1. Predicting the prognosis of Wilms tumor by peripheral blood cells: a real-world study of more than 30 years
- Author
-
Lin Jie, Shi Qin-Lin, Tian Xiao-Mao, Hong Peng, Wang Zhuang-Cheng, Hu Zai-Hong, Cui Kong-Kong, Gao Zhi-Qiang, Liu Feng, Lin Tao, and Wei Guang-Hui
- Subjects
Wilms tumor ,Blood cells ,Overall survival ,Risk stratification ,Prognosis ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Despite established excellent treatment strategies for Wilms tumor (WT), effective prognostic evaluation methods were lacking. This study aims to examine prognostic factors for WT through real-world peripheral blood cell profiling. Methods Basic data and pre-treatment laboratory indices from WT and non-WT children underwent Wilcoxon test analysis. Chi-square tests assessed the correlation between blood cells and the overall survival (OS) and event-free survival (EFS) of WT. Further the Log-rank test and multivariate Cox were used to identify independent prognostic factors for OS. Traditional accepted factors were included in multi-Cox and the nomogram was constructed to further validate the outcome. Results Blood cells significantly differed between WT and non-WT groups (P
- Published
- 2024
- Full Text
- View/download PDF