Search

Abstract Background Prostate-specific membrane antigen positron emission tomography (PSMA-PET) is an essential tool for patient selection before radioligand therapy (RLT). Interim-staging with PSMA-PET during RLT allows for therapy monitoring. However, its added value over post-treatment imaging is poorly elucidated. The aim of this study was to compare early treatment response assessed by post-therapeutic whole-body scans (WBS) with interim-staging by PSMA-PET after 2 cycles in order to prognosticate OS. Methods Men with metastasized castration-resistant PC (mCRPC) who had received at least two cycles of RLT, and interim PSMA-PET were evaluated retrospectively. PROMISE V2 framework was used to categorize PSMA expression and assess response to treatment. Response was defined as either disease control rate (DCR) for responders or progression for non-responders. Results A total of 188 men with mCRPC who underwent RLT between February 2015 and December 2021 were included. The comparison of different imaging modalities revealed a strong and significant correlation with Cramer V test: e.g. response on WBS during second cycle compared to interim PET after two cycles of RLT (cφ = 0.888, P

The concept of green buildings or green buildings is highly needed in the present era, considering the drastic decline in global climate conditions. However, its development is greatly hindered because the implementation of green building concepts is primarily focused on new constructions, while almost two-thirds of the world's buildings are already built. Therefore, the objective of this research is to enhance the Performance of Green Retrofitting Implementation Time, which is expected to accelerate the growth of existing green buildings in Indonesia by identifying the Procurement and Permitting Processes of Green Retrofitting in High-Rise Office Buildings in Jakarta based on PERMEN PU NO 21 TAHUN 2021 (Regulation of the Minister of Public Works and Housing Number 21 of 2021) and Green Building Council Indonesia (GBCI) through work breakdown structure (WBS) along with their high-risk activities and improvement strategies using a preventive approach that Influences the Performance of Green Retrofitting implementation time. This research analysis involves 15 respondents' data on risks in the procurement and permitting processes, which will be processed using a qualitative risk approach. Based on the results of literature studies, expert validation, and respondent questionnaires, a total of 83 activities in the procurement and permitting processes of green retrofitting were identified, 214 risk indicators that affect the performance of green retrofitting schedule, along with 56 prevention strategies for the high-risk situation, aiming to accelerate the growth of existing green buildings in Indonesia. [ABSTRACT FROM AUTHOR]

The inflow of foreign capital from multinational companies from all over the world, in the form of foreign direct investments (FDI), intensified economic dynamics and contributed to the improvement of macroeconomic performance. In certain economic sectors and activities, FDI has become the carrier of economic growth, encouraged by intensive processes of deindustrialization and reindustrialization. Namely, FDI can have both positive and negative impact on economic growth and development. This depends on the ability of the economic sectors to overcome the negative effects of FDI in a certain period of time, which can only be achieved if the sectors are export-oriented and introduce new technologies into their operations, thereby increasing productivity and competitiveness. Ordinary Least Squares (OLS) panel regression showed this was not the case in the primary and secondary sectors in the countries of Central and Eastern Europe (CEE) and the Western Balkans (WBs), which are still predominantly labor-intensive and therefore have a negative impact on economic development. As opposed to the agricultural and industrial sectors, the services, under the influence of technological progress, is profiled as a capital-intensive sector with a statistically significant positive impact on economic growth and development.

The risk identification stage that is a part of the risk analysis in construction project implementation mostly uses the Work Breakdown Structure (WBS), political, economic, social, technological, legal, and environmental (PESTLE) methods, or other partial methods. Partial risk identification with WBS or PESTLE does not yet provide adequate risk mapping, so it needs to be studied using a hybrid risk identification method between WBS and PESTLE. Qualitative descriptive methods were used in this research. The WBS and PESTLE hybrid risk identification methods were developed through a review of the literature and expert judgment. The risk assessment and evaluation of risk levels for qualitative risk analysis used the Probability-Impact (PI) method. The hybrid WBS and PESTLE risk identification method obtained was in the form of a WBS and PESTLE matrix framework model. The results of implementing risk identification based on the WBS and PESTLE risk sources provided more in-depth information on each task in the WBS, mapped to the PESTLE risk sources. The results of the analysis of the major risk categories consisting of unacceptable and undesirable risk levels can be traced to the WBS and PESTLE tasks. For construction project teams, the hybrid WBS and PESTLE method makes it easier to identify and map risks in detail so then the results of the risk analysis and evaluation can be handled and controlled in detail. [ABSTRACT FROM AUTHOR]

The growth in energy demand, particularly in the oil & gas sector, influences investment decisions for jetty development to enhance supply capacity. The Dolphin Jetty, a prevalent type used by the National Oil Company, incorporates cylindrical or pile-like structures called dolphins to guide and moor vessels safely. As energy consumption in Indonesia shows a consistent upward trend, optimizing the supply chain and fuel distribution becomes imperative. In this context, maritime transportation, specifically through dolphin jetties, emerges as a strategic choice to efficiently meet fuel distribution needs. This paper emphasizes the importance of preparing Capital Expenditure (CAPEX) documentation in the feasibility studies stage, influencing the economic value of the investment. The paper uses historical data to introduce a parametric modeling approach for Dolphin-configured jetties, considering variations in mooring capacity, dead weight tonnage (DWT), and estimated construction implementation years. The outcomes aim to inform the CAPEX Class 4 preparation, contributing valuable insights for the economic assessment of jetty construction projects. [ABSTRACT FROM AUTHOR]

In the face of escalating global energy demands, the construction and management of pier infrastructure emerge as pivotal challenges, particularly for energy companies like Pertamina Patra Niaga in Indonesia. This paper aims to optimize pier construction management through the implementation of an OmniClass Work Breakdown Structure (WBS), addressing the critical need for standardized project management methodologies in complex, large-scale construction projects. By integrating a multidimensional WBS approach, akin to the hypercube or tesseract model, this study explores the enhancement of project planning, execution, and management. Employing a comprehensive literature review and case study analysis, the research investigates the efficacy of OmniClass WBS in facilitating better project coordination, cost estimation, and risk management. The findings underscore the significant advantages of adopting a standardized, multidimensional WBS, including improved data management and project outcome predictability. This paper concludes that the OmniClass WBS framework not only optimizes pier construction projects but also serves as a model for future infrastructure development endeavors within the energy sector [ABSTRACT FROM AUTHOR]

Copyright of Serbian Journal of Management is the property of Serbian Journal of Management and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Patients with differentiated thyroid cancer (DTC) are referred to radioactive 131I (RAI) therapy and post-therapy 131I whole-body scintigraphy (WBS) to identify local and/or remote metastases. Positron emission tomography (PET)/computed tomography (CT) imaging with 18F-fluoro-D-glucose (FDG) or 18F-sodium fluoride (NaF) may also be used with these patients for the evaluation of bone metastases. We compared the role of 18F-NaF PET/CT and 18F-FDG-PET/CT in patients with DTC and documented bone metastases at post-therapy WBS. Methods: Ten consecutive DTC patients with iodine avid bone metastasis at post-therapy WBS referred to 18F-NaF PET/CT and 18F-FDG PET/CT were studied. The findings of the three imaging procedures were compared for abnormal detection rates and concordance. Results: At post-therapy 131I WBS, all patients had skeletal involvement with a total of 21 bone iodine avid lesions. At 18F-FDG PET/TC, 19 bone lesions demonstrated increased tracer uptake and CT pathological alterations, while 2 lesions did not show any pathological finding. At 18F-NaF PET/CT, the 19 bone lesions detected at 18F-FDG PET/TC also demonstrated abnormal tracer uptake, and the other 2 bone iodine avid foci did not show any pathological finding. Conclusions: In patients with DTC, 18F-NaF PET/CT did not obtain more information on the metastatic skeletal involvement than post-therapy 131I WBS and 18F-FDG PET/CT. [ABSTRACT FROM AUTHOR]

Quantifying viruses in wastewater via RT-qPCR provides total genomic data but does not indicate the virus capsid integrity or the potential risk for human infection. Assessing virus capsid integrity in sewage is important for wastewater-based surveillance, since discharged effluent may pose a public health hazard. While integrity assays using cell cultures can provide this information, they require specialised laboratories and expertise. One solution to overcome this limitation is the use of photo-reactive monoazide dyes (e.g., propidium monoazide [PMAxx]) in a capsid integrity-RT-qPCR assay (ci-RT-qPCR). In this study, we tested the efficiency of PMAxx dye at 50 μM and 100 μM concentrations on live and heat-inactivated model viruses commonly detected in wastewater, including adenovirus (AdV), hepatitis A (HAV), influenza A virus (IAV), and norovirus GI (NoV GI). The 100 μM PMAxx dye concentration effectively differentiated live from heat-inactivated viruses for all targets in buffer solution. This method was then applied to wastewater samples (n = 19) for the detection of encapsulated AdV, enterovirus (EV), HAV, IAV, influenza B virus (IBV), NoV GI, NoV GII, and SARS-CoV-2. Samples were negative for AdV, HAV, IAV, and IBV but positive for EV, NoV GI, NoV GII, and SARS-CoV-2. In the PMAxx-treated samples, EV, NoV GI, and NoV GII showed −0.52–1.15, 0.9–1.51, and 0.31–1.69 log reductions in capsid integrity, indicating a high degree of potentially infectious virus in wastewater. In contrast, SARS-CoV-2 was only detected using RT-qPCR but not after PMAxx treatment, indicating the absence of encapsulated and potentially infectious virus. In conclusion, this study demonstrates the utility of PMAxx dyes to evaluate capsid integrity across a diverse range of viruses commonly monitored in wastewater. [ABSTRACT FROM AUTHOR]

The optimization of project management processes within PERTAMINA through the strategic integration of Work Breakdown Structure (WBS) and Cost Breakdown Structure (CBS) methodologies. The study aims to improve project planning, resource allocation, and cost estimation by leveraging the synergy between these two structures. Through an empirical analysis, the paper demonstrates how the combined approach enhances project monitoring, control, and decision-making, leading to more efficient project execution and successful outcomes. This research contributes to project management by offering practical insights into leveraging WBS and CBS integration as a powerful tool for achieving greater efficiency and effectiveness in complex projects within the PERTAMINA context. The conclusion identifies areas where the integration of Work Breakdown Structure (WBS) and Cost Breakdown Structure (CBS) could be advantageous. Preparing for implementing Building Information Modeling (BIM) in PERTAMINA requires careful planning, coordination, and alignment with the organization's goals and objectives. Some potential areas for future research related to the integration of Work Breakdown Structure (WBS) and Cost Breakdown Structure (CBS) in the context of PERTAMINA: Optimal Coding Structures, Integration and Technology, and Cost Estimation Accuracy. [ABSTRACT FROM AUTHOR]

This research was done as being motivated by the prevailing fraud which commonly has still occured, especially in Islamic banking. The existing fraud cases are carried out by anyone, both internal and external parties. The purpose of this study is to obtain empirical evidence regarding the effect of good corporate governance, internal control, and the whistleblowing system on fraud in Islamic banks registered with the Financial Services Authority (OJK) for the 2018-2020 period. This research is quantitative using secondary data in the form of annual reports of Islamic banking companies for 2018-2020. This sample of 14 companies was taken by using a purposive sampling. They were analyzed using a multiple linear regression analysis with SPSS version 26 software. The results indicate that good corporate governance variable has an effect on fraud. Yet, the internal control variables have no effect on fraud and neither does the whistleblowing system variable on fraud. Good corporate governance, internal control, and the whistleblowing system simultaneously have an effect on fraud. The results of this study have implications for the management of Islamic banking to further strengthen the application of GCG to reduce the level of fraud in Islamic banking.

Quantifying viruses in wastewater via RT-qPCR provides total genomic data but does not indicate the virus capsid integrity or the potential risk for human infection. Assessing virus capsid integrity in sewage is important for wastewater-based surveillance, since discharged effluent may pose a public health hazard. While integrity assays using cell cultures can provide this information, they require specialised laboratories and expertise. One solution to overcome this limitation is the use of photo-reactive monoazide dyes (e.g., propidium monoazide [PMAxx]) in a capsid integrity-RT-qPCR assay (ci-RT-qPCR). In this study, we tested the efficiency of PMAxx dye at 50 μM and 100 μM concentrations on live and heat-inactivated model viruses commonly detected in wastewater, including adenovirus (AdV), hepatitis A (HAV), influenza A virus (IAV), and norovirus GI (NoV GI). The 100 μM PMAxx dye concentration effectively differentiated live from heat-inactivated viruses for all targets in buffer solution. This method was then applied to wastewater samples (n = 19) for the detection of encapsulated AdV, enterovirus (EV), HAV, IAV, influenza B virus (IBV), NoV GI, NoV GII, and SARS-CoV-2. Samples were negative for AdV, HAV, IAV, and IBV but positive for EV, NoV GI, NoV GII, and SARS-CoV-2. In the PMAxx-treated samples, EV, NoV GI, and NoV GII showed −0.52–1.15, 0.9–1.51, and 0.31–1.69 log reductions in capsid integrity, indicating a high degree of potentially infectious virus in wastewater. In contrast, SARS-CoV-2 was only detected using RT-qPCR but not after PMAxx treatment, indicating the absence of encapsulated and potentially infectious virus. In conclusion, this study demonstrates the utility of PMAxx dyes to evaluate capsid integrity across a diverse range of viruses commonly monitored in wastewater.

In order to balance economic growth with environmental preservation, the implementation of sustainable policies is necessary. As such, it is imperative to have a comprehensive understanding of the intricate relationship between the economy and the environment. This study examines the relationship between CO2 emissions and GDP per capita in five WB countries during 1960-2018, using a methodological framework that includes panel unit root testing, cointegration testing, and a Vector Error Correction Model. The study provides robust evidence of a long-term cointegration between CO2 emissions and GDP per capita. Furthermore, the study also reveals a short-run bidirectional causal relationship between CO2 emissions and GDP per capita. In the long run, no statistically significant causality exists from GDP per capita to CO2 emissions, but it is statistically significant from CO2 emissions to GDP per capita. These findings offer valuable insights for policymakers to develop comprehensive policies that promote economic growth and environmental sustainability, such as investing in clean energy, implementing stronger environmental regulations, and encouraging environmentally sound management practices. [ABSTRACT FROM AUTHOR]

Safety risk identification is the premise and foundation of safety risk management for railway construction. However, due to some characteristics of railway projects, which include large volumes of work, complex construction environments, and long construction cycles, etc., the risk factors of railway projects are often hidden in all stages of engineering construction. It results in the comprehensive identification of safety risks of railway projects being usually difficult, and this problem is more serious when the railway is constructed in complex and dangerous areas. Therefore, to identify the safety risks comprehensively, this paper constructs a safety risk identification method applicable to railway construction in complex and dangerous areas. This method studies the spatial and temporal distribution of risks and their relationship with subprojects by using a work breakdown structure (WBS), a risk breakdown structure (RBS), grid-based management, and forming a safety risk identification matrix, which can help researchers analyze the characteristics of risks. In order to verify the effectiveness of the method, the A Railway, which is located in the western of China, was selected as a case study, and risk identification for its civil engineering was carried out. The research results show that in the construction process of the A Railway, the main types of safety risks suffered by various branch projects were different. In addition, some risk factors only appeared at specific times in space, and there is a strong interaction between these risk factors. Based on this method, safety risk identification can intuitively discover the spatial and temporal distribution of risk factors and analyze the interaction between risk factors, which can provide help for the formulation of targeted risk control measures. [ABSTRACT FROM AUTHOR]

In projects where mufti-project management is required and processes for production activities are repeated and linked, it is very difficult to input processes for activity repeatedly or analyze loads by process in a method of managing processes step by step. In this paper, based on the definition of activity and project process, the connection process can be automatically created for activity, schedule and resource management for each process, schedule and resource plan can be established for each detailed process, and load analysis can be provided in real time. It presents a project management system that can significantly improve the time and cost of project progress management, predict various problems that may occur during the project, and effectively allocate the necessary amount of resources in the right place. [ABSTRACT FROM AUTHOR]

The detailed data including spatial concept is not transmitted in the detailed data including the spatial concept in the statement of internal construction sites, and the integrated management of cost and process is not carried out because the construction is carried out on the site with cost-oriented details. so doing a double task of generating the necessary work breakdown structure (WBS) and spatial concept detailed data. In order to solve these problems, in this paper, the classification of information using building information model (BIM) object-based properties, 3D object creation standards, cost, and process information are presented centering on the case of highway construction sites. In the future, BIM-based cost-process integration proposes an efficient construction management practice through management. [ABSTRACT FROM AUTHOR]

Project management is a strategy that needs to be done in achieving the efficiency and effectiveness of a company. Developments in the era of technology in this period are in line with the development of SMEs engaged in the field of karawo craft services, such as Rumah Karawo. The project planning can be prepared using Work Breakdown Structure (WBS). Project management can also be used to estimate the project acceleration (crasing) at Karawo House. With the preparation of a good project management, it can be estimated the time and cost needed to run the project, so as to minimize cost losses due to the possibility of project overturning. The development of a project management plan carried out using a waterfall.

These days e-medical services frameworks are getting famous for taking care of patients from far-off spots, so a lot of medical services information like the patient's name, area, contact number, states of being are gathered distantly to treat the patients. A lot of information gathered from the different assets is named big data. The enormous sensitive information about the patient contains delicate data like systolic BP, pulse, temperature, the current state of being, and contact number of patients that should be recognized and sorted appropriately to shield it from abuse. This article presents a weightbased similarity (WBS) strategy to characterize the enormous information of health care data into two classifications like sensitive information and normal information. In the proposed method, the training dataset is utilized to sort information and it comprises of three fundamental advances like information extraction, mapping of information with the assistance of the training dataset, evaluation of the weight of input data with the threshold value to classify the data. The proposed strategy produces better outcomes with various assessment boundaries like precision, recall, F1 score, and accuracy value 92% to categorize the big data. Weka tool is utilized for examination among WBS and different existing order procedures. [ABSTRACT FROM AUTHOR]

With the rapid development of the economy, increasingly large, complex, and systematic projects put forward new requirements to project scheduling management, which make the methods and technology innovation of project scheduling management to meet the diversified needs of different users. This paper proposed a WBS-free scheduling method, which separates scheduling activities and WBS. The novel method establishes a data set scheduling model based on database relational model, extracts the database schedule data through P6, and applies P6 activity code to implement scheduling method innovation through initialization, screening, classification, and composition function of P6. The case study on Pakistan NRL-ISBL national refinery project scheduling management proved that the combination of traditional scheduling methods and WBS-free scheduling method is feasible in project scheduling execution and that WBS-free scheduling method can reduce the work load greatly and optimize the workload of progress planning, so WBS-free scheduling method is able to simplify the scheduling, solve the problem of diversity in scheduling form and implement the innovation of scheduling method. [ABSTRACT FROM AUTHOR]

From small organisations to large, health projects are growing rapidly with the current situation related to the Covid-19 Pandemic. Efficient project management is increasingly more important to reach the objective while not wasting cost and time. An essential control element, the Work Breakdown Structure (WBS), has proven to be a tool to monitor and plan for projects. The WBS decomposes the project to manageable components. This helps the project team to execute the project in a more efficient way, properly estimate the schedule and cost, efficiently allocate and assign resources, and track the project progress and performance. This will lead to the success of the managed projects. Through this case study, we will see the different models of WBS will be explored, including a multidimensional breakdown structure. The technical paper will also propose, based on comparison and evidence, the multidimensional breakdown structure for hospital projects to adopt to achieve project success. [ABSTRACT FROM AUTHOR]

Williams–Beurens syndrome (WBS) is a rare genetic disorder caused by a recurrent 7q11.23 microdeletion. Clinical characteristics include typical facial dysmorphisms, weakness of connective tissue, short stature, mild to moderate intellectual disability and distinct behavioral phenotype. Cardiovascular diseases are common due to haploinsufficiency of ELN gene. A few cases of larger or smaller deletions have been reported spanning towards the centromeric or the telomeric regions, most of which included ELN gene. We report on three patients from two unrelated families, presenting with distinctive WBS features, harboring an atypical distal deletion excluding ELN gene. Our study supports a critical role of CLIP2, GTF2IRD1, and GTF2I gene in the WBS neurobehavioral profile and in craniofacial features, highlights a possible role of HIP1 in the autism spectrum disorder, and delineates a subgroup of WBS individuals with an atypical distal deletion not associated to an increased risk of cardiovascular defects. [ABSTRACT FROM AUTHOR]

The Company, as an energy provider, has the intention to engage in the battery manufacturing business by setting up a battery laboratory. Building the laboratory needs a standardized Work Breakdown Structure (WBS) or cost breakdown structure (CBS) to make better estimates, project execution plan, and reliable database. This paper aims to build multidimensional standardized WBS/CBS, cost estimation of battery laboratory, and cost breakdown for contractors. The method used to determine the selection of tables on the international WBS/CBS standard (OmniClass) uses chip voting. The cost estimation uses steps from the GAO Cost Estimating & Assessment Guide and templates from the Cost Estimating Requirements Handbook in the National Park Service (NPS). The result shows that the OmniClass tables used in WBS/CBS are tables 11, 13, and 22. The estimate obtained to build this battery lab is $ 1,049,591, with an area of 600m2 and the cost breakdown for the contractor using class A from the NPS template. The Company is recommended to use a standardized WBS/CBS to generate more organized and reliable data used in the next project. [ABSTRACT FROM AUTHOR]

Health-care related spending is growing worldwide. To increase efficiency and control costs, health economics are applied by hospital management. The purpose of this case study is, therefore, to explore the best solution to integrate and standardise the WBS/CBS comparing different methods. 2D Standard WBS/CBS approach researched to define if this is the best solution to allow local governments to reach financial and social goals while still maintaining control of the estimate and applying the best international practices and the highest ethical standards², this from the tendering process as the country is considered the 101 most corrupt nation out of 179 countries3, and one of the two hospitals considered in this case study was stopped due to corruption and cost overruns or if we need to look to new solutions to guarantee efficient delivery of the projects. [ABSTRACT FROM AUTHOR]

Introduction: Efficient therapy of recurrent differentiated thyroid cancer (DTC) is dependent on precise molecular imaging techniques targeting the human sodium iodide symporter (hNIS), which is a marker both of thyroid and DTC cells. Various iodine isotopes have been utilized for detecting DTC; however, these come with unfavorable radiation exposure and image quality ([131I]iodine) or limited availability ([124I]iodine). In contrast, [18F]tetrafluoroborate (TFB) is a novel radiolabeled PET substrate of hNIS, results in PET images with high-quality and low radiation doses, and should therefore be suited for imaging of DTC. The aim of the present study was to compare the diagnostic performance of [18F]TFB-PET to the clinical reference standard [131I]iodine scintigraphy in patients with recurrent DTC. Methods: Twenty-five patients with recurrent DTC were included in this retrospective analysis. All patients underwent [18F]TFB-PET combined with either CT or MRI due to newly discovered elevated TG levels, antiTG levels, sonographically suspicious cervical lymph nodes, or combinations of these findings. Correlative [131I]iodine whole-body scintigraphy (dxWBS) including SPECT-CT was present for all patients; correlative [18F]FDG-PET-CT was present for 21 patients. Histological verification of [18F]TFB positive findings was available in 4 patients. Results: [18F]TFB-PET detected local recurrence or metastases of DTC in significantly more patients than conventional [131I]iodine dxWBS and SPECT-CT (13/25 = 52% vs. 3/25 = 12%, p = 0.002). The diagnosis of 6 patients with cervical lymph node metastases that showed mildly increased FDG metabolism but negative [131I]iodine scintigraphy was changed: [18F]TFB-PET revealed hNIS expression in the metastases, which were therefore reclassified as only partly de-differentiated (histological confirmation present in two patients). Highest sensitivity for detecting recurrent DTC had the combination of [18F]TFB-PET-CT/MRI with [18F]FDG-PET-CT (64%). Conclusion: In the present cohort, [18F]TFB-PET shows higher sensitivity and accuracy than [131I]iodine WBS and SPECT-CT in detecting recurrent DTC. The combination of [18F]TFB-PET with [18F]FDG-PET-CT seems a reasonable strategy to characterize DTC tumor manifestations with respect to their differentiation and thereby also individually plan and monitor treatment. Future prospective studies evaluating the potential of [18F]TFB-PET in recurrent DTC are warranted. [ABSTRACT FROM AUTHOR]

Abstrak Manajemen proyek merupakan strategi yang perlu dilakukan dalam mencapai efisiensi dan efektifitas suatu perusahaan. Perkembangan pada era teknologi masa ini sejalan dengan berkembangnya perusahaan yang bergerak di bidang jasa teknologi, seperti Qiscus Pte Ltd. Perencanaan proyek tersebut dapat disusun menggunakan Work Breakdown Structure (WBS), Cirital Path Method (CPM) dan Program Evaluation and Review Technique (PERT). Manajemen proyek dapat pula digunakan untuk memperkirakan adanya percepatan proyek (crasing) pada Qiscus Pte Ltd. Dengan penyusunan suatu manajemen proyek yang baik, maka dapat dilakukan estimasi waktu dan biaya yang diperlukan dalam menjalankan proyek, sehingga dapat meminimasi kerugian biaya akibat kemungkinan keterlambaran proyek. Perencanaan manajemen proyek yang dilakukan untuk menjalankan proyek Hayyan, Qiscus Pte Ltd, menghasilkan estimasi percepatan pengerjaan proyek selama 6 hari, dengan penambahan biaya sebesar 2,8 juta. Abstract Project management is a strategy that needs to be done in achieving the efficiency and effectiveness of a company. Technology development in this era is along with the development company engaged in technology services, such as Qiscus Pte Ltd. Planning the project can be compiled using a Work Breakdown Structure (WBS), Cirital Path Method (CPM) and Program Evaluation and Review Technique (PERT). Project management can also be used to estimate the acceleration of the project (crasing) on Qiscus Pte Ltd. The preparation of a good project management can estimate the time and cost required to run the project, so as to minimize losses due to the possibility of delays in project costs. Keywords : Project Management, WBS, CPM, PERT, Crasing

Quantifying viruses in wastewater via RT-qPCR provides total genomic data but does not indicate the virus capsid integrity or the potential risk for human infection. Assessing virus capsid integrity in sewage is important for wastewater-based surveillance, since discharged effluent may pose a public health hazard. While integrity assays using cell cultures can provide this information, they require specialised laboratories and expertise. One solution to overcome this limitation is the use of photo-reactive monoazide dyes (e.g., propidium monoazide [PMAxx]) in a capsid integrity-RT-qPCR assay (ci-RT-qPCR). In this study, we tested the efficiency of PMAxx dye at 50 μM and 100 μM concentrations on live and heat-inactivated model viruses commonly detected in wastewater, including adenovirus (AdV), hepatitis A (HAV), influenza A virus (IAV), and norovirus GI (NoV GI). The 100 μM PMAxx dye concentration effectively differentiated live from heat-inactivated viruses for all targets in buffer solution. This method was then applied to wastewater samples ( n = 19) for the detection of encapsulated AdV, enterovirus (EV), HAV, IAV, influenza B virus (IBV), NoV GI, NoV GII, and SARS-CoV-2. Samples were negative for AdV, HAV, IAV, and IBV but positive for EV, NoV GI, NoV GII, and SARS-CoV-2. In the PMAxx-treated samples, EV, NoV GI, and NoV GII showed -0.52-1.15, 0.9-1.51, and 0.31-1.69 log reductions in capsid integrity, indicating a high degree of potentially infectious virus in wastewater. In contrast, SARS-CoV-2 was only detected using RT-qPCR but not after PMAxx treatment, indicating the absence of encapsulated and potentially infectious virus. In conclusion, this study demonstrates the utility of PMAxx dyes to evaluate capsid integrity across a diverse range of viruses commonly monitored in wastewater.

Objectives To evaluate the 99mTcMIBI whole body scintigraphy（WBS） and P-glycoprotein （PGP） in the prediction of multiple drug resistance（MDR） in the mid-late stage NSCLC patients in a half-year follow-up. Methods 57 patients with mid-late stage NSCLC（39 male，18 female，with a mean age of 59.5± 14.7 years） entered the study. 20 patients had no previous history of treatment and 37 had a history of previous chemo-radiotherapy. All patients underwent PET/CT imaging before the initial diagnosis or treatment，and the primary lesion or metastasis was confirmed by pathology as NSCLC （31 adenocarcinoma， 26 squamous cell carcinoma） . WBS and measurements of PGP were performed before initialization of treatment and the response to treatment was assessed by PET/CT after six months. The WBS was considered positive when at least one area of non-physiologic increased activity was noted. The presence of MDR was indicated when the patient had active disease but the WBS was negative．Results For WBS，the sensitivity， specificity， positive predictive value， negative predictive value and accuracy in NSCLC patients for the prediction of MDR were 40%、73.7% 、70.6% 、43.8% and 57.1%， respectively. Also the above values for PGP were 50%、52.6% 、65.2% 、38.5% and 51.0%， respectively. The risk of MDR in WBS negative patients was 1.25 times （0.60-1.72） higher than that in the WBS positive patients. Conclusion The value of WBS and PGP in the prediction of MDR in the mid-late stage NSCLC patients was limited. Studies using the method of WBS combined with PGP and including more samples may require further discussion. [ABSTRACT FROM AUTHOR]

Development teams and programmers must retain critical information about their work during work intervals and gaps in order to improve future performance when work resumes. Despite time lapses, project managers want to maximize coding efficiency and effectiveness. By developing a mathematically justified, practically useful, and computationally tractable quantitative and cognitive model of learning and memory retention, this study establishes calculations designed to maximize scheduling payoff and optimize developer efficiency and effectiveness.

The biochemical properties of the signal-induced multifunctional transcription factor II-I (TFII-I) indicate that it is involved in a variety of gene regulatory processes. Although gene ablation in murine models and cell-based assays show that it is encoded by an essential gene, GTF2I / Gtf2i , its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer. Here I bring together these diverse observations to illustrate its multiple pathophysiologic functions and further conjecture on how these could be related to its known biochemical properties. I expect that a better understanding of these ‘structure–function’ relationships would lead to future diagnostic and/or therapeutic potential. [ABSTRACT FROM AUTHOR]

Copyright of Military Science Review / Hadtudományi Szemle is the property of National University of Public Service and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

O escopo de um projeto requer especial atenção do profissional encarregado de executá-lo. Para tanto, é fundamental delimitar o escopo e compreender as necessidades do cliente para saber como e onde você e sua equipe podem ajudar na solução deste problema. Sem o entendimento completo do problema a ser tratado e um planejamento em mãos, você (gerente ou líder) e sua equipe não saberão onde querem e precisam chegar. Uma possível consequência é deparar-se com a inserção de erros logo cedo no desenvolvimento do projeto, os quais virão, possivelmente, apenas bem mais tarde, a serem descobertos. Isto geralmente acontece quando não há a devida ‘preocupação’ com o escopo e a gestão. Essas, dentre outras, são razões pelas quais muitos projetos se transformam em casos de insucesso. Embora o foco seja em projetos de tecnologia, esse conteúdo pode ser aplicado em outros projetos. O artigo explora questões de escopo e estimativas de projeto e, nesse sentido, discute aspectos importantes dessas atividades