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In this paper, we propose a mechanism for filtering e-mails by constructing spam mail prototypes by using genetic algorithm. Keywords extracted from e-mail's subject and body are categorized by their meaning into 8 categories. The binary representation of a chromosome string having 8 genes is constructed from keywords. Genetic operations are applied to create varieties of spam mail prototypes for filtering. From the experiments, the proposed technique shows the accuracy of filtering spam mails by 87.05% in average. When comparing with the other technique liked Bayesian, the proposed technique still has higher accuracy. [ABSTRACT FROM AUTHOR]