431 results on '"Wagner, Bridget"'
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2. Predicting compound activity from phenotypic profiles and chemical structures
3. An expanded universe of cancer targets.
4. Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
5. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
6. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
7. Chemical Approaches for Beta-cell Biology
8. SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
9. Small-molecule discovery in the pancreatic beta cell
10. Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines
11. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes
12. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
13. Nuisance compounds in cellular assays
14. An expanded universe of cancer targets
15. Identifying type 2 diabetes risk genes by β-cell CRISPR screening
16. Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial
17. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9
18. Introduction to Chemical Probes
19. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
20. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome
21. Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
22. Author response: Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
23. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes
24. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
25. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
26. KD025 Is a Casein Kinase 2 Inhibitor That Protects Against Glucolipotoxicity in β-Cells.
27. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
28. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
29. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
30. High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function
31. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery
32. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
33. Automated Structure–Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles
34. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses
35. Fluorescein-based sensors to purify human a-cells for functional and transcriptomic analyses.
36. Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
37. A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening
38. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
39. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
40. A Human Islet Cell Culture System for High-Throughput Screening
41. Reference compounds for characterizing cellular injury in high-content cellular morphology assays
42. 247-LB: Pancreatic Elastase Regulates ß-Cell Viability by Impairing the Mechanosignaling Pathway
43. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections
44. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
45. Small-molecule inducers of insulin expression in pancreatic α-cells
46. Gene Expression-Based Screening Identifies Microtubule Inhibitors as Inducers of PGC-1α and Oxidative Phosphorylation
47. Chemical strategies to understand and manipulate host-pathogen interactions
48. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
49. Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis–Interstitial Lung Disease: Open-Label Extension of a Phase 3 Randomized Controlled Trial
50. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling
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