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324 results on '"Wagner, Daniel R."'

1. The lost virtue of leadership

Author

Wagner, Daniel R., Capt

Subjects
LEADERSHIP, OFFICERS - Marine Corps - United States, DUTY AND RESPONSIBILITY, MILITARY, INTEGRITY
Abstract

illus

Published
1999

14. Genetic Variants Are Not Associated with Outcome in Patients with Coronary Artery Disease and Left Ventricular Dysfunction: Results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) Trials

Author

Feldman, Arthur M., She, Lilin, McNamara, Dennis M., Mann, Douglas L., Bristow, Michael R., Maisel, Alan S., Wagner, Daniel R., Andersson, Bert, Chiariello, Luigi, Hayward, Christopher S., Hendry, Paul, Parker, John D., Racine, Normand, Selzman, Craig H., Senni, Michele, Stepinska, Janina, Zembala, Marian, Rouleau, Jean, Velazquez, Eric J., and Lee, Kerry L.

Published
2015
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31. Third universal definition of myocardial infarction

Author

Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., White, Harvey D., Thygesen, Kristian, Alpert, Joseph S., White, Harvey D., Jaffe, Allan S., Katus, Hugo A., Apple, Fred S., Lindahl, Bertil, Morrow, David A., Chaitman, Bernard R., Clemmensen, Peter M., Johanson, Per, Hod, Hanoch, Underwood, Richard, Bax, Jeroen J., Bonow, Robert O., Pinto, Fausto, Gibbons, Raymond J., Fox, Keith A., Atar, Dan, Newby, L. Kristin, Galvani, Marcello, Hamm, Christian W., Uretsky, Barry F., Gabriel Steg, Ph., Wijns, William, Bassand, Jean-Pierre, Menasché, Phillippe, Ravkilde, Jan, Ohman, E. Magnus, Antman, Elliott M., Wallentin, Lars C., Armstrong, Paul W., Simoons, Maarten L., Januzzi, James L., Nieminen, Markku S., Gheorghiade, Mihai, Filippatos, Gerasimos, Luepker, Russell V., Fortmann, Stephen P., Rosamond, Wayne D., Levy, Dan, Wood, David, Smith, Sidney C., Hu, Dayi, Lopez-Sendon, José-Luis, Robertson, Rose Marie, Weaver, Douglas, Tendera, Michal, Bove, Alfred A., Parkhomenko, Alexander N., Vasilieva, Elena J., Mendis, Shanti, Bax, Jeroen J., Baumgartner, Helmut, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Popescu, Bogdan A., Reiner, Željko, Sechtem, Udo, Sirnes, Per Anton, Tendera, Michal, Torbicki, Adam, Vahanian, Alec, Windecker, Stephan, Morais, Joao, Aguiar, Carlos, Almahmeed, Wael, Arnar, David O., Barili, Fabio, Bloch, Kenneth D., Bolger, Ann F., Bøtker, Hans Erik, Bozkurt, Biykem, Bugiardini, Raffaele, Cannon, Christopher, de Lemos, James, Eberli, Franz R., Escobar, Edgardo, Hlatky, Mark, James, Stefan, Kern, Karl B., Moliterno, David J., Mueller, Christian, Neskovic, Aleksandar N., Pieske, Burkert Mathias, Schulman, Steven P., Storey, Robert F., Taubert, Kathryn A., Vranckx, Pascal, and Wagner, Daniel R.

Published
2012
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37. Unmodified Clay Nanosheets at the Air–Water Interface

Author

Michels-Brito, Paulo H., primary, Malfatti-Gasperini, Antonio, additional, Mayr, Lina, additional, Puentes-Martinez, Ximena, additional, Tenório, Rômulo P., additional, Wagner, Daniel R., additional, Knudsen, Kenneth D., additional, Araki, Koiti, additional, Oliveira, Rafael G., additional, Breu, Josef, additional, Cavalcanti, Leide P., additional, and Fossum, Jon Otto, additional

Published
2020
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40. Differential regulation of cardiac expression of IL-6 and TNF-alpha by A2- and A3-adenosine receptors

Author

Wagner, Daniel R., Kubota, Toru, Sanders, Virginia J., McTiernan, Charles F., and Feldman, Arthur M.

Subjects
Congestive heart failure -- Research, Interleukin-6 -- Research, Tumor necrosis factor -- Research, Cytokines -- Research, Adenosine -- Research, Biological sciences
Abstract

Research was conducted to examine the effect of adenosine and its three cardiac receptors on the expression of interleukin (IL)-6 and IL-1-beta in isolated cardiomyocytes, rat papillary muscles and trabecular muscles derived from human patients with advanced cardiomyopathy. Results indicate that A2 and A3 receptors differentially regulate cardiac expression of tumor necrosis factor-alpha and IL-6. It was also shown that rat cardiomyocytes and the failing human heart respond differently to adenosine.

Published
1999

46. Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction

Author

Devaux Yvan, Bousquenaud Melanie, Rodius Sophie, Marie Pierre-Yves, Maskali Fatiha, Zhang Lu, Azuaje Francisco, and Wagner Daniel R

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery of new biomarkers. Methods Blood samples were obtained upon admission in patients with acute ST-elevation MI who underwent primary percutaneous coronary intervention. Messenger RNA was extracted from whole blood cells. LV function was evaluated by echocardiography at 4-months. Results In a test cohort of 32 MI patients, integrated analysis of microarrays with a network of protein-protein interactions identified subgroups of genes which predicted LV dysfunction (ejection fraction ≤ 40%) with areas under the receiver operating characteristic curve (AUC) above 0.80. Candidate genes included transforming growth factor beta receptor 1 (TGFBR1). In a validation cohort of 115 MI patients, TGBFR1 was up-regulated in patients with LV dysfunction (P < 0.001) and was associated with LV function at 4-months (P = 0.003). TGFBR1 predicted LV function with an AUC of 0.72, while peak levels of troponin T (TnT) provided an AUC of 0.64. Adding TGFBR1 to the prediction of TnT resulted in a net reclassification index of 8.2%. When added to a mixed clinical model including age, gender and time to reperfusion, TGFBR1 reclassified 17.7% of misclassified patients. TGFB1, the ligand of TGFBR1, was also up-regulated in patients with LV dysfunction (P = 0.004), was associated with LV function (P = 0.006), and provided an AUC of 0.66. In the rat MI model induced by permanent coronary ligation, the TGFB1-TGFBR1 axis was activated in the heart and correlated with the extent of remodeling at 2 months. Conclusions We identified TGFBR1 as a new candidate prognostic biomarker after acute MI.

Published
2011
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47. Information encoded in a network of inflammation proteins predicts clinical outcome after myocardial infarction

Author

Devaux Yvan, Zhang Lu, Rodius Sophie, Azuaje Francisco J, and Wagner Daniel R

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Inflammation plays an important role in cardiac repair after myocardial infarction (MI). Nevertheless, the systems-level characterization of inflammation proteins in MI remains incomplete. There is a need to demonstrate the potential value of molecular network-based approaches to translational research. We investigated the interplay of inflammation proteins and assessed network-derived knowledge to support clinical decisions after MI. The main focus is the prediction of clinical outcome after MI. Methods We assembled My-Inflamome, a network of protein interactions related to inflammation and prognosis in MI. We established associations between network properties, disease biology and capacity to distinguish between prognostic categories. The latter was tested with classification models built on blood-derived microarray data from post-MI patients with different outcomes. This was followed by experimental verification of significant associations. Results My-Inflamome is organized into modules highly specialized in different biological processes relevant to heart repair. Highly connected proteins also tend to be high-traffic components. Such bottlenecks together with genes extracted from the modules provided the basis for novel prognostic models, which could not have been uncovered by standard analyses. Modules with significant involvement in transcriptional regulation are targeted by a small set of microRNAs. We suggest a new panel of gene expression biomarkers (TRAF2, SHKBP1 and UBC) with high discriminatory capability. Follow-up validations reported promising outcomes and motivate future research. Conclusion This study enhances understanding of the interaction network that executes inflammatory responses in human MI. Network-encoded information can be translated into knowledge with potential prognostic application. Independent evaluations are required to further estimate the clinical relevance of the new prognostic genes.

Published
2011
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49. High nocturnal body temperature in premenstrual syndrome and late luteal phase dysphoric disorder

Author

Severino, Sally K., Wagner, Daniel R., Moline, Margaret L., Hurt, Stephen W., Pollak, Charles P., and Zendell, Steven

Subjects
Menstrual cycle -- Psychological aspects, Menstrual cycle -- Complications, Body temperature -- Physiological aspects, Health, Psychology and mental health
Abstract

Women who experience emotional or physical symptoms prior to menstruation are said to suffer from premenstrual syndrome (PMS). Those with primarily affective symptoms (symptoms related to mood), such as depression, are diagnosed with late luteal phase dysphoric disorder (LLPDD). In the week preceding menstruation, women suffering from LLPDD suffer severe affective symptoms. Research has found higher than normal nighttime body temperature in depressed individuals, and depressed people often report restless sleep. It has been suggested that the sleep disruption is due to the higher than normal nighttime body temperatures. To investigate the relationship between body temperature, depression, and the four phases of the menstrual cycle, 10 women with PMS, six of whom had LLPDD as well, (the PMS/LLPDD group) were compared with six women with dysphoria but without PMS, and six normal women. Core body temperature was measured, along with sleep disruption (as indicated by wrist movements during sleep). PMS/LLPDD subjects had significantly higher nighttime body temperatures than other subjects during all four phases of the menstrual cycle. Sleep disruption, however, did not differ between groups. Interestingly, the dysphoric group had a nighttime body temperature similar to the PMS/LLPDD group, and for all subjects, nighttime temperature increased during the latter stages of menstruation. These findings are consistent with the hypothesized relationship between depression, menstruation, and body temperature. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

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