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7 results on '"Waldhueter, Nils"'

1. Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

Author

Christen, Friederike, Hoyer, Kaja, Yoshida, Kenichi, Hou, Hsin-An, Waldhueter, Nils, Heuser, Michael, Hills, Robert K., Chan, Willy, Hablesreiter, Raphael, Blau, Olga, Ochi, Yotaro, Klement, Piroska, Chou, Wen-Chien, Blau, Igor-Wolfgang, Tang, Jih-Luh, Zemojtel, Tomasz, Shiraishi, Yuichi, Shiozawa, Yusuke, Thol, Felicitas, Ganser, Arnold, Löwenberg, Bob, Linch, David C., Bullinger, Lars, Valk, Peter J.M., Tien, Hwei-Fang, Gale, Rosemary E., Ogawa, Seishi, and Damm, Frederik

Published
2019
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2. Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis

Author

Arends, Christopher Maximilian, Galan-Sousa, Joel, Hoyer, Kaja, Chan, Willy, Jäger, Marten, Yoshida, Kenichi, Seemann, Ricarda, Noerenberg, Daniel, Waldhueter, Nils, Fleischer-Notter, Helga, Christen, Friederike, Schmitt, Clemens A., Dörken, Bernd, Pelzer, Uwe, Sinn, Marianne, Zemojtel, Tomasz, Ogawa, Seishi, Märdian, Sven, Schreiber, Adrian, Kunitz, Annegret, Krüger, Ulrike, Bullinger, Lars, Mylonas, Elena, Frick, Mareike, and Damm, Frederik

Published
2018
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3. Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma

Author

Mansouri, Larry, Noerenberg, Daniel, Young, Emma, Mylonas, Elena, Abdulla, Maysaa, Frick, Mareike, Asmar, Fazila, Ljungström, Viktor, Schneider, Markus, Yoshida, Kenichi, Skaftason, Aron, Pandzic, Tatjana, Gonzalez, Blanca, Tasidou, Anna, Waldhueter, Nils, Rivas-Delgado, Alfredo, Angelopoulou, Maria, Ziepert, Marita, Arends, Christopher Maximilian, Couronné, Lucile, Lenze, Dido, Baldus, Claudia D., Bastard, Christian, Okosun, Jessica, Fitzgibbon, Jude, Dörken, Bernd, Drexler, Hans G., Roos-Weil, Damien, Schmitt, Clemens A., Munch-Petersen, Helga D., Zenz, Thorsten, Hansmann, Martin-Leo, Strefford, Jonathan C., Enblad, Gunilla, Bernard, Olivier A., Ralfkiaer, Elisabeth, Erlanson, Martin, Korkolopoulou, Penelope, Hultdin, Magnus, Papadaki, Theodora, Grønbæk, Kirsten, Lopez-Guillermo, Armando, Ogawa, Seishi, Küppers, Ralf, Stamatopoulos, Kostas, Stavroyianni, Niki, Kanellis, George, Rosenwald, Andreas, Campo, Elias, Amini, Rose-Marie, Ott, German, Vassilakopoulos, Theodoros P., Hummel, Michael, Rosenquist, Richard, and Damm, Frederik

Published
2016
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4. ΝFΚΒΙΕ Deletions: A Novel Marker of Clinical Aggressiveness in Primary Mediastinal B-Cell Lymphoma

Author

Noerenberg*, Daniel, primary, Mansouri*, Larry, additional, Young, Emma, additional, Mareike, Frick, additional, Abdulla, Maysaa, additional, Asmar, Fazila, additional, Gonzalez-Farre, Blanca, additional, Anna, Tasidou, additional, Waldhueter, Nils, additional, Ljungström, Viktor, additional, Rivas, Alfredo, additional, Angelopoulou, Maria K., additional, Ziepert, Marita, additional, Arends, Christopher M., additional, Couronne, Lucile, additional, Lenze, Dido, additional, Baldus, Claudia D., additional, Bastard, Christian, additional, Okosun, Jessica, additional, Fitzgibbon, Jude, additional, Dörken, Bernd, additional, Drexler, Hans G., additional, Roos-Weil, Damien, additional, Schmitt, Clemens A., additional, Munch-Petersen, Helga Duverger, additional, Zenz, Thorsten, additional, Strefford, Jonathan C., additional, Enblad, Gunilla, additional, Bernard, Olivier A., additional, Ralfkiaer, Elisabeth, additional, Korkolopoulou, Penelope, additional, Hultdin, Magnus, additional, Papadaki, Theodora, additional, Grønbæk, Kirsten, additional, Lopez-Guillermo, Armando, additional, Stamatopoulos, Kostas, additional, Stavroyianni, Niki, additional, Kanellis, George, additional, Rosenwald, Andreas, additional, Campo, Elias, additional, Amini, Rose-Marie, additional, Ott, German, additional, Vassilakopoulos, Theodoros, additional, Hummel, Michael, additional, Damm**, Frederik, additional, and Rosenquist**, Richard, additional

Published
2016
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5. Clonal Hematopoiesis: Cell of Origin, Lineage Repartition and Dynamic Evolution during Chemotherapy

Author

Frick, Mareike, Arends, Christopher Maximilian, Galan-Sousa, Joel, Hoyer, Kaja, Chan, Willy, Jäger, Marten, Yoshida, Kenichi, Seemann, Ricarda, Nörenberg, Daniel, Waldhüter, Nils, Fleischer-Notter, Helga, Christen, Friederike, Schmitt, Clemens A., Dorken, Bernd, Pelzer, Uwe, Sinn, Marianne, Zemojtel, Tomasz, Ogawa, Seishi, Märdian, Sven, Schreiber, Adrian, Kunitz, Annegret, Krüger, Ulrike, Mylona, Elena, and Damm, Frederik

Published
2017
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7. Frequent NFKBIEdeletions are associated with poor outcome in primary mediastinal B-cell lymphoma

Author

Mansouri, Larry, Noerenberg, Daniel, Young, Emma, Mylonas, Elena, Abdulla, Maysaa, Frick, Mareike, Asmar, Fazila, Ljungström, Viktor, Schneider, Markus, Yoshida, Kenichi, Skaftason, Aron, Pandzic, Tatjana, Gonzalez, Blanca, Tasidou, Anna, Waldhueter, Nils, Rivas-Delgado, Alfredo, Angelopoulou, Maria, Ziepert, Marita, Arends, Christopher Maximilian, Couronné, Lucile, Lenze, Dido, Baldus, Claudia D., Bastard, Christian, Okosun, Jessica, Fitzgibbon, Jude, Dörken, Bernd, Drexler, Hans G., Roos-Weil, Damien, Schmitt, Clemens A., Munch-Petersen, Helga D., Zenz, Thorsten, Hansmann, Martin-Leo, Strefford, Jonathan C., Enblad, Gunilla, Bernard, Olivier A., Ralfkiaer, Elisabeth, Erlanson, Martin, Korkolopoulou, Penelope, Hultdin, Magnus, Papadaki, Theodora, Grønbæk, Kirsten, Lopez-Guillermo, Armando, Ogawa, Seishi, Küppers, Ralf, Stamatopoulos, Kostas, Stavroyianni, Niki, Kanellis, George, Rosenwald, Andreas, Campo, Elias, Amini, Rose-Marie, Ott, German, Vassilakopoulos, Theodoros P., Hummel, Michael, Rosenquist, Richard, and Damm, Frederik

Abstract

We recently reported a truncating deletion in the NFKBIEgene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIEaberrations in other lymphoid malignancies, we screened a large patient cohort (n = 1460) diagnosed with different lymphoid neoplasms. While NFKBIEdeletions were infrequent in follicular lymphoma, splenic marginal zone lymphoma, and T-cell acute lymphoblastic leukemia (<2%), slightly higher frequencies were seen in diffuse large B-cell lymphoma, mantle cell lymphoma, and primary central nervous system lymphoma (3% to 4%). In contrast, a remarkably high frequency of NFKBIEaberrations (46/203 cases [22.7%]) was observed in primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (3/11 cases [27.3%]). NFKBIE-deleted PMBL patients were more often therapy refractory (P= .022) and displayed inferior outcome compared with wild-type patients (5-year survival, 59% vs 78%; P= .034); however, they appeared to benefit from radiotherapy (P =.022) and rituximab-containing regimens (P= .074). NFKBIEaberrations remained an independent factor in multivariate analysis (P= .003) and when restricting the analysis to immunochemotherapy-treated patients (P= .008). Whole-exome sequencing and gene expression profiling verified the importance of NF-κB deregulation in PMBL. In summary, we identify NFKBIEaberrations as a common genetic event across B-cell malignancies and highlight NFKBIEdeletions as a novel poor-prognostic marker in PMBL.

Published
2016
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