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1. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents

Author

Kim, Daeeun, Justice, Anne E., Chittoor, Geetha, Blanco, Estela, Burrows, Raquel, Graff, Mariaelisa, Howard, Annie Green, Wang, Yujie, Rohde, Rebecca, Buchanan, Victoria L., Voruganti, V. Saroja, Almeida, Marcio, Peralta, Juan, Lehman, Donna M., Curran, Joanne E., Comuzzie, Anthony G., Duggirala, Ravindranath, Blangero, John, Albala, Cecilia, Santos, José L., Angel, Bárbara, Lozoff, Betsy, Gahagan, Sheila, and North, Kari E.

Published
2022
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3. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium

Author

Fernández-Rhodes, Lindsay, Graff, Mariaelisa, Buchanan, Victoria L., Justice, Anne E., Highland, Heather M., Guo, Xiuqing, Zhu, Wanying, Chen, Hung-Hsin, Young, Kristin L., Adhikari, Kaustubh, Palmer, Nicholette D., Below, Jennifer E., Bradfield, Jonathan, Pereira, Alexandre C., Glover, LáShauntá, Kim, Daeeun, Lilly, Adam G., Shrestha, Poojan, Thomas, Alvin G., Zhang, Xinruo, Chen, Minhui, Chiang, Charleston W.K., Pulit, Sara, Horimoto, Andrea, Krieger, Jose E., Guindo-Martínez, Marta, Preuss, Michael, Schumann, Claudia, Smit, Roelof A.J., Torres-Mejía, Gabriela, Acuña-Alonzo, Victor, Bedoya, Gabriel, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Gallo, Carla, González-José, Rolando, Poletti, Giovanni, Rothhammer, Francisco, Hakonarson, Hakon, Igo, Robert, Adler, Sharon G., Iyengar, Sudha K., Nicholas, Susanne B., Gogarten, Stephanie M., Isasi, Carmen R., Papnicolaou, George, Stilp, Adrienne M., Qi, Qibin, Kho, Minjung, Smith, Jennifer A., Langefeld, Carl D., Wagenknecht, Lynne, Mckean-Cowdin, Roberta, Gao, Xiaoyi Raymond, Nousome, Darryl, Conti, David V., Feng, Ye, Allison, Matthew A., Arzumanyan, Zorayr, Buchanan, Thomas A., Ida Chen, Yii-Der, Genter, Pauline M., Goodarzi, Mark O., Hai, Yang, Hsueh, Willa, Ipp, Eli, Kandeel, Fouad R., Lam, Kelvin, Li, Xiaohui, Nadler, Jerry L., Raffel, Leslie J., Roll, Kathryn, Sandow, Kevin, Tan, Jingyi, Taylor, Kent D., Xiang, Anny H., Yao, Jie, Audirac-Chalifour, Astride, de Jesus Peralta Romero, Jose, Hartwig, Fernando, Horta, Bernando, Blangero, John, Curran, Joanne E., Duggirala, Ravindranath, Lehman, Donna E., Puppala, Sobha, Fejerman, Laura, John, Esther M., Aguilar-Salinas, Carlos, Burtt, Noël P., Florez, Jose C., García-Ortíz, Humberto, González-Villalpando, Clicerio, Mercader, Josep, Orozco, Lorena, Tusié-Luna, Teresa, Blanco, Estela, Gahagan, Sheila, Cox, Nancy J., Hanis, Craig, Butte, Nancy F., Cole, Shelley A., Comuzzie, Anthony G., Voruganti, V. Saroja, Rohde, Rebecca, Wang, Yujie, Sofer, Tamar, Ziv, Elad, Grant, Struan F.A., Ruiz-Linares, Andres, Rotter, Jerome I., Haiman, Christopher A., Parra, Esteban J., Cruz, Miguel, Loos, Ruth J.F., and North, Kari E.

Published
2022
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4. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function

Author

Xu, Jiayi, Bartz, Traci M, Chittoor, Geetha, Eiriksdottir, Gudny, Manichaikul, Ani W, Sun, Fangui, Terzikhan, Natalie, Zhou, Xia, Booth, Sarah L, Brusselle, Guy G, de Boer, Ian H, Fornage, Myriam, Frazier-Wood, Alexis C, Graff, Mariaelisa, Gudnason, Vilmundur, Harris, Tamara B, Hofman, Albert, Hou, Ruixue, Houston, Denise K, Jacobs, David R, Kritchevsky, Stephen B, Latourelle, Jeanne, Lemaitre, Rozenn N, Lutsey, Pamela L, O’Connor, George, Oelsner, Elizabeth C, Pankow, James S, Psaty, Bruce M, Rohde, Rebecca R, Rich, Stephen S, Rotter, Jerome I, Smith, Lewis J, Stricker, Bruno H, Voruganti, V Saroja, Wang, Thomas J, Zillikens, M Carola, Barr, R Graham, Dupuis, Josée, Gharib, Sina A, Lahousse, Lies, London, Stephanie J, North, Kari E, Smith, Albert V, Steffen, Lyn M, Hancock, Dana B, and Cassano, Patricia A

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Aging, Health Disparities, Nutrition, Minority Health, Respiratory, Adult, Aged, Black People, Cross-Sectional Studies, Female, Forced Expiratory Volume, Genome, Human, Heart, Heart Diseases, Humans, Lung, Lung Diseases, Male, Middle Aged, Molecular Epidemiology, Prospective Studies, Regression Analysis, Respiratory Function Tests, Smoking, Vital Capacity, Vitamin D, White People, Black or African American, 1, 25(OH)D 25-hydroxyvitamin D, AA African ancestry, AGES Age, ARIC Atherosclerosis Risk in Communities Study, CARDIA Coronary Artery Risk Development in Young Adults Study, CHARGE Cohorts for Heart and Aging Research in Genomic Epidemiology, CHS Cardiovascular Health Study, COPD chronic obstructive pulmonary disease, EA European ancestry, Environment, FEV1 forced expiratory volume in the 1st second, FHS (Gen3) Framingham Heart Study – Generation 3 Cohort, FHS (Offspring) Framingham Heart Study –Offspring Cohort, FVC forced vital capacity, Gene, HABC Health, Iceland, MESA Multi-Ethnic Study of Atherosclerosis, PFT pulmonary function test, RIA radioimmunoassay, Susceptibility Study − Reykjavik, and Body Composition Study, 25-(OH)2D 1, 25-dihydroxyvitamin D, African Americans, Forced expiratory volume, Respiratory function tests, Vital capacity, Whites, Animal Production, Food Sciences, Nutrition & Dietetics, Animal production, Food sciences, Nutrition and dietetics
Abstract

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P

Published
2018

8. Multiancestral Analysis of Inflammation-Related Genetic Variants and C-Reactive Protein in the Population Architecture Using Genomics and Epidemiology Study

Author

Kocarnik, Jonathan M, Pendergrass, Sarah A, Carty, Cara L, Pankow, James S, Schumacher, Fredrick R, Cheng, Iona, Durda, Peter, Ambite, José Luis, Deelman, Ewa, Cook, Nancy R, Liu, Simin, Wactawski-Wende, Jean, Hutter, Carolyn, Brown-Gentry, Kristin, Wilson, Sarah, Best, Lyle G, Pankratz, Nathan, Hong, Ching-Ping, Cole, Shelley A, Voruganti, V Saroja, Bůžkova, Petra, Jorgensen, Neal W, Jenny, Nancy S, Wilkens, Lynne R, Haiman, Christopher A, Kolonel, Laurence N, Lacroix, Andrea, North, Kari, Jackson, Rebecca, Le Marchand, Loic, Hindorff, Lucia A, Crawford, Dana C, Gross, Myron, and Peters, Ulrike

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Human Genome, Genetics, Health Disparities, Minority Health, American Indian or Alaska Native, Atherosclerosis, Heart Disease, 2.1 Biological and endogenous factors, Adult, Aged, Asian People, Black People, C-Reactive Protein, Female, Genetic Variation, Genome-Wide Association Study, Hispanic or Latino, Humans, Indians, North American, Inflammation, Male, Middle Aged, Polymorphism, Single Nucleotide, United States, Young Adult, Black or African American, C-reactive protein, continental population groups, ethnic groups, genetic pleiotropy, inflammation, molecular epidemiology, polymorphism, single nucleotide, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundC-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes mellitus, and obesity. We aimed to replicate previous CRP-SNP associations, assess whether these associations generalize to additional race/ethnicity groups, and evaluate inflammation-related SNPs for a potentially pleiotropic association with CRP.Methods and resultsWe selected and analyzed 16 CRP-associated and 250 inflammation-related GWAS SNPs among 40 473 African American, American Indian, Asian/Pacific Islander, European American, and Hispanic participants from 7 studies collaborating in the Population Architecture using Genomics and Epidemiology (PAGE) study. Fixed-effect meta-analyses combined study-specific race/ethnicity-stratified linear regression estimates to evaluate the association between each SNP and high-sensitivity CRP. Overall, 18 SNPs in 8 loci were significantly associated with CRP (Bonferroni-corrected P

Published
2014

9. Heritability and Preliminary Genome-Wide Linkage Analysis of Arsenic Metabolites in Urine

Author

Tellez-Plaza, Maria, Gribble, Matthew O, Voruganti, V Saroja, Francesconi, Kevin A, Goessler, Walter, Umans, Jason G, Silbergeld, Ellen K, Guallar, Eliseo, Franceschini, Nora, North, Kari E, Kao, Wen H, MacCluer, Jean W, Cole, Shelley A, and Navas-Acien, Ana

Subjects
Epidemiology, Health Sciences, Genetics, Substance Misuse, Human Genome, Foodborne Illness, Clinical Research, American Indian or Alaska Native, Minority Health, Aged, Arsenic, Female, Genetic Linkage, Genome-Wide Association Study, Humans, Life Style, Male, Middle Aged, American Indians, arsenic metabolism, arsenic species, determinants, heritability, linkage scan, Strong Heart Study, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundArsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in association studies. Other genes might also play roles in arsenic metabolism and excretion.ObjectiveWe evaluated genetic determinants of urine arsenic metabolites in American Indian adults from the Strong Heart Study (SHS).MethodsWe evaluated heritability of urine arsenic metabolites [percent inorganic arsenic (%iAs), percent monomethylarsonate (%MMA), and percent dimethylarsinate (%DMA)] in 2,907 SHS participants with urine arsenic measurements and at least one relative within the cohort. We conducted a preliminary linkage analysis in a subset of 487 participants with available genotypes on approximately 400 short tandem repeat markers using a general pedigree variance component approach for localizing quantitative trait loci (QTL).ResultsThe medians (interquartile ranges) for %iAs, %MMA, and %DMA were 7.7% (5.4-10.7%), 13.6% (10.5-17.1%), and 78.4% (72.5-83.1%), respectively. The estimated heritability was 53% for %iAs, 50% for %MMA, and 59% for %DMA. After adjustment for sex, age, smoking, body mass index, alcohol consumption, region, and total urine arsenic concentrations, LOD [logarithm (to the base of 10) of the odds] scores indicated suggestive evidence for genetic linkage with QTLs influencing urine arsenic metabolites on chromosomes 5 (LOD = 2.03 for %iAs), 9 (LOD = 2.05 for %iAs and 2.10 for %MMA), and 11 (LOD = 1.94 for %iAs). A peak for %DMA on chromosome 10 within 2 Mb of AS3MT had an LOD of 1.80.ConclusionsThis population-based family study in American Indian communities supports a genetic contribution to variation in the distribution of arsenic metabolites in urine and, potentially, the involvement of genes other than AS3MT.

Published
2013

10. Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates

Author

Vaidyanathan, Vidya, Bastarrachea, Raul A, Higgins, Paul B, Voruganti, V Saroja, Kamath, Subhash, DiPatrizio, Nicholas V, Piomelli, Daniele, Comuzzie, Anthony G, and Parks, Elizabeth J

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Nutrition, Obesity, Metabolic and endocrine, Acetic Acid, Animals, Biotransformation, Body Composition, Carbon Isotopes, Deuterium, Fatty Acids, Insulin Resistance, Kinetics, Lipolysis, Liver, Male, Palmitic Acid, Papio, Piperidines, Pyrazoles, Receptor, Cannabinoid, CB1, Rimonabant, Subcutaneous Fat, Abdominal, Triglycerides, Waist Circumference, endocannabinoid, adipose, fatty acid flux, stable isotopes, baboon, Biological Sciences, Medical and Health Sciences, Endocrinology & Metabolism, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

The goal of this study was to determine whether administration of the CB₁ cannabinoid receptor antagonist rimonabant would alter fatty acid flux in nonhuman primates. Five adult baboons (Papio Sp) aged 12.1 ± 4.7 yr (body weight: 31.9 ± 2.1 kg) underwent repeated metabolic tests to determine fatty acid and TG flux before and after 7 wk of treatment with rimonabant (15 mg/day). Animals were fed ad libitum diets, and stable isotopes were administered via diet (d₃₁-tripalmitin) and intravenously (¹³C₄-palmitate, ¹³C₁-acetate). Plasma was collected in the fed and fasted states, and blood lipids were analyzed by GC-MS. DEXA was used to assess body composition and a hyperinsulinemic euglycemic clamp used to assess insulin-mediated glucose disposal. During the study, no changes were observed in food intake, body weight, plasma, and tissue endocannabinoid concentrations or the quantity of liver-TG fatty acids originating from de novo lipogenesis (19 ± 6 vs. 16 ± 5%, for pre- and posttreatment, respectively, P = 0.39). However, waist circumference was significantly reduced 4% in the treated animals (P < 0.04), glucose disposal increased 30% (P = 0.03), and FFA turnover increased 37% (P = 0.02). The faster FFA flux was consistent with a 43% reduction in these fatty acids used for TRL-TG synthesis (40 ± 3 vs. 23 ± 4%, P = 0.02) and a twofold increase in TRL-TG turnover (1.5 ± 0.9 vs. 3.1 ± 1.4 μmol·kg⁻¹·h⁻¹, P = 0.03). These data support the potential for a strong effect of CB₁ receptor antagonism at the level of adipose tissue, resulting in improvements in fasting turnover of fatty acids at the whole body level, central adipose storage, and significant improvements in glucose homeostasis.

Published
2012

11. Duodenal adipose tissue is associated with obesity in baboons (Papio sp): a novel site of ectopic fat deposition in non-human primates

Author

Higgins, Paul B., Folli, Franco, Andrade, Marcia C. R., Foster, Jaydee, Mattern, Vicki, Paroni, Rita, Schlabritz-Loutsevitch, Natalia, Voruganti, V. Saroja, Kumar, Shyamesh, Guardado-Mendoza, Rodolfo, Bulfamante, Gaetano, Fiorina, Paolo, Pontiroli, Antonio E., Hubbard, Gene B., Owston, Michael, Dick, Jr., Edward J., and Comuzzie, Anthony G.

Published
2019
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16. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium

Author

Fernández-Rhodes, Lindsay, primary, Graff, Mariaelisa, additional, Buchanan, Victoria L., additional, Justice, Anne E., additional, Highland, Heather M., additional, Guo, Xiuqing, additional, Zhu, Wanying, additional, Chen, Hung-Hsin, additional, Young, Kristin L., additional, Adhikari, Kaustubh, additional, Palmer, Nicholette D., additional, Below, Jennifer E., additional, Bradfield, Jonathan, additional, Pereira, Alexandre C., additional, Glover, LáShauntá, additional, Kim, Daeeun, additional, Lilly, Adam G., additional, Shrestha, Poojan, additional, Thomas, Alvin G., additional, Zhang, Xinruo, additional, Chen, Minhui, additional, Chiang, Charleston W.K., additional, Pulit, Sara, additional, Horimoto, Andrea, additional, Krieger, Jose E., additional, Guindo-Martínez, Marta, additional, Preuss, Michael, additional, Schumann, Claudia, additional, Smit, Roelof A.J., additional, Torres-Mejía, Gabriela, additional, Acuña-Alonzo, Victor, additional, Bedoya, Gabriel, additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, González-José, Rolando, additional, Poletti, Giovanni, additional, Rothhammer, Francisco, additional, Hakonarson, Hakon, additional, Igo, Robert, additional, Adler, Sharon G., additional, Iyengar, Sudha K., additional, Nicholas, Susanne B., additional, Gogarten, Stephanie M., additional, Isasi, Carmen R., additional, Papnicolaou, George, additional, Stilp, Adrienne M., additional, Qi, Qibin, additional, Kho, Minjung, additional, Smith, Jennifer A., additional, Langefeld, Carl D., additional, Wagenknecht, Lynne, additional, Mckean-Cowdin, Roberta, additional, Gao, Xiaoyi Raymond, additional, Nousome, Darryl, additional, Conti, David V., additional, Feng, Ye, additional, Allison, Matthew A., additional, Arzumanyan, Zorayr, additional, Buchanan, Thomas A., additional, Chen, Yii-Der Ida, additional, Genter, Pauline M., additional, Goodarzi, Mark O., additional, Hai, Yang, additional, Hsueh, Willa, additional, Ipp, Eli, additional, Kandeel, Fouad R., additional, Lam, Kelvin, additional, Li, Xiaohui, additional, Nadler, Jerry L., additional, Raffel, Leslie J., additional, Roll, Kathryn, additional, Sandow, Kevin, additional, Tan, Jingyi, additional, Taylor, Kent D., additional, Xiang, Anny H., additional, Yao, Jie, additional, Audirac-Chalifour, Astride, additional, Peralta Romero, Jose de Jesus, additional, Hartwig, Fernando, additional, Horta, Bernando, additional, Blangero, John, additional, Curran, Joanne E., additional, Duggirala, Ravindranath, additional, Lehman, Donna E., additional, Puppala, Sobha, additional, Fejerman, Laura, additional, John, Esther M., additional, Aguilar-Salinas, Carlos, additional, Burtt, Noël P., additional, Florez, Jose C., additional, García-Ortíz, Humberto, additional, González-Villalpando, Clicerio, additional, Mercader, Josep, additional, Orozco, Lorena, additional, Tusié-Luna, Teresa, additional, Blanco, Estela, additional, Gahagan, Sheila, additional, Cox, Nancy J., additional, Hanis, Craig, additional, Butte, Nancy F., additional, Cole, Shelley A., additional, Comuzzie, Anthony G., additional, Voruganti, V. Saroja, additional, Rohde, Rebecca, additional, Wang, Yujie, additional, Sofer, Tamar, additional, Ziv, Elad, additional, Grant, Struan F.A., additional, Ruiz-Linares, Andres, additional, Rotter, Jerome I., additional, Haiman, Christopher A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Loos, Ruth J.F., additional, and North, Kari E., additional

Published
2023
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19. Integrating Genomic Analysis with the Genetic Basis of Gene Expression: Preliminary Evidence of the Identification of Causal Genes for Cardiovascular and Metabolic Traits Related to Nutrition in Mexicans

Author

Bastarrachea, Raúl A., Gallegos-Cabriales, Esther C., Nava-González, Edna J., Haack, Karin, Voruganti, V. Saroja, Charlesworth, Jac, Laviada-Molina, Hugo A., Veloz-Garza, Rosa A., Cardenas-Villarreal, Velia Margarita, Valdovinos-Chavez, Salvador B., Gomez-Aguilar, Patricia, Meléndez, Guillermo, López-Alvarenga, Juan Carlos, Göring, Harald H.H., Cole, Shelley A., Blangero, John, Comuzzie, Anthony G., and Kent, Jack W., Jr.

Published
2012
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27. Heart rate is associated with red blood cell fatty acid concentration: The Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study

Author

Ebbesson, Sven O.E., Devereux, Richard B., Cole, Shelley, Ebbesson, Lars O.E., Fabsitz, Richard R., Haack, Karin, Harris, William S., Howard, Wm. James, Laston, Sandra, Lopez-Alvarenga, Juan Carlos, MacCluer, Jean W., Okin, Peter M., Tejero, M. Elizabeth, Voruganti, V. Saroja, Wenger, Charlotte R., Howard, Barbara V., and Comuzzie, Anthony G.

Published
2010
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28. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents

Author

Kim, Daeeun, primary, Justice, Anne E., additional, Chittoor, Geetha, additional, Blanco, Estela, additional, Burrows, Raquel, additional, Graff, Mariaelisa, additional, Howard, Annie Green, additional, Wang, Yujie, additional, Rohde, Rebecca, additional, Buchanan, Victoria L., additional, Voruganti, V. Saroja, additional, Almeida, Marcio, additional, Peralta, Juan, additional, Lehman, Donna M., additional, Curran, Joanne E., additional, Comuzzie, Anthony G., additional, Duggirala, Ravindranath, additional, Blangero, John, additional, Albala, Cecilia, additional, Santos, José L., additional, Angel, Bárbara, additional, Lozoff, Betsy, additional, Gahagan, Sheila, additional, and North, Kari E., additional

Published
2021
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34. Gene-Environment Joint Linkage and Association Analysis of Arsenic Exposure and Diabetes-Related Traits in the Strong Heart Family Study

Author

Gribble, Matthew O., primary, Balakrishnan, Poojitha, additional, Haack, Karin, additional, Vaidya, Dhananjay, additional, Umans, Jason G., additional, Best, Lyle G., additional, Goessler, Walter, additional, Franceschini, Nora, additional, North, Kari E., additional, Cole, Shelley A., additional, Navas Acien, Ana, additional, and Voruganti, V. Saroja, additional

Published
2021
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37. A Chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study

Author

Rutherford, Sue, Blangero, John, Comuzzie, Anthony G., Cole, Shelley A., Goring, Harald H.H., MacCluer, Jean W., Moses, Eric K., Jowett, Jeremy B., Bastarrachea, Raul A., Atwood, Larry D., Cai, Guowen, Lopez-Alvarenga, Juan C., Curran, Joanne E., Johnson, Mathew P., Dyer, Thomas D, Jr Kent, Jack W., Voruganti, V. Saroja, and Proffitt, J Michael

Subjects
Quantitative trait loci -- Research, Mexican Americans -- Health aspects, Hypertension -- Care and treatment, Blood pressure -- Measurement, Blood pressure -- Usage, Biological sciences
Abstract

A study on the rates of change in systolic, diastolic and mean arterial blood pressure (BP) by using longitudinal data collected about the Mexican Americans of the San Antonio Family Heart Study was conducted. Result show that to calculate longitudinal BP data the rate of change in BP over time provides more information than the single time meaurements.

Published
2007

38. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

Author

Fernández-Rhodes, Lindsay, primary, Graff, Mariaelisa, additional, Buchanan, Victoria L., additional, Justice, Anne E., additional, Highland, Heather M., additional, Guo, Xiuqing, additional, Zhu, Wanying, additional, Chen, Hung-Hsin, additional, Young, Kristin L., additional, Adhikari, Kaustubh, additional, Allred, Nicholette (Palmer), additional, Below, Jennifer E., additional, Bradfield, Jonathan, additional, Pereira, Alexandre C., additional, Glover, LáShauntá, additional, Kim, Daeeun, additional, Lilly, Adam G., additional, Shrestha, Poojan, additional, Thomas, Alvin G., additional, Zhang, Xinruo, additional, Chen, Minhui, additional, Chiang, Charleston W. K., additional, Pulit, Sara, additional, Horimoto, Andrea, additional, Krieger, Jose E., additional, Guindo-Martinez, Marta, additional, Preuss, Michael, additional, Schumann, Claudia, additional, Smit, Roelof A.J., additional, Torres-Mejía, Gabriela, additional, Acuña-Alonzo, Victor, additional, Bedoya, Gabriel, additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, González-José, Rolando, additional, Poletti, Giovanni, additional, Rothhammer, Francisco, additional, Hakonarson, Hakon, additional, Igo, Robert, additional, Adler, Sharon G, additional, Iyengar, Sudha K., additional, Nicholas, Susanne B., additional, Gogarten, Stephanie M., additional, Isasi, Carmen R., additional, Papnicolaou, George, additional, Stilp, Adrienne M., additional, Qi, Qibin, additional, Kho, Minjung, additional, Smith, Jennifer A., additional, Langfeld, Carl, additional, Wagenknecht, Lynne, additional, Mckean-Cowdin, Roberta, additional, Gao, Xiaoyi Raymond, additional, Nousome, Darryl, additional, Conti, David V., additional, Feng, Ye, additional, Allison, Matthew A., additional, Arzumanyan, Zorayr, additional, Buchanan, Thomas A., additional, Chen, Yii-Der Ida, additional, Genter, Pauline M., additional, Goodarzi, Mark O., additional, Hai, Yang, additional, Hsueh, Willa, additional, Ipp, Eli, additional, Kandeel, Fouad R., additional, Lam, Kelvin, additional, Li, Xiaohui, additional, Nadler, Jerry L., additional, Raffel, Leslie J., additional, Roll, Kaye, additional, Sandow, Kevin, additional, Tan, Jingyi, additional, Taylor, Kent D., additional, Xiang, Anny H., additional, Yao, Jie, additional, Audirac-Chalifour, Astride, additional, de Jesus Peralta Romero, Jose, additional, Hartwig, Fernando, additional, Horta, Bernando, additional, Blangero, John, additional, Curran, Joanne E., additional, Duggirala, Ravindranath, additional, Lehman, Donna E., additional, Puppala, Sobha, additional, Fejerman, Laura, additional, John, Esther, additional, Aguilar-Salinas, Carlos, additional, Burtt, Noël P., additional, Florez, Jose C., additional, García-Ortíz, Humberto, additional, González-Villalpando, Clicerio, additional, Mercader, Josep, additional, Orozco, Lorena, additional, Tusié, Teresa, additional, Blanco, Estela, additional, Gahagan, Sheila, additional, Cox, Nancy J., additional, Hanis, Craig, additional, Butte, Nancy F., additional, Cole, Shelley A., additional, Commuzzie, Anthony G., additional, Voruganti, V. Saroja, additional, Rohde, Rebecca, additional, Wang, Yujie, additional, Sofer, Tamar, additional, Ziv, Elad, additional, Grant, Struan F.A., additional, Ruiz-Linares, Andres, additional, Rotter, Jerome I., additional, Haiman, Christopher A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Loos, Ruth J.F., additional, and North, Kari E., additional

Published
2021
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39. Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations: The PAGE Study

Author

Zhang, Lili, Spencer, Kylee L., Voruganti, V. Saroja, Jorgensen, Neal W., Fornage, Myriam, Best, Lyle G., Brown-Gentry, Kristin D., Cole, Shelley A., Crawford, Dana C., Deelman, Ewa, Franceschini, Nora, Gaffo, Angelo L., Glenn, Kimberly R., Heiss, Gerardo, Jenny, Nancy S., Kottgen, Anna, Li, Qiong, Liu, Kiang, Matise, Tara C., North, Kari E., Umans, Jason G., and Kao, W. H. Linda

Published
2013
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41. Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium

Author

Haiman, Christopher A., Fesinmeyer, Megan D., Spencer, Kylee L., Bůžková, Petra, Voruganti, V. Saroja, Wan, Peggy, Haessler, Jeff, Franceschini, Nora, Monroe, Kristine R., Howard, Barbara V., Jackson, Rebecca D., Florez, Jose C., Kolonel, Laurence N., Buyske, Steven, Goodloe, Robert J., Liu, Simin, Manson, JoAnn E., Meigs, James B., Waters, Kevin, Mukamal, Kenneth J., Pendergrass, Sarah A., Shrader, Peter, Wilkens, Lynne R., Hindorff, Lucia A., Ambite, Jose Luis, North, Kari E., Peters, Ulrike, Crawford, Dana C., Le Marchand, Loic, and Pankow, James S.

Published
2012
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46. Association of cardiometabolic genes with arsenic metabolism biomarkers in American Indian communities: the strong heart family study (SHFS)

Author

Balakrishnan, Poojitha, Vaidya, Dhananjay, Franceschini, Nora, Voruganti, V. Saroja, Gribble, Matthew O., Haack, Karin, Laston, Sandra, Umans, Jason G., Francesconi, Kevin A., Goessler, Walter, North, Kari E., Lee, Elisa, Yracheta, Joseph, Best, Lyle G., MacCluer, Jean W., Kent, Jr., Jack, Cole, Shelley A., and Navas-Acien, Ana

Subjects
Analysis, Physiological aspects, Research, Genetic aspects, Health aspects, Arsenic -- Physiological aspects -- Research, Type 2 diabetes -- Research, Single nucleotide polymorphisms -- Analysis, Native Americans -- Health aspects -- Genetic aspects -- Research, Biological markers -- Analysis
Abstract

Introduction Inorganic arsenic (iAs) is a toxic and carcinogenic metalloid that is found in groundwater, soil, food, and air (Welch et al. 1988). Experimental and epidemiological studies support the role [...], BACKGROUND: Metabolism of inorganic arsenic (iAs) is subject to inter-individual variability, which is explained partly by genetic determinants. OBJECTIVES: We investigated the association of genetic variants with arsenic species and principal components of arsenic species in the Strong Heart Family Study (SHFS). METHODS: We examined variants previously associated with cardiometabolic traits (~ 200,000 from Illumina Cardio MetaboChip) or arsenic metabolism and toxicity (670) among 2,428 American Indian participants in the SHFS. Urine arsenic species were measured by high performance liquid chromatography--inductively coupled plasma mass spectrometry (HPLC-ICP-MS), and percent arsenic species [iAs, monomethylarsonate (MMA), and dimethylarsinate (DMA), divided by their sum x 100] were logit transformed. We created two orthogonal principal components that summarized iAs, MMA, and DMA and were also phenotypes for genetic analyses. Linear regression was performed for each phenotype, dependent on allele dosage of the variant. Models accounted for familial relatedness and were adjusted for age, sex, total arsenic levels, and population stratification. Single nucleotide polymorphism (SNP) associations were stratified by study site and were meta-analyzed. Bonferroni correction was used to account for multiple testing. RESULTS: Variants at 10q24 were statistically significant for all percent arsenic species and principal components of arsenic species. The index SNP for iAs%, MMA%, and DMA% (rs12768205) and for the principal components (rs3740394, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA and DMA. Among the candidate arsenic variant associations, functional SNPs in AS3MTand 10q24 were most significant (p < 9.33 x [10.sup.-5]). CONCLUSIONS: This hypothesis-driven association study supports the role of common variants in arsenic metabolism, particularly AS3MT and 10q24. http://dx.doi.org/ 10.1289/EHP251.

Published
2017
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