Search

Your search keyword '"Voss, Anne K."' showing total 343 results
Start Over Author "Voss, Anne K."
343 results on '"Voss, Anne K."'

3. Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice

Author

Bergamasco, Maria I., Vanyai, Hannah K., Garnham, Alexandra L., Geoghegan, Niall D., Vogel, Adam P., Eccles, Samantha, Rogers, Kelly L., Smyth, Gordon K., Blewitt, Marnie E., Hannan, Anthony J., Thomas, Tim, and Voss, Anne K.

Subjects
Brain -- Genetic aspects -- Analysis -- Health aspects, Gene expression -- Genetic aspects -- Analysis -- Health aspects, Carnitine -- Analysis -- Genetic aspects -- Health aspects, Valproic acid -- Analysis -- Health aspects, Divalproex -- Analysis -- Health aspects, Mice -- Analysis -- Health aspects -- Genetic aspects, Cells -- Health aspects -- Analysis -- Genetic aspects, Health care industry
Abstract

Mutations in genes encoding chromatin modifiers are enriched among mutations causing intellectual disability. The continuing development of the brain postnatally, coupled with the inherent reversibility of chromatin modifications, may afford an opportunity for therapeutic intervention following a genetic diagnosis. Development of treatments requires an understanding of protein function and models of the disease. Here, we provide a mouse model of Say-Barber- Biesecker-Young-Simpson syndrome (SBBYSS) (OMIM 603736) and demonstrate proof-of-principle efficacy of postnatal treatment. SBBYSS results from heterozygous mutations in the KAT6B (MYST4/MORF/QFK) gene and is characterized by intellectual disability and autism-like behaviors. Using human cells carrying SBBYSS-specific KAT6B mutations and Kat6b heterozygous mice ([Kat6b.sup.-/-]), we showed that KAT6B deficiency caused a reduction in histone H3 lysine 9 acetylation. Kat6b mice displayed learning, memory, and social deficits, mirroring SBBYSS individuals. Treatment with a histone deacetylase inhibitor, valproic acid, or an acetyl donor, acetyL-carnitine (ALCAR), elevated histone acetylation levels in the human cells with SBBYSS mutations and in brain and blood cells of [Kat6b.sup.-/-] mice and partially reversed gene expression changes in [Kat6b.sup.-/-] cortical neurons. Both compounds improved sociability in Kat6b mice, and ALCAR treatment restored learning and memory. These data suggest that a subset of SBBYSS individuals may benefit from postnatal therapeutic interventions., Introduction Heterozygous mutations in the gene encoding the MYST family histone acetyltransferase, KAT6B, underlie 2 main intellectual disability disorders: the Say-Barber-Biesecker-Young-Simpson variant of Ohdo syndrome (SBBYSS) (OMIM 603736) (1) and [...]

Published
2024
Full Text
View/download PDF

6. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Published
2023
Full Text
View/download PDF

7. Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

Author

Sharma, Shikhar, Chung, Chi-Yeh, Uryu, Sean, Petrovic, Jelena, Cao, Joan, Rickard, Amanda, Nady, Nataliya, Greasley, Samantha, Johnson, Eric, Brodsky, Oleg, Khan, Showkhin, Wang, Hui, Wang, Zhenxiong, Zhang, Yong, Tsaparikos, Konstantinos, Chen, Lei, Mazurek, Anthony, Lapek, John, Kung, Pei-Pei, Sutton, Scott, Richardson, Paul F., Greenwald, Eric C., Yamazaki, Shinji, Jones, Rhys, Maegley, Karen A., Bingham, Patrick, Lam, Hieu, Stupple, Alexandra E., Kamal, Aileen, Chueh, Anderly, Cuzzupe, Anthony, Morrow, Benjamin J., Ren, Bin, Carrasco-Pozo, Catalina, Tan, Chin Wee, Bhuva, Dharmesh D., Allan, Elizabeth, Surgenor, Elliot, Vaillant, François, Pehlivanoglu, Havva, Falk, Hendrik, Whittle, James R., Newman, Janet, Cursons, Joseph, Doherty, Judy P., White, Karen L., MacPherson, Laura, Devlin, Mark, Dennis, Matthew L., Hattarki, Meghan K., De Silva, Melanie, Camerino, Michelle A., Butler, Miriam S., Dolezal, Olan, Pilling, Patricia, Foitzik, Richard, Stupple, Paul A., Lagiakos, H. Rachel, Walker, Scott R., Hediyeh-Zadeh, Soroor, Nuttall, Stewart, Spall, Sukhdeep K., Charman, Susan A., Connor, Theresa, Peat, Thomas S., Avery, Vicky M., Bozikis, Ylva E., Yang, Yuqing, Zhang, Ming, Monahan, Brendon J., Voss, Anne K., Thomas, Tim, Street, Ian P., Dawson, Sarah-Jane, Dawson, Mark A., Lindeman, Geoffrey J., Davis, Melissa J., Visvader, Jane E., and Paul, Thomas A.

Published
2023
Full Text
View/download PDF

8. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Author

Lalaoui, Najoua, Boyden, Steven E, Oda, Hirotsugu, Wood, Geryl M, Stone, Deborah L, Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E, Zaal, Kristien JM, Hoffmann, Patrycja M, Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D, Kuehn, Hye Sun, Yang, Dan, Anderton, Holly, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B, Gutierrez-Cruz, Gustavo, Ombrello, Amanda K, Pinto-Patarroyo, Gineth P, Kueh, Andrew J, Herold, Marco J, Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I, McKenzie, Mark, Light, Amanda, Barham, Beverly K, Jones, Anne, Romeo, Tina M, Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C, Gross, Andrew J, Shum, Anthony K, Hawkins, Edwin D, Masters, Seth L, Lenardo, Michael J, Boehm, Manfred, Rosenzweig, Sergio D, Pasparakis, Manolis, Voss, Anne K, Gadina, Massimo, Kastner, Daniel L, and Silke, John

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Biodefense, Prevention, Rare Diseases, Vaccine Related, 1.1 Normal biological development and functioning, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Caspase 3, Caspase 8, Female, Hereditary Autoinflammatory Diseases, Humans, MAP Kinase Kinase Kinases, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Pedigree, Receptor-Interacting Protein Serine-Threonine Kinases, General Science & Technology
Abstract

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term 'cleavage-resistant RIPK1-induced autoinflammatory syndrome'. To define the mechanism for this disease, we generated a cleavage-resistant Ripk1D325A mutant mouse strain. Whereas Ripk1-/- mice died postnatally from systemic inflammation, Ripk1D325A/D325A mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1D325A/D325A embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1D325A/D325A and Ripk1D325A/+ cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1D325A/+ mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.

Published
2020

14. Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

Author

La Marca, John E., primary, Aubrey, Brandon J., additional, Yang, Bruce, additional, Chang, Catherine, additional, Wang, Zilu, additional, Kueh, Andrew, additional, Tai, Lin, additional, Wilcox, Stephen, additional, Milla, Liz, additional, Heinzel, Susanne, additional, Vremec, David, additional, Whelan, Lauren, additional, König, Christina, additional, Kaloni, Deeksha, additional, Voss, Anne K., additional, Strasser, Andreas, additional, Diepstraten, Sarah T., additional, Herold, Marco J., additional, and Kelly, Gemma L., additional

Published
2023
Full Text
View/download PDF

15. HBO1 is required for the maintenance of leukaemia stem cells

Author

MacPherson, Laura, Anokye, Juliana, Yeung, Miriam M., Lam, Enid Y. N., Chan, Yih-Chih, Weng, Chen-Fang, Yeh, Paul, Knezevic, Kathy, Butler, Miriam S., Hoegl, Annabelle, Chan, Kah-Lok, Burr, Marian L., Gearing, Linden J., Willson, Tracy, Liu, Joy, Choi, Jarny, Yang, Yuqing, Bilardi, Rebecca A., Falk, Hendrik, Nguyen, Nghi, Stupple, Paul A., Peat, Thomas S., Zhang, Ming, de Silva, Melanie, Carrasco-Pozo, Catalina, Avery, Vicky M., Khoo, Poh Sim, Dolezal, Olan, Dennis, Matthew L., Nuttall, Stewart, Surjadi, Regina, Newman, Janet, Ren, Bin, Leaver, David J., Sun, Yuxin, Baell, Jonathan B., Dovey, Oliver, Vassiliou, George S., Grebien, Florian, Dawson, Sarah-Jane, Street, Ian P., Monahan, Brendon J., Burns, Christopher J., Choudhary, Chunaram, Blewitt, Marnie E., Voss, Anne K., Thomas, Tim, and Dawson, Mark A.

Published
2020
Full Text
View/download PDF

17. PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Author

McRae, Helen M., Garnham, Alexandra L., Hu, Yifang, Witkowski, Matthew T., Corbett, Mark A., Dixon, Mathew P., May, Rose E., Sheikh, Bilal N., Chiang, William, Kueh, Andrew J., Nguyen, Tan A., Man, Kevin, Gloury, Renee, Aubrey, Brandon J., Policheni, Antonia, Di Rago, Ladina, Alexander, Warren S., Gray, Daniel H.D., Strasser, Andreas, Hawkins, Edwin D., Wilcox, Stephen, Gécz, Jozef, Kallies, Axel, McCormack, Matthew P., Smyth, Gordon K., Voss, Anne K., and Thomas, Tim

Published
2019
Full Text
View/download PDF

18. ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.

Author

Mah, Sophia Y. Y., Vanyai, Hannah K., Li-Wai-Suen, Connie S. N., Garnham, Alexandra L., Wynn, Jessica, Bergamasco, Maria I., Malelang, Shezlie, Wilcox, Stephen, Biben, Christine, Smyth, Gordon K., Thomas, Tim, and Voss, Anne K.

Subjects
VENTRICULAR septal defects, ACETYLATION, LYSINE, HISTONE acetyltransferase, EMBRYOLOGY
Abstract

Inhibitor of growth 4 and 5 (ING4, ING5) are structurally similar chromatin-binding proteins in the KAT6A, KAT6B and KAT7 histone acetyltransferase protein complexes. Heterozygous mutations in the KAT6A or KAT6B gene cause human disorders with cardiac defects, but the contribution of their chromatin-adaptor proteins to development is unknown. We found that Ing5−/− mice had isolated cardiac ventricular septal defects. Ing4−/−Ing5−/− embryos failed to undergo chorioallantoic fusion and arrested in development at embryonic day 8.5, displaying loss of histone H3 lysine 14 acetylation, reduction in H3 lysine 23 acetylation levels and reduced developmental gene expression. Embryonic day 12.5 Ing4+/−Ing5−/− hearts showed a paucity of epicardial cells and epicardium-derived cells, failure of myocardium compaction, and coronary vasculature defects, accompanied by reduced expression of epicardium genes. Cell adhesion gene expression and proepicardium outgrowth were defective in the ING4- and ING5-deficient state. Our findings suggest that ING4 and ING5 are essential for heart development and promote epicardium and epicardium-derived cell fates and imply mutation of the human ING5 gene as a possible cause of isolated ventricular septal defects. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. Relative importance of MCL-1's Anti-Apoptotic versus Non-Apoptotic Functions in vivo

Author

Brinkmann, Kerstin, primary, McArthur, Kate, additional, Tee, Annli, additional, Kueh, Andrew J., additional, Malelang, Shezlie, additional, Wimmer, Verena, additional, Gibson, Leonie, additional, Rowe, Caitlin L, additional, Arandjelovic, Phil, additional, Dewson, Grant, additional, Putoczki, Tracy, additional, Bouillet, Philippe, additional, Fu, Naiyang, additional, Thomas, Tim, additional, Herold, Marco J, additional, Voss, Anne K, additional, and Strasser, Andreas, additional

Published
2023
Full Text
View/download PDF

20. Development of Hydrocephalus in Mice Lacking SOCS7

Author

Krebs, Danielle L., Metcalf, Donald, Merson, Tobias D., Voss, Anne K., Thomas, Tim, Zhang, Jian-Guo, Rakar, Steven, O'Bryan, Moira K., Wilson, Tracy A., Viney, Elizabeth M., Mielke, Lisa A., Nicola, Nicos A., Hilton, Douglas J., and Alexander, Warren S.

Published
2004

22. Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Author

Klein, Brianna J., Jang, Suk Min, Lachance, Catherine, Mi, Wenyi, Lyu, Jie, Sakuraba, Shun, Krajewski, Krzysztof, Wang, Wesley W., Sidoli, Simone, Liu, Jiuyang, Zhang, Yi, Wang, Xiaolu, Warfield, Becka M., Kueh, Andrew J., Voss, Anne K., Thomas, Tim, Garcia, Benjamin A., Liu, Wenshe R., Strahl, Brian D., Kono, Hidetoshi, Li, Wei, Shi, Xiaobing, Côté, Jacques, and Kutateladze, Tatiana G.

Published
2019
Full Text
View/download PDF

24. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Author

Baell, Jonathan B., Leaver, David J., Hermans, Stefan J., Kelly, Gemma L., Brennan, Margs S., Downer, Natalie L., Nguyen, Nghi, Wichmann, Johannes, McRae, Helen M., Yang, Yuqing, Cleary, Ben, Lagiakos, H. Rachel, Mieruszynski, Stephen, Pacini, Guido, Vanyai, Hannah K., Bergamasco, Maria I., May, Rose E., Davey, Bethany K., Morgan, Kimberly J., Sealey, Andrew J., Wang, Beinan, Zamudio, Natasha, Wilcox, Stephen, Garnham, Alexandra L., Sheikh, Bilal N., Aubrey, Brandon J., Doggett, Karen, Chung, Matthew C., de Silva, Melanie, Bentley, John, Pilling, Pat, Hattarki, Meghan, Dolezal, Olan, Dennis, Matthew L., Falk, Hendrik, Ren, Bin, Charman, Susan A., White, Karen L., Rautela, Jai, Newbold, Andrea, Hawkins, Edwin D., Johnstone, Ricky W., Huntington, Nicholas D., Peat, Thomas S., Heath, Joan K., Strasser, Andreas, Parker, Michael W., Smyth, Gordon K., Street, Ian P., Monahan, Brendon J., Voss, Anne K., and Thomas, Tim

Published
2018
Full Text
View/download PDF

29. The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK

Author

Ke, Francine S, Holloway, Steven, Uren, Rachel T, Wong, Agnes W, Little, Melissa H, Kluck, Ruth M, Voss, Anne K, and Strasser, Andreas

Subjects
Mice, Knockout, Mice, bcl-2 Homologous Antagonist-Killer Protein, Proto-Oncogene Proteins c-bcl-2, Animals, Embryonic Development, Apoptosis, Articles, bcl-2-Associated X Protein, BH3 Interacting Domain Death Agonist Protein
Abstract

The intrinsic apoptosis pathway, regulated by the BCL‐2 protein family, is essential for embryonic development. Using mice lacking all known apoptosis effectors, BAX, BAK and BOK, we have previously defined the processes during development that require apoptosis. Rare Bok(−/−)Bax(−/−)Bak(−/−) triple knockout (TKO) mice developed to adulthood and several tissues that were thought to require apoptosis during development appeared normal. This raises the question if all apoptosis had been abolished in the TKO mice or if other BCL‐2 family members could act as effectors of apoptosis. Here, we investigated the role of BID, generally considered to link the extrinsic and intrinsic apoptosis pathways, acting as a BH3‐only protein initiating apoptosis upstream of BAX and BAK. We found that Bok(−/−)Bax(−/−) Bak(−/−)Bid(−/−) quadruple knockout (QKO) mice have additional developmental anomalies compared to TKO mice, consistent with a role of BID, not only upstream but also in parallel to BAX, BAK and BOK. Mitochondrial experiments identified a small cytochrome c‐releasing activity of full‐length BID. Collectively, these findings suggest a new effector role for BID in the intrinsic apoptosis pathway.

Published
2022

31. Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Author

Lawrenson, Isobel D., Krebs, Danielle L., Linossi, Edmond M., Zhang, Jian-Guo, McLennan, Tamara J., Collin, Caitlin, McRae, Helen M., Kolesnik, Tatiana B., Koh, Katrina, Britto, Joanne M., Kueh, Andrew J., Sheikh, Bilal N., El-Saafin, Farrah, Nicola, Nicos A., Tan, Seong-Seng, Babon, Jeffrey J., Nicholson, Sandra E., Alexander, Warren S., Thomas, Tim, and Voss, Anne K.

Published
2017
Full Text
View/download PDF

33. Correction: The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis

Author

Grant, Zoe L., primary, Hickey, Peter F., additional, Abeysekera, Waruni, additional, Whitehead, Lachlan, additional, Lewis, Sabrina M., additional, Symons, Robert C. A., additional, Baldwin, Tracey M., additional, Amann-Zalcenstein, Daniela, additional, Garnham, Alexandra L., additional, Naik, Shalin H., additional, Smyth, Gordon K., additional, Thomas, Tim, additional, Voss, Anne K., additional, and Coultas, Leigh, additional

Published
2021
Full Text
View/download PDF

34. The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis

Author

Grant, Zoe L., primary, Hickey, Peter F., additional, Abeysekera, Waruni, additional, Whitehead, Lachlan, additional, Lewis, Sabrina M., additional, Symons, Robert C. A., additional, Baldwin, Tracey M., additional, Amann-Zalcenstein, Daniela, additional, Garnham, Alexandra L., additional, Naik, Shalin H., additional, Smyth, Gordon K., additional, Thomas, Tim, additional, Voss, Anne K., additional, and Coultas, Leigh, additional

Published
2021
Full Text
View/download PDF

35. Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER+ breast cancer with KAT6A dysregulation

Author

Sharma, Shikhar, primary, Chung, Jay, additional, Uryu, Sean, additional, Rickard, Amanda, additional, Nady, Natalie, additional, Khan, Showkhin, additional, Wang, Zhenxiong, additional, Zhang, Yong, additional, Zhang, Haikuo, additional, Kung, Pei-Pei, additional, Greenwald, Eric, additional, Maegley, Karen, additional, Bingham, Patrick, additional, Lam, Hieu, additional, Bozikis, Ylva E., additional, Falk, Hendrik, additional, Allan, Elizabeth, additional, Avery, Vicky M., additional, Butler, Miriam S., additional, Camerino, Michelle A., additional, Carrasco-Pozo, Catalina, additional, Charman, Susan A., additional, Davis, Melissa J., additional, Dawson, Mark A., additional, Sarah-Jane, Dawson, additional, de Silva, Melanie, additional, Dennis, Matthew L., additional, Dolezal, Olan, additional, Lagiakos, Rachel, additional, Lindeman, Geoffrey J., additional, MacPherson, Laura, additional, Nuttall, Stewart, additional, Peat, Thomas S., additional, Ren, Bin, additional, Stupple, Alexandra E., additional, Surgenor, Elliot, additional, Tan, Chin Wee, additional, Thomas, Tim, additional, Visvader, Jane E., additional, Voss, Anne K., additional, Vaillant, Francois, additional, White, Karen L., additional, Whittle, James, additional, Yang, Yuqing, additional, Hediyeh-Zadeh, Soroor, additional, Stupple, Paul A., additional, Street, Ian P., additional, Monahan, Brendon J., additional, and Paul, Thomas, additional

Published
2021
Full Text
View/download PDF

37. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene

Author

Hirst, Claire E., Ng, Elizabeth S., Azzola, Lisa, Voss, Anne K., Thomas, Tim, Stanley, Edouard G., and Elefanty, Andrew G.

Subjects
Genetic research -- Analysis, Genetic research -- Genetic aspects, Embryonic stem cells -- Analysis, Embryonic stem cells -- Genetic aspects, Mice -- Analysis, Mice -- Genetic aspects, Anopheles -- Analysis, Anopheles -- Genetic aspects, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2006.01.023 Byline: Claire E. Hirst (a), Elizabeth S. Ng (a), Lisa Azzola (a), Anne K. Voss (b), Tim Thomas (b), Edouard G. Stanley (a), Andrew G. Elefanty (a) Keywords: Embryonic stem cell; Cell differentiation; Transcriptional profiling; SLAIN1 Abstract: We analyzed the transcriptional profiles of differentiating mouse embryonic stem cells (mESCs) and show that embryoid bodies (EBs) sequentially expressed genes associated with the epiblast, primitive streak, mesoderm and endoderm of the developing embryo, validating ESCs as a model system for identifying cohorts of genes marking specific stages of embryogenesis. By comparing the transcriptional profiles of undifferentiated ESCs to those of their differentiated progeny, we identified 503 mESC and 983 hESC genes selectively expressed in undifferentiated ES cells. Over 75% of the mESC genes were expressed in hESC and vice versa, attesting to the underlying similarity of mESCs and hESCs. The expression of a cohort of 68 genes decreased greater than 2-fold during differentiation in both mESCs and hESCs. As well as containing many validated ESC genes such as Oct4 [Pou5f1], Nanog and Nodal, this cohort included an uncharacterised gene (FLJ30046), which we designated SLAIN1/Slain1. Slain1 was expressed at the stem cell and epiblast stages of ESC differentiation and in the epiblast, nervous system, tailbud and somites of the developing mouse embryo. SLAIN1 and its more widely expressed homologue SLAIN2 comprise a new family of structurally unique genes conserved throughout vertebrate evolution. Author Affiliation: (a) Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, VIC 3800, Australia (b) The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, VIC 3050, Australia Article History: Received 16 December 2005; Accepted 20 January 2006

Published
2006

39. Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3

Author

Ting, Stephen B, Wilanowski, Tomasz, Auden, Alana, Hall, Mark, Voss, Anne K, Thomas, Tim, Parekh, Vishwas, Cunningham, John M, and Jane, Stephen M

Subjects
Epithelial cells -- Physiological aspects, Drug resistance -- Research, Folic acid -- Health aspects, Inositol -- Health aspects, Neural tube -- Abnormalities, Neural tube -- Research
Abstract

The neural tube defects (NTDs) spina bifida and anencephaly are widely prevalent severe birth defects. The mouse mutant curly tail (ct/ct) has served as a model of NTDs for 50 years, even though the responsible genetic defect remained unrecognized. Here we show by gene targeting, mapping and genetic complementation studies that a mouse homolog of the Drosophila grainyhead (grh) gene, grainyhead-like-3 (Grhl3), is a compelling candidate for the gene underlying the curly tail phenotype. The NTDs in Grhl3-null mice are more severe than those in the curly tail strain, as the Grhl3 alleles in ct/ct mice are hypomorphic. Spina bifida in ct/ct mice is folate resistant, but its incidence can be markedly reduced by maternal inositol supplementation periconceptually. The NTDs in Grhl3[sup.-/-] embryos are also folate resistant, but unlike those in ct/ct mice, they are resistant to inositol. These findings suggest that residual Grhl3 expression in ct/ct mice may be required for inositol rescue of folate-resistant NTDs., Author(s): Stephen B Ting [1]; Tomasz Wilanowski [1]; Alana Auden [1]; Mark Hall [1]; Anne K Voss [2]; Tim Thomas [2]; Vishwas Parekh [3]; John M Cunningham [3]; Stephen M [...]

Published
2003
Full Text
View/download PDF

40. Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan Syndrome, including severe congenital cataract, dental anomalies, and mental retardation

Author

Burdon, Kathryn P., McKay, James D., Sale, Michele M., Russell-Eggitt, Isabelle M., Mackey, David A., Wirth, M. Gabriela, Elder, James E., Nicoll, Alan, Clarke, Michael P., FitzGerald, Liesel M., Stankovich, James M., Shaw, Marie A., Sharma, Shiwani, Gajovic, Srecko, Gruss, Peter, Ross, Shelley, Thomas, Paul, Voss, Anne K., Thomas, Tim, Gecz, Jozef, and Craig, Jamie E.

Subjects
Human genetics -- Research, Biological sciences
Published
2003

42. The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.

Author

Heinlein, Melanie, Gandolfo, Luke C., Zhao, Kelin, Teh, Charis E., Nguyen, Nghi, Baell, Jonathan B., Goldfarb, Yael, Abramson, Jakub, Wichmann, Johannes, Voss, Anne K., Strasser, Andreas, Smyth, Gordon K., Thomas, Tim, and Gray, Daniel H. D.

Abstract

The autoimmune regulator (AIRE) induces the transcription of thousands of peripheral tissue genes (PTGs) in thymic epithelial cells (TECs) to mediate immunological tolerance. The chromatin state required for optimal AIRE function in TECs and how this state is induced remains unclear. We tested the role of the histone acetyltransferase, KAT7 (also known as HBO1 or MYST2), which is essential for acetylation of histone 3 lysine 14, in TEC differentiation, AIRE-mediated PTG expression, and thymic tolerance. We find that KAT7 is required for optimal expansion of medullary TEC and has a major role in the expression of AIRE-dependent PTGs, associated with enhanced chromatin accessibility at these gene loci in TECs. Mice with TEC-specific Kat7 deletion develop organ-specific autoimmunity with features resembling those observed in Aire-deficient mice. These findings highlight critical roles for KAT7-mediated acetylation in promoting a chromatin state at PTG loci that enables AIRE function and the establishment of immunological tolerance. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

44. Purification of a pluripotent neural stem cell from the adult mouse brain

Author

Rietze, Rodney L., Valcanis, Helen, Brooker, Gordon F., Thomas, Tim, Voss, Anne K., and Bartlett, Perry F.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Rodney L. Rietze [1]; Helen Valcanis [2]; Gordon F. Brooker [1]; Tim Thomas [1]; Anne K. Voss [1]; Perry F. Bartlett (corresponding author) [1] As the precise location of [...]

Published
2001
Full Text
View/download PDF

45. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Author

Priebbenow, Daniel L., primary, Leaver, David J., additional, Nguyen, Nghi, additional, Cleary, Benjamin, additional, Lagiakos, H. Rachel, additional, Sanchez, Julie, additional, Xue, Lian, additional, Huang, Fei, additional, Sun, Yuxin, additional, Mujumdar, Prashant, additional, Mudududdla, Ramesh, additional, Varghese, Swapna, additional, Teguh, Silvia, additional, Charman, Susan A., additional, White, Karen L., additional, Shackleford, David M., additional, Katneni, Kasiram, additional, Cuellar, Matthew, additional, Strasser, Jessica M., additional, Dahlin, Jayme L., additional, Walters, Michael A., additional, Street, Ian P., additional, Monahan, Brendon J., additional, Jarman, Kate E., additional, Jousset Sabroux, Helene, additional, Falk, Hendrik, additional, Chung, Matthew C., additional, Hermans, Stefan J., additional, Downer, Natalie L., additional, Parker, Michael W., additional, Voss, Anne K., additional, Thomas, Tim, additional, and Baell, Jonathan B., additional

Published
2020
Full Text
View/download PDF

46. Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response

Author

Gan, Linhua, primary, Sun, Jingjing, additional, Yang, Shuo, additional, Zhang, Xiaocui, additional, Chen, Wu, additional, Sun, Yiyu, additional, Wu, Xiaohua, additional, Cheng, Cheng, additional, Yuan, Jing, additional, Li, Anan, additional, Corbett, Mark A., additional, Dixon, Mathew P., additional, Thomas, Tim, additional, Voss, Anne K., additional, Gécz, Jozef, additional, Wang, Guang-Zhong, additional, Bonni, Azad, additional, Li, Qian, additional, and Huang, Ju, additional

Published
2020
Full Text
View/download PDF

50. HBO1 is required for the maintenance of leukaemia stem cells

Author

MacPherson, Laura, primary, Anokye, Juliana, additional, Yeung, Miriam M., additional, Lam, Enid Y. N., additional, Chan, Yih-Chih, additional, Weng, Chen-Fang, additional, Yeh, Paul, additional, Knezevic, Kathy, additional, Butler, Miriam S., additional, Hoegl, Annabelle, additional, Chan, Kah-Lok, additional, Burr, Marian L., additional, Gearing, Linden J., additional, Willson, Tracy, additional, Liu, Joy, additional, Choi, Jarny, additional, Yang, Yuqing, additional, Bilardi, Rebecca A., additional, Falk, Hendrik, additional, Nguyen, Nghi, additional, Stupple, Paul A., additional, Peat, Thomas S., additional, Zhang, Ming, additional, de Silva, Melanie, additional, Carrasco-Pozo, Catalina, additional, Avery, Vicky M., additional, Khoo, Poh Sim, additional, Dolezal, Olan, additional, Dennis, Matthew L., additional, Nuttall, Stewart, additional, Surjadi, Regina, additional, Newman, Janet, additional, Ren, Bin, additional, Leaver, David J., additional, Sun, Yuxin, additional, Baell, Jonathan B., additional, Dovey, Oliver, additional, Vassiliou, George S., additional, Grebien, Florian, additional, Dawson, Sarah-Jane, additional, Street, Ian P., additional, Monahan, Brendon J., additional, Burns, Christopher J., additional, Choudhary, Chunaram, additional, Blewitt, Marnie E., additional, Voss, Anne K., additional, Thomas, Tim, additional, and Dawson, Mark A., additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results