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162 results on '"Wan, Kelvin H"'

7. Minimally Invasive Glaucoma Surgery in Primary Angle-Closure Glaucoma

Author

Song, Yunhe, Zhang, Hengli, Zhang, Yingzhe, Tang, Guangxian, Wan, Kelvin H, Lee, Jacky W Y, Congdon, Nathan, Zhang, Mingzhi, He, Mingguang, Tham, Clement C, Leung, Christopher K S, Weinreb, Robert N, Lam, Dennis S C, and Zhang, Xiulan

Subjects
Ophthalmology, Phacoemulsification, Glaucoma, Angle-Closure/surgery, Humans, Trabeculectomy, Glaucoma, Open-Angle/surgery, General Medicine, Intraocular Pressure
Abstract

Primary angle-closure glaucoma (PACG) is responsible for half of the glaucoma-related blindness worldwide. Cataract surgery with or without trabeculectomy has been considered to be the first-line treatment in eyes with medically uncontrolled PACG. While minimally invasive glaucoma surgery has become an important surgical approach for primary open-angle glaucoma, its indications and benefits in PACG are less clear. This review summarizes the efficacy and safety profile of minimally invasive glaucoma surgery in PACG to unfold new insights into the surgical management of PACG.

Published
2022

11. Dry Eyes After SMILE

Author

Wong, Angela H.Y., Cheung, Rachel K.Y., Kua, Wee Nie, Shih, Kendrick C., Chan, Tommy C.Y., and Wan, Kelvin H.

Published
2019
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20. Initial observations of Jinhua Qinggan Granules, a Chinese medicine, in the mitigation of hospitalization and mortality in high-risk elderly with COVID-19 infection: A retrospective study in an old age home in Hong Kong

Author

Lin, Timothy P. H., primary, Lau, Edith M. C., additional, Wan, Kelvin H., additional, Zhong, Linda, additional, Leung, Enne, additional, Ko, Chung Nga, additional, Lu, Aiping, additional, Shah, Muhammad R., additional, Bian, Zhaoxiang, additional, and Lam, Dennis S. C., additional

Published
2022
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22. Ocular surface disturbance in patients after acute COVID‐19

Author

Wan, Kelvin H., primary, Lui, Grace C. Y., additional, Poon, Ken C. F., additional, Ng, Susanna S. S., additional, Young, Alvin L., additional, Hui, David S. C., additional, Tham, Clement C. Y., additional, Chan, Paul K. S., additional, Pang, Chi Pui, additional, and Chong, Kelvin K. L., additional

Published
2022
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28. Accelerated corneal collagen cross-linking in progressive keratoconus: Five-year results and predictors of visual and topographic outcomes.

Author

Chan, Tommy, Tsui, Rachel, Chow, Vanissa, Lam, Jasmine, Wong, Victoria, Wan, Kelvin, Chan, Tommy C Y, Tsui, Rachel W Y, Chow, Vanissa W S, Lam, Jasmine K M, Wong, Victoria W Y, and Wan, Kelvin H

Subjects
KERATOCONUS, COLLAGEN, VITAMIN B2, CORNEAL topography, PHOTOSENSITIZERS, CORNEAL cross-linking, CHEMICAL reagents, LONGITUDINAL method, ULTRAVIOLET radiation
Abstract

Purpose: To analyze the 5-year results of accelerated corneal collagen crosslinking (CXL) for progressive keratoconus and identify preoperative characteristics predictive of visual and topographic outcomes.Methods: A prospective interventional case series. Nineteen eyes of 19 patients receiving accelerated CXL with settings of 18 mW/cm2 for 5 min were included. Clinical and topographic parameters were assessed. Linear regression and logistic regression were used to compare the R2 and odds ratio (OR), respectively, between baseline characteristics and postoperative outcomes.Results: Corrected distance visual acuity (CDVA) remained stable from 0.28 ± 0.21 to 0.25 ± 0.18 logMAR (P = 0.486). The mean cylindrical refraction was stable (P = 0.119). The maximal keratometry (Kmax) decreased from 61.99 ± 10.37 to 59.25 ± 7.75 D (P < 0.001), flattening in the flattest and steepest meridians and mean keratometry were also observed (P ≤ 0.040). The mean anterior elevation at the apex reduced from 21.42 ± 16.69 to 18.53 ± 12.74 μm (P = 0.013) and changes in posterior elevation were non-significant (P = 0.629). Preoperative Kmax best predicted the postoperative change in Kmax (R2 = 0.55, P < 0.001) compared to the other baseline characteristics (P ≤ 0.028), whereas preoperative CDVA was the only significant predictor of postoperative change in CDVA (R2 = 0.41, P = 0.003). Accelerated CXL is less likely to fail in eyes with a steeper preoperative Kmax (OR = 0.74, P = 0.040) or greater posterior elevation at the apex (OR = 0.91, P = 0.042).Conclusion: Kmax significantly decreased following accelerated CXL. Eyes with worse preoperative CDVA and higher Kmax were more likely to have an improvement in visual acuity and corneal flattening. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Review of rodent hypertensive glaucoma models.

Author

Biswas, Sayantan and Wan, Kelvin H.

Subjects
*RETINAL ganglion cells, *GLAUCOMA, *INTRAOCULAR pressure, *SALINE injections, *RODENTS
Abstract

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. An ideal glaucoma animal model should be easy to induce, reproducible, biologically plausible and predictable. Of the available animal models of glaucoma, rodents are commonly studied because they have a relatively short life span and can be genetically altered. A successful hypertensive glaucoma model should induce structural glaucomatous changes: including loss of retinal nerve fibres, retinal ganglion cells and optic‐disc cupping along with IOP elevation. The level and duration of IOP elevation should be titratable depending on the targeted glaucomatous damage. This review summarizes the outcomes of induced rodent hypertensive glaucoma models including intracameral injection of microbeads, laser photocoagulation, episcleral vein cauterization, injection of hypertonic saline and hyaluronic acid. We aim to provide a detailed overview of each of the models with a focus on parameters that defines a successful glaucoma model. The induced IOP elevation and duration of elevation varied among the different models and strain of rodent; nonetheless, they all achieved a sustainable raised IOP with corresponding RGC loss. The limitations of each model are discussed. [ABSTRACT FROM AUTHOR]

Published
2019
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