18 results on '"Vrushali Angadi"'
Search Results
2. The Effect of Maximum Phonation Time Goal on Efficacy of Vocal Function Exercises
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Maria Bane, Vrushali Angadi, Richard Andreatta, and Joseph Stemple
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Speech and Hearing ,Otorhinolaryngology ,LPN and LVN - Published
- 2023
- Full Text
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3. Vocal Function Exercises With and Without Maximally Sustained Phonation: A Randomized Controlled Trial of Individuals With Normal Voice
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Maria Bane, Mariah Morton, Vrushali Angadi, Richard Andreatta, and Joseph Stemple
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Speech and Hearing ,Otorhinolaryngology ,LPN and LVN - Abstract
To determine the effect of maximally sustained phonation on efficacy of Vocal Function Exercises as measured by percent of maximum phonation time goal attained. The hypothesis was that maximally sustained phonation would result in greater improvements in percent of maximum phonation time goal attained.Randomized controlled trial.A convenience sample of individuals with normal voice were recruited in a university academic clinic setting. Of 34 participants who volunteered for the study, 31 completed baseline assessment and 23 completed all study procedures. Participants were randomized to complete Vocal Function Exercises (traditional group TG), modified Vocal Function Exercises with reduced requirement for maximally sustained phonation (midpoint group MG), or modified Vocal Function Exercises with removed requirement for maximally sustained phonation (baseline group BG). The primary outcome measure was percent of maximum phonation time goal obtained during Vocal Function Exercises.The MG (p = 0.008) and TG (p = 0.001) groups significantly improved percent of maximum phonation time goal attained after six weeks of exercise, while the BG group (p = 0.0202) did not (ɑ = 0.0125). Difference among groups was not statistically significant (p = 0.67, ɑ = 0.0125). Hedges' g effect sizes of 0.29 (-0.66, 1.25) and 0.51 (-0.57, 1.58) were obtained comparing MG and TG groups, and BG and TG groups, respectively.Greater requirements for maximally sustained phonation improved efficacy of Vocal Function Exercises in enhancing normal voice as measured by percent of maximum phonation time goal attained. Maximally sustained phonation may be modified to some extent while preserving efficacy of Vocal Function Exercises, however complete elimination of maximally sustained phonation may attenuate improvement. Additional research in a clinical population is warranted.
- Published
- 2022
4. Biobehavioral Measures of Presbylaryngeus
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Colleen A. McMullen, Maria Dietrich, Timothy L. Uhl, Vrushali Angadi, Richard D. Andreatta, and Joseph C. Stemple
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Male ,Aging ,Voice Quality ,Physical activity ,Article ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Current sample ,0302 clinical medicine ,Speech Production Measurement ,Group differences ,Predictive Value of Tests ,Humans ,Medicine ,030223 otorhinolaryngology ,Geriatric Assessment ,Aged ,Aged, 80 and over ,Voice Disorders ,Anthropometry ,business.industry ,Airway Resistance ,Age Factors ,Nonparametric statistics ,Acoustics ,Middle Aged ,LPN and LVN ,Laryngeal airway ,Functional Status ,Otorhinolaryngology ,Case-Control Studies ,Female ,Observational study ,General health ,Inflammation Mediators ,0305 other medical science ,business ,Biomarkers ,Clinical psychology - Abstract
Summary Objective The objective of this observational study was to assess the relationship between established aging biobehavioral measures and voice decline in normally aging adults. Study design Cross-sectional study. Methods Participants 60–85 years of age were divided into two age and sex-matched groups, based on the presence or absence of presbylaryngeus. Both groups underwent a battery of tests measuring anthropometric variables, inflammatory markers, general health measures, and vocal function parameters. Differences from the norm were calculated for all variables. Parametric and nonparametric tests were performed to assess group differences. In addition, variable selection analysis was performed to determine variables that were most influential in predicting the occurrence of presbylaryngeus in our current sample. Results Fifty-three participants were divided into age and sex-matched groups of “presbylaryngeus” (n = 26) and “non-presbylaryngeus” (n = 27). The two groups were statistically different in select measures of inflammatory markers, general health measures, and vocal function parameters. Anthropometric measures were not statistically different. Based on variable selection, the variables most predictive of the presence of presbylaryngeus were measures of the Physical Activity Scale of the Elderly, C-reactive protein, laryngeal airway resistance, and vocal roughness. Conclusions In addition to group differences in vocal function measures, results for the presbylaryngeus group consistently trended sub-optimally on anthropometric measures, two inflammatory markers, and general health measures. These results suggest that this sample of individuals with presbylaryngeus demonstrated greater biobehavioral deficits associated with aging as compared to age and sex-matched non-presbylaryngeus individuals.
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- 2020
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5. Does a Systematic Vocal Exercise Program Enhance the Physiologic Range of Voice Production in Classical Singing Graduate-Level Students?
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Christopher Catalan, Vrushali Angadi, Marco Guzman, Daniel J. Croake, Joseph C. Stemple, Richard D. Andreatta, Constanza Romero, Camilo Quezada, and Gabriela Acuña
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Linguistics and Language ,medicine.medical_specialty ,Range (music) ,Voice Quality ,Singing ,Audiology ,Language and Linguistics ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Exercise program ,Primary outcome ,Graduate level ,medicine ,Humans ,Students ,030223 otorhinolaryngology ,Voice production ,Music education ,Exercise Therapy ,Voice Training ,Vocal function ,0305 other medical science ,Psychology - Abstract
Purpose The purpose of this study was to assess the effects of vocal function exercises (VFEs) on the physiologic range of the operatic voice. The primary outcome measure was total voice range profile (VRP) area. Method Forty graduate-level opera majors were randomly assigned to experimental (training with VFE + vocal hygiene) and control (vocal hygiene only) groups. All participants underwent an acoustic voice assessment (modified VRP) pre and post 10 weeks of the assigned intervention. VRP total area was calculated and compared between and within the two groups. The total VRP area was subsequently divided into three area thirds (low, medium, and high). Results A significant improvement (increase) was observed in the VFE group for the primary outcome measure of VRP area when pre- and postvoice conditions were compared for total area, upper third, and middle third. No significant improvement was found in the vocal hygiene–only group. Conclusion Vocal training with VFEs over a 10-week period demonstrated positive effects on physiologic voice range as evidenced by an increase in the total VRP area and therefore may enhance the potential of those who already have professional voice training.
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- 2020
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6. Developing and Testing A Smartphone Application To Enhance Adherence to Voice Therapy
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Vrushali Angadi, Ming Yuan-Chih, and Joseph Stemple
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2023
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7. Prophylactic Versus Reactive Gastrostomy Tubes in Head and Neck Cancer: Making Joint Decisions
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Daniel J. Croake and Vrushali Angadi
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medicine.medical_specialty ,business.industry ,Head and neck cancer ,medicine.disease ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous gastrostomy ,Gastrostomy tube ,030220 oncology & carcinogenesis ,Swallowing problems ,medicine ,Tube (fluid conveyance) ,030223 otorhinolaryngology ,business - Abstract
Purpose Patients undergoing chemoradiation for treatment of head and neck cancer often develop swallowing problems that necessitate a percutaneous gastrostomy (PEG) tube. Studies comparing various outcomes related to timing of PEG tubes placed either prophylactically or reactively do not show a clear advantage to either method; however, pertinent patient factors may help determine an educated and evidence-based decision. Additionally, patients may not be included in decision making regarding PEG placement and may not receive adequate education regarding PEG tubes, resulting in fears and concerns. Thus, patients may wish to avoid or at least delay PEG tube placement until necessary. The purpose of this viewpoint article is to review relevant literature and describe patient concerns to better facilitate joint decision making of PEG tube timing with the patient and care team. Conclusion Patient counseling and inclusion can be useful in helping patients understand why and when a PEG tube may be beneficial or necessary during treatment. A simplified decision tree is introduced that incorporates several relevant patient factors based on the current literature and can be used jointly by clinicians and patients to reach a mutual decision by incorporating clinical factors while being mindful of patient values.
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- 2019
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8. Cultural and Linguistic Adaptation of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) Into Hindi
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Ashwini Joshi, Isha Baheti, and Vrushali Angadi
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Hindi ,Observer Variation ,Linguistics and Language ,Consensus ,media_common.quotation_subject ,Indo-European languages ,Reproducibility of Results ,Linguistics ,Dysphonia ,Language and Linguistics ,language.human_language ,Speech and Hearing ,Inter-rater reliability ,Perception ,language ,Humans ,Adaptation (computer science) ,Psychology ,Reliability (statistics) ,media_common ,Language - Abstract
Aim The purpose of this study was to develop and assess the reliability of a Hindi version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V). Reliability was assessed by comparing Hindi CAPE-V ratings with English CAPE-V ratings and by the Grade, Roughness, Breathiness, Asthenia and Strain (GRBAS) scale. Method Hindi sentences were created to match the phonemic load of the corresponding English CAPE-V sentences. The Hindi sentences were adapted for linguistic content. The original English and adapted Hindi CAPE-V and GRBAS were completed for 33 bilingual individuals with normal voice quality. Additionally, the Hindi CAPE-V and GRBAS were completed for 13 Hindi speakers with disordered voice quality. The agreement of CAPE-V ratings was assessed between language versions, GRBAS ratings, and two rater pairs (three raters in total). Pearson product–moment correlation was completed for all comparisons. Results A strong correlation ( r > .8, p < .01) was found between the Hindi CAPE-V scores and the English CAPE-V scores for most variables in normal voice participants. A weak correlation was found for the variable of strain ( r < .2, p = .400) in the normative group. A strong correlation ( r > .6, p < .01) was found between the overall severity/grade, roughness, and breathiness scores in the GRBAS scale and the CAPE-V scale in normal and disordered voice samples. Significant interrater reliability ( r > .75) was present in overall severity and breathiness. Conclusions The Hindi version of the CAPE-V demonstrates good interrater reliability and concurrent validity with the English CAPE-V and the GRBAS. The Hindi CAPE-V can be used for the auditory-perceptual voice assessment of Hindi speakers.
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- 2020
9. Efficacy of Voice Therapy in Improving Vocal Function in Adults Irradiated for Laryngeal Cancers: A Pilot Study
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Mahesh Kudrimoti, Joseph C. Stemple, Thomas J. Gal, Joseph Valentino, Vrushali Angadi, Rony K. Aouad, and Emily V. Dressler
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Adult ,medicine.medical_specialty ,Voice Quality ,medicine.medical_treatment ,Population ,Psychological intervention ,Pilot Projects ,Article ,law.invention ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Randomized controlled trial ,law ,Humans ,Medicine ,Generalizability theory ,030223 otorhinolaryngology ,education ,Laryngeal Neoplasms ,education.field_of_study ,Voice Disorders ,business.industry ,Cancer ,LPN and LVN ,medicine.disease ,Voice therapy (transgender) ,Radiation therapy ,Treatment Outcome ,Voice Training ,Otorhinolaryngology ,Sample size determination ,Physical therapy ,Larynx ,0305 other medical science ,business - Abstract
Summary Background Radiation therapy (XRT) for laryngeal cancers causes acute and chronic vocal dysfunction. Although these deleterious effects of XRT are well-established, there is a dearth of research with respect to effective voice rehabilitation following XRT for laryngeal cancers. Objective To obtain preliminary data on the efficacy of voice rehabilitation, using vocal function exercises (VFEs) in improving vocal function in adults irradiated for laryngeal cancer. The comparison treatment group (VH) received vocal hygiene counseling. Study design Randomized clinical trial. Methods Participants were randomized to the VFE + VH or VH group. Both interventions lasted 6 weeks. The primary outcome measure was improvement in VHI scores. Secondary outcome measures included auditory-perceptual assessments, acoustic and aerodynamic measures, and laryngeal imaging. Results Ten participants were recruited for the study. The VFE + VH (n = 6) group demonstrated a statistically significant improvement in the primary outcome measure (P = 0.03), as well as select parameters of all secondary outcome measures. The VH (n = 4) group did not demonstrate a statistically significant improvement in primary or secondary outcome measures. Conclusions This study offers preliminary data for the utility of VFEs in the irradiated laryngeal cancer population. However, findings in the VFE + VH group lack generalizability, secondary to sample heterogeneity, and limited sample size.
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- 2020
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10. Vocal function exercises for normal voice: With and without semi-occlusion
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Maria Bane, Joseph C. Stemple, Daniel J. Croake, Richard D. Andreatta, Vrushali Angadi, and Megan Brown
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Adult ,030506 rehabilitation ,medicine.medical_specialty ,Time Factors ,Adolescent ,Normal voice ,Voice Quality ,Acoustics ,Vocal Cords ,Audiology ,Language and Linguistics ,Speech Acoustics ,Article ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Young Adult ,Phonation ,Occlusion ,otorhinolaryngologic diseases ,Medicine ,Humans ,Human voice ,Research and Theory ,business.industry ,Maximum phonation time ,respiratory system ,LPN and LVN ,Voice Training ,Otorhinolaryngology ,Vocal function ,Female ,0305 other medical science ,business ,Vocal tract - Abstract
PURPOSE: This study examined the effect of varying degrees of vocal tract (VT) occlusion used during Vocal Function Exercises (VFEs) on attainment of maximum phonation time (MPT) goals in normal voice. Greater VT occlusion was expected to result in increased MPT. The overarching goal was to determine whether the semi-occluded vocal tract (SOVT) posture used during VFEs could be modified while preserving efficacy. METHOD: Twenty-six females ages 18–30 participated in this pre-post longitudinal group study. Participants were randomly assigned to three experimental groups and completed a six-week VFE protocol. The first group performed exercises using the prescribed SOVT posture; the second group used the vowel /o/; group three used the vowel /a/. The primary outcome measure was MPT as performed on the exercise tasks using the assigned vocal tract posture. RESULT: MPT significantly improved in the prescribed SOVT group, but did not significantly improve in the modified /o/ and /a/ groups. CONCLUSION: The SOVT posture used during VFEs is modifiable to a small extent without significantly undermining efficacy. Changes in MPT are less robust with reduced VT occlusion. Research in a clinical population is warranted.
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- 2018
11. Vocal function exercises for normal voice: The effects of varying dosage
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Vrushali Angadi, Joseph C. Stemple, Emily V. Dressler, Maria Bane, and Richard D. Andreatta
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Adult ,030506 rehabilitation ,medicine.medical_specialty ,Research and Theory ,Adolescent ,Normal voice ,Maximum phonation time ,Audiology ,LPN and LVN ,Language and Linguistics ,Article ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Young Adult ,Voice Training ,Otorhinolaryngology ,Vocal function ,medicine ,Humans ,Female ,Norm (social) ,Longitudinal Studies ,0305 other medical science ,Mathematics - Abstract
PURPOSE: This study examined the effect of varying dosage of vocal function exercise (VFE) home practice on attainment of pre-established maximum phonation time (MPT) goals in individuals with normal voice. High dosage VFE practice was expected to result in greatest MPT. The overarching goal of this study was to contribute to a VFE dosage-response curve, potentially including a point of observable toxicity. METHOD: Twenty-eight females ages 18–25 with normal voice participated in this pre-post longitudinal group study. Participants were randomly assigned to one of three experimental groups and completed a six-week VFE protocol with practice twice daily. The low dosage group performed each exercise once, the traditional group twice, and the high dosage group four times. The primary outcome measure was MPT as performed on the fourth VFE using the prescribed semi-occluded vocal tract posture. RESULT: No toxic effects were observed. MPT increased for all participants, with significant improvement for traditional and high dosage groups. CONCLUSION: High dosage VFEs may yield more rapid improvement in MPT, however benefits must be weighed against the risk of increased attrition. Low dosage VFEs insufficiently improved MPT. Further research on dosage is warranted, and should include individuals with disordered voice.
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- 2017
12. A Multidimensional Study of Vocal Function Following Radiation Therapy for Laryngeal Cancers
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Emily V. Dressler, Joseph C. Stemple, and Vrushali Angadi
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Oncology ,Male ,medicine.medical_specialty ,Self-Assessment ,Laryngeal Cancers ,Voice Quality ,medicine.medical_treatment ,Vocal Cords ,Speech Acoustics ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Stroboscopy ,030223 otorhinolaryngology ,Laryngeal Neoplasms ,Aged ,Modality (human–computer interaction) ,Radiotherapy ,business.industry ,General Medicine ,Middle Aged ,Radiation therapy ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Vocal function ,Auditory Perception ,Female ,Larynx ,business ,Pulmonary Ventilation - Abstract
Background: Radiation therapy (XRT) has proven to be an effective curative modality in the treatment of laryngeal cancers. However, XRT also has deleterious effects on vocal function. Aim: To demonstrate the multidimensional nature of deficits in vocal function as a result of radiation therapy for laryngeal cancer. Study Design: Cohort study. Methodology: Vocal function parameters were chosen from the 5 domains of voice assessment to complete a multidimensional assessment battery. Adults irradiated (XRT group) for laryngeal cancers were compared to a control group of individuals with no history of head and neck cancers or radiation therapy. The control group was matched in age, sex, and pack years of smoking. Results: Eighteen participants were recruited for the study. The XRT group demonstrated significantly worse clinical values as compared to the control group across select parameters in the each of the 5 domains of voice assessment. Discussion: Radiation therapy for laryngeal cancers results in multidimensional deficits in vocal function. Notably, these deficits persist long term. In the present study sample, multidimensional deficits were persistent 2 to 7 years following completion of XRT. The observed multidimensional persistent vocal difficulties highlight the importance of vocal rehabilitation in the irradiated larynx cancer population.
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- 2017
13. Contribution of Glottic Insufficiency to Perceived Breathiness in Classically Trained Singers
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Vrushali Angadi, Ellen Graham, JoAnna Sloggy, and Joseph C. Stemple
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Adult ,Male ,medicine.medical_specialty ,Glottis ,Voice Quality ,Singing ,Audiology ,Articulatory phonetics ,Cohort Studies ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,History and Philosophy of Science ,medicine ,Humans ,030223 otorhinolaryngology ,Breathy voice ,Laryngeal stroboscopy ,Voice Disorders ,business.industry ,Maximum phonation time ,General Medicine ,Middle Aged ,Laryngeal airway ,Voice assessment ,Occupational Diseases ,medicine.anatomical_structure ,Vocal Cord Dysfunction ,Vocal folds ,Female ,0305 other medical science ,business - Abstract
Breathiness in the singing voice is problematic for classical singers. Voice students and singing teachers typically attribute breathiness to breath management issues and breathing technique. The present study sought to determine whether glottic insufficiency may also contribute to breathiness in a singer’s voice. Studies have revealed a relationship between insufficient vocal fold closure and inefficiency in the speaking voice. However, the effect of insufficient vocal fold closure on vocal efficiency in singers has yet to be determined. Two groups of voice students identified with and without breathiness issues underwent aerodynamic and acoustic voice assessment as well as laryngeal stroboscopy of the vocal folds to quantify the prevalence of insufficient vocal fold closure, also known as glottic insufficiency. These assessments revealed four groups: 1) those with glottic insufficiency and no perceived voice breathiness; 2) those with glottic sufficiency and perceived voice breathiness; 3) those with glottic insufficiency and perceived breathiness; and 4) those with glottic sufficiency and no perceived breathiness. Results suggest that previously undiscovered glottal insufficiency is common in young singers, particularly women, though the correlation with identified breathiness was not statistically significant. Acoustic and aerodynamic measures including noise-to-harmonics ratio, maximum phonation time, airflow rate, subglottal pressure, and laryngeal airway resistance were most sensitive to glottic insufficiency.
- Published
- 2016
14. New Frontiers and Emerging Technologies in Comprehensive Voice Care
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Joseph C. Stemple and Vrushali Angadi
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Medical education ,medicine.medical_specialty ,Health professionals ,Voice therapy ,Emerging technologies ,education ,medicine ,Treatment team ,Audiology ,Singing ,Psychology ,Patient care - Abstract
The nature of voice therapy has progressed since the 1930s when treatment for voice disorders was chiefly in the medical domain. The role of the speech-language-pathologist (SLP) in the treatment of voice disorders has evolved steadily over the years with advances in diagnosis and the growing base of evidence in the literature with respect to treatment. The speech-language pathologist is now an important part of the treatment team that includes the otolaryngologist, singing teacher, vocal coach, and other allied health professionals. This team approach has improved patient care with a greater focus on the individual that goes beyond the disorder. In this article, we will provide a brief history of the evolution of voice therapy that encompasses the past and present, as well as providing directions for the future.
- Published
- 2012
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15. Effects of Vocal Function Exercises: A Systematic Review
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Vrushali Angadi, Joseph C. Stemple, and Daniel J. Croake
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medicine.medical_specialty ,Visual perception ,Voice therapy ,Audiology ,Outcome (game theory) ,Speech Acoustics ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Speech Production Measurement ,medicine ,Humans ,Patient Reported Outcome Measures ,030223 otorhinolaryngology ,Association (psychology) ,Voice Disorders ,Evidence-based medicine ,LPN and LVN ,Voice production ,Voice assessment ,Voice Training ,Otorhinolaryngology ,Vocal function ,0305 other medical science ,Psychology - Abstract
Summary Objectives The purpose of the present review was to systematically analyze the evidence for the effectiveness of vocal function exercises (VFEs) in improving voice production. Methods A systematic literature search was performed by two independent reviewers using PubMed and EBSCOHost to access relevant databases and to locate outcome studies that used VFEs as an intervention. Articles that met inclusion criteria were appraised based on the American Speech-Language and Hearing Association's levels of evidence. Effect sizes for outcomes were calculated using Hedge's g. Voice outcomes were categorized according to the five domains of voice assessment: visual perceptual analysis, acoustic analysis, aerodynamic analysis, auditory-perceptual analysis, and patient self-report measures. Results Twenty-one articles were included for the final appraisal. All studies demonstrated positive effects of VFEs as demonstrated by effect sizes across selected voice parameters. Effect sizes across parameters ranged from −0.59 to 1.55. None of the included studies reported adverse voice outcomes as a result of VFEs. Conclusions Outcome studies demonstrate that VFEs are efficacious in enhancing vocal function in individuals with normal and disordered voices, presbylaryngeus, and professional voice users. The available research suggests moderate to strong evidence to support the use of VFEs for a variety of voice disorders.
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- 2019
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16. Enhancement of aging rat laryngeal muscles with endogenous growth factor treatment
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Vrushali Angadi, Tanya Seward, Joseph C. Stemple, Colleen A. McMullen, Richard D. Andreatta, and Maria Dietrich
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0301 basic medicine ,Aging ,medicine.medical_specialty ,Pathology ,muscle ,Physiology ,Neuromuscular Junction ,Neuromuscular transmission ,Ageing and Degeneration ,Muscular Conditions, Disorders and Treatments ,NTF4 ,Neuromuscular junction ,Receptor tyrosine kinase ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Rats, Inbred BN ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Nerve Growth Factors ,Neurotransmitter ,Original Research ,larynx ,Denervation ,Respiratory Conditions Disorder and Diseases ,biology ,neurotrophic ,Rats, Inbred F344 ,Rats ,Treatment Outcome ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Laryngeal Muscle ,Trk receptor ,biology.protein ,Intercellular Signaling Peptides and Proteins ,Laryngeal Muscles ,Growth factors ,030217 neurology & neurosurgery ,Neurotrophin - Abstract
Clinical evidence suggests that laryngeal muscle dysfunction is associated with human aging. Studies in animal models have reported morphological changes consistent with denervation in laryngeal muscles with age. Life‐long laryngeal muscle activity relies on cytoskeletal integrity and nerve–muscle communication at the neuromuscular junction (NMJ). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. We hypothesized that treatment with neurotrophin 4 (NTF4) would modify the morphology and functional innervation of aging rat laryngeal muscles. Fifty‐six Fischer 344xBrown Norway rats (6‐ and 30‐mo age groups) were used to evaluate to determine if NTF4, given systemically ( n = 32) or directly ( n = 24), would improve the morphology and functional innervation of aging rat thyroarytenoid muscles. Results demonstrate the ability of rat laryngeal muscles to remodel in response to neurotrophin application. Changes were demonstrated in fiber size, glycolytic capacity, mitochondrial, tyrosine kinase receptors (Trk), NMJ content, and denervation in aging rat thyroarytenoid muscles. This study suggests that growth factors may have therapeutic potential to ameliorate aging‐related laryngeal muscle dysfunction.
- Published
- 2016
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17. Testing a Smart Phone App to Enhance Voice Therapy Adherence
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Vrushali Angadi, Assistant Professor
- Published
- 2019
18. The Efficacy of Vocal Function Exercises for Laryngeal Cancers
- Author
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Vrushali Angadi, Principal Investigator
- Published
- 2018
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