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845 results on '"Voogd, A. C."'

4. Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status

Author

Wang, Yuwei, Dackus, Gwen M. H. E., Rosenberg, Efraim H., Cornelissen, Sten, de Boo, Leonora W., Broeks, Annegien, Brugman, Wim, Chan, Terry W. S., van Diest, Paul J., Hauptmann, Michael, ter Hoeve, Natalie D., Isaeva, Olga I., de Jong, Vincent M. T., Jóźwiak, Katarzyna, Kluin, Roelof J. C., Kok, Marleen, Koop, Esther, Nederlof, Petra M., Opdam, Mark, Schouten, Philip C., Siesling, Sabine, van Steenis, Charlaine, Voogd, Adri C., Vreuls, Willem, Salgado, Roberto F., Linn, Sabine C., and Schmidt, Marjanka K.

Published
2024
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10. Oncologic outcomes of de-escalating axillary treatment in clinically node-positive breast cancer patients treated with neoadjuvant systemic therapy – A two center cohort study

Author

Schipper, Robert-Jan, de Bruijn, Anne, van der Sangen, Maurice J.C., Bloemen, Johanne G., van den Hoven, Ingrid, Schepers, Ester E.M., Vriens, Birgit E.P., Boerman, Thom, Rijkaart, Dorien C., van de Winkel, Linda M.H., Brouwer, Christel, van Warmerdam, Laurence J.C., Gielens, Maaike P.M., van Bommel, Rob M.G., van Riet, Yvonne E., Voogd, Adri C., and Nieuwenhuijzen, Grard A.P.

Published
2024
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12. The role of 18F-FDG PET/CT in detecting synchronous regional and distant metastatic disease in patients with an in-breast tumour recurrence

Author

Zeillemaker, A.M., Luiten, E.J.T., van der Velden, S., Doeksen, A., Frakking, T.T., Jeuriens, S., Brokx, H.A.P., de Widt, L., Jansen, P., Lemaire, B.M.D., Koppert, L.B., Klem, T.M.A.L., Truin, W., van Beurden, A., Merkus, J., Vles, W.J., Liefers, G.J., Maaskant-Braat, A.J., Straver, M., Dassen, A.E., Gooiker, G.A., Schlooz-Vries, M.S., Rutter, J.E., Brink, A.C., Smit, L.H., Aarts, F., Brookman, S., Muller, S., de Roos, W., Evers, D.J., van Dessel, E., van Bastelaar, J., Outmani, L., Postma, E.L., Bargon, C.A., Besten, S. den, Peters, H., Daniels, L., Verheuvel, N., Zeestraten, E.C.M., Raben, A.M.T.J., van de Wetering, J.C., Hagenaars, S.C., van Roosendaal L. Cornelissen, L.M., Stokmans, S., van Bergen, E., Broek, R.P.G. ten, van Uden, D.J.P., Schreurs, S., Hardon, S.F., Dulfer, R.R., de Rooij, L., Walstra, Coco J.E.F., Schipper, Robert-Jan, Voogd, Adri C., van der Sangen, Maurice J.C., van Duin, Ruben T.N.W., van Riet, Yvonne E., Smidt, Marjolein L., Bloemen, Johanne G., Wyndaele, Dirk N.J., and Nieuwenhuijzen, Grard A.P.

Published
2025
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14. External validation and clinical utility assessment of PREDICT breast cancer prognostic model in young, systemic treatment-naïve women with node-negative breast cancer

Author

Wang, Yuwei, Broeks, Annegien, Giardiello, Daniele, Hauptmann, Michael, Jóźwiak, Katarzyna, Koop, Esther A., Opdam, Mark, Siesling, Sabine, Sonke, Gabe S., Stathonikos, Nikolas, ter Hoeve, Natalie D., van der Wall, Elsken, van Deurzen, Carolien H.M., van Diest, Paul J., Voogd, Adri C., Vreuls, Willem, Linn, Sabine C., Dackus, Gwen M.H.E., and Schmidt, Marjanka K.

Published
2023
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17. De-escalation of radiotherapy after primary chemotherapy in cT1–2N1 breast cancer (RAPCHEM; BOOG 2010–03): 5-year follow-up results of a Dutch, prospective, registry study

Author

de Wild, Sabine R, de Munck, Linda, Simons, Janine M, Verloop, Janneke, van Dalen, Thijs, Elkhuizen, Paula H M, Houben, Ruud M A, van Leeuwen, A Elise, Linn, Sabine C, Pijnappel, Ruud M, Poortmans, Philip M P, Strobbe, Luc J A, Wesseling, Jelle, Voogd, Adri C, and Boersma, Liesbeth J

Published
2022
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18. Adding Anti-HER2 Therapy to Neoadjuvant Endocrine Therapy Seems Effective in Hormone Receptor and HER2 Positive Breast Cancer Patients Unfit for Chemotherapy: A Nationwide Population-Based Cohort Study.

Author

de Bruijn, Anne, Schipper, Robert-Jan, Voogd, Adri C., Pullens, Marleen J. J., Bloemen, Johanne G., de Munck, Linda, van Riet, Yvonne E., Siesling, Sabine, Vriens, Birgit E. P., and Nieuwenhuijzen, Grard A. P.

Subjects
THERAPEUTIC use of antineoplastic agents, HORMONE receptor positive breast cancer, TREATMENT effectiveness, QUANTITATIVE research, RETROSPECTIVE studies, CANCER patients, CANCER chemotherapy, LONGITUDINAL method, COMBINED modality therapy, COMPARATIVE studies
Abstract

Simple Summary: Data are lacking on the optimal neoadjuvant systemic treatment of patients with hormone receptor and HER2 positive breast cancer who are unfit for the combination of chemotherapy and anti-HER2 therapy. A nationwide series of 190 breast cancer patients treated with neoadjuvant endocrine treatment (NET) or NET+anti-HER2 were evaluated. The ypT0 rate was significantly higher after NET+anti-HER2, with 10.0% (4/40) versus 1.3% (2/150) following NET (p = 0.019). The ypN0 rate was significantly higher after NET+anti-HER2, with 25.0% (6/24) versus 5.5% (3/55) following NET in cN+ patients (p = 0.020) and 81.3% (13/16) versus 55.8% (53/95) after NET in cN- patients (p = 0.047). In cN- patients, ypN0 status was independently associated with age (p = 0.008) and administration of NET+anti-HER2 (p = 0.016). These findings suggest a clinical benefit of treatment with NET+anti-HER2 if patients are unfit for the combination of anti-HER2 therapy with chemotherapy. Introduction: Data are lacking on the optimal neoadjuvant systemic treatment (NST) for women with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-positive (HER2+) breast cancer if they are unfit to receive the combination of chemotherapy and anti-HER2 therapy. The aim of this study was to determine whether the rates of ypT0 and ypN0 differ between patients treated with neoadjuvant endocrine therapy (NET) versus NET combined with anti-HER2 therapy (NET+aHER2). Materials and Methods: Data from the Netherlands Cancer Registry were analysed to identify women diagnosed with primary HR+/HER2+ breast cancer between 2008 and 2019, treated with either NET or NET+aHER2. The ypT0 and ypN0 rates were analysed (using uni- and multivariable logistic regression analyses, as applicable) in relation to the characteristics of the patient, the tumour, and the treatment. Results: Of the 190 patients identified (median age 77), 150 had been treated with NET and 40 with NET+aHER2. Patients with clinically node-positive disease (cN+) were significantly more likely to have been treated with NET+aHER2 (p = 0.029). The ypT0 rate was significantly higher after NET+aHER2, with 10.0% (4/40) versus 1.3% (2/150) following NET (p = 0.019). The ypN0 rate was significantly higher after NET+aHER2, with 25.0% (6/24) versus 5.5% (3/55) following NET in the cN+ patients (p = 0.020) and 81.3% (13/16) versus 55.8% (53/95) after NET in the cN- patients (p = 0.047). In the cN- patients, the ypN0 status was independently associated with age (p = 0.008) and the administration of NET+aHER2 (p = 0.016). Conclusions: The rates of ypT0 and ypN0 in women with HR+/HER2+ breast cancer treated with NST was significantly higher following NET+aHER2 than after NET. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Breast conserving surgery with intraoperative electron beam radiation therapy for low‐risk breast cancer: Five‐year follow‐up of 306 patients.

Author

de Jonge, Charlotte, Schipper, Robert‐Jan, Walstra, Coco J. E. F., Van Riet, Yvonne E., Verrijssen, An‐Sofie E., Voogd, Adri C., van der Sangen, Maurice J. C., Theuws, Jacqueline, Degreef, Ellen, Gielens, Maaike P. M., Bloemen, Johanne G., van den Berg, Hetty A., and Nieuwenhuijzen, Grard A. P.

Subjects
SENTINEL lymph node biopsy, PATIENT selection, ELECTRON beams, BREAST surgery, DISEASE relapse
Abstract

Recent studies have reported a higher than expected risk of ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) and a single dose of electron beam intra‐operative radiotherapy (IORT). This finding was the rationale to perform a retrospective single center cohort study evaluating the oncologic results of consecutive patients treated with BCS and IORT. Women were eligible if they had clinical low‐risk (N0, ≤2 cm unifocal, Bloom and Richardson grade 1–2), estrogen receptor‐positive and human‐epidermal‐growth‐factor‐receptor‐2‐negative breast cancer. Prior to BCS, pN0 status was determined by sentinel lymph node biopsy. Data on oncologic follow‐up were analyzed. Between 2012 and 2019, 306 consecutive patients were treated and analyzed, with a median age of 67 (50–86) years at diagnosis. Median follow‐up was 60 (8–120) months. Five‐year cumulative risk of IBTR was 13.4% (95% confidence interval [CI] 9.4–17.4). True in field recurrence was present in 3.9% of the patients. In 4.6% of the patients, the IBRT was classified as a local recurrence due to seeding of tumor cells in the cutis or subcutis most likely related to percutaneous biopsy. In 2.9% of the patients, the IBRT was a new outfield primary tumor. Three patients had a regional lymph node recurrence and two had distant metastases as first event. One breast cancer‐related death was observed. Estimated 5‐year overall survival was 89.8% (95% CI 86.0–93.6). In conclusion, although some of IBTR cases could have been prevented by adaptations in biopsy techniques and patient selection, BCS followed by IORT was associated with a substantial risk of IBTR. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Invasive recurrence after breast conserving treatment of ductal carcinoma in situ of the breast in the Netherlands: time trends and the association with tumour grade.

Author

O'Leary, Rebecca L., Duijm, Lucien E. M., Boersma, Liesbeth J., van der Sangen, Maurice J. C., de Munck, Linda, Wesseling, Jelle, Schipper, Robert-Jan, and Voogd, Adri C.

Abstract

Background: The first aim of this study was to examine trends in the risk of ipsilateral invasive breast cancer (iIBC) after breast-conserving surgery (BCS) of ductal carcinoma in situ (DCIS). A second aim was to analyse the association between DCIS grade and the risk of iIBC following BCS. Patients and methods: In this population-based, retrospective cohort study, the Netherlands Cancer Registry collected information on 25,719 women with DCIS diagnosed in the period 1989–2021 who underwent BCS. Of these 19,034 received adjuvant radiotherapy (RT). Kaplan–Meier analyses and Cox regression models were used. Results: A total of 1135 patients experienced iIBC. Ten-year cumulative incidence rates of iIBC for patients diagnosed in the periods 1989–1998, 1999–2008 and 2009–2021 undergoing BCS without RT, were 12.6%, 9.0% and 5.0% (P < 0.001), respectively. For those undergoing BCS with RT these figures were 5.7%, 3.7% and 2.2%, respectively (P < 0.001). In the multivariable analyses, DCIS grade was not associated with the risk of iIBC. Conclusion: Since 1989 the risk of iIBC has decreased substantially and has become even lower than the risk of invasive contralateral breast cancer. No significant association of DCIS grade with iIBC was found, stressing the need for more powerful prognostic factors to guide the treatment of DCIS. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis

Author

Pan, Kuan-Yu, primary, van Tuijl, Lonneke, additional, Basten, Maartje, additional, Rijnhart, Judith J. M., additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Geerlings, Mirjam I., additional, Hoogendoorn, Adriaan, additional, Ranchor, Adelita V., additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Hollander, Monika, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Picavet, Susan, additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Teyhan, Alison, additional, Twait, Emma L., additional, van der Willik, Kimberly D., additional, and Lamers, Femke, additional

Published
2024
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27. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

28. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Published
2024

29. Long-term trends in incidence, characteristics and prognosis of screen-detected and interval cancers in women participating in the Dutch breast cancer screening programme

Author

Ten Velde, Daniëlle E, Duijm, Lucien E M, van der Sangen, Maurice J C, Schipper, Robert-Jan, Tjan-Heijnen, Vivianne C G, Vreuls, Willem, Strobbe, Luc J A, Voogd, Adri C, Ten Velde, Daniëlle E, Duijm, Lucien E M, van der Sangen, Maurice J C, Schipper, Robert-Jan, Tjan-Heijnen, Vivianne C G, Vreuls, Willem, Strobbe, Luc J A, and Voogd, Adri C

Abstract

BACKGROUND: No studies are available in which changes over time in characteristics and prognosis of patients with interval breast cancers (ICs) and screen-detected breast cancers (SDCs) have been compared. The aim was to study these trends between 1995 and 2018. METHODS: All women with invasive SDCs (N?=?4290) and ICs (N?=?1352), diagnosed in a southern mammography screening region in the Netherlands, were included and followed until date of death or 31 December 2022. RESULTS: The 5-year overall survival rate of women with SDCs increased from 91.4% for those diagnosed in 1995-1999 to 95.0% for those diagnosed in 2013-2018 (P?

Published
2024

30. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Published
2024

31. Psychosocial factors, health behaviors and risk of cancer incidence:Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

32. Long-term outcomes of young, node-negative, chemotherapy-naïve, triple-negative breast cancer patients according to BRCA1 status

Author

Pathologie, Cancer, Pathologie Pathologen staf, Wang, Yuwei, Dackus, Gwen M H E, Rosenberg, Efraim H, Cornelissen, Sten, de Boo, Leonora W, Broeks, Annegien, Brugman, Wim, Chan, Terry W S, van Diest, Paul J, Hauptmann, Michael, Ter Hoeve, Natalie D, Isaeva, Olga I, de Jong, Vincent M T, Jóźwiak, Katarzyna, Kluin, Roelof J C, Kok, Marleen, Koop, Esther, Nederlof, Petra M, Opdam, Mark, Schouten, Philip C, Siesling, Sabine, van Steenis, Charlaine, Voogd, Adri C, Vreuls, Willem, Salgado, Roberto F, Linn, Sabine C, Schmidt, Marjanka K, Pathologie, Cancer, Pathologie Pathologen staf, Wang, Yuwei, Dackus, Gwen M H E, Rosenberg, Efraim H, Cornelissen, Sten, de Boo, Leonora W, Broeks, Annegien, Brugman, Wim, Chan, Terry W S, van Diest, Paul J, Hauptmann, Michael, Ter Hoeve, Natalie D, Isaeva, Olga I, de Jong, Vincent M T, Jóźwiak, Katarzyna, Kluin, Roelof J C, Kok, Marleen, Koop, Esther, Nederlof, Petra M, Opdam, Mark, Schouten, Philip C, Siesling, Sabine, van Steenis, Charlaine, Voogd, Adri C, Vreuls, Willem, Salgado, Roberto F, Linn, Sabine C, and Schmidt, Marjanka K

Published
2024

33. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, Linn, S C, Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, and Linn, S C

Published
2024

34. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., Linn, S. C., de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., and Linn, S. C.

Abstract

Background: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported. Materials and methods: We studied all 485 patients with node-negative eTNBC from the population-based PARADIGM cohort which selected women aged <40 years diagnosed between 1989 and 2000. None of the patients had received (neo)adjuvant chemotherapy according to standard practice at the time. Associations between histopathologic traits and breast cancer-specific survival (BCSS) were analyzed with Cox proportional hazard models. Results: With a median follow-up of 20.0 years, an independent prognostic value for BCSS was observed for lymphovascular invasion (LVI) [adjusted (adj.) hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.49-3.69], fibrotic focus (adj. HR 1.61, 95% CI 1.09-2.37) and sTILs (per 10% increment adj. HR 0.75, 95% CI 0.69-0.82). In the sTILs <30% subgroup, the presence of LVI resulted in a higher cumulative incidence of breast cancer death (at 20 years, 58%; 95% CI 41% to 72%) compared with when LVI was absent (at 20 years, 32%; 95% CI 26% to 39%). In the ≥75% sTILs subgroup, the presence of LVI might be associated with poor survival (HR 11.45, 95% CI 0.71-182.36, two deaths). We confirm the lack of prognostic value of androgen receptor expression and human epidermal growth factor receptor 2 -low status. Conclusions: sTILs, LVI and fibrotic focus provide independent prognostic information in young women with node-negat

Published
2024

40. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta‐analysis

Author

Basten, Maartje, primary, Pan, Kuan‐Yu, additional, van Tuijl, Lonneke A., additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Hoogendoorn, Adriaan W., additional, Lamers, Femke, additional, Ranchor, Adelita V., additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Rosmalen, Judith G. M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Twait, Emma L., additional, Teyhan, Alison, additional, Verschuren, W. M. Monique, additional, van der Willik, Kimberly D., additional, and Geerlings, Mirjam I., additional

Published
2024
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46. Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis

Author

van Tuijl, Lonneke A., primary, Basten, Maartje, additional, Pan, Kuan‐Yu, additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, de Graeff, Alexander, additional, Dekker, Joost, additional, Geerlings, Mirjam I., additional, Hoogendoorn, Adriaan, additional, Lamers, Femke, additional, Voogd, Adri C., additional, Abell, Jessica, additional, Awadalla, Philip, additional, Beekman, Aartjan T. F., additional, Bjerkeset, Ottar, additional, Boyd, Andy, additional, Cui, Yunsong, additional, Frank, Philipp, additional, Galenkamp, Henrike, additional, Garssen, Bert, additional, Hellingman, Sean, additional, Huisman, Martijn, additional, Huss, Anke, additional, de Jong, Trynke R., additional, Keats, Melanie R., additional, Kok, Almar A. L., additional, Krokstad, Steinar, additional, van Leeuwen, Flora E., additional, Luik, Annemarie I., additional, Noisel, Nolwenn, additional, Onland‐Moret, N. Charlotte, additional, Payette, Yves, additional, Penninx, Brenda W. J. H., additional, Rissanen, Ina, additional, Roest, Annelieke M., additional, Ruiter, Rikje, additional, Schoevers, Robert A., additional, Soave, David, additional, Spaan, Mandy, additional, Steptoe, Andrew, additional, Stronks, Karien, additional, Sund, Erik R., additional, Sweeney, Ellen, additional, Twait, Emma L., additional, Teyhan, Alison, additional, Verschuren, W. M. Monique, additional, van der Willik, Kimberly D., additional, Rosmalen, Judith G. M., additional, and Ranchor, Adelita V., additional

Published
2023
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47. Breast magnetic resonance imaging use in patients undergoing neoadjuvant chemotherapy is associated with less mastectomies in large ductal cancers but not in lobular cancers

Author

Vriens, Ingeborg J.H., Keymeulen, Kristien, Lobbes, Marc B.I., van Bommel, Annelotte C.M., Nieuwenhuijzen, Grard A.P., Smidt, Marjolein L., Boersma, Liesbeth J., van Dalen, Thijs, Smorenburg, Carolien H., Struikmans, Henk, Siesling, Sabine, Voogd, Adri C., and Tjan-Heijnen, Vivianne C.G.

Published
2017
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48. Accuracy of the online prognostication tools PREDICT and Adjuvant! for early-stage breast cancer patients younger than 50 years

Author

Engelhardt, Ellen G., van den Broek, Alexandra J., Linn, Sabine C., Wishart, Gordon C., Rutgers, Emiel J. Th., van de Velde, Anthonie O., Smit, Vincent T.H.B.M., Voogd, Adri C., Siesling, Sabine, Brinkhuis, Mariël, Seynaeve, Caroline, Westenend, Pieter J., Stiggelbout, Anne M., Tollenaar, Rob A.E.M., van Leeuwen, Flora E., van 't Veer, Laura J., Ravdin, Peter M., Pharaoh, Paul D.P., and Schmidt, Marjanka K.

Published
2017
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