author

Andrejević, Tina P., primary, Aleksic, Ivana, additional, Kljun, Jakob, additional, Počkaj, Marta, additional, Zlatar, Matija, additional, Vojnovic, Sandra, additional, Nikodinovic-Runic, Jasmina, additional, Turel, Iztok, additional, Djuran, Miloš I., additional, and Glišić, Biljana Đ., additional

Published
2023
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27. Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates

Author

Garcia, Eduardo Lanzagorta, primary, Mojicevic, Marija, additional, Milivojevic, Dusan, additional, Aleksic, Ivana, additional, Vojnovic, Sandra, additional, Stevanovic, Milena, additional, Murray, James, additional, Attallah, Olivia Adly, additional, Devine, Declan, additional, and Fournet, Margaret Brennan, additional

Published
2022
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29. Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117

Author

Lazic Jelena, Bogojevic Skaro Sanja, Vojnovic Sandra, Aleksic Ivana, Milivojevic Dusan, Kretzschmar Martin, Gulder Tanja, Petkovic Milos, and Nikodinovic Runic Jasmina

Subjects
prodigiosin, Serratia, halogenation, bromination, anticancer activity, embryotoxicity, zebrafish
Abstract

Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessibleSerratia marcescensATCC 27117 strain has been achieved to levels of 14 mg/L of culture within 24 h. Furthermore, environmentally friendly bromination of produced PG was used to afford both novel mono- and dibrominated derivatives of PG. PG and its Br derivatives showed anticancer potential with IC50values range 0.62–17.00 µg/mL for all tested cancer cell lines and induction of apoptosis but low selectivity against healthy cell lines. All compounds did not affectCaenorhabditiselegansat concentrations up to 50 µg/mL. However, an improved toxicity profile of Br derivatives in comparison to parent PG was observed in vivo using zebrafish (Danio rerio) model system, when 10 µg/mL applied at 6 h post fertilization caused death rate of 100%, 30% and 0% by PG, PG-Br, and PG-Br2,respectively, which is a significant finding for further structural optimizations of bacterial prodigiosins. The drug-likeness of PG and its Br derivatives was examined, and the novel Br derivatives obey the Lipinski’s “rule of five”, with an exemption of being more lipophilic than PG, which still makes them good targets for further structural optimization.

Published
2022

30. Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117

Author

Lazic, Jelena, primary, Skaro Bogojevic, Sanja, additional, Vojnovic, Sandra, additional, Aleksic, Ivana, additional, Milivojevic, Dusan, additional, Kretzschmar, Martin, additional, Gulder, Tanja, additional, Petkovic, Milos, additional, and Nikodinovic-Runic, Jasmina, additional

Published
2022
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31. Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo

Author

Hertrampf, Gesa, Kusserow, Kalina, Vojnovic, Sandra, Pavic, Aleksandar, Müller, Jonas I., Nikodinovic-Runic, Jasmina, Gulder, Tobias A. M., Hertrampf, Gesa, Kusserow, Kalina, Vojnovic, Sandra, Pavic, Aleksandar, Müller, Jonas I., Nikodinovic-Runic, Jasmina, and Gulder, Tobias A. M.

Abstract

The increasing emergence of resistances against established antibiotics is a substantial threat to human health. The discovery of new compounds with potent antibiotic activity is thus of utmost importance. Within this work, we identify strong antibiotic activity of the natural product myxocoumarin B from Stigmatella aurantiaca MYX-030 against a range of clinically relevant bacterial pathogens, including clinical isolates of MRSA. A focused library of structural analogs was synthesized to explore initial structure-activity relationships and to identify equipotent myxocoumarin derivatives devoid of the natural nitro substituent to significantly streamline synthetic access. The cytotoxicity of the myxocoumarins as well as their potential to cure bacterial infections in vivo was established using a zebrafish model system. Our results reveal the exceptional antibiotic activity of the myxocoumarin scaffold and hence its potential for the development of novel antibiotics.

Published
2022

43. Silver(i) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens

Author

Andrejević, Tina P., primary, Milivojevic, Dusan, additional, Glišić, Biljana Đ., additional, Kljun, Jakob, additional, Stevanović, Nevena Lj., additional, Vojnovic, Sandra, additional, Medic, Strahinja, additional, Nikodinovic-Runic, Jasmina, additional, Turel, Iztok, additional, and Djuran, Miloš I., additional

Published
2020
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44. Dinuclear silver(i) complexes with a pyridine-based macrocyclic type of ligand as antimicrobial agents against clinically relevant species: the influence of the counteranion on the structure diversification of the complexes

Author

Savić, Nada D., primary, Petković, Branka B., additional, Vojnovic, Sandra, additional, Mojicevic, Marija, additional, Wadepohl, Hubert, additional, Olaifa, Kayode, additional, Marsili, Enrico, additional, Nikodinovic-Runic, Jasmina, additional, Djuran, Miloš I., additional, and Glišić, Biljana Đ., additional

Published
2020
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45. Antiplasmodial activity and in vivo bio-distribution of chloroquine molecules released with a 4-(4-ethynylphenyl)-triazole moiety from organometallo-cobalamins

Author

Rossier, Jeremie, Sovari, Sara Nasiri, Pavic, Aleksandar, Vojnovic, Sandra, Stringer, Tameryn, Bättig, Sarah, Smith, Gregory S., Nikodinovic-Runic, Jasmina, Zobi, Fabio, Rossier, Jeremie, Sovari, Sara Nasiri, Pavic, Aleksandar, Vojnovic, Sandra, Stringer, Tameryn, Bättig, Sarah, Smith, Gregory S., Nikodinovic-Runic, Jasmina, and Zobi, Fabio

Abstract

We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots on the preparation of azide- functionalized drugs which, after coupling to the vitamin, are released with a 4-(4- ethynylphenyl)-triazole functionality. Three chloroquine and one imidazolopiperazine derivative (based on the KAF156 structure) were selected as model drugs. One hybrid chloroquine conjugate was extensively studied via fluorescent labelling for in vitro and in vivo bio-distribution studies and gave proof-of-concept for the design. It showed no toxicity in vivo (zebrafish model) as well as no hepatotoxicity, no cardiotoxicity or developmental toxicity of the embryos. All 4-(4-ethynylphenyl)-triazole derivatives of chloroquine were equally active against chloroquine-resistant (CQR) and chloroquine- sensitive (CQS) Plasmodium falciparum strains.

Published
2019

49. Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

Author

Ilić-Tomić, Tatjana, Soković, Marina, Vojnovic, Sandra, Ciric, Ana, Veljić, Milan, Nikodinović-Runić, Jasmina, Novaković, Miroslav, Ilić-Tomić, Tatjana, Soković, Marina, Vojnovic, Sandra, Ciric, Ana, Veljić, Milan, Nikodinović-Runić, Jasmina, and Novaković, Miroslav

Abstract

Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.

Published
2017

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