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113 results on '"Voltarelli, Júlio C."'

4. Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation

Author

Arruda, Lucas C.M., de Azevedo, Júlia T.C., de Oliveira, Gislane L.V., Scortegagna, Gabriela T., Rodrigues, Evandra S., Palma, Patrícia V.B., Brum, Doralina G., Guerreiro, Carlos T., Marques, Vanessa D., Barreira, Amilton A., Covas, Dimas T., Simões, Belinda P., Voltarelli, Júlio C., Oliveira, Maria Carolina, and Malmegrim, Kelen C.R.

Published
2016
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6. Risks of Immune System Treatments

Author

BURT, RICHARD K., ABINUN, MARIO, FARGE-BANCEL, DOMINIQUE, FASSAS, ATHANASIOS, HIEPE, FALK, HAVRDOVÁ, EVA, IKEHARA, SUSUMU, LOH, YVONNE, DU HAUT CHAMP, ALBERTO MARMONT, VOLTARELLI, JÚLIO C., SNOWDEN, JOHN, and SLAVIN, SHIMON

Published
2010

11. Neurovascular Aspects of Amyotrophic Lateral Sclerosis

Author

Rodrigues, Maria Carolina O., primary, Hernandez-Ontiveros, Diana G., additional, Louis, Michael K., additional, Willing, Alison E., additional, Borlongan, Cesario V., additional, Sanberg, Paul R., additional, Voltarelli, Júlio C., additional, and Garbuzova-Davis, Svitlana, additional

Published
2012
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16. C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

Author

Couri, Carlos E. B., Oliveira, Maria C. B., Stracieri, Ana B. P. L., Moraes, Daniela A., Pieroni, Fabiano, Barros, George M. N., Madeira, Maria Isabel A., Malmegrim, Kelen C. R., Foss-Freitas, Maria C., Simões, Belinda P., Martinez, Edson Z., Foss, Milton C., Burt, Richard K., and Voltarelli, Júlio C.

Published
2009
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20. Stem cell transplantation for type 1 diabetes mellitus

Author

Voltarelli Júlio C and Couri Carlos

Subjects
Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide β cell regeneration. Conclusion High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mellitus.

Published
2009
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21. Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

Author

Malmegrim, Kelen C. R., primary, de Azevedo, Júlia T. C., additional, Arruda, Lucas C. M., additional, Abreu, Joana R. F., additional, Couri, Carlos E. B., additional, de Oliveira, Gislane L. V., additional, Palma, Patricia V. B., additional, Scortegagna, Gabriela T., additional, Stracieri, Ana B. P. L., additional, Moraes, Daniela A., additional, Dias, Juliana B. E., additional, Pieroni, Fabiano, additional, Cunha, Renato, additional, Guilherme, Luiza, additional, Santos, Nathália M., additional, Foss, Milton C., additional, Covas, Dimas T., additional, Burt, Richard K., additional, Simões, Belinda P., additional, Voltarelli, Júlio C., additional, Roep, Bart O., additional, and Oliveira, Maria C., additional

Published
2017
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22. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras

Author

Voltarelli,Júlio C., Stracieri,Ana Beatriz P. L., Oliveira,Maria Carolina B., Godoi,Dannielle F., Moraes,Daniela A., Pieroni,Fabiano, Malmegrim,Kelen C. R., Coutinho,Marina A., Simões,Belinda P., Massumoto,Celso, Hamerschlak,Nelson, Scheinberg,Morton, Ferreira,Eurípides, Coutinho,Mariana, Ostronoff,Maurício, Sturaro,Daniel, and Dulley,Frederico

Subjects
doenças reumáticas, transplante de medula óssea, células-tronco hematopoéticas
Abstract

Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto; entre os 7 de esclerose sistêmica, houve 3 remissões após o TCTH e 2 após mobilização, um óbito pós-mobilização das CTH e outro após a primeira dose do condicionamento, este último em uma superposição com LES; em dois pacientes com vasculite, houve uma remissão em arterite de Takayasu e outra em doença de Behçet; uma paciente com artrite inflamatória juvenil foi incluída muito recentemente no protocolo. O seguimento dos pacientes sobreviventes variou de 0 a 48 meses, com uma mediana de 29 meses. Conclui-se com uma discussão do custo-benefício do TCTH em face das novas formas de imunossupressão disponíveis e das perspectivas futuras em países desenvolvidos, onde se iniciaram recentemente estudos prospectivos randomizados comparando o transplante com a melhor terapia medicamentosa disponível, e no Brasil, onde o custo do transplante é muito inferior ao das novas terapias biológicas.

Published
2005

23. Transplante de células-tronco hematopoéticas em doenças reumáticas. Parte 2: experiência brasileira e perspectivas futuras

Author

Voltarelli, Júlio C., Stracieri, Ana Beatriz P. L., Oliveira, Maria Carolina B., Godoi, Dannielle F., Moraes, Daniela A., Pieroni, Fabiano, Malmegrim, Kelen C. R., Coutinho, Marina A., Simões, Belinda P., Massumoto, Celso, Hamerschlak, Nelson, Scheinberg, Morton, Ferreira, Eurípides, Coutinho, Mariana, Ostronoff, Maurício, Sturaro, Daniel, and Dulley, Frederico

Subjects
bone marrow transplantation, rheumatic diseases, doenças reumáticas, transplante de medula óssea, células-tronco hematopoéticas, hematopoietic stem cells
Abstract

Nesta revisão, discutem-se os resultados dos transplantes de células-tronco hematopoéticas (TCTH) para doenças reumáticas graves e refratárias à terapia convencional realizados no Brasil. São analisados os resultados preliminares obtidos no Brasil com o TCTH autólogo em casos esporádicos (N=3) e no protocolo cooperativo iniciado em 2001 (N=18). Neste protocolo, dentre os 8 casos de nefrite lúpica, houve 3 remissões sustentadas, 3 óbitos, 1 falha de mobilização e 1 seguimento ainda muito curto; entre os 7 de esclerose sistêmica, houve 3 remissões após o TCTH e 2 após mobilização, um óbito pós-mobilização das CTH e outro após a primeira dose do condicionamento, este último em uma superposição com LES; em dois pacientes com vasculite, houve uma remissão em arterite de Takayasu e outra em doença de Behçet; uma paciente com artrite inflamatória juvenil foi incluída muito recentemente no protocolo. O seguimento dos pacientes sobreviventes variou de 0 a 48 meses, com uma mediana de 29 meses. Conclui-se com uma discussão do custo-benefício do TCTH em face das novas formas de imunossupressão disponíveis e das perspectivas futuras em países desenvolvidos, onde se iniciaram recentemente estudos prospectivos randomizados comparando o transplante com a melhor terapia medicamentosa disponível, e no Brasil, onde o custo do transplante é muito inferior ao das novas terapias biológicas. In this review, we discuss the results of hematopoietic stem cell transplantation (HSCT) for severe and refractory rheumatic diseases performed in Brazil. We analyze preliminary results obtained in Brazil with autologous HSCT in anecdotal cases (N = 3) and in the cooperative protocol initiated in 2001 (N = 18). In 8 lupus nephritis patients there were 3 sustained remissions, 3 deaths, 1 mobilisation failure and 1 short follow-up; in 7 systemic sclerosis patients there were 3 sustained remissions after transplantation and 2 after mobilisation, 1 death before mobilisation and another after the first dose of the conditioning in an overlapping syndrome of SLE and SSc, and between 2 patients with vasculitis there was 1 sustained remission in Takayasu's arteritis and another in Behçet's disease. One patient with juvenile idiopathic arthritis was included in the protocol very recently. The follow-up of the patients varied from 0 to 48 months with a median of 29 months. We conclude the study with a discussion of future prospectives in developed countries, where randomized trials comparing transplantation with the best pharmacological therapy available have started recently, and in Brazil, where several adaptations of existing protocols are required and the cost of transplantation is much lower than that of new biological therapies.

Published
2005

24. Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis

Author

Sousa, Alessandra de Paula A., primary, Malmegrim, Kelen C. R., additional, Panepucci, Rodrigo A., additional, Brum, Doralina S., additional, Barreira, Amilton A., additional, Carlos Dos Santos, Antonio, additional, Araújo, Amélia G., additional, Covas, Dimas Tadeu, additional, Oliveira, Maria C., additional, Moraes, Daniela A., additional, Pieroni, Fabiano, additional, Barros, George M., additional, Simões, Belinda P., additional, Nicholas, Richard, additional, Burt, Richard K., additional, Voltarelli, Júlio C., additional, and Muraro, Paolo A., additional

Published
2014
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26. Allogeneic Stem Cell Transplantation for Sickle Cell Disease in Brazil: The Time Is Now!

Author

Simoes, Belinda Pinto, primary, Navarro, George B, additional, Pieroni, Fabiano, additional, Darrigo, Luiz G, additional, Moraes, Daniela, additional, Stracieri, Ana Beatriz PL, additional, Fernandes, Juliana F, additional, Bonfim, Carmem, additional, Teixeira, Gustavo Machado, additional, Aranha, Francisco J P, additional, and Voltarelli, Júlio C., additional

Published
2011
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27. Stem cell therapy for diabetes mellitus

Author

Voltarelli, Júlio C., primary, Couri, Carlos E.B., additional, Oliveira, Maria C., additional, Moraes, Daniela A., additional, Stracieri, Ana B.P.L., additional, Pieroni, Fabiano, additional, Barros, George M.N., additional, Malmegrim, Kelen C.R., additional, Simões, Belinda P., additional, Leal, Angela M.O., additional, and Foss, Milton C., additional

Published
2011
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29. The Development of Hematopoietic Stem Cell Transplantation (HSCT) in Patients with Chronic Myeloid Leukemia (CML), in First Chronic Phase (CP), with HLA Identical Siblings Donors at the Bone Marrow Transplantation Unity–Jau, São Paulo/Brazil and Regional Cooperative Group

Author

Colturato, Vergilio Antônio Rensi, primary, de Souza, Mair Pedro, primary, Mauad, Marcos Augusto, primary, de Azevedo, Wellington Morais, primary, de Mattos, Éderson Roberto, primary, Machado, Clarisse Martins, primary, Pontes, Érica R., primary, Voltarelli, Júlio C., primary, Simoes, Belinda, primary, Paton, Eduardo J. A., primary, and de Abreu Machado, Paulo Eduardo, primary

Published
2008
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32. Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis.

Author

de Paula A. Sousa, Alessandra, Malmegrim, Kelen C. R., Panepucci, Rodrigo A., Brum, Doralina S., Barreira, Amilton A., Dos Santos, Antonio Carlos, Araújo, Amélia G., Covas, Dimas Tadeu, Oliveira, Maria C., Moraes, Daniela A., Pieroni, Fabiano, Barros, George M., Simões, Belinda P., Nicholas, Richard, Burt, Richard K., Voltarelli, Júlio C., and Muraro, Paolo A.

Subjects
MULTIPLE sclerosis treatment, HEMATOPOIETIC stem cell transplantation, IMMUNE system, GENE expression, AUTOTRANSPLANTATION, CD8 antigen, CD4 antigen, GENETICS, THERAPEUTICS
Abstract

Autologous haematopoietic stem-cell transplantation (AHSCT) has been experimented as a treatment in patients affected by severe forms of multiple sclerosis (MS) who failed to respond to standard immunotherapy. The rationale of AHSCT is to 'reboot' the immune system and reconstitute a new adaptive immunity. The aim of our study was to identify, through a robust and unbiased transcriptomic analysis, any changes of gene expression in T-cells potentially underlying the treatment effect in patients who underwent non-myeloablative AHSCT for treatment of MS. We evaluated by microarray DNA-chip technology the gene expression of peripheral CD4+ and CD8+ T-cell subsets sorted from patients with MS patients before AHSCT, at 6 months, 1 year and 2 years after AHSCT and from healthy control subjects. Hierarchical clustering analysis revealed that reconstituted CD8+ T-cells of MS patients at 2 years post-transplantation, aggregated together with healthy controls, suggesting a normalization of gene expression in CD8+ cells post-therapy. When we compared the gene expression in MS patients before and after therapy, we detected a large number of differentially expressed genes (DEG) in both CD8+ and CD4+ T-cell subsets at all time points after transplantation. We catalogued the biological function of DEG and we selected 27 genes known to be involved in immune function for accurate quantification of gene expression by real-time PCR. The analysis confirmed and extended with quantitative data, a number of significant changes in both the CD4+ and CD8+ T-cells subsets from MS post-transplant. Notably, CD8+ T-cells revealed more extensive changes in the expression of genes involved in effector immune responses. [ABSTRACT FROM AUTHOR]

Published
2015
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33. Mobilization, Collection, Infusion and Granulocyte Recovery of PBSC in Type 1 Diabets Mellitus Pacients after High Dose Immunosupression.

Author

Prata, Karen L., primary, De Santis, Gil C., additional, Oliveira, Maria Carolina B., additional, Moraes, Daniela A., additional, Júnior, Benedito P.A. Prado, additional, Orellana, Maristela D., additional, Palma, Patricia V.B., additional, Stracieri, Ana Beatriz P.L., additional, Pieroni, Fabiano, additional, Coutinho, Marina A., additional, Simões, Belinda P., additional, Covas, Dimas T., additional, and Voltarelli, Júlio C., additional

Published
2006
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46. Aspectos psicológicos e psiquiátricos do transplante de medula óssea

Author

Contel, José Onildo Betioli, primary, Sponholz Jr, Alcion, additional, Torrano-Masetti, Luciana M., additional, Almeida, Ângela C., additional, Oliveira, Érika A., additional, Jesus, Jorge Silvandro, additional, Santos, Manoel Antônio, additional, Loureiro, Sonia R., additional, and Voltarelli, Júlio C., additional

Published
2000
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