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Single-crystalline Al-doped Ba0.6Sr0.4TiO3 (BST) thin films have been pulsed-laser deposited onto Ir/MgO buffered Si substrates. Spectral-resolved microprobe cathodoluminescence measurements of Al-doped BST thin films at room temperature clearly showed three detectable luminescence bands in the wavelength range between 200 and 900 nm. We assigned the first shoulder peak to saturation of phonon-assisted processes, with a band gap transition resulting in the second sharp band. The band-maximum position of a third (defect-related) broad luminescence band varied with varying the concentration of Al dopant. By fitting this latter band as the sum of three superimposed Gaussian curves, it was revealed that the incorporation of Al dopant into the BST crystal lattice had a direct impact on the defect population existing in the single-crystalline film. For perovskite ABO3-structured BST thin films, it is suggested that the Al dopant occupies the B site (Ti) in a low range of dopant concentrations, while at higher dopant concentrations Al might occupy both A sites (Ba or Sr) and B sites. [ABSTRACT FROM AUTHOR]

Introduction: An elevated serum urate level is recognised as a cause of gouty arthritis and uric acid stone. The level of serum uric acid that accelerates kidney stone formation, however, has not yet been clarified. This study aimed to find out if a high serum urate level is associated with nephrolithiasis., Methods: Patients were recruited from the rheumatology clinic of Taipei City Hospital (Renai and Zhongxing branches) in Taiwan from March 2015 to February 2016. A total of 120 Chinese male patients with newly diagnosed gout and serum urate concentration of >7 mg/dL and no history of kidney stones were divided into two groups according to their serum urate level: <10 mg/dL (group 1, n=80) and ≥10 mg/dL (group 2, n=40). The mean body mass index, blood urea nitrogen level, creatinine level, urinary pH, and kidney ultrasonography were compared between the two groups., Results: There were no significant differences in blood urea nitrogen or creatinine level between the two groups. The urine pH in both groups was similar and not statistically significant. Kidney stone formation was detected via ultrasonography in 6.3% (5/80) and 82.5% (33/40) of patients in groups 1 and 2, respectively (P<0.05)., Conclusion: A serum urate level of ≥10 mg/dL may precipitate nephrolithiasis. Further studies are warranted to substantiate the relationship between serum urate level and kidney stone formation.

Aim: Intranasal corticosteroids (INS) have been proven effective in controlling postnasal drip, decreasing inflammatory response, reducing nasal swelling, and increasing aeration of the sinuses such that INS are recommended as treatment of sinusitis., Methods: Fifty children with acute rhinosinusitis, 50 children with acute rhiniosinusitis and allergic rhinitis (AR), and 20 rhiniosinusitis children as control were selected for investigation. Each group had a single-blind treatment of three types: with coamoxiclav only, with coamoxiclav plus INS, and with matched placebo (without antibiotics and INS) for two weeks. Nasal symptoms were then evaluated. The outcome was measured by using major symptom score (MSS) after treatment for 14 days., Results: Therapeutic effectiveness was 92% in rhinosinusitis patients treated with co-amoxiclav and 84% in those treated with co-amoxiclav plus INS. Among patients with sinusitis combined with AR, therapeutic efficacy was 88% for those treated with co-amoxiclav and 96% for those treated with co-amoxiclav plus INS. Only 30% of the symptoms were reduced in the placebo group., Conclusion: There are no statistical differences in the acute sinusitis group treated with co-amoxiclav with or without INS. In the sinusitis with AR group, the efficacy of co-amoxiclav with INS is higher than in children treated with co-amoxiclav alone.

Background: Atopic diseases, including asthma, allergic rhinitis, and atopic eczema, are major illnesses among children. Recent studies conducted worldwide have shown diverse trends in the prevalence of asthma, with a steady increase detected in industrialized countries. Other studies, however, have revealed a leveling trend or even a declining prevalence., Objective: The purpose of this study was to evaluate the current prevalence of allergic conditions in 6-to7-year-old schoolchildren in Taipei, Taiwan, and to analyze time trends., Methods: We evaluated the prevalence and severity of asthma and other allergic conditions using a phase I International Study of Asthma and Allergies in Childhood core written questionnaire previously administered in Taipei in 1994 and 2002., Results: A total of 24 999 first-grade students from 153 elementary schools completed the questionnaire. The proportion of children with wheeze ever and nocturnal cough in the past 12 months was significantly increased in 2007 compared to 1994 and 2002. No significant differences were detected in the prevalence of current wheeze or physician-diagnosed asthma. The prevalence of severe wheezing symptoms in the past 12 months (> or = 4 attacks of wheeze, > or = 1 night of sleep disturbance due to wheeze per week, wheeze-limiting speech, and exercise-induced wheeze) decreased significantly. The prevalence and severity of rhinitis symptoms increased significantly during the 13-year period analyzed. The prevalence of eczema symptoms-defined as recurrent itchy rash and typical atopic eczema distribution in the past 12 months--also increased., Conclusions: We observed an increase only in the prevalence and severity of current allergic symptoms in allergic rhinitis and atopic eczema.

Objectives: To compare the effects of living alone versus living in a group setting on the health, nutrition, personal cognition and general living function of a group of elderly Taiwanese. We also hypothesized that older adults living alone would have poorer indices of function and health than would elderly persons living in a group setting., Design and Participants: We conducted a cross-sectional validation study of 360 men and women older than 65 y. The subjects were 120 solitary (living alone) elders and 240 were non-solitary elders., Measurements: Both groups completed a series of questionnaires, including the Nutrition Screening Initiative (NSI), Mini Nutritional Assessment (MNA), Activities of Daily Living (ADLs/Barthel scales), Instrumental Activities of Daily Living (IADLs/Lawton scales), Short Portable Mental State Questionnaire (SPMSQ), and Geriatric Depression Scale (GDS). The participants were then administered by specially trained field workers. Blood samples were taken and body mass index, and mid-arm and calf circumferences were measured. The results for each group were statistically analyzed. A p-value < 0.05 was considered significant., Results: The nutritional and health status of the solitary elders, especially males, was poor compared to that of the non-solitary elders. In the solitary elders group, the average scores on the NSI, MNA, ADL, IADL, SPMSQ, and GDS were: 4.6, 23.7, 95.6, 7.6, 0.5, and 13%, respectively., Conclusion: Solitary elders, especially males, have a significantly increased risk of poor nutrition (MNA < 24), poor health status, impaired cognition, and impaired activities of daily living.

DO11.10 transgenic mice, expressing an OVA-specific TCR, were used to study pulmonary T cell responses to inhaled Ags. Before OVA inhalation, the activation of lung parenchymal T cells elicited both strong proliferative responses and IL-2 production. However, following Ag inhalation the proliferative responses of the lung T cells, when restimulated in vitro with OVA323-339 peptide or immobilized anti-CD3, were severely attenuated and associated with a decrease in the level of production of IL-2 but not IFN-gamma. Such immune regulation was tissue-specific, because T cell responses in the lymph nodes and spleens were normal. This dramatic aerosol-induced attenuation of parenchymal T cell proliferation was also observed in BALB/c mice immunized with OVA and in BALB/c mice following adoptive transfer of DO11.10 T cells bearing either a Th1 or Th2 phenotype. In mice that had received Th2 cells, the reduced proliferative responses were associated with a decrease in IL-2 expression but augmented IL-4 and IL-5 production. Invariably, the inhibition of proliferation was a consequence of the action of F4/80+ interstitial macrophages and did not involve alveolar macrophages or their products. These observations demonstrate that clonal expansion of T cells in the lung compartment is prevented following the onset of either Th1- or Th2-mediated inflammation. This form of immune regulation, which appears as a selective defect in IL-2-driven proliferation, may serve to prevent the development of chronic pulmonary lymphoproliferative responses.

DBA/2J mice were immunized daily for 3 days per os with 10(8)-10(9) colony forming units (c.f.u.) of two different temperature-sensitive (TS) mutants of Pseudomonas aeruginosa. At varying times after the final immunization the animals were exposed to aerosols of the parental immunotype 1, and the ability of the immunized and control mice to clear their lungs of the wild-type (WT) challenge was measured 4 h later. The number of c.f.u. remaining in the lungs of mice immunized with one mutant, D/1/8, was significantly less (p less than 0.01) than the number remaining in the lungs of control mice and mice immunized with a second TS mutant, E/9/9.