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6 results on '"Wai Teng Cheng"'

1. A three-dimensional (3D) printing approach to fabricate an isolation chip for high throughput in situ cultivation of environmental microbes

Author

Calvin Bok Sun Goh, Clariss Hui Peng Goh, Li Wen Wong, Wai Teng Cheng, Catherine Mary Yule, Kuan Shion Ong, Sui Mae Lee, Pooria Pasbakhsh, and Joash Ban Lee Tan

Subjects
Biomedical Engineering, Bioengineering, General Chemistry, Biochemistry
Abstract

The 3D-printed iChip version made from thermoplastics or photopolymers can isolate microbial populations of a peat swamp in situ with a population profile different from that isolated via the standard in vitro Petri dish cultivation method.

Published
2022
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3. List of contributors

Author

Ahmed S. Abo Dena, Caleb Acquah, Tanvir Ahmed, Azilah Ajit, Yahya S. Al-Awthan, Tânia Albuquerque, Sukumaran Anil, Nuvia Marina Apolonio–Hernandez, Leonard Ionut Atanase, Omar Bahattab, Anindita Behera, Muhammad Bilal, Branko Bugarski, A.C. Campa-Mada, Ireri Alejandra Carbajal-Valenzuela, E. Carvajal-Millan, Long Chen, Wai Teng Cheng, Custodiana A. Colmenarez Lobo, Diana Costa, Eduardo Costa, Pandurang Appana Dalavi, Michael K. Danquah, Y. De Anda-Flores, Harshal Deshmukh, Amal Kumar Dhara, Ibrahim M. El-Sherbiny, Rúben Faria, Ana Angelica Feregrino-Pérez, M.D. Figueroa-Pizano, D.A.S. Gamage, Beatriz González-Arias, Natanamurugaraj Govindan, Ramón Gerardo Guevara-González, Diana Vanesa Gutierrez-Chavez, Md Saquib Hasnain, Shafiul Hossain, Muhammad Imran, Hafiz M.N. Iqbal, Jaison Jeevanandam, Alejandra Jimenez-Hernandez, Zhengyu Jin, Sumaya F. Kabir, Krishnan Kanny, Jaya Lakkakula, J. Lizardi-Mendoza, Manuela Machado, T. Madhujith, Gaanty Pragas Maniam, Verónica E. Manzano, A.L. Martínez-López, K.G. Martínez-Robinson, David Julian McClements, Ming Miao, Milan Milivojevic, Md. Minhajul Islam, Aurelie Sarah Mok Tsze Chung, Mohammad S. Mubarak, Naveed Muhammad, Hira Munir, Sesha Subramanian Murugan, Amit Kumar Nayak, Ana R. Neves, Ahmed Olatunde, Ivana Pajic-Lijakovic, Dilipkumar Pal, Aristeidis Papagiannopoulos, Manuela Pintado, Marcel Popa, Sarmad Ahmad Qamar, Telma Quintela, Stefania Racovita, Hamza Rafeeq, Mohd Hasbi Ab. Rahim, Ashiqur Rahman, Mohammed Mizanur Rahman, Khushboo Raj, Ajay Vasudeo Rane, A. Rascón-Chu, Abdur Rauf, Evangelina Repetto, Enrique Rico-García, Supriyo Saha, Md. Sazedul Islam, Md. Shahruzzaman, Sara Silva, Ângela Sousa, Ahmad Ziad Sulaiman, Sabrina Sultana, Joash Ban Lee Tan, J. Tanori-Cordova, Yong Kiat Teo, Himja Tiwari, Irineo torres-Pacheco, Tabussam Tufail, Silvia Vasiliu, Jayachandran Venkatesan, Eleni Vlassi, Nilesh Shirish Wagh, N.E. Wedamulla, Deepti Yadav, and Zhongyu Yang

Published
2022
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4. Structure–activity relationship of biological macromolecules

Author

Joash Ban Lee Tan, Yong Kiat Teo, Wai Teng Cheng, and Aurelie Sarah Mok Tsze Chung

Subjects
biology, Synthetic derivatives, Drug discovery, Chemistry, Lactonase, biology.protein, Structure–activity relationship, Computational biology, Organization level, Primary screening, Macromolecule
Abstract

Biological macromolecules are naturally occurring large cellular components responsible for a wide array of functions necessary for the growth and survival of living organisms. They also possess various bioactivities such as antimicrobial, antioxidant, antitumor, antiviral, antiinflammatory, antiproliferative, and hypoglycemic activities. The growing interest in bioactive macromolecules as potential therapeutical drugs has driven scientists to further study the association between their chemical structures and corresponding functions/activities. This chapter aims to provide a short overview on the structural features influencing the bioactivities of several biological macromolecules, namely l -amino acid oxidases, lysostaphin and metallo-β-lactamase-like lactonase and chitosan. As observed in this chapter, establishing the structure–activity relationship (SAR) can often prove to be challenging for macromolecules given the complexity of the three-dimensional organization level of proteins and the branched chains of the carbohydrates. Nevertheless, certain structural features influencing the bioactivities of macromolecules have been identified and could help to accelerate their development and application in the biomedical field. Indeed, a comprehensive understanding of biomacromolecule SARs remains necessary as information inferred from these studies may be crucial to many aspects of drug discovery and development, whether it is for primary screening or lead optimization, as well as for the designing of synthetic derivatives with improved properties.

Published
2022
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6. The Mechanism of Bacteroides fragilis Toxin Contributes to Colon Cancer Formation.

Author

Wai Teng CHENG, KANTILAL, Haresh Kumar, and DAVAMANI, Fabian

Subjects
*CELL proliferation, *BACTEROIDES, *CELLULAR signal transduction, *COLON tumors, *GENE expression, *INTERLEUKINS, *TOXINS, *GENOTYPES, *DISEASE risk factors
Abstract

The Bacteroides fragilis (B. fragilis) produce biofilm for colonisation in the intestinal tract can cause a series of inflammatory reactions due to B. fragilis toxin (BFT) which can lead to chronic intestinal inflammation and tissue injury and play a crucial role leading to colorectal cancer (CRC). The enterotoxigenic B. fragilis (ETBF) forms biofilm and produce toxin and play a role in CRC, whereas the non-toxigenic B. fragilis (NTBF) does not produce toxin. The ETBF triggers the expression of cyclooxygenase (COX)-2 that releases PGE2 for inducing inflammation and control cell proliferation. From chronic intestinal inflammation to cancer development, it involves signal transducers and activators of transcription (STAT)3 activation. STAT3 activates by the interaction between epithelial cells and BFT. Thus, regulatory T-cell (Tregs) will activates and reduce interleukin (IL)-2 amount. As the level of IL-2 drops, T-helper (Th17) cells are generated leading to increase in IL-17 levels. IL-17 is implicated in early intestinal inflammation and promotes cancer cell survival and proliferation and consequently triggers IL-6 production that activate STAT3 pathway. Additionally, BFT degrades E-cadherin, hence alteration of signalling pathways can upregulate spermine oxidase leading to cell morphology and promote carcinogenesis and irreversible DNA damage. Patient with familial adenomatous polyposis (FAP) disease displays a high level of tumour load in the colon. This disease is caused by germline mutation of the adenomatous polyposis coli (APC) gene that increases bacterial adherence to the mucosa layer. Mutated-APC gene genotype with ETBF increases the chances of CRC development. Therefore, the colonisation of the ETBF in the intestinal tract depicts tumour aetiology can result in risk of hostility and effect on human health. [ABSTRACT FROM AUTHOR]

Published
2020
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