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It is known that Duodenal adenocarcinoma (DA) is a rare malignant solid tumor that cause occlusion symptoms with orthodox dysphagia when locally advanced. Pancreatic neuroendocrine tumors (PanNETs) account for about 2% of all pancreatic neoplasms. The combination of these two lesions, with the synchronous presence of ectopic pancreatic tissue (EPT) of the duodenum, has never been described in literature, to our knowledge. Here we report a case of combined DA, EPT and PanNET affecting a 71-year-old woman., Highlights • Simultaneous presence of Duodenal adenocarcinoma pancreatic neuroendocrine tumor ectopic pancreatic tissue of duodenum. • Biochemical tests did not reveal abnormalities: CA 19-9 was normal, CEA was 153 U/L. • Ultrasonography confirmed a nodule dislocating pancreas investigated with contrast-enhanced CT and esophagogastroduodenoscopy. • The association between duodenal adenocarcinomas, PanNET and ectopic pancreatic tissue (EPT) of the duodenum is really rare.

Ameloblastic fibroma (AF) is an uncommon odontogenic tumour that may present an aggressive behaviour and may have potential for malignant transformation. Ghost cell (GC) differentiation within AF is extremely rare. There are only seven cases in the international literature in which ghost cells are found in AF.In this study, we report a case of a 8-year-old female child with a cystic-solid mass, measuring 3 x 1.7 x 1.2 cm, characterised by mixed odontogenic tumour, with AF in most of the lesion, with areas characterised by GC, while ameloblastic and ameloblastic fibrodontoma areas were also detected. Other histological sections showed only AF tissue, with areas of Calcifying Odontogenic Cyst. The immunohistochemical characterisation of the lesion was also performed. A comparative table of the immunoistochemical staining of the AF and COC areas revealed some differences in the expression of markers.