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1. Long-term outcomes of patients with large B-cell lymphoma treated with axicabtagene ciloleucel and prophylactic corticosteroids

Author

Oluwole, Olalekan O., Forcade, Edouard, Muñoz, Javier, de Guibert, Sophie, Vose, Julie M., Bartlett, Nancy L., Lin, Yi, Deol, Abhinav, McSweeney, Peter, Goy, Andre H., Kersten, Marie José, Jacobson, Caron A., Farooq, Umar, Minnema, Monique C., Thieblemont, Catherine, Timmerman, John M., Stiff, Patrick, Avivi, Irit, Tzachanis, Dimitrios, Zheng, Yan, Vardhanabhuti, Saran, Nater, Jenny, Shen, Rhine R., Miao, Harry, Kim, Jenny J., and van Meerten, Tom

Published
2024
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2. Epcoritamab monotherapy in patients with relapsed or refractory follicular lymphoma (EPCORE NHL-1): a phase 2 cohort of a single-arm, multicentre study

Author

Linton, Kim M, Vitolo, Umberto, Jurczak, Wojciech, Lugtenburg, Pieternella J, Gyan, Emmanuel, Sureda, Anna, Christensen, Jacob Haaber, Hess, Brian, Tilly, Hervé, Cordoba, Raul, Lewis, David John, Okada, Craig, Hutchings, Martin, Clausen, Michael Roost, Sancho, Juan-Manuel, Cochrane, Tara, Leppä, Sirpa, Chamuleau, Martine E D, Gernhardt, Diana, Altıntaş, Işıl, Liu, Yan, Ahmadi, Tahamtan, Dinh, Minh H, Hoehn, Daniela, Favaro, Elena, Elliott, Brian, Thieblemont, Catherine, and Vose, Julie M

Published
2024
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4. Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium

Author

Vose, Julie M., Fu, Kai, Wang, Lu, Mansoor, Adnan, Stewart, Douglas, Cheng, Hongxia, Smith, Lynette, Yuan, Ji, Qureishi, Hina Naushad, Link, Brian K., Cessna, Melissa H., Barr, Paul M., Kahl, Brad S., Mckinney, Matthew S., Khan, Nadia, Advani, Ranjana H., Martin, Peter, Goy, Andre H., Phillips, Tycel J., Mehta, Amitkumar, Kamdar, Manali, Crump, Michael, Pro, Barbara, Flowers, Christopher R., Jacobson, Caron A., Smith, Sonali M., Stephens, Deborah M., Bachanova, Veronika, Jin, Zhaohui, Wu, Shishou, Hernandez-Ilizaliturri, Francisco, Torka, Pallawi, Anampa-Guzmán, Andrea, Kashef, Farshid, Li, Xing, Sharma, Sunandini, Greiner, Timothy C., Armitage, James O., Lunning, Matthew, Weisenburger, Dennis D., Bociek, Robert G., Iqbal, Javeed, Yu, Guohua, and Bi, Chengfeng

Published
2023
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5. Bridging therapy with axicabtagene ciloleucel for large B-cell lymphoma: results from the US Lymphoma CAR-T Consortium

Author

Jain, Michael D., Jacobs, Miriam T., Gao, Feng, Nastoupil, Loretta J., Spiegel, Jay Y., Lin, Yi, Dahiya, Saurabh, Lunning, Matthew, Lekakis, Lazaros, Reagan, Patrick, Oluwole, Olalekan, McGuirk, Joseph, Deol, Abhinav, Sehgal, Alison R., Goy, Andre, Hill, Brian T., Andreadis, Charalambos, Munoz, Javier, Chavez, Julio C, Bennani, N. Nora, Rapoport, Aaron P., Vose, Julie M., Miklos, David, Neelapu, Sattva S., Locke, Frederick L., and Ghobadi, Armin

Published
2024
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6. Prophylactic corticosteroid use in patients receiving axicabtagene ciloleucel for large B‐cell lymphoma

Author

Oluwole, Olalekan O, Bouabdallah, Krimo, Muñoz, Javier, De Guibert, Sophie, Vose, Julie M, Bartlett, Nancy L, Lin, Yi, Deol, Abhinav, McSweeney, Peter A, Goy, Andre H, Kersten, Marie José, Jacobson, Caron A, Farooq, Umar, Minnema, Monique C, Thieblemont, Catherine, Timmerman, John M, Stiff, Patrick, Avivi, Irit, Tzachanis, Dimitrios, Kim, Jenny J, Bashir, Zahid, McLeroy, Jeff, Zheng, Yan, Rossi, John M, Johnson, Lisa, Goyal, Lovely, and Meerten, Tom

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lymphoma, Rare Diseases, Cancer, Hematology, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Immunological, Biological Products, Cytokine Release Syndrome, Dexamethasone, Female, Humans, Immunotherapy, Adoptive, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, large B-cell lymphoma, axi-cel, chimaeric antigen receptor-T cell, prophylaxis, corticosteroids, cytokine release syndrome, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular medicine and haematology
Abstract

ZUMA-1 (NCT02348216) examined the safety and efficacy of axicabtagene ciloleucel (axi-cel), an autologous CD19-directed chimaeric antigen receptor (CAR)-T cell therapy, in refractory large B-cell lymphoma. To reduce treatment-related toxicity, several exploratory safety management cohorts were added to ZUMA-1. Specifically, cohort 6 investigated management of cytokine release syndrome (CRS) and neurologic events (NEs) with prophylactic corticosteroids and earlier corticosteroid and tocilizumab intervention. CRS and NE incidence and severity were primary end-points. Following leukapheresis, patients could receive optional bridging therapy per investigator discretion. All patients received conditioning chemotherapy (days -5 through -3), 2 × 106  CAR-T cells/kg (day 0) and once-daily oral dexamethasone [10 mg, day 0 (before axi-cel) through day 2]. Forty patients received axi-cel. CRS occurred in 80% of patients (all grade ≤2). Any grade and grade 3 or higher NEs occurred in 58% and 13% of patients respectively. Sixty-eight per cent of patients did not experience CRS or NEs within 72 h of axi-cel. With a median follow-up of 8·9 months, objective and complete response rates were 95% and 80% respectively. Overall, prophylactic corticosteroids and earlier corticosteroid and/or tocilizumab intervention resulted in no grade 3 or higher CRS, a low rate of grade 3 or higher NEs and high response rates in this study population.

Published
2021

7. Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma

Author

Gerson, James N., Handorf, Elizabeth, Villa, Diego, Gerrie, Alina S., Chapani, Parv, Li, Shaoying, Medeiros, L. Jeffrey, Wang, Michael, Cohen, Jonathon B., Churnetski, Michael, Hill, Brian T., Sawalha, Yazeed, Hernandez-Ilizaliturri, Francisco J., Kothari, Shalin, Vose, Julie M., Bast, Martin, Fenske, Timothy, Rao Gari, Swapna Narayana, Maddocks, Kami J., Bond, David, Bachanova, Veronika, Kolla, Bhaskar, Chavez, Julio, Shah, Bijal, Lansigan, Frederick, Burns, Timothy, Donovan, Alexandra M., Wagner-Johnston, Nina, Messmer, Marcus, Mehta, Amitkumar, Anderson, Jennifer K., Reddy, Nishitha, Kovach, Alexandra E., Landsburg, Daniel J., Glenn, Martha, Inwards, David J., Ristow, Kay, Karmali, Reem, Kaplan, Jason B., Caimi, Paolo F., Rajguru, Saurabh, Evens, Andrew, Klein, Andreas, Umyarova, Elvira, Pulluri, Bhargavi, Amengual, Jennifer E., Lue, Jennifer K., Diefenbach, Catherine, Fisher, Richard I., and Barta, Stefan K.

Published
2023
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8. High-grade B-cell lymphoma, not otherwise specified: a multi-institutional retrospective study

Author

Zayac, Adam S., Landsburg, Daniel J., Hughes, Mitchell E., Bock, Allison M., Nowakowski, Grzegorz S., Ayers, Emily C., Girton, Mark, Hu, Marie, Beckman, Amy K., Li, Shaoying, Medeiros, L. Jeffrey, Chang, Julie E., Stepanovic, Adam, Kurt, Habibe, Sandoval-Sus, Jose, Ansari-Lari, M. Ali, Kothari, Shalin K., Kress, Anna, Xu, Mina L., Torka, Pallawi, Sundaram, Suchitra, Smith, Stephen D., Naresh, Kikkeri N., Karimi, Yasmin H., Epperla, Narendranath, Bond, David A., Farooq, Umar, Saad, Mahak, Evens, Andrew M., Pandya, Karan, Naik, Seema G., Kamdar, Manali, Haverkos, Bradley, Karmali, Reem, Oh, Timothy S., Vose, Julie M., Nutsch, Heather, Rubinstein, Paul G., Chaudhry, Amina, and Olszewski, Adam J.

Published
2023
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9. Benchmarks for Academic Oncology Faculty.

Author

Anthony, Lowell, Atweh, George, Bhatia, Ravi, Carey, Lisa A, Chang, Jenny C, Edelman, Martin J, Kantoff, Philip W, Markham, Merry Jennifer, Messersmith, Wells, Nelson, Edward L, Oettel, Kurt, O'Regan, Ruth, Verschraegen, Claire F, and Vose, Julie M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, 6.9 Resources and infrastructure (treatment evaluation), Evaluation of treatments and therapeutic interventions, Benchmarking, Faculty, Medical, Humans, Leadership, Medical Oncology, Research Personnel, Oncology and carcinogenesis
Abstract

The role of clinical researchers is vital to cancer progress. The teaching, research, and leadership roles that academic oncologists hold need to be accounted for and appropriately compensated. National metrics are currently inexistent, but are necessary to move the oncology research field forward. Clinical research and routine clinical care must be harmoniously integrated without competing. This article reviews the national landscape of clinical cancer research and proposes a call for action.

Published
2021

10. Standard-of-Care Axicabtagene Ciloleucel for Relapsed or Refractory Large B-Cell Lymphoma: Results From the US Lymphoma CAR T Consortium.

Author

Nastoupil, Loretta J, Jain, Michael D, Feng, Lei, Spiegel, Jay Y, Ghobadi, Armin, Lin, Yi, Dahiya, Saurabh, Lunning, Matthew, Lekakis, Lazaros, Reagan, Patrick, Oluwole, Olalekan, McGuirk, Joseph, Deol, Abhinav, Sehgal, Alison R, Goy, Andre, Hill, Brian T, Vu, Khoan, Andreadis, Charalambos, Munoz, Javier, Westin, Jason, Chavez, Julio C, Cashen, Amanda, Bennani, N Nora, Rapoport, Aaron P, Vose, Julie M, Miklos, David B, Neelapu, Sattva S, and Locke, Frederick L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Lymphoma, Hematology, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Antigens, CD19, Biological Products, Clinical Trials, Phase II as Topic, Comorbidity, Cytokine Release Syndrome, Female, Humans, Immunotherapy, Adoptive, L-Lactate Dehydrogenase, Leukapheresis, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Organizational Policy, Patient Selection, Progression-Free Survival, Recurrence, Retrospective Studies, Severity of Illness Index, Standard of Care, Survival Rate, Young Adult, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeAxicabtagene ciloleucel (axi-cel) is an autologous CD19-directed chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory large B-cell lymphoma (LBCL) on the basis of the single-arm phase II ZUMA-1 trial, which showed best overall and complete response rates in infused patients of 83% and 58%, respectively. We report clinical outcomes with axi-cel in the standard-of-care (SOC) setting for the approved indication.Patients and methodsData were collected retrospectively from all patients with relapsed/refractory LBCL who underwent leukapheresis as of September 30, 2018, at 17 US institutions with the intent to receive SOC axi-cel. Toxicities were graded and managed according to each institution's guidelines. Responses were assessed as per Lugano 2014 classification.ResultsOf 298 patients who underwent leukapheresis, 275 (92%) received axi-cel therapy. Compared with the registrational ZUMA-1 trial, 129 patients (43%) in this SOC study would not have met ZUMA-1 eligibility criteria because of comorbidities at the time of leukapheresis. Among the axi-cel-treated patients, grade ≥ 3 cytokine release syndrome and neurotoxicity occurred in 7% and 31%, respectively. Nonrelapse mortality was 4.4%. Best overall and complete response rates in infused patients were 82% (95% CI, 77% to 86%) and 64% (95% CI, 58% to 69%), respectively. At a median follow-up of 12.9 months from the time of CAR T-cell infusion, median progression-free survival was 8.3 months (95% CI, 6.0 to15.1 months), and median overall survival was not reached. Patients with poor Eastern Cooperative Oncology Group performance status of 2-4 and elevated lactate dehydrogenase had shorter progression-free and overall survival on univariable and multivariable analysis.ConclusionThe safety and efficacy of axi-cel in the SOC setting in patients with relapsed/refractory LBCL was comparable to the registrational ZUMA-1 trial.

Published
2020

11. Data from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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12. Table S2 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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13. Supplementary Methods from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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14. Figure S4 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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15. FIGURE 3 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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16. BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia

Author

Smith, Audrey L., primary, Skupa, Sydney A., additional, Eiken, Alexandria P., additional, Reznicek, Timothy E., additional, Schmitz, Elizabeth, additional, Williams, Nolan, additional, Moore, Dalia Y., additional, D’Angelo, Christopher R., additional, Kallam, Avyakta, additional, Lunning, Matthew A., additional, Bociek, R. Gregory, additional, Vose, Julie M., additional, Mohamed, Eslam, additional, Mahr, Anna R., additional, Denton, Paul W., additional, Powell, Ben, additional, Bollag, Gideon, additional, Rowley, M. Jordan, additional, and El-Gamal, Dalia, additional

Published
2024
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17. FIGURE 4 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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18. FIGURE 5 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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19. FIGURE 1 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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20. FIGURE 6 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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21. FIGURE 2 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects

Author

Eiken, Alexandria P., primary, Smith, Audrey L., primary, Skupa, Sydney A., primary, Schmitz, Elizabeth, primary, Rana, Sandeep, primary, Singh, Sarbjit, primary, Kumar, Siddhartha, primary, Mallareddy, Jayapal Reddy, primary, de Cubas, Aguirre A, primary, Krishna, Akshay, primary, Kalluchi, Achyuth, primary, Rowley, M. Jordan, primary, D'Angelo, Christopher R., primary, Lunning, Matthew A., primary, Bociek, R. Gregory, primary, Vose, Julie M., primary, Natarajan, Amarnath, primary, and El-Gamal, Dalia, primary

Published
2024
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22. Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

Author

Eiken, Alexandria P, primary, Smith, Audrey L, additional, Skupa, Sydney A, additional, Schmitz, Elizabeth, additional, Rana, Sandeep, additional, Singh, Sarbjit, additional, Kumar, Siddhartha, additional, Mallareddy, Jayapal Reddy, additional, de Cubas, Aguirre A, additional, Krishna, Akshay, additional, Kalluchi, Achyuth, additional, Rowley, M. Jordan, additional, D'Angelo, Christopher R, additional, Lunning, Matthew A., additional, Bociek, R Gregory, additional, Vose, Julie M., additional, Natarajan, Amarnath, additional, and El-Gamal, Dalia, additional

Published
2024
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23. Severity of Cytokine Release Syndrome Influences Outcome After Axicabtagene Ciloleucel for Large B cell Lymphoma: Results from the US Lymphoma CAR-T Consortium

Author

Jacobs, Miriam T., Jain, Michael D., Gao, Feng, Nastoupil, Loretta J., Spiegel, Jay Y., Lin, Yi, Dahiya, Saurabh, Lunning, Matthew, Lekakis, Lazaros, Reagan, Patrick M., Oluwole, Olalekan O., McGuirk, Joseph, Deol, Abhinav, Sehgal, Alison, Goy, Andre, Hill, Brian T., Andreadis, Charalambos, Munoz, Javier, Chavez, Julio C., Bennani, N. Nora, Rapoport, Aaron P., Vose, Julie M., Miklos, David B., Neelapu, Sattva S., Ghobadi, Armin, and Locke, Frederick L.

Published
2022
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24. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Author

Campo, Elias, Jaffe, Elaine S., Cook, James R., Quintanilla-Martinez, Leticia, Swerdlow, Steven H., Anderson, Kenneth C., Brousset, Pierre, Cerroni, Lorenzo, de Leval, Laurence, Dirnhofer, Stefan, Dogan, Ahmet, Feldman, Andrew L., Fend, Falko, Friedberg, Jonathan W., Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M., King, Rebecca L., Salles, Gilles, San-Miguel, Jesus, Seymour, John F., Treon, Steven P., Vose, Julie M., Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I., d'Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M., Goodlad, John R., Gribben, John G., Hsi, Eric D., Kahl, Brad S., Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S., Laurent, Camille, Lenz, Georg, Leonard, John P., Link, Michael P., Lopez-Guillermo, Armando, Mateos, Maria Victoria, Macintyre, Elizabeth, Melnick, Ari M., Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Pavlovsky, Astrid, Pileri, Stefano A., Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T., Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A., Smith, Sonali M., Staudt, Louis M., Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H., Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W., Winter, Jane N., and Zelenetz, Andrew D.

Published
2022
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26. Complementary and Alternative Medicine in Cancer Care: Does It Have a Role?

Author

Vose, Julie M.

Subjects
Cancer patients -- Care and treatment, Cancer -- Care and treatment, Alternative medicine, Evidence-based medicine, Health
Abstract

Frequently patients with cancer ask about alterations in their lifestyle, taking vitamins or supplements, or other treatments or practices that will improve their outcome following a cancer diagnosis. Complementary and [...]

Published
2024

28. MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications

Author

Bi, Chengfeng, primary, Huang, Yuhua, additional, Ali, Roshia, additional, Wang, Fang, additional, Yang, Xia, additional, Bouska, Alyssa, additional, Xu, Lu, additional, Hao, Xinbao, additional, Lunning, Matthew A., additional, Chan, Wing C., additional, Iqbal, Javeed, additional, Weisenburger, Dennis D., additional, Vose, Julie M., additional, and Fu, Kai, additional

Published
2024
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29. ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International T-Cell Project

Author

Shustov, Andrei, Cabrera, Maria Elena, Civallero, Monica, Bellei, Monica, Ko, Young Hyeh, Manni, Martina, Skrypets, Tetiana, Horwitz, Steven M., De Souza, Carmino Antonio, Radford, John A., Bobillo, Sabela, Prates, Maria Virginia, Ferreri, Andrés J.M., Chiattone, Carlos, Spina, Michele, Vose, Julie M., Chiappella, Annalisa, Laszlo, Daniele, Marino, Dario, Stelitano, Caterina, and Federico, Massimo

Published
2021
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30. Electronic Medical Records and Physicians: A Love-Hate Relationship

Author

Vose, Julie M.

Subjects
Health care reform, Medical records, Physicians, Electronic records, Health
Abstract

As the use of the electronic medical record (EMR) has greatly expanded over the past couple of decades, it has (partially) improved communication among health care professionals and allowed data [...]

Published
2024

31. Outcomes of patients with limited-stage aggressive large B-cell lymphoma with high-risk cytogenetics

Author

Torka, Pallawi, Kothari, Shalin K., Sundaram, Suchitra, Li, Shaoying, Medeiros, L. Jeffrey, Ayers, Emily C., Landsburg, Daniel J., Bond, David A., Maddocks, Kami J., Giri, Anshu, Hess, Brian, Pham, Luu Q., Advani, Ranjana, Liu, Yang, Barta, Stefan Klaus, Vose, Julie M., Churnetski, Michael C., Cohen, Jonathon B., Burkart, Madelyn, Karmali, Reem, Zurko, Joanna, Mehta, Amitkumar, Olszewski, Adam J., Lee, Sarah, Hill, Brian T., Burns, Timothy F., Lansigan, Frederick, Rabinovich, Emma, Peace, David, Groman, Adrienne, Attwood, Kristopher, and Hernandez-Ilizaliturri, Francisco J.

Published
2020
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32. NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023

Author

Zelenetz, Andrew D., primary, Gordon, Leo I., additional, Abramson, Jeremy S., additional, Advani, Ranjana H., additional, Andreadis, Babis, additional, Bartlett, Nancy L., additional, Budde, L. Elizabeth, additional, Caimi, Paolo F., additional, Chang, Julie E., additional, Christian, Beth, additional, DeVos, Sven, additional, Dholaria, Bhagirathbhai, additional, Fayad, Luis E., additional, Habermann, Thomas M., additional, Hamid, Muhammad Saad, additional, Hernandez-Ilizaliturri, Francisco, additional, Hu, Boyu, additional, Kaminski, Mark S., additional, Karimi, Yasmin, additional, Kelsey, Christopher R., additional, King, Rebecca, additional, Krivacic, Susan, additional, LaCasce, Ann S., additional, Lim, Megan, additional, Messmer, Marcus, additional, Narkhede, Mayur, additional, Rabinovitch, Rachel, additional, Ramakrishnan, Praveen, additional, Reid, Erin, additional, Roberts, Kenneth B., additional, Saeed, Hayder, additional, Smith, Stephen D., additional, Svoboda, Jakub, additional, Swinnen, Lode J., additional, Tuscano, Joseph, additional, Vose, Julie M., additional, Dwyer, Mary A., additional, and Sundar, Hema, additional

Published
2023
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33. CCL3 and CCL4 are biomarkers for B cell receptor pathway activation and prognostic serum markers in diffuse large B cell lymphoma

Author

Takahashi, Koichi, Sivina, Mariela, Hoellenriegel, Julia, Oki, Yasuhiro, Hagemeister, Fredrick B, Fayad, Luis, Romaguera, Jorge E, Fowler, Nathan, Fanale, Michelle A, Kwak, Larry W, Samaniego, Felipe, Neelapu, Sattva, Xiao, Lianchun, Huang, Xuelin, Kantarjian, Hagop, Keating, Michael J, Wierda, William, Fu, Kai, Chan, Wing C, Vose, Julie M, O'Brien, Susan, Davis, Richard E, and Burger, Jan A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Cancer, Rare Diseases, Lymphoma, Hematology, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adenine, Antineoplastic Agents, B-Cell Activation Factor Receptor, Biomarkers, Tumor, Cell Line, Tumor, Chemokine CCL3, Chemokine CCL4, Enzyme-Linked Immunosorbent Assay, Epidemiologic Methods, Humans, Lymphoma, Large B-Cell, Diffuse, Piperidines, Prognosis, Pyrazoles, Pyrimidines, Signal Transduction, chemokines, diffuse large B-cell lymphoma, lymphoma, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular medicine and haematology
Abstract

B cell receptor (BCR) signalling is an important pathway in diffuse large B cell lymphoma (DLBCL). In response to BCR triggering, normal and malignant B cells secrete the chemokines CCL3 and CCL4 to attract accessory cells to the tissue microenvironment. We measured CCL3 and CCL4 serum concentrations in 102 patients with newly diagnosed DLBCL by enzyme-linked immunosorbent assay, investigated their prognostic impact and validated our findings in an independent cohort of 51 patient samples. We also tested CCL3 and CCL4 secretion by DLBCL cells, and the influence of BTK inhibitors on the secretion of these chemokines. High CCL3 (≥40 pg/ml) serum concentrations correlated with higher international prognostic index, lactate dehydrogenase and β2 microglobulin, as did CCL4 (≥180 pg/ml) with advanced Ann Arbor stages. High CCL3 levels correlated with significantly shorter progression-free and overall survival. The in vitro studies demonstrated that activated B cell-like, but not germinal centre B cell-like DLBCL cells, secrete high levels of CCL3 and CCL4 after BCR triggering, which was exquisitely sensitive to BCR pathway inhibition. These findings support CCL3 and CCL4 protein concentrations as biomarkers for BCR pathway activation and prognosis in DLBCL.

Published
2015

35. Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015.

Author

Zelenetz, Andrew D, Gordon, Leo I, Wierda, William G, Abramson, Jeremy S, Advani, Ranjana H, Andreadis, C Babis, Bartlett, Nancy, Byrd, John C, Czuczman, Myron S, Fayad, Luis E, Fisher, Richard I, Glenn, Martha J, Habermann, Thomas M, Harris, Nancy Lee, Hoppe, Richard T, Horwitz, Steven M, Kelsey, Christopher R, Kim, Youn H, Krivacic, Susan, LaCasce, Ann S, Nademanee, Auayporn, Porcu, Pierluigi, Press, Oliver, Rabinovitch, Rachel, Reddy, Nishitha, Reid, Erin, Saad, Ayman A, Sokol, Lubomir, Swinnen, Lode J, Tsien, Christina, Vose, Julie M, Wilson, Lynn, Yahalom, Joachim, Zafar, Nadeem, Dwyer, Mary, and Sundar, Hema

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Orphan Drug, Hematology, Clinical Research, Rare Diseases, Lymphoma, Cancer, Algorithms, Comorbidity, Disease Management, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Neoplasm Staging, Prognosis, National comprehension cancer network, Oncology & Carcinogenesis, Oncology and carcinogenesis, Health services and systems
Abstract

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. The recently approved small molecule kinase inhibitors (ibrutinib and idelalisib) are effective treatment options for CLL in elderly patients with decreased tolerance for aggressive regimens and in patients with poor prognostic features who do not benefit from conventional chemoimmunotherapy regimens. This portion of the NCCN Guidelines for Non-Hodgkin's Lymphomas describes the recent specific to the incorporation of recently approved targeted therapies for the management of patients with newly diagnosed and relapsed or refractory CLL/SLL.

Published
2015

37. 2023 Year in Review: Topics in Hematology/Oncology

Author

Vose, Julie M.

Subjects
Health
Abstract

The year 2023 has been an important one, with many discoveries of new therapies for diverse types of malignancies. There are also some big-picture topics in hematology/oncology that have some [...]

Published
2023

38. Multidisciplinary Team Approach Is Integral to Oncology Care

Author

Vose, Julie M.

Subjects
Palliative treatment, Chemotherapy, Cancer -- Chemotherapy, Radiotherapy, Health
Abstract

Treating and caring for patients with cancer can require a complex team of medical professionals who work together toward a common goal. This type of approach emerged in the 1980s [...]

Published
2023

39. Tolerability and activity of ublituximab, umbralisib, and ibrutinib in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: a phase 1 dose escalation and expansion trial

Author

Nastoupil, Loretta J, Lunning, Matthew A, Vose, Julie M, Schreeder, Marshall T, Siddiqi, Tanya, Flowers, Christopher R, Cohen, Jonathon B, Burger, Jan A, Wierda, William G, O'Brien, Susan, Sportelli, Peter, Miskin, Hari P, Purdom, Michelle A, Weiss, Michael S, and Fowler, Nathan H

Published
2019
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41. Non-Hodgkin's lymphomas, version 4.2014.

Author

Zelenetz, Andrew D, Gordon, Leo I, Wierda, William G, Abramson, Jeremy S, Advani, Ranjana H, Andreadis, C Babis, Bartlett, Nancy, Byrd, John C, Czuczman, Myron S, Fayad, Luis E, Fisher, Richard I, Glenn, Martha J, Harris, Nancy Lee, Hoppe, Richard T, Horwitz, Steven M, Kelsey, Christopher R, Kim, Youn H, Krivacic, Susan, LaCasce, Ann S, Nademanee, Auayporn, Porcu, Pierluigi, Press, Oliver, Rabinovitch, Rachel, Reddy, Nishitha, Reid, Erin, Saad, Ayman A, Sokol, Lubomir, Swinnen, Lode J, Tsien, Christina, Vose, Julie M, Yahalom, Joachim, Zafar, Nadeem, Dwyer, Mary, and Sundar, Hema

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Cancer, Hematology, Rare Diseases, Stem Cell Research, Lymphoma, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 6.2 Cellular and gene therapies, Humans, Lymphoma, Non-Hodgkin, Neoplasm Staging, Recurrence, National comprehensive cancer network, Oncology & Carcinogenesis, Oncology and carcinogenesis, Health services and systems
Abstract

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL cases. Radiation therapy with or without systemic therapy is a reasonable approach for the few patients who present with early-stage disease. Rituximab-based chemoimmunotherapy followed by high-dose therapy and autologous stem cell rescue (HDT/ASCR) is recommended for patients presenting with advanced-stage disease. Induction therapy followed by rituximab maintenance may provide extended disease control for those who are not candidates for HDT/ASCR. Ibrutinib, a Bruton tyrosine kinase inhibitor, was recently approved for the treatment of relapsed or refractory disease. This manuscript discusses the recommendations outlined in the NCCN Guidelines for NHL regarding the diagnosis and management of patients with MCL.

Published
2014

44. An International Real-World Analysis of Relapsed/Refractory Lymphoma Occurring During Pregnancy

Author

Farooq, Faheem, primary, Brandt, Justin S., additional, Cardonick, Elyce, additional, Polushkina, Evgeniya, additional, Vose, Julie M, additional, Ahmed, Sairah, additional, Ramakrishnan Geethakumari, Praveen, additional, Olszewski, Adam J, additional, Yasin, Hesham, additional, Farooq, Umar, additional, Hamad, Nada, additional, Lin, Yong, additional, Maggen, Charlotte, additional, Fruscio, Robert, additional, Gziri, Mina Mhallem, additional, Steffensen, Karina Dahl, additional, Amant, Frédéric, additional, and Evens, Andrew M, additional

Published
2023
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45. Final results of a phase II study of CHOEP plus lenalidomide as initial therapy for patients with stage II–IV peripheral T‐cell lymphoma

Author

Stuver, Robert, primary, Horwitz, Steven M., additional, Advani, Ranjana H., additional, Vose, Julie M., additional, Lee, Hun Ju, additional, Mehta‐Shah, Neha, additional, Zain, Jasmine M., additional, Haverkos, Bradley, additional, Lechowicz, Mary Jo, additional, Moskowitz, Alison J., additional, Pham, Luu Q., additional, Leyden, Elizabeth, additional, Ansell, Stephen M., additional, and Lunning, Matthew A., additional

Published
2023
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46. The SALENTO prognostic model for limited-stage peripheral T-cell lymphoma from the International T-Cell Project Network

Author

Hapgood, Greg, primary, Civallero, Monica, additional, Stepanishyna, Yana, additional, Vose, Julie M, additional, Cabrera, Maria Elena, additional, Advani, Ranjana H, additional, Pileri, Stefano A, additional, Manni, Martina, additional, Horwitz, Steven M, additional, Foss, Francine M, additional, Hitz, Felicitas, additional, Radford, John, additional, Dlouhy, Ivan, additional, Chiattone, Carlos Sérgio, additional, Kim, Won-Seog, additional, Skrypets, Tetiana, additional, Nagler, Arnon, additional, Trotman, Judith, additional, Luminari, Stefano, additional, and Federico, Massimo, additional

Published
2023
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47. Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium

Author

Wang, Yucai, primary, Jain, Preetesh, additional, Locke, Frederick L., additional, Maurer, Matthew J., additional, Frank, Matthew J., additional, Munoz, Javier L., additional, Dahiya, Saurabh, additional, Beitinjaneh, Amer M., additional, Jacobs, Miriam T., additional, Mcguirk, Joseph P., additional, Vose, Julie M., additional, Goy, Andre, additional, Andreadis, Charalambos, additional, Hill, Brian T., additional, Dorritie, Kathleen A., additional, Oluwole, Olalekan O., additional, Deol, Abhinav, additional, Paludo, Jonas, additional, Shah, Bijal, additional, Wang, Trent, additional, Banerjee, Rahul, additional, Miklos, David B., additional, Rapoport, Aaron P., additional, Lekakis, Lazaros, additional, Ghobadi, Armin, additional, Neelapu, Sattva S., additional, Lin, Yi, additional, Wang, Michael L., additional, and Jain, Michael D., additional

Published
2023
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48. Lenalidomide maintenance following high‐dose therapy and autologous haematopoietic stem cell transplantation in chemo‐resistant or high‐risk non‐ H odgkin lymphoma: A phase I/ II study

Author

Vose, Julie M., primary, Ganguly, Siddhartha, additional, Bierman, Philip J., additional, Bociek, R. Gregory, additional, Lunning, Matthew, additional, Lyden, Liz, additional, Meza, Jane L., additional, Caimi, Paolo F., additional, and Armitage, James O., additional

Published
2023
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