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4. Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, de Celis, Elena, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbrig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hametner, Christian, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Haeusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefaloykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, de Leciñana, Alonso, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zamani, Mahtab, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2024
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6. Performance of a GPU- and Time-Efficient Pseudo 3D Network for Magnetic Resonance Image Super-Resolution and Motion Artifact Reduction

Author

Li, Hao, Liu, Jianan, Schell, Marianne, Huang, Tao, Lauer, Arne, Schregel, Katharina, Jesser, Jessica, Vollherbst, Dominik F, Bendszus, Martin, Heiland, Sabine, and Hilgenfeld, Tim

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Physics - Medical Physics
Abstract

Shortening acquisition time and reducing motion artifacts are the most critical challenges in magnetic resonance imaging (MRI). Deep learning-based image restoration has emerged as a promising solution capable of generating high-resolution and motion-artifact-free MRI images from low-resolution images acquired with shortened acquisition times or from motion-artifact-corrupted images. To facilitate clinical integration, a time- and GPU-efficient network with reliable accuracy is essential. In this study, we adopted a unified 2D deep learning framework for pseudo-3D MRI image super-resolution reconstruction (SRR) and motion artifact reduction (MAR). The optimal down-sampling factors to optimize the acquisition time in SRR were identified. Training for MAR was performed using publicly available in vivo data, employing a novel standardized method to induce motion artifacts of varying severity in a controlled way. The accuracy of the network was evaluated through a pixel-wise uncertainty map, and performance was benchmarked against state-of-the-art methods. The results demonstrated that the down-sampling factor of 1x1x2 for x2 acceleration and 2x2x2 for x4 acceleration was optimal. For SRR, the proposed TS-RCAN outperformed the 3D networks of mDCSRN and ReCNN, with an improvement of more than 0.01 in SSIM and 1.5 dB in PSNR while reducing GPU load by up to and inference time by up to 90%. For MAR, TS-RCAN exceeded UNet's performance by up to 0.014 in SSIM and 1.48 dB in PSNR. Additionally, TS-RCAN provided uncertainty information, which can be used to estimate the quality of the reconstructed images. TS-RCAN has potential use for SRR and MAR in the clinical setting., Comment: 16 pages, 9 figures

Published
2021

12. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, Celis, Elena de, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Häusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefalaykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, Leciñana, Alonso de, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2023
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18. Iatrogenic air embolism: influence of air bubble size on cerebral infarctions in an experimental in vivo and numerical simulation model.

Author

Schaefer, Tabea C., Greive, Svenja, Bierwisch, Claas, Mohseni-Mofidi, Shoya, Heiland, Sabine, Kramer, Martin, Möhlenbruch, Markus A., Bendszus, Martin, and Vollherbst, Dominik F.

Subjects
COMPUTER simulation, RISK assessment, BIOLOGICAL models, IATROGENIC diseases, ENDOVASCULAR surgery, IN vivo studies, MAGNETIC resonance imaging, RATS, ANIMAL experimentation, GAS embolism, CEREBRAL infarction, CEREBROVASCULAR disease, DISEASE risk factors, DISEASE complications
Abstract

Background Cerebral infarctions resulting from iatrogenic air embolism (AE), mainly caused by small air bubbles, are a well-known and often overlooked event in endovascular interventions. Despite their significance, the underlying pathophysiology remains largely unclear. Methods In 24 rats, AEs were induced using a microcatheter, positioned in the carotid artery via femoral access. Rats were divided into two study groups, based on the size of the bubbles (85 and 120 µm) and two sub-groups, differing in air volume (0.39 and 0.64 µl). Ultra-high-field magnetic resonance imaging (MRI) was performed 1.5 hours after intervention. MRI findings including the number, single volume and total volume of the infarctions were assessed. A software-based numerical simulation was performed to qualitatively assess the microvascular pathomechanisms. Results In the study groups 22 of 24 rats (92%) revealed cerebral infarctions. The number of infarctions per rat was higher for the smaller bubbles, for the lower (medians: 5 vs 3; p=0.049) and higher air volume subgroups (medians: 6 vs 4; p=0.012). Correspondingly, total infarction volume was higher for the smaller bubbles (1.67 vs 0.5 mm³; p=0.042). Simulations confirmed the results of the experiments and suggested that fusion of microbubbles to larger bubbles is the underlying pathomechanism of vascular occlusions. Conclusion In iatrogenic AE, the size of the bubbles can have a major impact on the number and total volume of cerebral infarctions. These findings can help to better understand the pathophysiology of this frequent, often underestimated adverse event in endovascular interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Safety and efficacy of coated flow diverters in the treatment of ruptured intracranial aneurysms: a retrospective multicenter study

Author

Goertz, Lukas, primary, Hohenstatt, Sophia, additional, Vollherbst, Dominik F, additional, Weyland, Charlotte Sabine, additional, Nikoubashman, Omid, additional, Styczen, Hanna, additional, Gronemann, Christian, additional, Weiss, Daniel, additional, Kaschner, Marius, additional, Pflaeging, Muriel, additional, Siebert, Eberhard, additional, Zopfs, David, additional, Kottlors, Jonathan, additional, Pennig, Lenhard, additional, Schlamann, Marc, additional, Bohner, Georg, additional, Liebig, Thomas, additional, Turowski, Bernd, additional, Dorn, Franziska, additional, Deuschl, Cornelius, additional, Wiesmann, Martin, additional, Möhlenbruch, Markus A, additional, and Kabbasch, Christoph, additional

Published
2024
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24. MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome.

Author

Karimian-Jazi, Kianush, Vollherbst, Dominik F., Schwarz, Daniel, Fischer, Manuel, Schregel, Katharina, Bauer, Gregor, Kocharyan, Anna, Sturm, Volker, Neuberger, Ulf, Jesser, Jessica, Herweh, Christian, Ulfert, Christian, Hilgenfeld, Tim, Seker, Fatih, Preisner, Fabian, Schmitt, Niclas, Charlet, Tobias, Hamelmann, Stefan, Sahm, Felix, and Heiland, Sabine

Subjects
THROMBOSIS surgery, THROMBOLYTIC therapy, ERYTHROCYTES, TREATMENT effectiveness, MAGNETIC resonance imaging, DESCRIPTIVE statistics, LONGITUDINAL method, BLOOD platelets, THROMBECTOMY, MICROSCOPY, THROMBOSIS, SENSITIVITY & specificity (Statistics)
Abstract

Background Mechanical thrombectomy (MT) is the standard of care for patients with a stroke and large vessel occlusion. Clot composition is not routinely assessed in clinical practice as no specific diagnostic value is attributed to it, and MT is performed in a standardized 'non-personalized' approach. Whether different clot compositions are associated with intrinsic likelihoods of recanalization success or treatment outcome is unknown. Methods We performed a prospective, nonrandomized, single-center study and analyzed the clot composition in 60 consecutive patients with ischemic stroke undergoing MT. Clots were assessed by ex vivo multiparametric MRI at 9.4 T (MR microscopy), cone beam CT, and histopathology. Clot imaging was correlated with preinterventional CT and clinical data. Results MR microscopy showed red blood cell (RBC)- rich (21.7%), platelet-rich (white,38.3%) or mixed clots (40.0%) as distinct morphological entities, and MR microscopy had high accuracy of 95.4% to differentiate clots. Clot composition could be further stratified on preinterventional non-contrast head CT by quantification of the hyperdense artery sign. During MT, white clots required more passes to achieve final recanalization and were not amenable to contact aspiration compared with mixed and RBC-rich clots (maneuvers: 4.7 vs 3.1 and 1.2 passes, P<0.05 and P<0.001, respectively), whereas RBC-rich clots showed higher probability of first pass recanalization (76.9%) compared with white clots (17.4%). White clots were associated with poorer clinical outcome at discharge and 90 days after MT. Conclusion Our study introduces MR microscopy to show that the hyperdense artery sign or MR relaxometry could guide interventional strategy. This could enable a personalized treatment approach to improve outcome of patients undergoing MT. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Technique and impact on first pass effect primary results of the ASSIST global registry

Author

Gupta, Rishi, primary, Miralbés, Salvador, additional, Calleja Bonilla, Angel, additional, Naravetla, Bharath, additional, Majjhoo, Aniel Q, additional, Rayes, Mahmoud, additional, Spiotta, Alejandro M, additional, Loehr, Christian, additional, Cioltan, Andreea, additional, Vollherbst, Dominik F, additional, Martínez-Galdámez, Mario, additional, Galván-Fernandez, Jorge, additional, Khaldi, Ahmad, additional, McTaggart, Ryan A., additional, Jayaraman, Mahesh V, additional, Defreyne, Luc, additional, Dhondt, Elisabeth, additional, Vega, Pedro, additional, Murias, Eduardo, additional, Lin, Eugene, additional, Chaubal, Varun, additional, Price, Lori Lyn, additional, Liebeskind, David S, additional, and Möhlenbruch, Markus A, additional

Published
2024
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27. Non-ischemic cerebral enhancing (NICE) lesions after flow diversion for intracranial aneurysms: a multicenter study

Author

Richter, Cindy, primary, Möhlenbruch, Markus A, additional, Vollherbst, Dominik F, additional, Taschner, Christian A, additional, Elsheikh, Samer, additional, Klisch, Joachim, additional, Lobsien, Donald, additional, Bester, Maxim, additional, Ramdani, Nora, additional, Kaiser, Daniel P O, additional, Gerber, Johannes C, additional, Schob, Stefan, additional, Gazis, Angelos, additional, Smirnov, Paulina, additional, Scherlach, Cordula, additional, Hoffmann, Karl-Titus, additional, and Gawlitza, Matthias, additional

Published
2024
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31. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Author

Bendszus, Martin, primary, Fiehler, Jens, additional, Subtil, Fabien, additional, Bonekamp, Susanne, additional, Aamodt, Anne Hege, additional, Fuentes, Blanca, additional, Gizewski, Elke R, additional, Hill, Michael D, additional, Krajina, Antonin, additional, Pierot, Laurent, additional, Simonsen, Claus Z, additional, Zeleňák, Kamil, additional, Blauenfeldt, Rolf A, additional, Cheng, Bastian, additional, Denis, Angélique, additional, Deutschmann, Hannes, additional, Dorn, Franziska, additional, Flottmann, Fabian, additional, Gellißen, Susanne, additional, Gerber, Johannes C, additional, Goyal, Mayank, additional, Haring, Jozef, additional, Herweh, Christian, additional, Hopf-Jensen, Silke, additional, Hua, Vi Tuan, additional, Jensen, Märit, additional, Kastrup, Andreas, additional, Keil, Christiane Fee, additional, Klepanec, Andrej, additional, Kurča, Egon, additional, Mikkelsen, Ronni, additional, Möhlenbruch, Markus, additional, Müller-Hülsbeck, Stefan, additional, Münnich, Nico, additional, Pagano, Paolo, additional, Papanagiotou, Panagiotis, additional, Petzold, Gabor C, additional, Pham, Mirko, additional, Puetz, Volker, additional, Raupach, Jan, additional, Reimann, Gernot, additional, Ringleb, Peter Arthur, additional, Schell, Maximilian, additional, Schlemm, Eckhard, additional, Schönenberger, Silvia, additional, Tennøe, Bjørn, additional, Ulfert, Christian, additional, Vališ, Kateřina, additional, Vítková, Eva, additional, Vollherbst, Dominik F, additional, Wick, Wolfgang, additional, Thomalla, Götz, additional, Adamczewski, Olaf, additional, Alektoror, Kirill, additional, Alexander, März, additional, Alexandrou, Maria, additional, Alias, Quentin, additional, Al-Kuzae, Fadha Elawi, additional, Allard, Julien, additional, Al-Schameri, Rahman, additional, Álvarez, Alberto, additional, Andersen, Grethe, additional, AnkerlundBlaufeldt, Rolf, additional, Antje, Riedel, additional, Appelbohm, Hannes, additional, Argren, Maria, additional, Assmann, Anne, additional, Augustin, Michael, additional, Bach, Elke, additional, Bar, Michal, additional, Barleben, Maria, additional, Baronnet, Flore, additional, Barrios, Andrés, additional, Bavúzová, Xénia, additional, BayThomsen, Rikke, additional, Becker, Sandra, additional, Beer, Sylvia, additional, Behme, Daniel, additional, Bellut, Maximilian, additional, Bendszus, Martin, additional, Berkefeld, Joachim, additional, Bester, Maximillian, additional, Bode, Felix J., additional, Boehme, Christian, additional, Boese, Ramona, additional, Bohmann, Ferdinand, additional, Borggrefe, Jan, additional, Boss, Erendira Gabriela, additional, Boutchakova, Maria, additional, Boxhammer, Elfi, additional, Brandhofe, Annemarie, additional, Breckwoldt, Michael, additional, Brekenfeld, Casper, additional, Brehm, Alex, additional, Brem, Christian, additional, Breuer, Stella, additional, Breyer, Tobias, additional, Brodová, Petra, additional, Broocks, Gabriel, additional, Brosinski, Christoph, additional, Bubel, Nele, additional, Búřil, Jiří, additional, Čábal, Martin, additional, Casado, Laura, additional, Celis, Elena de, additional, Chabert, Emmanuel, additional, Charisse, Daniel, additional, Chovanec, Vendelín, additional, Cidlinsky, Peter, additional, Cisár, Juraj, additional, Clarençon, Fréderic, additional, Crozier, Sophie, additional, Čurdová, Nina, additional, Damaskinos, Michele, additional, Damgaard, Dorte, additional, Daniš, Martin, additional, Dazinger, Florian, additional, Deb-Chatterji, Milani, additional, Delalic, Asima, additional, Delekta, Agnieszka, additional, Delorme, Stephen, additional, Diamandis, Elie, additional, Diedrichsen, Tove, additional, Doležalová, Irena, additional, du Mesnil de Rochemont, Richard, additional, DupontHougaard, Kristina, additional, Ebrahimi, Taraneh, additional, Eff, Florian, additional, Eliášová, Ilona, additional, Enriquez, Brian, additional, Ergawy, Mostafa, additional, Essig, Fabian, additional, Falkesgaard, Maiken, additional, Fandler-Höfler, Simon, additional, Fernández, Andrés, additional, Ferré, Jean-Christophe, additional, Ferrier, Anna, additional, Figlewski, Krystian, additional, Fischer, Sebastian, additional, Fischer, Urs, additional, Forbig, Robert, additional, Förch, Christian, additional, Fromm, Annette, additional, Gaedke, Ines, additional, Galczak, Romana, additional, Galijasevic, Malik, additional, Ganser, Bernhard, additional, Gattringer, Thomas, additional, Gawlitza, Matthias, additional, Gelhard, Sarah, additional, Gerber, Johannes, additional, Giannakakis, Michail Panagiotis, additional, Gindlhuber, Karin, additional, Gizewski, Elke R., additional, Glodny, Bernhard, additional, Godel, Tim, additional, Goebell, Einar, additional, Goldemund, David, additional, Görtler, Michael, additional, Grams, Astrid E., additional, Gruber, Joachim, additional, Gruber, Katharina, additional, Günthner-Lengsfeld, Thomas, additional, Haase, Kathrin, additional, Hacker-Ivan, Floriana, additional, Hallerstig, Erika, additional, Hanning, Uta, additional, Haršány, Michal, additional, Haršány, Ján, additional, Hartmann, Christian, additional, Hassler, Eva Maria, additional, Hauptmann, Kristina, additional, Häusler, Karl Georg, additional, Hecker, Constantin, additional, Hellstern, Victoria, additional, Henkes, Hans, additional, Hernández, Victoria, additional, Hilgenfeld, Tim, additional, Hill, Michael D., additional, Hjort, Niels, additional, HjortJensen, Nina, additional, Hoelter, Maya, additional, Hoffmann, Karl-Titus, additional, Holst, Brigitte, additional, Holtmannspoetter, Markus, additional, Hoppe, Julia, additional, Horner, Susanne, additional, HougaardSoerensen, Leif, additional, Hubert, Alexander, additional, Hurtíková, Eva, additional, Jakubíček, Stanislava, additional, Janjic, Tanja, additional, Jaramillo, Kirsten, additional, Jedlitschka, Angela, additional, Jensen, Schiela, additional, Jesser, Jessica, additional, Jestaedt, Leonie, additional, Johnson, Sabine, additional, Jonszta, Tomáš, additional, Kalmar, Peter, additional, Karabegovic, Sanja, additional, Karen, Kollo, additional, Katja, Hopp, additional, Keeba, Natalia, additional, Keese, Petra, additional, Kefalaykos, Christina, additional, Keil, Fee, additional, Kellert, Lars, additional, Kellinghaus, Christoph, additional, Kestner, Roxane-Isabelle, additional, Kiechl, Stefan, additional, Killer-Oberpfalzer, Monika, additional, Knispel, Casjupea, additional, Knoflach, Michael, additional, Kohler, Sabine, additional, Kohlhase, Konstantin, additional, Kollikowski, Alexander Marco, additional, Kovář, Martin, additional, Krajina, Antonín, additional, Kral, Michael, additional, Krastev, Georgi, additional, Krause, Lars Udo, additional, Kreidenhuber, Rudolf, additional, Křivka, Tomáš, additional, Krkoška, Adam, additional, Kröger, Jan Robert, additional, Kronlage, Moritz, additional, Krukowski, Pawel, additional, Kühn, Julia, additional, Kurka, Natalia, additional, Kuschnerow, Michael, additional, Lachmund, Rita, additional, Lamprecht, Susanne, additional, Lange, Rüdiger, additional, Lauer, Monika, additional, Leciñana, Alonso de, additional, Leder, Sara, additional, Leger, Anne, additional, Lehnen, Nils, additional, Lehrieder, Dominik, additional, Leißner, Maximilian, additional, Leitinger, Markus, additional, Leitner, Ursula, additional, Lenck, Stéphanie, additional, Lenzenweger, Eva, additional, Liebig, Thomas, additional, Lowens, Stephan, additional, Lunzer, Manuel, additional, Maegerlein, Christian, additional, Magyar, Marton, additional, Marques, Leonardo, additional, Matyáš, David, additional, Maurer, Gabriele, additional, Mauritz, Matthias, additional, Maximilian, Thormann, additional, Mayer-Süß, Lukas, additional, Meckel, Stephan, additional, Medek, Oldřich, additional, Meissner, Julius N., additional, Mencl, Pavel, additional, Merkle, Andrea, additional, Mesche, Birte, additional, Michalski, Dominik, additional, Mikulík, Robert, additional, Modrau, Boris, additional, Möhlenbruch, Markus A., additional, Mohr, Alexander, additional, Mönninghoff, Christoph, additional, Moser, Tobias, additional, Mücke, Ramona, additional, Müller-Thies-Broussalis, Erasmia, additional, Mutzenbach, Sebastian, additional, Navia, Pedro, additional, Neuberger, Ulf, additional, Neugebauer, Hermann, additional, Neumann, Jens, additional, Nguyên, Anh, additional, Niederkorn, Kurt, additional, Nosál', Vladimír, additional, Novobilský, Richard, additional, Ntoulias, Nikos, additional, Nussbaum, Lukas, additional, Oder, Joanna, additional, Oldag, Andreas, additional, Ondrejkovič, Marián, additional, Otto, Ferdinand, additional, Otto, Dagmar, additional, Paech, Daniel, additional, Pallesen, Lars-Peder, additional, Panský, Michal, additional, Patrick, Samp, additional, Paukisch, Harald, additional, Pelz, Johann, additional, Petersen, Inga, additional, Petersen, Martina, additional, Petzold, Gabor C., additional, Pfaff, Johannes, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pikija, Slaven, additional, PlougmannPovlsen, Jan, additional, Polkowski, Christoph, additional, Polomac, Nenad, additional, Portugaller, Rupert Horst, additional, Poulsen, Marika, additional, Preiß, Michael, additional, Premat, Kévin, additional, Prestsæter, Sjur, additional, Prieto-Pérez, Rocio, additional, Psychogios, Marios, additional, Purrucker, Jan, additional, Rai, Heike, additional, Rauch, Maximilian, additional, Reimann, Georg, additional, Reitz, Sarah, additional, Renc, Ondřej, additional, Retzlaff, Jasmin, additional, Rigual, Ricardo, additional, Rivera-Bengoa, Carlota, additional, Rodríguez, Jorge, additional, Rohde, Stefan, additional, Rohler, Siegfried, additional, Rosso, Charlotte, additional, Roth, Christian, additional, Röttcher, Thomas, additional, Roubec, Martin, additional, Roztočilová, Milada, additional, Rudnicka, Svetlana, additional, Ruiz, Gerardo, additional, Ryan, Stephen, additional, Ryckborst, Karla J., additional, Sandvik, Simen, additional, Schäfer, Jan-Hendrik, additional, Schaller-Paule, Martin, additional, Schell, Maximillian, additional, Schellinger, Peter, additional, Schmid, Florian, additional, Schmidt, Christoph, additional, Schmitz, Marie Louise, additional, Schneider, Claus, additional, Scholtz, Jan-Erik, additional, Schröter, Andreas, additional, Schwarz, Daniel, additional, Schwarz, Stephan, additional, Schwarzenhofer, Daniel, additional, Seifert-Held, Thomas, additional, Seiler, Alexander, additional, Seker, Fatih, additional, Shotar, Eimad, additional, Simonsen, Claus Z., additional, Simonsen, Maria Theresa, additional, Sivák, Jozef, additional, Skagen, Karolina, additional, Skjelland, Mona, additional, Šnajdrová, Alena, additional, Solymosi, Lazlo, additional, Sømark, Jesper, additional, Sonnberger, Michael, additional, Soršák, Jakub, additional, Sourour, Nader, additional, Søyland, Jogrim, additional, Spitzer, Daniel, additional, Sporns, Peter, additional, Städt, Michael, additional, Steidl, Eike, additional, Størdal, Anne Margrethe Kaalaas, additional, Stösser, Sebastian, additional, Strickmann, Sarah, additional, Strýček, Ondřej, additional, Suškevič, Igor, additional, Sýkora, Jan, additional, Thaler, Daniela, additional, Theisen, Sara, additional, Trendafilov, Petar, additional, Trenkler, Johannes, additional, Trumm, Christoph, additional, Tsogkas, Ioannis, additional, Tunold, Jon-Anders, additional, Tveit, Lars, additional, Vaníček, Jiří, additional, Vassilev, Christine, additional, Voit-Höhne, Heinz-Leonhard, additional, Vojtíšek, Bohuslav, additional, Volderauer, Karoline, additional, Vollherbst, Dominik, additional, Vollmuth, Christoph, additional, Volna, Kamila, additional, Volný, Ondřej, additional, VonWeitzel-Mudersbach, Poul, additional, Vorčák, Martin, additional, Wagner, Marlies, additional, Wathle, Gaute Kjellevold, additional, Weber, Werner, additional, Weber, Anushe, additional, Weiss, Viktor, additional, Weller, Johannes M., additional, Wenger-Alakmeh, Katharina, additional, Weyland, Cyrill, additional, Weymayr, Friedrich, additional, Wießpeiner, Ulrike, additional, Willeit, Johannes, additional, Wittwer, Aymeric, additional, Wollenweber, Frank, additional, Wortmann, Ginette, additional, Wunderlich, Silke, additional, Xiong, Yanyan, additional, You, Se-Jong, additional, ZachoSpeiser, Lasse, additional, Zelenak, Kamil, additional, Zeleňáková, Jana, additional, and Zubel, Seraphine, additional

Published
2023
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36. MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome

Author

Karimian-Jazi, Kianush, primary, Vollherbst, Dominik F, additional, Schwarz, Daniel, additional, Fischer, Manuel, additional, Schregel, Katharina, additional, Bauer, Gregor, additional, Kocharyan, Anna, additional, Sturm, Volker, additional, Neuberger, Ulf, additional, Jesser, Jessica, additional, Herweh, Christian, additional, Ulfert, Christian, additional, Hilgenfeld, Tim, additional, Seker, Fatih, additional, Preisner, Fabian, additional, Schmitt, Niclas, additional, Charlet, Tobias, additional, Hamelmann, Stefan, additional, Sahm, Felix, additional, Heiland, Sabine, additional, Wick, Wolfgang, additional, Ringleb, Peter A, additional, Schirmer, Lucas, additional, Bendszus, Martin, additional, Möhlenbruch, Markus A, additional, and Breckwoldt, Michael O, additional

Published
2023
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38. Prediction and outcomes of cerebral vasospasm in ischemic stroke patients receiving anterior circulation endovascular stroke treatment

Author

Jesser, Jessica, primary, Awounvo, Sinclair, additional, Vey, Johannes A, additional, Vollherbst, Dominik F, additional, Hilgenfeld, Tim, additional, Chen, Min, additional, Nguyen, Thanh N, additional, Schönenberger, Silvia, additional, Bendszus, Martin, additional, Möhlenbruch, Markus A, additional, and Weyland, Charlotte S, additional

Published
2023
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39. LIQUID - Treatment of high-grade dural arteriovenous fistulas with Squid liquid embolic agent: a prospective, observational multicenter study.

Author

Vollherbst, Dominik F., Boppel, Tobias, Wallocha, Marta, Berlis, Ansgar, Maurer, Christoph J., Weber, Werner, Fischer, Sebastian, Bock, Alexander, Meckel, Stephan, Bohner, Georg, Liebig, Thomas, Herweh, Christian, Bendszus, Martin, Chapot, René, and Möhlenbruch, Markus A.

Subjects
SCIENTIFIC observation, CLINICAL trials, THERAPEUTIC embolization, ARTERIOVENOUS fistula, TREATMENT effectiveness, POLYMERS, RESEARCH funding, ENDOVASCULAR surgery, ARTERIOVENOUS malformation, PATIENT safety, LONGITUDINAL method, CRANIAL sinuses
Abstract

Background Endovascular embolization is a feasible treatment for cranial dural arteriovenous fistulas (DAVFs). New embolic agents aim to improve the success of DAVF embolization. Objective To assess the safety, efficacy, and short-term outcome of the treatment of DAVFs using the new liquid embolic agent Squid. Methods The LIQUID study is a prospective, observational multicenter study on the treatment of highgrade (Cognard type ≥3) DAVFs with the embolic agent Squid. The primary outcome measures were safety (ie, morbidity and mortality), as well as the occlusion rate 90 to 180 days after treatment. Results In eight centers, 53 patients (mean age 59.8 years, 22.6% female) were treated in 55 treatment sessions. Of the DAVFs, 56.6% were Cognard type III, 41.5% type IV, and 18.9% were ruptured. Squid 18 was used in 83.6% and Squid 12 in 32.7% of the treatments. The overall rate of intraprocedural or postprocedural adverse events (AEs) was 18.2%. Procedure-related AEs resulting in permanent morbidity were observed in 3.6%. One patient (1.8%) died unrelated to the procedure due to pulmonary embolism. The final complete occlusion rate at 90 to 180 days was 93.2%. After a mean follow-up of 5.5 months, the modified Rankin Scale (mRS) score was stable or improved in 93.0%. In one of the patients, worsening of the mRS score was related to the procedure (1.8%). Conclusion Squid is a safe and effective liquid embolic agent for the treatment of high-grade DAVFs. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Visibility of liquid embolic agents in fluoroscopy: a systematic in vitro study.

Author

Schmitt, Niclas, Wucherpfennig, Lena, Hohenstatt, Sophia, Weyland, Charlotte S., Sommer, Christof M., Bendszus, Martin, Möhlenbruch, Markus A., and Vollherbst, Dominik F.

Subjects
IN vitro studies, CEREBROVASCULAR disease, THERAPEUTIC embolization, QUANTITATIVE research, CONTRAST media, FLUOROSCOPY, QUALITATIVE research, DESCRIPTIVE statistics, ENDOVASCULAR surgery
Abstract

Background Endovascular embolization using liquid embolic agents (LEAs) is frequently applied for the treatment of intracranial vascular malformations. Appropriate visibility of LEAs during embolization is essential for visual control and to prevent complications. Since LEAs contain different radiopaque components of varying concentrations, our aim was the systematic assessment of the visibility of the most used LEAs in fluoroscopy. Methods A specifically designed in vitro model, resembling cerebral vessels, was embolized with Onyx 18, Squid 18, Squid 12, PHIL (precipitating hydrophobic injectable liquid) 25%, PHIL LV (low viscosity) and NBCA (n-butyl cyanoacrylate) mixed with iodized oil (n=3 for each LEA), as well as with contrast medium and saline, both serving as a reference. Fluoroscopic image acquisition was performed in accordance with clinical routine settings. Visibility was graded quantitatively (contrast to noise ratio, CNR) and qualitatively (five-point scale). Results Overall, all LEAs provided at least acceptable visibility in this in vitro model. Onyx and Squid as well as NBCA mixed with iodized oil were best visible at a comparable level and superior to the formulations of PHIL, which did not differ in quantitative and qualitative analyses (eg, Onyx 18 vs PHIL 25% along the 2.0 mm sector: mean CNR±SD: 3.02±0.42 vs 1.92±0.35; mean score±SD: 5.00±0.00 vs 3.75±0.45; p≤0.001, respectively). Conclusion In this systematic in vitro study, relevant differences in the fluoroscopic visibility of LEAs in neurointerventional embolization procedures were demonstrated, while all investigated LEAs provided acceptable visibility in our in vitro model. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Investigation of Experimental Endovascular Air Embolisms Using a New Model for the Generation and Detection of Highly Calibrated Micro Air Bubbles.

Author

C. Schaefer, Tabea, Greive, Svenja, Heiland, Sabine, Kramer, Martin, Bendszus, Martin, and Vollherbst, Dominik F.

Abstract

Background: Air embolism (AE), especially when affecting the brain, is an underrated and potentially life-threatening complication in various endovascular interventions. This study aims to investigate experimental AEs using a new model to generate micro air bubbles (MAB), to assess the impact of a catheter on these MAB, and to demonstrate the applicability of this model in vivo. Materials and Methods: Micro air bubbles were created using a system based on microfluidic channels. The MAB were detected and analyzed automatically. Micro air bubbles, with a target size of 85 µm, were generated and injected through a microcatheter. The MAB diameters proximal and distal to the catheter were assessed and compared. In a subsequent in vivo application, 2000 MAB were injected into the aorta (at the aortic valve) and into the common carotid artery (CCA) of a rat, respectively, using a microcatheter, resembling AE occurring during cardiovascular interventions. Results: Micro air bubbles with a highly calibrated size could be successfully generated (median: 85.5 µm, SD 1.9 µm). After passage of the microcatheter, the MAB were similar in diameter (median: 86.6 µm) but at a lower number (60.1% of the injected MAB) and a substantially higher scattering of diameters (SD 29.6 µm). In vivo injection of MAB into the aorta resulted in cerebral microinfarctions in both hemispheres, whereas injection into the CCA caused exclusively ipsilateral microinfarctions. Conclusion: Using this new AE model, MAB can be generated precisely and reproducibly, resulting in cerebral microinfarctions. This model is feasible for further studies on the pathophysiology and prevention of AE in cardiovascular procedures. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Metal artifacts and artifact reduction of neurovascular coils in photon-counting detector CT versus energy-integrating detector CT — in vitro comparison of a standard brain imaging protocol

Author

Schmitt, Niclas, primary, Wucherpfennig, Lena, additional, Rotkopf, Lukas T., additional, Sawall, Stefan, additional, Kauczor, Hans-Ulrich, additional, Bendszus, Martin, additional, Möhlenbruch, Markus A., additional, Schlemmer, Heinz-Peter, additional, and Vollherbst, Dominik F., additional

Published
2022
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48. sj-docx-1-jet-10.1177_15266028221082010 ��� Supplemental material for Investigation of Experimental Endovascular Air Embolisms Using a New Model for the Generation and Detection of Highly Calibrated Micro Air Bubbles

Author

C. Schaefer, Tabea, Greive, Svenja, Heiland, Sabine, Kramer, Martin, Bendszus, Martin, and Vollherbst, Dominik F.

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110323 Surgery
Abstract

Supplemental material, sj-docx-1-jet-10.1177_15266028221082010 for Investigation of Experimental Endovascular Air Embolisms Using a New Model for the Generation and Detection of Highly Calibrated Micro Air Bubbles by Tabea C. Schaefer, Svenja Greive, Sabine Heiland, Martin Kramer, Martin Bendszus and Dominik F. Vollherbst in Journal of Endovascular Therapy

Published
2022
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49. First clinical multicenter experience with the new Pipeline Vantage flow diverter

Author

Vollherbst, Dominik F, primary, Cekirge, H Saruhan, additional, Saatci, Isil, additional, Baltacioglu, Feyyaz, additional, Onal, Baran, additional, Koc, Osman, additional, Rautio, Riitta, additional, Sinisalo, Matias, additional, Tomasello, Alejandro, additional, Vega, Pedro, additional, Martínez-Galdámez, Mario, additional, Lynch, Jeremy, additional, Mendes Pereira, Vitor, additional, Bendszus, Martin, additional, and Möhlenbruch, Markus A, additional

Published
2022
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