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2. Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke.

Author

Wang, Rui-Hong, Lu, Ai-Li, Li, Hui-Ping, Ma, Zhao-Hui, Wu, Shi-Biao, Lu, Hong-Ji, Wen, Wan-Xin, Huang, Yan, Wang, Li-Xin, and Yuan, Fang

Subjects
ADULT respiratory distress syndrome, HEART failure, STROKE, BRAIN natriuretic factor, ISCHEMIC stroke, INTRACEREBRAL hematoma, NEUROLOGICAL intensive care
Abstract

Objectives: Patients with severe stroke are at high risk of developing acute respiratory distress syndrome (ARDS), but this severe complication was often under-diagnosed and rarely explored in stroke patients. We aimed to investigate the prevalence, early predictors, and outcomes of ARDS in severe stroke. Methods: This prospective study included consecutive patients admitted to neurological intensive care unit (neuro-ICU) with severe stroke, including acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage. The incidence of ARDS was examined, and baseline characteristics and severity scores on admission were investigated as potential early predictors for ARDS. The in-hospital mortality, length of neuro-ICU stay, the total cost in neuro-ICU, and neurological functions at 90 days were explored. Results: Of 140 patients included, 35 (25.0%) developed ARDS. Over 90% of ARDS cases occurred within 1 week of admission. Procalcitonin (OR 1.310 95% CI 1.005–1.707, P = 0.046) and PaO2/FiO2 on admission (OR 0.986, 95% CI 0.979–0.993, P < 0.001) were independently associated with ARDS, and high brain natriuretic peptide (OR 0.994, 95% CI 0.989–0.998, P = 0.003) was a red flag biomarker warning that the respiratory symptoms may be caused by cardiac failure rather than ARDS. ARDS patients had longer stays and higher expenses in neuro-ICU. Among patients with ARDS, 25 (62.5%) were moderate or severe ARDS. All the patients with moderate to severe ARDS had an unfavorable outcome at 90 days. Conclusions: ARDS is common in patients with severe stroke, with most cases occurring in the first week of admission. Procalcitonin and PaO2/FiO2 on admission are early predictors of ARDS. ARDS worsens both short-term and long-term outcomes. The conflict in respiratory support strategies between ARDS and severe stroke needs to be further studied. [ABSTRACT FROM AUTHOR]

Published
2024
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3. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage

Author

Wang, Rui-Hong, primary, Wen, Wan-Xin, additional, Jiang, Ze-Ping, additional, Du, Zhen-Ping, additional, Ma, Zhao-Hui, additional, Lu, Ai-Li, additional, Li, Hui-Ping, additional, Yuan, Fang, additional, Wu, Shi-Biao, additional, Guo, Jian-Wen, additional, Cai, Ye-Feng, additional, Huang, Yan, additional, Wang, Li-Xin, additional, and Lu, Hong-Ji, additional

Published
2023
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20. Joining of SiO2f/SiO2 composite to Ti-6Al-4V using Ag-Cu-In-Ti brazing fillers, the joint strengths, and microstructures

Author

WU Shi‐Biao, LI Wen‐Wen, Xiong Hua‐Ping, Zou Wen‐Jiang, and Chen Bo

Subjects
010302 applied physics, Materials science, Mechanical Engineering, Metallurgy, Alloy, Composite number, Metals and Alloys, 02 engineering and technology, engineering.material, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Contact angle, Sessile drop technique, Mechanics of Materials, 0103 physical sciences, Shear strength, engineering, Brazing, Wetting, Composite material, 0210 nano-technology
Abstract

Three novel Ag-Cu-In-Ti brazing fillers were designed for joining of SiO2f/SiO2 composite to Ti-6Al-4V. The wettability of the three brazing fillers on the composite was studied with the sessile drop method at 1073 K for 30 min. The results showed that the three brazing fillers exhibited contact angles of 27°, 33°, and 35°, respectively. The joints brazed with Ag-(22~26)Cu-(8~12)In-(4.5~6.0)Ti at 1073 K for 10 min presented the maximum average shear strength of 19.6 MPa, whereas the strength of the joints brazed with Ag-(22~26)Cu-(8~12)In-(3.2~3.8)Ti was only 10.5 MPa. During the brazing process, the active element Ti diffused significantly from the Ag-Cu-In-Ti alloy to the surface of the SiO2f/SiO2 composite and a thin reaction layer was formed close to SiO2f/SiO2 composite. Sound interfacial bonding was also achieved at the Ti-6Al-4V side. According to micro-analysis results, Ag, Ni3Ti3O, Cu4Ti3, Cu3Ti, and TiSi2 phases were identified at the fracture surface of SiO2f/SiO2/Ag-(22~26)Cu-(8~12)In-(4.5~6.0)Ti/Ti-6Al-4V by the XRD method. The interface structure of the joint brazed with Ag-(22~26)Cu-(8~12)In-(4.5~6.0)Ti alloy can be described as the following sequence: SiO2f/SiO2 → Cu-Ti-O + Ti-Si phases → Ag-based solid solution + Cu-Ti + Ti-In phases → Ti-6Al-4V.

Published
2017

22. Bioactive and Marker Compounds from Two Edible Dark-Colored MyrciariaFruits and the Synthesis of Jaboticabin

Author

Wu, Shi-Biao, Wu, Jing, Yin, Zhiwei, Zhang, Jinzhu, Long, Chunlin, Kennelly, Edward J., and Zheng, Shengping

Abstract

Jaboticaba (Myrciaria cauliflora) and false jaboticaba (Myrciaria vexator) fruits are two pleasant-tasting, dark-colored fruits, native to Brazil. They are rich sources of phenolic compounds, including anthocyanins, flavonoids, phenolic acids, and tannins, as well as less well known polyphenols such as depsides. These two fruits are very similar in morphology, but their taste profiles differ markedly. This study was focused on identifying the marker compounds between them using HPLC-PDA and LC-TOF-MS, combined with principal component analysis. As a result, cyanidin-3-O-glucoside was found as the major anthocyanin in Myrciariafruits. Delphinidin-3-O-glucoside was found to be the marker compound for jaboticaba, while cyanidin-3-O-galactoside and cyanidin-3-O-arabinose were two marker compounds distinguishing false jaboticaba. In addition, two ellagitannins, iso-oenothein C and oenothein C, were isolated and identified from both of these fruits for the first time. Jaboticabin, a minor bioactive depside, occurred in both fruits and, because of its potential to treat chronic obstructive pulmonary disease, was successfully synthesized in the laboratory.

Published
2024
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28. Cytotoxic oplopane sesquiterpenoids from Arnoglossum atriplicifolium.

Author

Clement, Jason A., Bleich, Rachel M., Campbell, Hailey E., Naylor, Kristin, Flood, Matthew J., Kelly, Ryan M., Wu, Shi-Biao, Kennelly, Edward J., and Schmitt, Jeffrey D.

Abstract

Pale Indian plantain (Arnoglossum atriplicifolium (L.) H. Rob.) is a plant with traditional medicinal usage among the Cherokee Native American tribe for treating cancer. Two oplopane sesquiterpenoids were isolated from an extract of A. atriplicifolium from Western North Carolina. The compounds were isolated by bioassay-guided fractionation using an MCF-7 breast tumour cell line assay. The known compound (1S,6R,7R,8R)-1-acetoxy-6,7-diangeloxy-8,10-epoxy-2-oxo-oplopa-3,14Z,11,12-dien-13-al (1) had an EC50 value of 9.0 μM against MCF-7 cells, while the new compound (1S,3R,6R,7R,8R,11S)-1-acetoxy-6,7-diangeloxy-8,10,11,13-bisepoxyoplopan-2-one (2) had an EC50 value of 96 μM. The compounds were characterised by 1D and 2D NMR spectroscopy and by comparison with literature values in the case for 1. Based on NOESY analysis, a correction of the relative configuration for 1 is presented. The presence of these compounds may help to explain the folk remedy usage of this plant as an anticancer agent. [ABSTRACT FROM AUTHOR]

Published
2016
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40. Joining of SiO2f/SiO2composite to Al2O3ceramic using AgCu-Ti brazing filler metal

Author

Wu, Shi-Biao, Xiong, Hua-Ping, Chen, Bo, and Cheng, Yao-Yong

Abstract

SiO2f/SiO2composite was joined to Al2O3ceramic using AgCu-Ti active filler at brazing temperature of 1153 K for 10 and 60 min, respectively, and sound joints were achieved. It was found that a thin reaction layer had been formed close to each of the joined materials, and the brazing seam matrix was composed of homogeneous Ag-Cu eutectic alloy. The joint interface was analyzed by SEM, EDS, and XRD. The typical interface structure of joint brazed at 1153 K for 10 min could be described as the following sequence: SiO2f/SiO2→ TiO2+ Ti5Si4→ TiO2+ Cu3Ti3O → Ag-Cu eutectic alloy → (Ti-O) + (Ti-Cu-O) → Al2O3. However, Cu2Ti4O but not Cu3Ti3O was detected in the joints brazed at 1153 K for 60 min. Besides, the reaction layers of joint brazed at 1153 K for 60 min were much thicker than those for 10 min. The SiO2f/SiO2-Al2O3joints brazed at 1153 K for 10 min showed an average shear strength of 38.6 MPa, evidently higher than that (26.0MPa) brazed at 1153 K for 60 min.

Published
2017
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49. Antioxidants from Gerbera piloselloides : an ethnomedicinal plant from southwestern China.

Author

Wang, Jianjun, Petrova, Vanya, Wu, Shi-Biao, Zhu, Mingjing, Kennelly, Edward J., and Long, Chunlin

Abstract

Gerbera piloselloides is a very important ethnobotanical and ethnomedicinal plant used by indigenous peoples in southwestern China. Ten compounds were obtained using activity-guided isolation, including a parasorbosid derivative, two caffeic acid derivatives, two coumarins and five flavonoids, and identified from the whole plant of G. piloselloides. This is the first report of compound 5 as natural product. Six compounds were reported in the Gerbera genus for the first time. The antioxidant activity of all the compounds was evaluated by using ABTS assay, and the chemotaxonomic implication of this study was also discussed. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Chemical constituents from Hedyotis cryptantha.

Author

XU Li, LI Ping, TANG Gui-Hua, WU Shi-Biao, WANG Ye-Ling, KENNELLY, Edward, and LONG Chun-Lin

Abstract

Eleven known compounds were isolated from the whole plant of Hedyotis cryptantha .On the basis of spectroscopic data, their structures were identified as asperuloside (1), asperulosidic acid (2), asperulosidic acid methyl ester (3), asperulosidic acid ethyl ester (4 ), 3,4-dihydro-3-methoxy asperuloside (5), kaempferol (6), kaempferol 3,7-di-O -β-D-glucoside (7), kaempferol 3-O -β-D-galactopyranosyl- (1 → 3) -β-D-galactopyranoside (8), ursonic acid (9), stigmasterol (10), and β-sitosterol (11) .All of these compounds were isolated from this plant for the first time, while compounds 7 and 8 were found from the genus Hedyotis for the first time. [ABSTRACT FROM AUTHOR]

Published
2014
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