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1. 14th Annual Meeting Oberrheinische Arbeitsgemeinschaft für Onkologie (OAO). Groupe de Travail des Oncologues du Rhin Supérieur (GTOR), Metz, February 6–7, 1998

Author

Herbert Rübben, C. Stegmaier, Jürgen Bauer, J. Bertz, S.C. Carlstedt, K. Krauss, L.H. Ujjainwala, H.-H. Wöltjen, Willi Sauerbrei, M. Scherrer, H.-P. Waidelich, H. Ziegler, T. Daikeler, P.R. Desai, G.F. Springer, N.A. Willich, H. Sperling, Lothar Kanz, R. Brinkmann, A. Melms, T. Otto, H.H. Bartsch, W.G. Rossmanith, N. Victor, G. Köhler, Carsten Bokemeyer, Martin Schumacher, E. Kubista, Andreas Jakob, F. Daschner, Hermann Einsele, B. Görsch, G. Lümmen, A. Hauschild, H. Luboldt, and Maria Blettner

Subjects
Cancer Research, Oncology, Hematology
Published
1997

2. Contents, Vol. 20, 1997

Author

B. Görsch, H. Sperling, R. Brinkmann, W.G. Rossmanith, M. Scherrer, S.C. Carlstedt, C. Stegmaier, Hermann Einsele, N. Victor, E. Kubista, L.H. Ujjainwala, A. Melms, H.-P. Waidelich, Herbert Rübben, Willi Sauerbrei, J. Bertz, H.-H. Wöltjen, Lothar Kanz, H.H. Bartsch, Martin Schumacher, H. Luboldt, N.A. Willich, K. Krauss, Maria Blettner, Andreas Jakob, G.F. Springer, P.R. Desai, Jürgen Bauer, F. Daschner, Carsten Bokemeyer, T. Daikeler, T. Otto, G. Köhler, H. Ziegler, G. Lümmen, and A. Hauschild

Subjects
Cancer Research, Oncology, Hematology
Published
1997

3. Hormone Replacement Therapy and Gynecologic Cancer

Author

W.G. Rossmanith and K. Krauss

Subjects
Oncology, Cancer Research, medicine.medical_specialty, education.field_of_study, business.industry, medicine.drug_class, Endometrial cancer, medicine.medical_treatment, Population, Hypoestrogenism, Hormone replacement therapy (menopause), Hematology, medicine.disease, Endometrial hyperplasia, Breast cancer, Internal medicine, medicine, Hormone therapy, business, education, Progestin
Abstract

In view of the growing number of postmenopausal women using estrogen replacement therapy for the prevention of acute and chronic consequences of hypoestrogenism, any possible associations between hormone therapy and manifestations of gynecologic cancer are an issue of increasing importance. We reviewed the published literature to evaluate the impact of estrogen replacement therapy on the occurrence of gynecologic malignancies including breast cancer. The tumor growth of ovarian, cervical, vaginal, and vulvar neoplasias is not fundamentally influenced by hormone therapy. However, long-term replacement therapy may be associated with an increased incidence of endometrial hyperplasia and even of neoplasia. This increased risk is related to the duration and cumulative dose of estrogen therapy. Addition of progestin probably reduces the risk of endometrial cancer to that observed in the general population. With regard to the relationship between hormone replacement therapy and the incidence of breast cancer, available epidemiologic data are contradictory. While therapy of less than 5 years appears not to be associated with an increased risk, long-term use may be related to a small but significant increase in the risk of developing breast cancer. It is important to note that the cyclic addition of a progestin to estrogen replacement does not affect this risk. After discontinuation of hormone replacement the increased relative risk returns to that of non-users. In conclusion, when considering estrogen replacement therapy for a postmenopausal woman, a slightly increased risk of developing breast cancer and the need to add progestin for protection of the endome-trium need to be mentioned. Bearing this in mind, the benefits of estrogen therapy in terms of a better quality of life and perhaps of a disease-free prolongation of life justify a wide use of hormonal preparations.

Published
1997

4. Contents, Vol. 35, Supplement 1, 1995

Author

M.F. Press, T. Cunze, H.J. Schröder, W. Lichtenegger, E. Halberstadt, T. Schill, Nadia Harbeck, A. Huber, A. Fischer, A. von Daimling, T. Strohmeyer, Ch. Thomssen, C. Zoll, C. Marth, R. Lissner, P.G. Knapstein, D. Macchiella, G. Daxenbichler, T. Beck, B. Wartusch, H. Günes, B. Föst, R. Conradi, F. Kainer, O. Dapunt, E. Petru, W. Friedmann, C. Villena-Heinsen, U. Schwuléra, G. Büge, G.B. Lipford, A. Lopens, T. Nebe, G. Huber, G. Weber, R. Höpfl, S. Anthuber, S. Al-Hasani, Klara Fizi, L. Pache, S. Wilhelm, W.G. Rossmanith, A. Schiller, B. Gerber, U. Ulrich, O. Wilhelm, P. Berger, B. Lechner, E. Kaiserling, W. Schmidt, W. Küpker, J.W. Kreider, M. Frank, A. Luttkus, Sanyukta Runkel, B. Djuricic, P. Dettmar, W. Kuhn, W. Nathrath, M. Neises, H. Schaider, H.G. Bender, W. Kühnel, H. Graeff, S. Ditz, E. Bierhoff, P. Mallmann, J. Bläser, R. Felberbaum, C. Rybakowski, A. Jensen, A. Bergant, K. Marzusch, J.W. Dudenhausen, W. Weikel, G. Fleckenstein, S. Herzog, B.U. Sevin, K. Heim, H.-P. Horny, S. Rimbach, N. Ruth, N.D. Christensen, K. Ulm, E. Merz, Veronika Schlamp, H. Meden, J. Keckstein, R. Kimmig, J. Haas, W. Bunk, D. Wallwiener, E. Çetin, K. Diedrich, M.P. Dierich, Annette Krause, G.E. Morfill, F. Melchert, W. Rath, R. Moll, H. Tschesche, Andrea Steinbron, A. Wischnik, R. Berger, W. Wuttke, W. Schröder, M. Cervar, Ch. Sohn, S. Mielke, U. Janssen, P. Ruck, Cosima Brucker, K. Maag, O.D. Wiestler, M. Kolben, G. Bastert, H. Zwierzina, C. Brumm, E. Melchert, C. Anthuber, K. Wayss, M. Schmitt, B. Hüneke, Antje Keberle, Rita K. Schmutzler, D. Krebs, T. Reissmann, B. Aydeniz, G.v. Herder, W. Schulze, G. Kuhn, W. Paschen, J. Gnirs, G. Desoye, I. Tossounidis, F. Bahlmann, C. Larcher, Petra Ziffer, K.T.M. Schneider, J. Dietl, S. Meyer, F. Jänicke, R. Osmers, G. Pirschner, U. Bartels, C. Diedrich, Angela Reles, A. Zeimet, A. Homann, R. Handgretinger, Ines Schönborn, K. Friese, I. Pündmann, D. Labeit, and D. Mink

Subjects
Obstetrics and Gynecology, General Medicine
Published
1995

5. Sex steroid dependent prolactin secretion

Author

W.G. Rossmanith

Subjects
Prolactin cell, medicine.medical_specialty, Endocrinology, business.industry, Sex steroid, Internal medicine, medicine, Secretion, Sex hormone receptor, business, Prolactin
Published
2012

6. Influence of sex steroids on TSH secretion

Author

W.G. Rossmanith and W.A. Scherbaum

Subjects
medicine.medical_specialty, Endocrinology, business.industry, TSH secretion, Internal medicine, medicine, business
Published
2012

7. The distribution of hypothalamic nitric oxide synthase mRNA in relation to gonadotrophin-releasing hormone neurons

Author

R.A. Steiner, G. Cadd, Clifton Dk, Ashley B. Grossman, W.G. Rossmanith, and E.B. Kabigting

Subjects
Male, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Central nervous system, Hypothalamus, In situ hybridization, Gonadotropin-Releasing Hormone, Rats, Sprague-Dawley, Endocrinology, Internal medicine, medicine, Animals, RNA, Messenger, In Situ Hybridization, Neurons, Messenger RNA, biology, Diagonal band of Broca, Rats, Nitric oxide synthase, medicine.anatomical_structure, nervous system, Oxytocin, biology.protein, Female, Amino Acid Oxidoreductases, Nitric Oxide Synthase, DNA Probes, Nucleus, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Using probes for rat neural nitric oxide synthase (NOS) mRNA and GnRH mRNA, we performed in situ hybridization to survey NOS mRNA distribution within the hypothalamus of the male and female rat and sought evidence for its expression in GnRH neurons. The NOS cRNA probe was radiolabelled with 35S, and a digoxigenin-labeled rat GnRH cRNA probe was used for double-label studies. NOS mRNA was localized in discrete hypothalamic areas, in grain clusters suggestive of individual neurons. NOS mRNA-positive cells were located mainly in the supraoptic and paraventricular nucleus, particularly overlying the magnocellular division. Rostrally, cells expressing NOS mRNA were especially prominent in the diagonal band of Broca, in a distribution very similar to GnRH neurons. Nevertheless, only one of 370 cells labeled for GnRH mRNA appeared to be positive for NOS mRNA. We conclude that NOS mRNA is located prominently in regions where CRH, AVP and oxytocin cells are located. NOS mRNA-positive cells are located in close proximity to GnRH neurons, but rarely do such neurons express NOS mRNA.

Published
1994

8. Contents, Vol. 31, Supplement 2, 1991

Author

R. Schröck, M. Menton, G. Freude, K. Czerwenka, E. Holm, J. Hermann, G. Mitterschiffthaler, W.D. Skodler, C. Marth, B. Schießl, J. Spona, R. Faber, K. Kupf, Kerstin Hiller, Elisabeth Vytiska-Binstorfer, G. Gmoser, A. Beck, A. Rosen, J. Lahodny, Eva Ostermayer, B. Wartusch, M. Stumpfe, G. Luschin-Ebengreuth, P. Wieacker, E. Kuβ, D. Lampe, Cornelia Schweighart, G. Tulzer, R. Steldinger, R. Voigt, W. Schnedl, B. Sitte, E. Doringer, W. Walcher, J.C. Huber, E. Greimel, U. Ruppitsch, E. Stumberger, U. Steinhart, W. Rosenkranz, P.H. Wünsch, H. Kölbl, R. Zeillinger, P. Fritsch, W. Kozak, D. Szendzielorz, R. Krepler, U. Fürstenau, H. Steiner, C. Thomssen, G. Debus-Thiede, T. Strowitzki, P. Kentner, H. Hofbauer, A. Riehn, R.v. Hugo, H. Salzer, M.S. Zach, B. Hofwarter, S. Schramm, R. Winter, H.O. Mayer, J. Baltzer, Lieselotte Winkler, H. Janisch, W. Oettle, D. Kölle, K.T.M. Schneider, E. Arnold, F. Welponer, W. Schramm, C. Schatten, F. Wierrani, M. Schuster, E. Petru, B. Wang-Artner, Ch. Kainz, P. Eberl-Lehmann, H. Pickel, N. Lack, G. Tatra, L. Wildt, J. Jawny, D. Weiss, T. Schramm, G. Tews, M. Medl, P. Scheidel, B. Rudelstorfer, A. Reinthaller, V. Fabrizii, Beate Kästner, C. Lauritzen, Nadia Harbeck, F. Staufer, Ch. Thieme, B. Oberwaldner, M. Hölscher, E. Müller-Holzner, K.-E. Ruckhäberle, M. Wolters, K. Radivojevic, S. Leodolter, Barbel Justus, G. Hagen, J. Kurbacher, Maria Simml, K. Weghaupt, H. HÖfler, M. Eisenmenger, Ter Meulen, W.G. Rossmanith, M. Seifert, C. Baseler, I. Jochmus-Kudielka, H. Strampfer, M. Schwiersch, H. Schenk, R. Robel, B. Getz, H. Rollett, M. Heydarfadai, P. Kohlberger, E. Merkle, E. Holböck, J. Haas, J.W. Hosmann, R. Deckardt, H. Sommer, M. Barrada, J. Buschmann, H. Hepp, E. Müller-Tyl, J. Burkl, M. Woltsche, P. Schwegel, G. Berclaz, T. Steck, T. Wagner, R. Rudelstorfer, T. Gyr, N. Endler, N. Moniwa, T. Lang, H. Joos, H. Kucera, Ch. Nowotny, M. Korell, Christine Kurz, N. Pateisky, G. Quittan, Ute Herzog, V. Sasse, G. Schüle, D. Spitzer, L. Gissmann, G. Methfessel, P. Speiser, R. Kürzl, D. Amberg-Wendland, E. Brusis, F. Kury, K. Ketscher, W. Lechner, E.A. Dumler, M. Lahousen, P. Kristen, K. Fiedler, S. Gudmundsson, A. Pflaumer, W. Kuhn, N. Lang, J. Wisser, M. Schmitt, U. Finsterer, P. Hirsch, W. Hönigl, J. Egger, P. Balcke, F. Allerberger, Ch. Dadak, H. Enzelsberger, K. Derfler, Marina Marcovich, E.D. Mauch, H.U. Bratschi, A. Bergant, F. Fischl, F. Mittermayer, P. Sevelda, Ildiko Salanki, D. Täubert, E. Pastner, C. Breuel, R. Austin, W. Knogler, Anna Streitmatter, W. Jäger, E. Beinder, Ch. Kurz, Brigitte Pechter, B. Viehweg, K. Kosian, A. Obermair, M. Sandbichler, D. Markus, J. Schöffel, R. Wiborny, M. Neises, H.P. Dimai, U. Wirth, V. Maaβen, D.C. Wood, B. Schüβler, E. Reinold, Ivo Fischer, Birgit Seelbach-GÖbel, M.C.H. Häusler, M. Manavi, S. Krone, Ch. Vutuc, F. Fischbach, A. Delucca, A. Feiks, F. Friedrich, Edeltraud Kurt, B. Bartosch, H. Graeff, F. Seibert, Sabine Schweiberer, N. Sepp, H.D. Methfessel, R. von Hugo, G. Ralph, A. Waitz-Penz, M. Saks, A. Hümpfner, A. Schaller, Riehn F, H. Nöschel, Ch. Bieglmayer, A.C. Stuckert-Klein, N.E. Adelwöhrer, O. Dapunt, M. Schelling, E. Abfalter, K. Swoboda, M. Schemper, L. Michelitsch, E. Beck, F. Jänicke, J.C. Huhta, H. Kaesemann, K.-Ph. Gloning, B. Meier, K. Riedel, R. Fitz, G. Krüsmann, E. Sölder, C.M. Kurbacher, P. Brock, F. Girardi, J. Auner, A. Lörken, B. Schurz, H. Zech, N. Vavra, K. Höbarth, G. Pinzger, K. Brandt, P. Strigl, M. Breckwoldt, A.H. Tulusan, E. Paterok, W. Heis, A. Berg, K.F. Czerwenka, M. Batka, T. Genz, L. Pache, R. Klieber, H.J. Voigt, H. Caffier, G. Guggenbichler, G. Lorenz-Eberhardt, M. Peschke, G. Breitenecker, A. Adler, S. Petraki, A. Wischnik, H. Wernze, M. Glawischnig, W. Weise, K. Heim, U.V. Wisiak, M.W. Beckmann, R. Hegerfeld, K. Eglau, R. Senekowitsch, Maria Haidinger, J. Stepien, M. Meyer, H. Heidegger, R. Lassmann, E. Busch, H.-J. Beier, K. Spatzier, U. Hesse, K. Tamussino, P. DÖrffler, U. Denison, H. Schneider, R. Knitza, W. Kopp, R. Höpfl, A. Schlager, H. Kirchler, M. Klein, T. Sander, H.H. Pusch, A. Staudach, W. Freidl, E. Mauch, H. Schröcksnadel, D. Stech, A. Rempen, B. Hartmann, R. Benz, E. Wiest, W. Urdl, Katrin Schaudig, S. Schüßler, U. Artmeier, M. Häusler, C. Fellbaum, W. Grünberger, J. Keckstein, P.A.M. Weiβ, J. Forberg, T. Dimpfl, H.P. Friedl, H. Schaffer, M. Kolben, W. Würfel, Ulla Link, M. Halaška, Cornelia Schweighardt, A. Alge, H. Schünemann, P.J. Albert, Edith Rammer, E. Siebzehnrübl, G. Gitsch, G. Daxenbichler, G. Hofer, S. Renz, S. Todorow, and E. Kubista

Subjects
Obstetrics and Gynecology, General Medicine
Published
1991

9. Mitteilungen onkologischer Gesellschaften

Author

Andreas Jakob, H.-P. Waidelich, K. Krauss, N. Victor, M. Blettner, Jürgen Bauer, H.H. Bartsch, Martin Schumacher, Carsten Bokemeyer, S.C. Carlstedt, H.-H. Wöltjen, G.F. Springer, A. Hauschild, B. Görsch, H. Sperling, Willi Sauerbrei, N.A. Willich, F. Daschner, P.R. Desai, Hermann Einsele, Lothar Kanz, E. Kubista, W.G. Rossmanith, C. Stegmaier, A. Melms, H. Luboldt, G. Lümmen, Herbert Rübben, J. Bertz, R. Brinkmann, L.H. Ujjainwala, T. Daikeler, T. Otto, G. Köhler, M. Scherrer, and H. Ziegler

Subjects
Cancer Research, Oncology, Hematology
Published
1997

10. Eröffnungsansprache des Tagungspräsidenten

Author

C. Larcher, T. Reissmann, G.v. Herder, G. Huber, B. Lechner, G. Pirschner, U. Bartels, J. Gnirs, S. Herzog, W. Rath, Andrea Steinbron, H. Tschesche, C. Diedrich, Cosima Brucker, S. Anthuber, A. Luttkus, E. Halberstadt, N. Ruth, S. Al-Hasani, O.D. Wiestler, R. Lissner, J. Keckstein, R. Kimmig, B. Föst, R. Conradi, E. Çetin, G. Kuhn, Klara Fizi, G. Büge, O. Dapunt, W. Bunk, D. Wallwiener, Petra Ziffer, E. Petru, K. Wayss, M. Schmitt, W. Paschen, W. Küpker, J. Dietl, W. Weikel, G. Fleckenstein, T. Schill, Antje Keberle, R. Höpfl, Rita K. Schmutzler, I. Tossounidis, F. Bahlmann, S. Meyer, F. Melchert, F. Kainer, A. Bergant, A. Lopens, Annette Krause, S. Ditz, D. Krebs, B. Aydeniz, L. Pache, T. Nebe, E. Kaiserling, W. Nathrath, F. Jänicke, P.G. Knapstein, A. Wischnik, R. Osmers, R. Berger, D. Macchiella, W. Wuttke, A. Fischer, S. Rimbach, G. Bastert, K. Marzusch, U. Ulrich, H.-P. Horny, W. Schulze, H. Günes, G.B. Lipford, N.D. Christensen, K. Ulm, K.T.M. Schneider, J.W. Dudenhausen, M. Neises, C. Brumm, G. Daxenbichler, Ch. Thomssen, E. Melchert, H. Zwierzina, Ch. Sohn, M.P. Dierich, U. Schwuléra, E. Merz, H.G. Bender, O. Wilhelm, J.W. Kreider, G. Desoye, C. Anthuber, A. Schiller, E. Bierhoff, M. Frank, B. Djuricic, J. Bläser, S. Mielke, B. Hüneke, P. Berger, Sanyukta Runkel, U. Janssen, W. Schmidt, W. Friedmann, C. Villena-Heinsen, A. Jensen, P. Mallmann, G.E. Morfill, R. Felberbaum, H. Schaider, Nadia Harbeck, A. von Daimling, H. Graeff, Veronika Schlamp, T. Cunze, H.J. Schröder, W. Lichtenegger, T. Beck, A. Huber, C. Zoll, G. Weber, S. Wilhelm, Angela Reles, A. Zeimet, A. Homann, R. Handgretinger, Ines Schönborn, R. Moll, I. Pündmann, P. Ruck, W.G. Rossmanith, D. Labeit, K. Friese, C. Marth, K. Diedrich, K. Heim, P. Dettmar, W. Kuhn, D. Mink, M.F. Press, K. Maag, M. Kolben, W. Kühnel, B. Wartusch, B. Gerber, J. Haas, T. Strohmeyer, C. Rybakowski, W. Schröder, M. Cervar, B.U. Sevin, and H. Meden

Subjects
Obstetrics and Gynecology, General Medicine
Published
1995

11. Subject Index Vol. 20, 1997

Author

H. Ziegler, L.H. Ujjainwala, H. Luboldt, P.R. Desai, Carsten Bokemeyer, S.C. Carlstedt, G. Köhler, A. Melms, Maria Blettner, T. Daikeler, W.G. Rossmanith, T. Otto, B. Görsch, M. Scherrer, H.H. Bartsch, K. Krauss, Jürgen Bauer, E. Kubista, Herbert Rübben, H.-H. Wöltjen, G. Lümmen, R. Brinkmann, J. Bertz, Lothar Kanz, G.F. Springer, C. Stegmaier, A. Hauschild, Willi Sauerbrei, N.A. Willich, Hermann Einsele, H.-P. Waidelich, Andreas Jakob, Martin Schumacher, F. Daschner, N. Victor, and H. Sperling

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), Hematology, Mathematics
Published
1997

12. Sachwortverzeichnis Band 20, 1997

Author

H.-H. Wöltjen, Lothar Kanz, H.H. Bartsch, H. Ziegler, A. Hauschild, C. Stegmaier, Jürgen Bauer, A. Melms, B. Görsch, Martin Schumacher, N. Victor, K. Krauss, G. Lümmen, H.-P. Waidelich, L.H. Ujjainwala, N.A. Willich, M. Scherrer, H. Sperling, G.F. Springer, M. Blettner, P.R. Desai, F. Daschner, T. Daikeler, Andreas Jakob, Herbert Rübben, E. Kubista, H. Luboldt, Carsten Bokemeyer, Willi Sauerbrei, T. Otto, J. Bertz, R. Brinkmann, G. Köhler, W.G. Rossmanith, Hermann Einsele, and S.C. Carlstedt

Subjects
Cancer Research, Oncology, Hematology
Published
1997

13. Contents, Vol. 29, Supplement 2, 1989

Author

K. Kosian, S. Leodolter, L. Abét, Eva Ostermayer, Elisabeth Müller-Holzner, K. Philipp, J. Spona, E. Sader, F. Kainer, H. Kessler, U. Denison, H. Salzer, E. Gitsch, A. Lapin, E. Kuss, H.A. Krone, S. Szalay, B. Wartusch, A. Hümpfner, W. Jäger, J.C. Huber, D. Kölblinger, M. Manavi, O. Dapunt, H.J. Voigt, W. Albrich, K. Hecher, W. Walcher, P. Wagenbichler, W. Knogler, G. Grospietsch, P. Fuchs, W. Rosenkranz, R. Rudelstorfer, P. Lang, G. Tscherne, G. Machill, Ch. Dadak, O. Ipsiroglu, W. Kronich, E. Holböck, T. Steck, J. Behr, Edith Rammer, G. Gell, G. Breitenecker, B. Maly, A. Kainhofer, D. Grabow, P. Albert, P. Riss, K. Schmidt-Gollwitzer, R. Schwarz, R. Haidbauer, B. Schweitzer, E. Struck, H. Ludwig, G. Keckstein, G. Sunder-Plassmann, G. Göretzlehner, W. Arzt, G. Tews, F. Taxer, R. Reichel, A. Dittmar, K. Rotte, H. Kölbl, K. Müller, E. Wild, J. Haas, W. Lechner, J. Deutinger, C. Tovar, A. Bichler, H. Welsch, M. Untch, G. Heytmanek, Gunhild Barten, K. Reiz, O. Huter, T. Sautter, F. Wolf, P. Sevelda, P. Husslein, N. Harbeck, H. Piza, H.-J. Beier, J. Überfuhr, M. Bayr, K. Czerwenka, Kinga Chalubinski, M. Metka, W. Eiermann, F. Conrad, Ch. Brezinka, G. Daxenbichler, M. Stiglbauer, W.D. Zwierzina, W. Schröder, U. Grimm, Ch. Kurz, M. Weppler, Sabine Nikschick, St. Förster, Andra Leminski, Ch. Voller, G. Mitterschiffthaler, T. Bohaumilitzky, F. Melchert, H. Schlögl, J. Lembke, J. Schläfke, J. Wallner, C. Anthuber, R. Seufert, H. Wilken, W. Reider, R. Wenzel, T. Schramm, W. Wodrig, J. Martius, R. Schmidt, A. Staudach, R. Taschner, M. Ott, F. Nagl, J.A. Pinotti, H.-J. Seewald, A. Nerlich, A. Schäfer, W. Friedmann, A. Laczkovics, H. Pusch, K.-H. Eichhorn, C. Breuel, W. Knoll, W.G. Rossmanith, H. Boenisch, M. Sachsenmaier, H. Mickan, L. Schausberger, E.F. Karpf, Richard Fikentscher, I. Walter, U. Hasbargen, R. Winter, M. Winkler, H.P. Friedl, A. Schultz, M. DiPaolo, M. Schaffer, Eva Berger, B. Reitter, L. Linhardt, G. Hug, F. Kunz, Ch. Pechlaner, E.M. Keppke, M. Rothenaicher, G. Ralph, K. Renziehausen, H. Schröcksnadel, I. Sander, T. Angerpointner, K.Ph. Gloning, I.v. Hertwig, Brigitte Schurz, W. Urdl, W. Hönigl, L.C. Fuith, E. Röhrig, E. Voigsberger, E. Golob, W. Lichtenegger, H. Janisch, H. Heidegger, A. Berlinger, F. Casper, P. Hirsch, A. Reinthaller, E. Reinold, H. Denecke, G. Gitsch, K.H. Wulf, H. Feistel, W. Zieger, P. Anderl, E. Oberlechner, E. Kubista, A. Tomesch, Elisabeth Vytiska-Binstorfer, W. Groß, Heidrun Flores-Genger, R. Tiller, A. Marczewski, Heidrun Genger, P. Stieber, L. Höhne, J. Kirchheimer, G. Fichtel, N. Lang, F. Girardi, E. Ostermayer, G. Pinzger, F. Nagele, G. Ronay, S. Krone, L.C. Faith, R. Bollmann, C. Homm, G. Mursch, M. Lahousen, H. Gründling, S. Querbach, Ch. Marth, P. Hofer, A. Rokitansky, H. Caffier, H. Stettner, G. Krüsmann, J. Heinrich, B. Gerber, H.O. Mayer, N. Pateisky, F. Friedrich, G. Tatra, G. Wunderer, M. Roggendorf, D. Spitzer, E. Brusis, H. Fröhlich, A. Prestel, N.v. Obernitz, E. Rothemund, G. Wirnsberger, W. Eppel, R. Zeillinger, K. Derfler, J. Scholler, A. Sperl, A. Rempen, H. Suschke, J. Huber, R. Spernol, P. Kirchebner, H. Kucera, E.M. Paterok, H.J. Schön, W. Becker, Irene Fellinger, Margit Endler, U. Link, R. Budiman, H. Segerer, W. Sterniste, Ch. Bieglmayer, K. Rudolf, R. Knitza, M. Kirsch, J. Auner, E. Sölder, H. Hepp, J. Wessel, A. Tuchmann, R. Maier, A. Wischnik, C.M. Schlotter, D. Kölle, E. Jiminez, B. Schüßler, D. Adam, E. Artner-Dworzak, M. Reizenstein, W. Grünsteidel, N. Vavra, A. Beck, D. Weiss, W. Hütter, W. Grünberger, L. Fuith, A. Hettenbach, A. Fateh-Moghadam, K. Fiedler, A. Ortner, W. Stummvoll, G. Mursch-Edlmayr, W. Gruber, T. Keim, M. Häusler, R. Terinde, M. Kunze, E. Petru, R. Reitsamer, G. Leitner, H. Versmold, H.G. Mutke, G. Luschin-Ebengreuth, Ch. Kainz, H. Bösch, H. Seidel, H. Rehder, J. Wisser, H. Spingler, A. Weber, G.J. Gerstner, P. Krause, A.H. Tulusan, E. Lasnik, P. Hintermüller, E. Merkle, G. Seidlitz, A. Rosen, H.M.H. Hofmann, W.D. Schönegg, K.Ph. Cloning, S. Bartho, M. Barrada, M. Weninger, K.F. Czerwenka, B. Högel, A. Feiks, W. Würfel, Christine Nowotny, R. Fitz, K. Weber, M. Tabarelli, R. Koch, W. Natho, G. Freude, F. Stechele, C. Schmidt, H. Haas, H. Kaesemann, R. Wenzl, W. Meier, T. Schwarz, E. Müller-Holzner, P. Kristen, P. Prenzlau, M. Klein, H. Pickel, H. Concin, D. Grab, K. Heim, P. Balcke, C. Faschingbauer, U. Herzog, Schatten C, H. Enzelsberger, and E. Scharnagl

Subjects
Obstetrics and Gynecology, General Medicine
Published
1989

14. Effects of acute hyperprolactinemia on LH pulsatile secretion in hypogonadal and early follicular phase women

Author

J.F. Mortola, S. S. C. Yen, and W.G. Rossmanith

Subjects
Adult, medicine.medical_specialty, Metoclopramide, Early follicular phase, medicine.medical_treatment, media_common.quotation_subject, Pulsatile flow, General Biochemistry, Genetics and Molecular Biology, Receptors, Dopamine, Internal medicine, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Saline, Menstrual cycle, media_common, Postmenopausal women, business.industry, General Medicine, Luteinizing Hormone, Middle Aged, Hyperprolactinemia, Endocrinology, Follicular Phase, Dopamine receptor, Female, Pulsatile secretion, Menopause, business, Sleep, Algorithms, medicine.drug
Abstract

To investigate the effects of acute hyperprolactinemia on the 24 h LH pulsatile pattern, 11 women in the early follicular phase (EF, days 3 and 4) and 8 postmenopausal women (PMW) were studied before and during administration of metoclopramide, a dopamine receptor antagonist. Sequential 24 h infusions of either metoclopramide (MCP, 30 micrograms/kg/h) or normal saline were conducted and pulsatile LH activity assessed for 48 hrs. In both EF women and PMW, a prompt (within 90 min, p less than 0.001) and sustained (greater than 45 micrograms/L, p less than 0.001) release of PRL was induced by MCP infusions. MCP-induced hyperprolactinemia failed to modify the LH pulsatile activity in both EF women and PMW. These observations suggest that acute hyperprolactinemia due to dopaminergic blockade has no discernible effect on LH pulsatility and that the reduced LH pulse frequency observed in association with endogenous hyperprolactinemia may result from different neuroendocrine mechanism(s) and/or is time dependent.

Published
1988

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