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1. Charge transfer of polyatomic molecules in ion-atom hybrid traps: Stereodynamics in the millikelvin regime

Author

Voute, Alexandre, Dörfler, Alexander, Wiesenfeld, Laurent, Dulieu, Olivier, Gatti, Fabien, Peláez, Daniel, and Willitsch, Stefan

Subjects
Physics - Atomic Physics, Physics - Chemical Physics
Abstract

Rate constants for the charge transfer reaction between N${}_{2}$H${}^{+}$ and Rb in the mK regime are measured in an ion-atom hybrid trap and are found to be lower than the Langevin capture limit. Multireference ab initio computation of the potential energy surfaces involved in the reaction reveals that the low-temperature charge transfer is hindered by short-range features highly dependent on the collision angle and is promoted by a deformation of the molecular frame. The present study highlights the importance of polyatomic effects and of stereodynamics in cold molecular ion-neutral collisions., Comment: See supplemental material for details on electronic structure methods, estimates of transition probabilities and timescales, and other PES cuts

Published
2023

4. Charge transfer of polyatomic molecules in ion-atom hybrid traps: Stereodynamics in the millikelvin regime

Author

Alexandre Voute, Alexander Dörfler, Laurent Wiesenfeld, Olivier Dulieu, Fabien Gatti, Daniel Peláez, and Stefan Willitsch

Subjects
Physics, QC1-999
Abstract

Rate constants for the charge-transfer reaction between N_{2}H^{+} and Rb in the millikelvin regime are measured in an ion-atom hybrid trap and are found to be lower than the Langevin capture limit. Multireference ab initio computation of the potential energy surfaces involved in the reaction reveals that the low-temperature charge transfer is hindered by short-range features highly dependent on the collision angle and is promoted by a deformation of the molecular frame. The present study highlights the importance of polyatomic effects and of stereodynamics in cold molecular ion-neutral collisions.

Published
2023
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6. Topical Lidocaine for Chronic Pain Treatment

Author

Voute M, Morel V, and Pickering G

Subjects
lidocaine plaster, topical, local, neuropathic pain, musculoskeletal pain, Therapeutics. Pharmacology, RM1-950
Abstract

Marion Voute,1 Véronique Morel,1 Gisèle Pickering1,2 1CHU Clermont-Ferrand, Plateforme d’Investigation Clinique - Centre d’Investigation Clinique, CIC Inserm 1405, Clermont–Ferrand, F-63000, France; 2Université Clermont Auvergne, Inserm 1107, Clermont-Ferrand, F-63000, FranceCorrespondence: Gisèle PickeringCHU Clermont-Ferrand, Plateforme d’Investigation Clinique - Centre d’Investigation Clinique, CIC Inserm 1405, Clermont–Ferrand, F-63000, FranceTel +33 4 73 17 84 16Fax +33 4 73 17 84 12Email gisele.pickering@uca.frAbstract: Topical lidocaine is widely used in current practice for a variety of pain conditions. This literature review shows that its limited absorption and relative lack of systemic adverse events are an attractive analgesic option for a number of vulnerable patients. Topical lidocaine has been approved by health authorities for the treatment of post-herpetic neuralgia in a number of countries, and studies present some degree of evidence of its efficacy and safety in postsurgical pain, diabetic peripheral neuropathy, carpal tunnel syndrome, chronic lower back pain and osteoarthritis. Topical lidocaine may be a great alternative alone or in addition to systemic drugs and non-pharmacological approaches for an optimized pain management and in multimodal analgesia.Keywords: lidocaine plaster, topical, local, neuropathic pain, musculoskeletal pain

Published
2021

7. Patients with a Ruptured Abdominal Aortic Aneurysm Are Better Informed in Hospitals with an “EVAR-preferred” Strategy: An Instrumental Variable Analysis of the Dutch Surgical Aneurysm Audit

Author

Van den Akker, P.J., Akkersdijk, G.J., Akkersdijk, G.P., Akkersdijk, W.L., van Andringa de Kempenaer, M.G., Arts, C.H., Avontuur, J.A., Bakker, O.J., Balm, R., Barendregt, W.B., Bekken, J.A., Bender, M.H., Bendermacher, B.L., van den Berg, M., Berger, P., Beuk, R.J., Blankensteijn, J.D., Bleker, R.J., Blok, J.J., Bode, A.S., Bodegom, M.E., van der Bogt, K.E., Boll, A.P., Booster, M.H., Borger van der Burg, B.L., de Borst, G.J., Bos- van Rossum, W.T., Bosma, J., Botman, J.M., Bouwman, L.H., Brehm, V., de Bruijn, M.T., de Bruin, J.L., Brummel, P., van Brussel, J.P., Buijk, S.E., Buijs, M.A., Buimer, M.G., Burger, D.H., Buscher, H.C., Cancrinus, E., Castenmiller, P.H., Cazander, G., Coester, A.M., Cuypers, P.H., Daemen, J.H., Dawson, I., Dierikx, J.E., Dijkstra, M.L., Diks, J., Dinkelman, M.K., Dirven, M., Dolmans, D.E., van Doorn, R.C., van Dortmont, L.M., Drouven, J.W., van der Eb, M.M., Eefting, D., van Eijck, G.J., Elshof, J.W., Elsman, B.H., van der Elst, A., van Engeland, M.I., van Eps, R.G., Faber, M.J., de Fijter, W.M., Fioole, B., Fokkema, T.M., Frans, F.A., Fritschy, W.M., Fung Kon Jin, P.H., Geelkerken, R.H., van Gent, W.B., Glade, G.J., Govaert, B., Groenendijk, R.P., de Groot, H.G., van den Haak, R.F., de Haan, E.F., Hajer, G.F., Hamming, J.F., van Hattum, E.S., Hazenberg, C.E., Hedeman Joosten, P.P., Helleman, J.N., van der Hem, L.G., Hendriks, J.M., van Herwaarden, J.A., Heyligers, J.M., Hinnen, J.W., Hissink, R.J., Ho, G.H., den Hoed, P.T., Hoedt, M.T., van Hoek, F., Hoencamp, R., Hoffmann, W.H., Hogendoorn, W., Hoksbergen, A.W., Hollander, E.J., Hommes, M., Hopmans, C.J., Huisman, L.C., Hulsebos, R.G., Huntjens, K.M., Idu, M.M., Jacobs, M.J., van der Jagt, M.F., Jansbeken, J.R., Janssen, R.J., Jiang, H.H., de Jong, S.C., Jongbloed-Winkel, T.A., Jongkind, V., Kapma, M.R., Keller, B.P., Khodadade Jahrome, A., Kievit, J.K., Klemm, P.L., Klinkert, P., Koedam, N.A., Koelemaij, M.J., Kolkert, J.L., Koning, G.G., Koning, O.H., Konings, R., Krasznai, A.G., Krol, R.M., Kropman, R.H., Kruse, R.R., van der Laan, L., van der Laan, M.J., van Laanen, J.H., van Lammeren, G.W., Lamprou, D.A., Lardenoye, J.H., Lauret, G.J., Leenders, B.J., Legemate, D.A., Leijdekkers, V.J., Lemson, M.S., Lensvelt, M.M., Lijkwan, M.A., Lind, R.C., van der Linden, F.T., Liqui Lung, P.F., Loos, M.J., Loubert, M.C., van de Luijtgaarden, K.M., Mahmoud, D.E., Manshanden, C.G., Mattens, E.C., Meerwaldt, R., Mees, B.M., von Meijenfeldt, G.C., Menting, T.P., Metz, R., Minnee, R.C., de Mol van Otterloo, J.C., Molegraaf, M.J., Montauban van Swijndregt, Y.C., Morak, M.J., van de Mortel, R.H., Mulder, W., Nagesser, S.K., Naves, C.C., Nederhoed, J.H., Nevenzel-Putters, A.M., de Nie, A.J., Nieuwenhuis, D.H., Nieuwenhuizen, J., van Nieuwenhuizen, R.C., Nio, D., Noyez, V.J., Oomen, A.P., Oranen, B.I., Oskam, J., Palamba, H.W., Peppelenbosch, A.G., van Petersen, A.S., Petri, B.J., Pierie, M.E., Ploeg, A.J., Pol, R.A., Ponfoort, E.D., Post, I.C., Poyck, P.P., Prent, A., ten Raa, S., Raymakers, J.T., Reichart, M., Reichmann, B.L., Reijnen, M.M., de Ridder, J.A., Rijbroek, A., van Rijn, M.J., de Roo, R.A., Rouwet, E.V., Saleem, B.R., Salemans, P.B., van Sambeek, M.R., Samyn, M.G., van ’t Sant, H.P., van Schaik, J., van Schaik, P.M., Scharn, D.M., Scheltinga, M.R., Schepers, A., Schlejen, P.M., Schlosser, F.J., Schol, F.P., Scholtes, V.P., Schouten, O., Schreve, M.A., Schurink, G.W., Sikkink, C.J., te Slaa, A., Smeets, H.J., Smeets, L., Smeets, R.R., de Smet, A.A., Smit, P.C., Smits, T.M., Snoeijs, M.G., Sondakh, A.O., Speijers, M.J., van der Steenhoven, T.J., van Sterkenburg, S.M., Stigter, D.A., Stokmans, R.A., Strating, R.P., Stultiëns, G.N., Sybrandy, J.E., Teijink, J.A., Telgenkamp, B.J., Teraa, M., Testroote, M.J., Tha-In, T., The, R.M., Thijsse, W.J., Thomassen, I., Tielliu, I.F., van Tongeren, R.B., Toorop, R.J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R.P., Ünlü, Ç., Vaes, R.H., Vafi, A.A., Vahl, A.C., Veen, E.J., Veger, H.T., Veldman, M.G., Velthuis, S., Verhagen, H.J., Verhoeven, B.A., Vermeulen, C.F., Vermeulen, E.G., Vierhout, B.P., van der Vijver-Coppen, R.J., Visser, M.J., van der Vliet, J.A., Vlijmen - van Keulen, C.J., Voorhoeve, R., van der Vorst, J.R., Vos, A.W., de Vos, B., Vos, C.G., Vos, G.A., Voute, M.T., Vriens, B.H., Vriens, P.W., de Vries, A.C., de Vries, D.K., de Vries, J.P., de Vries, M., van der Waal, C., Waasdorp, E.J., Wallis de Vries, B.M., van Walraven, L.A., van Wanroij, J.L., Warlé, M.C., van de Water, W., van Weel, V., van Well, A.M., Welten, G.M., Welten, R.J., Wever, J.J., Wiersema, A.M., Wikkeling, O.R., Willaert, W.I., Wille, J., Willems, M.C., Willigendael, E.M., Wilschut, E.D., Wisselink, W., Witte, M.E., Wittens, C.H., Wong, C.Y., Wouda, R., Yazar, O., Yeung, K.K., Zeebregts, C.J., van Zeeland, M.L., Karthaus, Eleonora G., Lijftogt, Niki, Vahl, Anco, van der Willik, Esmee M., Amodio, Sonia, van Zwet, Erik W., and Hamming, Jaap F.

Published
2020
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8. A Composite Measure for Quality of Care in Patients with Symptomatic Carotid Stenosis Using Textbook Outcome

Author

Van den Akker, P.J., Akkersdijk, G.J., Akkersdijk, G.P., Akkersdijk, W.L., van Andringa de Kempenaer, M.G., Arts, C.H., Avontuur, J.A., Bakker, O.J., Balm, R., Barendregt, W.B., Bekken, J.A., Bender, M.H., Bendermacher, B.L., van den Berg, M., Berger, P., Beuk, R.J., Blankensteijn, J.D., Bleker, R.J., Blok, J.J., Bode, A.S., Bodegom, M.E., van der Bogt, K.E., Boll, A.P., Booster, M.H., Borger van der Burg, B.L., de Borst, G.J., Bos-van Rossum, W.T., Bosma, J., Botman, J.M., Bouwman, L.H., Brehm, V., de Bruijn, M.T., de Bruin, J.L., Brummel, P., van Brussel, J.P., Buijk, S.E., Buijs, M.A., Buimer, M.G., Burger, D.H., Buscher, H.C., Cancrinus, E., Castenmiller, P.H., Cazander, G., Coester, A.M., Cuypers, P.H., Daemen, J.H., Dawson, I., Dierikx, J.E., Dijkstra, M.L., Diks, J., Dinkelman, M.K., Dirven, M., Dolmans, D.E., van Doorn, R.C., van Dortmont, L.M., Drouven, J.W., van der Eb, M.M., Eefting, D., van Eijck, G.J., Elshof, J.W., Elsman, B.H., van der Elst, A., van Engeland, M.I., van Eps, R.G., Faber, M.J., de Fijter, W.M., Fioole, B., Fokkema, T.M., Frans, F.A., Fritschy, W.M., Fung Kon Jin, P.H., Geelkerken, R.H., van Gent, W.B., Glade, G.J., Govaert, B., Groenendijk, R.P., de Groot, H.G., van den Haak, R.F., de Haan, E.F., Hajer, G.F., Hamming, J.F., van Hattum, E.S., Hazenberg, C.E., Hedeman Joosten, P.P., Helleman, J.N., van der Hem, L.G., Hendriks, J.M., van Herwaarden, J.A., Heyligers, J.M., Hinnen, J.W., Hissink, R.J., Ho, G.H., den Hoed, P.T., Hoedt, M.T., van Hoek, F., Hoencamp, R., Hoffmann, W.H., Hogendoorn, W., Hoksbergen, A.W., Hollander, E.J., Hommes, M., Hopmans, C.J., Huisman, L.C., Hulsebos, R.G., Huntjens, K.M., Idu, M.M., Jacobs, M.J., van der Jagt, M.F., Jansbeken, J.R., Janssen, R.J., Jiang, H.H., de Jong, S.C., Jongbloed-Winkel, T.A., Jongkind, V., Kapma, M.R., Keller, B.P., Khodadade Jahrome, A., Kievit, J.K., Klemm, P.L., Klinkert, P., Koedam, N.A., Koelemaij, M.J., Kolkert, J.L., Koning, G.G., Koning, O.H., Konings, R., Krasznai, A.G., Krol, R.M., Kropman, R.H., Kruse, R.R., van der Laan, L., van der Laan, M.J., van Laanen, J.H., van Lammeren, G.W., Lamprou, D.A., Lardenoye, J.H., Lauret, G.J., Leenders, B.J., Legemate, D.A., Leijdekkers, V.J., Lemson, M.S., Lensvelt, M.M., Lijkwan, M.A., Lind, R.C., van der Linden, F.T., Liqui Lung, P.F., Loos, M.J., Loubert, M.C., van de Luijtgaarden, K.M., Mahmoud, D.E., Manshanden, C.G., Mattens, E.C., Meerwaldt, R., Mees, B.M., von Meijenfeldt, G.C., Menting, T.P., Metz, R., Minnee, R.C., de Mol van Otterloo, J.C., Molegraaf, M.J., Montauban van Swijndregt, Y.C., Morak, M.J., van de Mortel, R.H., Mulder, W., Nagesser, S.K., Naves, C.C., Nederhoed, J.H., Nevenzel-Putters, A.M., de Nie, A.J., Nieuwenhuis, D.H., Nieuwenhuizen, J., van Nieuwenhuizen, R.C., Nio, D., Noyez, V.J., Oomen, A.P., Oranen, B.I., Oskam, J., Palamba, H.W., Peppelenbosch, A.G., van Petersen, A.S., Petri, B.J., Pierie, M.E., Ploeg, A.J., Pol, R.A., Ponfoort, E.D., Post, I.C., Poyck, P.P., Prent, A., ten Raa, S., Raymakers, J.T., Reichart, M., Reichmann, B.L., Reijnen, M.M., de Ridder, J.A., Rijbroek, A., van Rijn, M.J., de Roo, R.A., Rouwet, E.V., Saleem, B.R., Salemans, P.B., van Sambeek, M.R., Samyn, M.G., van ’t Sant, H.P., van Schaik, J., van Schaik, P.M., Scharn, D.M., Scheltinga, M.R., Schepers, A., Schlejen, P.M., Schlosser, F.J., Schol, F.P., Scholtes, V.P., Schouten, O., Schreve, M.A., Schurink, G.W., Sikkink, C.J., te Slaa, A., Smeets, H.J., Smeets, L., Smeets, R.R., de Smet, A.A., Smit, P.C., Smits, T.M., Snoeijs, M.G., Sondakh, A.O., Speijers, M.J., van der Steenhoven, T.J., van Sterkenburg, S.M., Stigter, D.A., Stokmans, R.A., Strating, R.P., Stultiëns, G.N., Sybrandy, J.E., Teijink, J.A., Telgenkamp, B.J., Teraa, M., Testroote, M.J., Tha-In, T., The, R.M., Thijsse, W.J., Thomassen, I., Tielliu, I.F., van Tongeren, R.B., Toorop, R.J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R.P., Ünlü, Ç., Vaes, R.H., Vafi, A.A., Vahl, A.C., Veen, E.J., Veger, H.T., Veldman, M.G., Velthuis, S., Verhagen, H.J., Verhoeven, B.A., Vermeulen, C.F., Vermeulen, E.G., Vierhout, B.P., van der Vijver-Coppen, R.J., Visser, M.J., van der Vliet, J.A., Vlijmen - van Keulen, C.J., Voorhoeve, R., van der Vorst, J.R., Vos, A.W., de Vos, B., Vos, C.G., Vos, G.A., Voute, M.T., Vriens, B.H., Vriens, P.W., de Vries, A.C., de Vries, D.K., de Vries, J.P., de Vries, M., van der Waal, C., Waasdorp, E.J., Wallis de Vries, B.M., van Walraven, L.A., van Wanroij, J.L., Warlé, M.C., van de Water, W., van Weel, V., van Well, A.M., Welten, G.M., Welten, R.J., Wever, J.J., Wiersema, A.M., Wikkeling, O.R., Willaert, W.I., Wille, J., Willems, M.C., Willigendael, E.M., Wilschut, E.D., Wisselink, W., Witte, M.E., Wittens, C.H., Wong, C.Y., Wouda, R., Yazar, O., Yeung, K.K., Zeebregts, C.J., van Zeeland, M.L., Kuhrij, Laurien S., Karthaus, Eleonora G., Vahl, Anco C., Willems, Martine C.M., Elshof, Jan W., and de Borst, Gert J.

Published
2020
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9. National Numbers of Secondary Aortic Reinterventions after Primary Abdominal Aortic Aneurysm Surgery from the Dutch Surgical Aneurysm Audit

Author

Van den Akker, P.J., Akkersdijk, G.J., Akkersdijk, G.P., Akkersdijk, W.L., van Andringa de Kempenaer, M.G., Arts, C.H., Avontuur, J.A., Bakker, O.J., Balm, R., Barendregt, W.B., Bekken, J.A., Bender, M.H., Bendermacher, B.L., van den Berg, M., Berger, P., Beuk, R.J., Blankensteijn, J.D., Bleker, R.J., Blok, J.J., Bode, A.S., Bodegom, M.E., van der Bogt, K.E., Boll, A.P., Booster, M.H., Borger van der Burg, B.L., de Borst, G.J., Bos-van Rossum, W.T., Bosma, J., Botman, J.M., Bouwman, L.H., Brehm, V., de Bruijn, M.T., de Bruin, J.L., Brummel, P., van Brussel, J.P., Buijk, S.E., Buijs, M.A., Buimer, M.G., Burger, D.H., Buscher, H.C., Cancrinus, E., Castenmiller, P.H., Cazander, G., Coester, A.M., Cuypers, P.H., Daemen, J.H., Dawson, I., Dierikx, J.E., Dijkstra, M.L., Diks, J., Dinkelman, M.K., Dirven, M., Dolmans, D.E., van Doorn, R.C., van Dortmont, L.M., Drouven, J.W., van der Eb, M.M., Eefting, D., van Eijck, G.J., Elshof, J.W., Elsman, B.H., van der Elst, A., van Engeland, M.I., van Eps, R.G., Faber, M.J., de Fijter, W.M., Fioole, B., Fokkema, T.M., Frans, F.A., Fritschy, W.M., Fung Kon Jin, P.H., Geelkerken, R.H., van Gent, W.B., Glade, G.J., Govaert, B., Groenendijk, R.P., de Groot, H.G., van den Haak, R.F., de Haan, E.F., Hajer, G.F., Hamming, J.F., van Hattum, E.S., Hazenberg, C.E., Hedeman Joosten, P.P., Helleman, J.N., van der Hem, L.G., Hendriks, J.M., van Herwaarden, J.A., Heyligers, J.M., Hinnen, J.W., Hissink, R.J., Ho, G.H., den Hoed, P.T., Hoedt, M.T., van Hoek, F., Hoencamp, R., Hoffmann, W.H., Hogendoorn, W., Hoksbergen, A.W., Hollander, E.J., Hommes, M., Hopmans, C.J., Huisman, L.C., Hulsebos, R.G., Huntjens, K.M., Idu, M.M., Jacobs, M.J., van der Jagt, M.F., Jansbeken, J.R., Janssen, R.J., Jiang, H.H., de Jong, S.C., Jongbloed-Winkel, T.A., Jongkind, V., Kapma, M.R., Keller, B.P., Khodadade Jahrome, A., Kievit, J.K., Klemm, P.L., Klinkert, P., Koedam, N.A., Koelemaij, M.J., Kolkert, J.L., Koning, G.G., Koning, O.H., Konings, R., Krasznai, A.G., Krol, R.M., Kropman, R.H., Kruse, R.R., van der Laan, L., van der Laan, M.J., van Laanen, J.H., van Lammeren, G.W., Lamprou, D.A., Lardenoye, J.H., Lauret, G.J., Leenders, B.J., Legemate, D.A., Leijdekkers, V.J., Lemson, M.S., Lensvelt, M.M., Lijkwan, M.A., Lind, R.C., van der Linden, F.T., Liqui Lung, P.F., Loos, M.J., Loubert, M.C., van de Luijtgaarden, K.M., Mahmoud, D.E., Manshanden, C.G., Mattens, E.C., Meerwaldt, R., Mees, B.M., von Meijenfeldt, G.C., Menting, T.P., Metz, R., Minnee, R.C., de Mol van Otterloo, J.C., Molegraaf, M.J., Montauban van Swijndregt, Y.C., Morak, M.J., van de Mortel, R.H., Mulder, W., Nagesser, S.K., Naves, C.C., Nederhoed, J.H., Nevenzel-Putters, A.M., de Nie, A.J., Nieuwenhuis, D.H., Nieuwenhuizen, J., van Nieuwenhuizen, R.C., Nio, D., Noyez, V.J., Oomen, A.P., Oranen, B.I., Oskam, J., Palamba, H.W., Peppelenbosch, A.G., van Petersen, A.S., Petri, B.J., Pierie, M.E., Ploeg, A.J., Pol, R.A., Ponfoort, E.D., Post, I.C., Poyck, P.P., Prent, A., ten Raa, S., Raymakers, J.T., Reichart, M., Reichmann, B.L., Reijnen, M.M., de Ridder, J.A., Rijbroek, A., van Rijn, M.J., de Roo, R.A., Rouwet, E.V., Saleem, B.R., Salemans, P.B., van Sambeek, M.R., Samyn, M.G., van't Sant, H.P., van Schaik, J., van Schaik, P.M., Scharn, D.M., Scheltinga, M.R., Schepers, A., Schlejen, P.M., Schlosser, F.J., Schol, F.P., Scholtes, V.P., Schouten, O., Schreve, M.A., Schurink, G.W., Sikkink, C.J., te Slaa, A., Smeets, H.J., Smeets, L., Smeets, R.R., de Smet, A.A., Smit, P.C., Smits, T.M., Snoeijs, M.G., Sondakh, A.O., Speijers, M.J., van der Steenhoven, T.J., van Sterkenburg, S.M., Stigter, D.A., Stokmans, R.A., Strating, R.P., Stultiëns, G.N., Sybrandy, J.E., Teijink, J.A., Telgenkamp, B.J., Teraa, M., Testroote, M.J., Tha-In, T., The, R.M., Thijsse, W.J., Thomassen, I., Tielliu, I.F., van Tongeren, R.B., Toorop, R.J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R.P., Ünlü, Ç., Vaes, R.H., Vafi, A.A., Vahl, A.C., Veen, E.J., Veger, H.T., Veldman, M.G., Velthuis, S., Verhagen, H.J., Verhoeven, B.A., Vermeulen, C.F., Vermeulen, E.G., Vierhout, B.P., van der Vijver-Coppen, R.J., Visser, M.J., van der Vliet, J.A., Vlijmen-van Keulen, C.J., Voorhoeve, R., van der Vorst, J.R., Vos, A.W., de Vos, B., Vos, C.G., Vos, G.A., Voute, M.T., Vriens, B.H., Vriens, P.W., de Vries, A.C., de Vries, D.K., de Vries, J.P., de Vries, M., van der Waal, C., Waasdorp, E.J., de Vries, W., van Walraven, L.A., van Wanroij, J.L., Warlé, M.C., van de Water, W., van Weel, V., van Well, A.M., Welten, G.M., Welten, R.J., Wever, J.J., Wiersema, A.M., Wikkeling, O.R., Willaert, W.I., Wille, J., Willems, M.C., Willigendael, E.M., Wilschut, E.D., Wisselink, W., Witte, M.E., Wittens, C.H., Wong, C.Y., Wouda, R., Yazar, O., Yeung, K.K., Zeebregts, C.J., van Zeeland, M.L., Karthaus, Eleonora G., Vahl, Anco, Elsman, Bernard H.P., Wouters, Michel W.J.M., de Borst, Gert J., and Hamming, Jaap F.

Published
2020
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15. Ultrasound‐guided perineural injection of the tibial nerve in the horse versus a 'blind' technique.

Author

Bellitto, Nicholas A., Voute, Lance, Reardon, Richard, and Withers, Jonathan M.

Subjects
*TIBIAL nerve, *LAMENESS in horses, *INJECTIONS, *MANN Whitney U Test, *FISHER exact test, *SKIN tests
Abstract

Summary: Background: Tibial perineural analgesia has often been reported to fail to achieve nerve desensitisation in horses. Ultrasound‐guided (US‐guided) techniques have recently been described to improve tibial perineural desensitisation. Objectives: To compare US‐guided and 'blind' tibial perineural analgesia techniques in lameness investigation. Study design: Randomised clinical trial. Methods: Horses presenting for lameness investigation, which required tibial perineural analgesia, were randomly assigned either to a US‐guided or blind injection group. The efficacy of perineural analgesia was assessed by testing the loss of skin sensation at the medial and lateral heel bulbs. Skin sensation was assessed, prior to injection and then at four intervals post‐injection (10–15, 20–25, 30–35 and 40–45 min) using a hand‐held digital algometer with a 1 mm diameter pin; a value of 25 N was defined as indicative of skin desensitisation. The time taken to perform each injection technique and any adverse reactions were recorded. Summary statistics were performed to examine differences between groups. The frequency of skin desensitisation was compared between groups using a Fisher's exact test and the length of time taken to perform injections was compared using a Mann–Whitney U test. Results: Sixteen US‐guided and 11 blind injections were included in the study. All cases undergoing US‐guided injection lost skin sensation, whereas this occurred in only one case receiving the blind injection. The US‐guided group had a significantly higher probability of skin sensation loss (p < 0.001), although the injection technique took significantly longer to complete compared to the blind group (p < 0.001). No adverse reactions were noted with either perineural injection technique. Main limitations: Limited number of cases for each injection group. Conclusions: These findings suggest that US‐guided tibial perineural injection is more likely to result in adequate and prompt tibial perineural analgesia compared to the blind injection technique, although it takes longer to complete. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial

Author

Nicolas Macian, Christian Dualé, Marion Voute, Vincent Leray, Marion Courrent, Paula Bodé, Fatiha Giron, Sylvie Sonneville, Lise Bernard, Fabienne Joanny, Katell Menard, Gilles Ducheix, Bruno Pereira, and Gisèle Pickering

Subjects
stress, magnesium, fibromyalgia, pain, magnesium supplementation, Nutrition. Foods and food supply, TX341-641
Abstract

Patients suffering from fibromyalgia often report stress and pain, with both often refractory to usual drug treatment. Magnesium supplementation seems to improve fibromyalgia symptoms, but the level of evidence is still poor. This study is a randomized, controlled, double-blind trial in fibromyalgia patients that compared once a day oral magnesium 100 mg (Chronomag®, magnesium chloride technology formula) to placebo, for 1 month. The primary endpoint was the level of stress on the DASS-42 scale, and secondary endpoints were pain, sleep, quality of life, fatigue, catastrophism, social vulnerability, and magnesium blood concentrations. After 1 month of treatment, the DASS-42 score decreased in the magnesium and placebo groups but not significantly (21.8 ± 9.6 vs. 21.6 ± 10.8, respectively, p = 0.930). Magnesium supplementation significantly reduced the mild/moderate stress subgroup (DASS-42 stress score: 22.1 ± 2.8 to 12.3 ± 7.0 in magnesium vs. 21.9 ± 11.9 to 22.9 ± 11.9 in placebo, p = 0.003). Pain severity diminished significantly (p = 0.029) with magnesium while the other parameters were not significantly different between both groups. These findings show, for the first time, that magnesium improves mild/moderate stress and reduces the pain experience in fibromyalgia patients. This suggests that daily magnesium could be a useful treatment to improve the burden of disease of fibromyalgia patients and calls for a larger clinical trial.

Published
2022
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18. Nieuwvormingen

Author

Voûte, P.A., Veerman, A.J.P., van den Brande, J.L., Heymans, H.S.A., Kock, I., Monnens, L.A.H., den Ridder, K., and Ulijn, R.

Published
2017
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23. The effect of alkylation on the micro-solvation of ethers revealed by highly localized water librational motion.

Author

Mihrin, D., Voute, A., Jakobsen, P. W., Feilberg, K. L., and Wugt Larsen, R.

Subjects
*INTERMOLECULAR forces, *ETHER (Anesthetic), *ETHERS, *ALKYLATION, *NATURAL orbitals, *METHYL ether, *SOLVATION
Abstract

The specific far-infrared spectral signatures associated with highly localized large-amplitude out-of-plane librational motion of water molecules have recently been demonstrated to provide sensitive spectroscopic probes for the micro-solvation of organic molecules [Mihrin et al., Phys. Chem. Chem. Phys. 21(4), 1717 (2019)]. The present work employs this direct far-infrared spectroscopic approach to investigate the non-covalent intermolecular forces involved in the micro-solvation of a selection of seven ether molecules with systematically varied alkyl substituents: dimethyl ether, diethyl ether, diisopropyl ether, ethyl methyl ether, t-butyl methyl ether, and t-butyl ethyl ether. The ranking of the observed out-of-plane water librational band signatures for this selected series of ether–water complexes embedded in inert neon matrices at 4 K reveals information about the interplay of directional intermolecular hydrogen bond motifs and non-directional and long-range dispersion interactions for the micro-solvated structures. These far-infrared observables differentiate minor subtle effects introduced by specific alkyl substituents and serve as rigorous experimental benchmarks for modern quantum chemical methodologies of various levels of scalability, which often fail to accurately predict the structural variations and corresponding vibrational signatures of the closely related systems. The accurate interaction energies of the series of ether–water complexes have been predicted by the domain based local pair natural orbital coupled cluster theory with single-, double-, and perturbative triple excitations, followed by a local energy decomposition analysis of the energy components. In some cases, the secondary dispersion forces are in direct competition with the primary intermolecular hydrogen bonds as witnessed by the specific out-of-plane librational signatures. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Implementation research: reactive mass vaccination with single-dose oral cholera vaccine, Zambia/Recherche sur la mise en oeuvre: vaccination reactive de masse a l'aide d'un vaccin anticholerique oral a dose unique en Zambie/Investigaciones sobre la aplicacion: vacunacion masiva reactiva con una sola dosis de vacuna oral contra el colera en Zambia

Author

Poncin, Marc, Zulu, Gideon, Voute, Caroline, Ferreras, Eva, Muleya, Clara Mbwili, Malama, Kennedy, Pezzoli, Lorenzo, Mufunda, Jacob, Robert, Hugues, Uzzeni, Florent, Luquero, Francisco J., Chizema, Elizabeth, and Ciglenecki, Iza

Subjects
Cholera -- Prevention, Vaccination -- Methods, Public health administration -- Methods, Health
Abstract

Objective To describe the implementation and feasibility of an innovative mass vaccination strategy--based on single- dose oral cholera vaccine--to curb a cholera epidemic in a large urban setting. Method In April 2016, in the early stages of a cholera outbreak in Lusaka, Zambia, the health ministry collaborated with Medecins Sans Frontieres and the World Health Organization in organizing a mass vaccination campaign, based on single-dose oral cholera vaccine. Over a period of 17 days, partners mobilized 1700 health ministry staff and community volunteers for community sensitization, social mobilization and vaccination activities in 10 townships. On each day, doses of vaccine were delivered to vaccination sites and administrative coverage was estimated. Findings Overall, vaccination teams administered 424100 doses of vaccine to an estimated target population of 578043, resulting in an estimated administrative coverage of 73.4%. After the campaign, few cholera cases were reported and there was no evidence of the disease spreading within the vaccinated areas. The total cost of the campaign--2.31 United States dollars (US$) per dose-- included the relatively low cost of local delivery--US$ 0.41 per dose. Conclusion We found that an early and large-scale targeted reactive campaign using a single-dose oral vaccine, organized in response to a cholera epidemic within a large city, to be feasible and appeared effective. While cholera vaccines remain in short supply, the maximization of the number of vaccines in response toa cholera epidemic, by the use of just one dose per member of an at-risk community, should be considered. Objectif Rendre compte de la mise en oeuvre et de la faisabilite d'une strategie de vaccination de masse innovante--fondee sur un vaccin anticholerique oral a dose unique--pour enrayer une epidemie de cholera dans une vaste zone urbaine. Methodes En avril 2016, aux premiers stades d'une flambee de cholera a 'Lusaka, en Zambie, le ministere de la Sante a collabore avec Medecins Sans Frontieres et l'Organisation mondiale.de la Sante pour organiser une campagne de vaccination de masse fondee sur un vaccin anticholerique oral a dose unique. Pendant 17 jours, ees partenaires ont fait appel a 1700 membres du personnel du ministere de la Sante et benevoles communautaires pour mener des activites de sensibilisation des communautes, de mobilisation sociale et de vaccination dans 10 municipalites. Chaque jour, des doses de vaccins ont ete livrees sur les sites de vaccination et une estimation de la couverture administrative a ete effectuee. Resultats En tout, les equipes de vaccination ont administre 424 100 doses de vaccins a une population cible estimee a 578 043 individus, ce qui se traduit par une couverture administrative estimee a 73,4%. Apres la campagne, seuls de rares cas de cholera ont ete signales et aucun signe de propagation de la maladie dans les zones de vaccination n'a ete note. Le cout total de la campagne--2,31 dollars des Etats-Unis ($US) par dose--incluait le cout relativement bas de la livraison locale--0,41 $US par dose. Conclusion L'organisation d'une campagne de vaccination reactive precoce, ciblee et a grande echelle--fondee sur un vaccin oral a dose unique--pour repondre a une epidemie de cholera dans une grande ville s'est averee faisable et efficace. Alors que les vaccins anticholeriques demeurent rares, il convient d'envisager la maximisation du nombre de vaccins pour faire face a une epidemie de cholera a travers ('utilisation d'une seule dose par membre d'une communaute vulnerable. Objetivo describir la aplicacion y la viabilidad de una estrategia innovadora de vacunacion masiva, basada en una vacuna oral contra el colera de una sola dosis, para frenar una epidemia de colera en un entorno urbano grande. Metodo en abril de 2016, en las primeras etapas de un brote de colera en Lusaka, Zambia, el Ministerio de Salud colaboro con Medecins Sans Frontieres y la Organizacion Mundial de la Salud en la organizacion de una campana masiva de vacunacibn basada en una vacuna oral contra el colera de una sola dosis. Durante un periodo de 17 dias, los socios movilizaron a 1700 voluntarios de personal sanitario y voluntarios de la comunidad para sensibilizar a la comunidad y para actividades de vacunacion y movilizacion social en 10 municipios. Cada dia, las dosis de la vacuna se entregaron en los lugares de vacunacion y se estimo la cobertura administrativa. Resultados en general, los equipos de vacunacion administraron 424.100 dosis de la vacuna a una poblacion objetivo de unos 578.043 habitantes, lo que resulto en una cobertura administrativa estimada del 73,4%. Despues de la campana, se registraron pocos casos de colera y no hubo pruebas de propagacion de la enfermedad dentro de laszonas vacunadas. El costo total de la campana (2,31 dolares estadounidenses (USD) por dosis) incluyo el coste relativamente bajo de la entrega local (0,41 $ por dosis). Conclusion se descubrio que una campana reactiva temprana dirigida y en gran escala con una vacuna oral de dosis unica, organizada en respuesta a una epidemia de colera dentro de una gran ciudad, era factible y aparentemente efectiva. Si bien las vacunas contra el colera siguen siendoescasas, se debe considerar la maximizacion del numero de vacunados en respuesta a una epidemia de colera, mediante el uso de una sola dosis por miembro de una comunidad en riesgo., Introduction The World Health Organization (WHO) has estimated that there are 1.3-4 million cholera cases and 21000-143 000 cholera-related deaths each year. (1) Cholera is a poverty-related disease and large-scale [...]

Published
2018
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32. Ketamine in chronic pain: A Delphi survey

Author

Marion, Voute, Thibault, Riant, Jean-Marie, Amodéo, Gilbert, André, Mario, Barmaki, Olivier, Collard, Caroline, Colomb, Christelle, Créac'h, Rodrigue, Deleens, Claire, Delorme, Géraldine, de Montgazon, Véronique, Dixneuf, Lénaïg, Dy, Jacques, Gaillard, Christian, Gov, Xavier, Kieffer, Michel, Lanteri-Minet, Jean-Marie, Le Borgne, Franck, Le Caër, Fadel, Maamar, Caroline, Maindet, Fabienne, Marcaillou, Frédéric, Plantevin, Yves-Marie, Pluchon, Bruno, Rioult, Sylvie, Rostaing, Eric, Salvat, Virith, Sep Hieng, Marc, Sorel, Pascale, Vergne-Salle, Véronique, Morel, Ingrid, de Chazeron, and Gisèle, Pickering

Subjects
Anesthesiology and Pain Medicine, Humans, Neuralgia, Ketamine, Chronic Pain, Complex Regional Pain Syndromes, Pain, Intractable
Abstract

There is no recommendation in Europe for the use of ketamine in patients with chronic pain. The heterogeneity of practice highlights the need to seek the advice of experts in order to establish a national consensus. This Delphi survey aimed to reach a national consensus on the use of ketamine in chronic pain in Pain clinics.A collaborative four-round internet-based questionnaire was used. It was created after literature search on ketamine administration in chronic pain and included about 96 items. It discussed utility and advantages, adverse events and deleterious aspects, methods of administration, concomitant treatments and assessment of results.Twenty-eight experts completed all rounds of the survey with a total of 81.3% items reaching a consensual answer. Neuropathic pain represents the first indication to use ketamine, followed, with a good to moderate utility, by other situations (fibromyalgia, complex regional pain syndrome, central neuropathic pain, peripheral neuropathic pain, nociceptive pain, sensitization, opioid withdrawal, palliative care, depression). Experts agreed on the rare occurrence of adverse events. Concerning routes of administration, intravenous infusion with doses of 0.5-0.9 mg/kg/d for 4 days of treatment is preferred. Place of care is hospital, as in- or out-patient, with a quarterly administration of ketamine. Finally, ketamine effectiveness is assessed 1 month after infusion, and experts encourage combination with non-pharmacological treatment.This Delphi survey established a consensus of pain specialists on the use of ketamine in refractory chronic pain, thus providing a basis for future comparative trials.This Delphi survey in chronic pain reached agreement on four main aspects: (1) Priority to treat neuropathic pain with evaluation of effectiveness at 1 month; (2) No deleterious effects in the majority of listed diseases/situations with the absence or3% of suggested adverse events; (3) 0.5-0.9 mg/kg/d IV infusion; (4) Combination with non-pharmacological treatment.

Published
2022

36. Predicting Pain Trajectories in the One Year Following Breast Cancer Diagnosis—An Observational Study

Author

Marion Voute, Véronique Morel, Dominique Joly, Christine Villatte, Elodie Martin, Xavier Durando, Bruno Pereira, and Gisèle Pickering

Subjects
breast cancer, pain trajectories, predictive profile, psychosocial vulnerability, Medicine
Abstract

The impact of psychosocial vulnerability on pain in the year following breast cancer diagnosis has been little studied. To identify a score of psychosocial vulnerability (cognitive, emotional, quality of life and precariousness parameters) as a predictor of a pain trajectory, we conducted an observational prospective study and included women with newly diagnosed breast cancer. One year follow-up with 3 visits (day of breast cancer diagnosis; 6 and 12 months) aimed to identify distinct pain-time trajectories. Baseline psychosocial vulnerability was characterized by z-score transformation, a higher score representing a more vulnerable patient. A total of 89 patients were included (59.3 ± 10.7 years). Two trajectories of pain were identified—“Transient Pain trajectory” (TP) (39/89 patients) and “Persistent Pain trajectory” (PP) (50/89). A significant difference of pain over time between trajectories (PP vs. TP at 6 months: 2.23 ± 0.23 vs. 0.27 ± 0.09, p < 0.001) was observed. Psychosocial vulnerability showed a large effect size (d, −0.82; 95% CI, −1.25 to −0.38; p < 0.001) and a higher score in “Persistent pain trajectory” (PP vs. TP: 0.12 ± 0.36 vs. −0.14 ± 0.26, p < 0.001). A predictive vulnerability marker of pain development is proposed and could be used at cancer diagnosis to orientate the care pathway of patients experiencing breast cancer.

Published
2020
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37. Assessment of Initial Depressive State and Pain Relief With Ketamine in Patients With Chronic Refractory Pain

Author

Marion Voute, Céline Lambert, Bruno Pereira, and Gisèle Pickering

Subjects
General Medicine
Abstract

ImportanceRepeated ketamine administration is common in treatment-refractory chronic pain, but ketamine analgesic and antidepressant effects are poorly understood in patients with chronic pain with depression symptoms.ObjectiveTo determine clinical pain trajectories with repeated ketamine administrations, exploring whether ketamine dose and/or pretreatment depressive and/or anxiety symptoms may mediate pain relief.Design, Setting, and ParticipantsThis nationwide, multicenter, prospective cohort study included patients in France with treatment-refractory chronic pain who received repeated ketamine administration, over 1 year, according to ketamine use in their pain clinic. Data were collected from July 7, 2016, through September 21, 2017. Linear mixed models for repeated data, trajectory analysis, and mediation analysis were performed from November 15 to December 31, 2022.InterventionsKetamine administration in cumulative dose (milligrams) over 1 year.Main Outcomes and MeasuresPrimary outcome was mean pain intensity (0-10 on the Numerical Pain Rating Scale [NPRS]), assessed every month for 1 year by telephone, after inclusion in the hospital. Depression and anxiety (Hospital Anxiety and Depression Scale [HADS]), quality of life (12-item Short Form Health Survey [SF-12]), cumulative ketamine dose, adverse effects, and concomitant treatments were secondary outcomes.ResultsA total of 329 patients (mean [SD] age, 51.4 [11.0] years; 249 women [75.7%] and 80 men [24.3%]) were enrolled. Repeated ketamine administration was associated with a decrease of NPRS (effect size = −0.52 [95% CI, −0.62 to −0.41]; P P P = .02) dimension scores over 1 year. Adverse effects were in the normal range. There was a significant difference between patients without and with depressive symptoms in pain diminution (regression coefficient, −0.04 [95% CI, −0.06 to −0.01]; omnibus P = .002 for interaction of time × baseline depression [HADS score ≤7 or >7]). The mediation model showed that ketamine dose was not associated with pain diminution (r = 0.01; P = .61) and not correlated with depression (r = −0.06; P = .32), and that depression was associated with pain diminution (regression coefficient, 0.03 [95% CI, 0.01-0.04]; P P = .67). The proportion of reduction of pain mediated by baseline depression was 64.6%.Conclusions and RelevanceThe findings of this cohort study on chronic refractory pain suggest that depression (and not ketamine dose or anxiety) was the mediator of the association of ketamine with pain diminution. This finding provides radically new insights on how ketamine reduces pain primarily by dampening depression. This reinforces the need for systematic holistic assessment of patients with chronic pain to diagnose severe depressive symptoms where ketamine would be a very valuable therapeutic option.

Published
2023

38. Single-Dose Cholera Vaccine in Response to an Outbreak in Zambia

Author

Ferreras, Eva, Chizema-Kawesha, Elizabeth, Blake, Alexandre, Chewe, Orbrie, Mwaba, John, Zulu, Gideon, Poncin, Marc, Rakesh, Ankur, Page, Anne-Laure, Stoitsova, Savina, Voute, Caroline, Uzzeni, Florent, Robert, Hugues, Serafini, Micaela, Matapo, Belem, Eiros, Jose-María, Quilici, Marie-Laure, Pezzoli, Lorenzo, Azman, Andrew S., Cohuet, Sandra, Ciglenecki, Iza, Malama, Kennedy, and Luquero, Francisco J.

Published
2018
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40. Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial

Author

Macian, Nicolas, primary, Dualé, Christian, additional, Voute, Marion, additional, Leray, Vincent, additional, Courrent, Marion, additional, Bodé, Paula, additional, Giron, Fatiha, additional, Sonneville, Sylvie, additional, Bernard, Lise, additional, Joanny, Fabienne, additional, Menard, Katell, additional, Ducheix, Gilles, additional, Pereira, Bruno, additional, and Pickering, Gisèle, additional

Published
2022
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43. Rhabdomyosarcoma

Author

Flamant, F., Voûte, P. A., Sommelet, D., Bamberg, Michael, editor, Voûte, P. A., editor, Barrett, Ann, editor, and Lemerle, Jean, editor

Published
1992
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47. Femtochemistry of bimolecular reactions from weakly bound complexes: computational study of the H + H′OD → H′OH + D or HOD + H′ exchange reactions

Author

Alexandre P. Voute, Fabien Gatti, Klaus Braagaard Møller, and Niels Engholm Henriksen

Subjects
Chemistry, Photodissociation, Ab initio, General Physics and Astronomy, Hydrogen atom, Dissociation (chemistry), Potential energy surface, Atom, Physics::Atomic and Molecular Clusters, Physical chemistry, Physics::Atomic Physics, Physics::Chemical Physics, Physical and Theoretical Chemistry, Ground state, Femtochemistry
Abstract

A full-dimensional wavepacket propagation describing the bimolecular exchange reactions H + H'OD → H'OH + D or HOD + H' initiated by photolysis of HCl in the hydrogen-bound complex (HCl)⋯(HOD) is reported. The dynamics of this reaction is carried out with the MCTDH method on an ab initio potential energy surface (PES) of H3O and the initial state is derived from the ground state wavefunction of the complex obtained by relaxation on its own electronic ground state ab initio PES. The description of the system makes use of polyspherical coordinates parametrizing a set of Radau and Jacobi vectors. The calculated energy- and time-resolved reaction probabilities show, owing to the large collision energies at play stemming from the (almost full) photolysis of HCl, that the repulsion between oxygen in the H'OD molecule and the incoming hydrogen atom is the main feature of the collision and leads to non-reactive scattering. No abstraction reaction products are observed. However, both exchange processes are still observable, with a preference in O-H' bond dissociation over that of O-D. The selectivity is reversed upon vibrational pre-excitation of the O-D stretching mode in the H'OD molecule. It is shown that, after the collision, the hydrogen atom of HCl does most likely not encounter the almost stationary chlorine atom again but we also consider the limit case where the H atom is forced to collide multiple times against H'OD as a result of being pushed back by the Cl atom.

Published
2021

48. Nationwide Outcomes of Octogenarians Following Open or Endovascular Management After Ruptured Abdominal Aortic Aneurysms

Author

Anna J. Alberga, Jorg L. de Bruin, Frederico Bastos Gonçalves, Eleonora G. Karthaus, Janneke A. Wilschut, Joost A. van Herwaarden, Jan J. Wever, Hence J. M. Verhagen, Van den Akker PJ, Akkersdijk GJ, Akkersdijk GP, Akkersdijk WL, van Andringa de Kempenaer MG, Arts CH, Avontuur JA, Bakker OJ, Balm R, Barendregt WB, Bekken JA, Bender MH, Bendermacher BL, van den Berg M, Berger P, Beuk RJ, Blankensteijn JD, Bleker RJ, Blok JJ, Bode AS, Bodegom ME, van der Bogt KE, Boll AP, Booster MH, Borger van der Burg BL, de Borst GJ, Bos-van Rossum WT, Bosma J, Botman JM, Bouwman LH, Brehm V, de Bruijn MT, de Bruin JL, Brummel P, van Brussel JP, Buijk SE, Buijs MA, Buimer MG, Burger DH, Buscher HC, Cancrinus E, Castenmiller PH, Cazander G, Coester AM, Cuypers PH, Daemen JH, Dawson I, Dierikx JE, Dijkstra ML, Diks J, Dinkelman MK, Dirven M, Dolmans DE, van Doorn RC, van Dortmont LM, Drouven JW, van der Eb MM, Eefting D, van Eijck GJ, Elshof JW, Elsman BH, van der Elst A, van Engeland MI, van Eps RG, Faber MJ, de Fijter WM, Fioole B, Fokkema TM, Frans FA, Fritschy WM, Fung Kon Jin PH, Geelkerken RH, van Gent WB, Glade GJ, Govaert B, Groenendijk RP, de Groot HG, van den Haak RF, de Haan EF, Hajer GF, Hamming JF, van Hattum ES, Hazenberg CE, Hedeman Joosten PP, Helleman JN, van der Hem LG, Hendriks JM, van Herwaarden JA, Heyligers JM, Hinnen JW, Hissink RJ, Ho GH, den Hoed PT, Hoedt MT, van Hoek F, Hoencamp R, Hoffmann WH, Hogendoorn W, Hoksbergen AW, Hollander EJ, Hommes M, Hopmans CJ, Huisman LC, Hulsebos RG, Huntjens KM, Idu MM, Jacobs MJ, van der Jagt MF, Jansbeken JR, Janssen RJ, Jiang HH, de Jong SC, Jongbloed-Winkel TA, Jongkind V, Kapma MR, Keller BP, Khodadade Jahrome A, Kievit JK, Klemm PL, Klinkert P, Koedam NA, Koelemaij MJ, Kolkert JL, Koning GG, Koning OH, Konings R, Krasznai AG, Krol RM, Kropman RH, Kruse RR, van der Laan L, van der Laa n MJ, van Laanen JH, van Lammeren GW, Lamprou DA, Lardenoye JH, Lauret GJ, Leenders BJ, Legemate DA, Leijdekkers VJ, Lemson MS, Lensvelt MM, Lijkwan MA, Lind RC, van der Linden FT, Liqui Lung PF, Loos MJ, Loubert MC, van de Luijtgaarden KM, Mahmoud DE, Manshanden CG, Mattens EC, Meerwaldt R, Mees BM, von Meijenfeldt GC, Menting TP, Metz R, Minnee RC, de Mol van Otterloo JC, Molegraaf MJ, Montauban van Swijndregt YC, Morak MJ, van de Mortel RH, Mulder W, Nagesser SK, Naves CC, Nederhoed JH, Nevenzel-Putters AM, de Nie AJ, Nieuwenhuis DH, Nieuwenhuizen J, van Nieuwenhuizen RC, Nio D, Noyez VJ, Oomen AP, Oranen BI, Oskam J, Palamba HW, Peppelenbosch AG, van Petersen AS, Petri BJ, Pierie ME, Ploeg AJ, Pol RA, Ponfoort ED, Post IC, Poyck PP, Prent A, ten Raa S, Raymakers JT, Reichart M, Reichmann BL, Reijnen MM, de Ridder JA, Rijbroek A, van Rijn MJ, de Roo RA, Rouwet EV, Saleem BR, Salemans PB, van Sambeek MR, Samyn MG, van ‘t Sant HP, van Schaik J, van Schaik PM, Scharn DM, Scheltinga MR, Schepers A, Schlejen PM, Schlosser FJ, Schol FP, Scholtes VP, Schouten O, Schreve MA, Schurink GW, Sikkink CJ, te Slaa A, Smeets HJ, Smeets L, Smeets RR, de Smet AA, Smit PC, Smits TM, Snoeijs MG, Sondakh AO, Speijers MJ, van der Steenhoven TJ, van Sterkenburg SM, Stigter DA, Stokmans RA, Strating RP, Stultiëns GN, Sybrandy JE, Teijink JA, Telgenkamp BJ, Teraa M, Testroote MJ, Tha-In T, The RM, Thijsse WJ, Thomassen I, Tielliu IF, van Tongeren RB, Toorop RJ, Tournoij E, Truijers M, Türkcan K, Tutein Nolthenius RP, Ünlü Ç, Vaes RH, Vafi AA, Vahl AC, Veen EJ, Veger HT, Veldman MG, Velthuis S, Verhagen HJ, Verhoeven BA, Vermeulen CF, Vermeulen EG, Vierhout BP, van der Vijver-Coppen RJ, Visser MJ, van der Vliet JA, Vlijmen—van Keulen CJ, Voorhoeve R, van der Vorst JR, Vos AW, de Vos B, Vos CG, Vos GA, Voute MT, Vriens BH, Vriens PW, de Vries AC, de Vries DK, de Vries JP, de Vries M, van der Waal C, Waasdorp EJ, Wallis de Vries BM, van Walraven LA, van Wanroij JL, Warlé MC, van de Water W, van Weel V, van Well AM, Welten GM, Welten RJ, Wever JJ, Wiersema AM, Wikkeling OR, Willaert WI, Wille J, Willems MC, Willigendael EM, Wilschut ED, Wisselink W, Witte ME, Wittens CH, Wong CY, Wouda R, Yazar O, Yeung KK, Zeebregts CJ, van Zeeland ML, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Surgery

Subjects
Radiology, Nuclear Medicine and imaging, Surgery, Cardiology and Cardiovascular Medicine
Abstract

Purpose: Octogenarians are known to have less-favorable outcomes following ruptured abdominal aortic aneurysm (rAAA) repair compared with their younger counterparts. Accurate information regarding perioperative outcomes following rAAA-repair is important to evaluate current treatment practice. The aim of this study was to evaluate perioperative outcomes of octogenarians and to identify factors associated with mortality and major complications after open surgical repair (OSR) or endovascular aneurysm repair (EVAR) of a rAAA using nationwide, real-world, contemporary data. Methods: All patients that underwent EVAR or OSR of an infrarenal or juxtarenal rAAA between January 1, 2013, and December 31, 2018, were prospectively registered in the Dutch Surgical Aneurysm Audit (DSAA) and included in this study. The primary outcome was the comparison of perioperative outcomes of octogenarians versus non-octogenarians, including adjustment for confounders. Secondary outcomes were the identification of factors associated with mortality and major complications in octogenarians. Results: The study included 2879 patients, of which 1146 were treated by EVAR (382 octogenarians, 33%) and 1733 were treated by OSR (410 octogenarians, 24%). Perioperative mortality of octogenarians following EVAR was 37.2% versus 14.8% in non-octogenarians (adjusted OR=2.9, 95% CI=2.8–3.0) and 50.0% versus 29.4% following OSR (adjusted OR=2.2, 95% CI=2.2–2.3). Major complication rates of octogenarians were 55.4% versus 31.8% in non-octogenarians following EVAR (OR=2.7, 95% CI=2.1–3.4), and 68% versus 49% following OSR (OR=2.2, 95% CI=1.8–2.8). Following EVAR, 30.6% of the octogenarians had an uncomplicated perioperative course (UPC) versus 49.5% in non-octogenarians (OR=0.5, 95% CI=0.4–0.6), while following OSR, UPC rates were 20.7% in octogenarians versus 32.6% in non-octogenarians (OR=0.5, 95% CI=0.4–0.7). Cardiac or pulmonary comorbidity and loss of consciousness were associated with mortality and major complications in octogenarians. Interestingly, female octogenarians had lower mortality rates following EVAR than male octogenarians (adjusted OR=0.7, 95% CI=0.6–0.8). Conclusion: Based on this nationwide study with real-world registry data, mortality rates of octogenarians following ruptured AAA-repair were high, especially after OSR. However, a substantial proportion of these octogenarians following OSR and EVAR had an uneventful recovery. Known preoperative factors do influence perioperative outcomes and reflect current treatment practice.

Published
2022

49. The effect of alkylation on the micro-solvation of ethers revealed by highly localized water librational motion

Author

D. Mihrin, A. Voute, P. W. Jakobsen, K. L. Feilberg, and R. Wugt Larsen

Subjects
General Physics and Astronomy, Physics::Chemical Physics, Physical and Theoretical Chemistry
Abstract

The specific far-infrared spectral signatures associated with highly localized large-amplitude out-of-plane librational motion of water molecules have recently been demonstrated to provide sensitive spectroscopic probes for the micro-solvation of organic molecules [Mihrin et al., Phys. Chem. Chem. Phys. 21(4), 1717 (2019)]. The present work employs this direct far-infrared spectroscopic approach to investigate the non-covalent intermolecular forces involved in the micro-solvation of a selection of seven ether molecules with systematically varied alkyl substituents: dimethyl ether, diethyl ether, diisopropyl ether, ethyl methyl ether, t-butyl methyl ether, and t-butyl ethyl ether. The ranking of the observed out-of-plane water librational band signatures for this selected series of ether–water complexes embedded in inert neon matrices at 4 K reveals information about the interplay of directional intermolecular hydrogen bond motifs and non-directional and long-range dispersion interactions for the micro-solvated structures. These far-infrared observables differentiate minor subtle effects introduced by specific alkyl substituents and serve as rigorous experimental benchmarks for modern quantum chemical methodologies of various levels of scalability, which often fail to accurately predict the structural variations and corresponding vibrational signatures of the closely related systems. The accurate interaction energies of the series of ether–water complexes have been predicted by the domain based local pair natural orbital coupled cluster theory with single-, double-, and perturbative triple excitations, followed by a local energy decomposition analysis of the energy components. In some cases, the secondary dispersion forces are in direct competition with the primary intermolecular hydrogen bonds as witnessed by the specific out-of-plane librational signatures.

Published
2022

50. Haematogenous synovial sepsis of the digital flexor tendon sheath following contralateral limb foot abscessation in a horse

Author

Christian A. Byrne, Victoria J. Tannahill, and Lance C. Voute

Subjects
General Veterinary
Abstract

A 5-year-old Shire mare was presented for investigation of severe right hindlimb lameness and was diagnosed with extensive right hind subsolar and submural foot abscessation. The mare developed severe contralateral limb lameness 11 days following right hind abscess debridement, with investigation revealing synovial sepsis of the left hind digital flexor tendon sheath. Synovial sepsis persisted despite aggressive surgical and medical treatment, resulting in euthanasia. Microbial culture of synovial fluid isolated Bacteroides sp., consistent with haematogenous synovial sepsis. This is the first report to describe haematogenous synovial sepsis as a cause of contralateral limb lameness during the management of foot abscessation in the horse.

Published
2022

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