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351 results on '"Wan, Yanjian"'

10. Research on Fuzzy Iterative Learning Control of Pneumatic Artificial Muscle

Author

Duan, Huiru, Xie, Shenglong, Liu, Zijing, Wan, Yanjian, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Yang, Huayong, editor, Liu, Honghai, editor, Zou, Jun, editor, Yin, Zhouping, editor, Liu, Lianqing, editor, Yang, Geng, editor, Ouyang, Xiaoping, editor, and Wang, Zhiyong, editor

Published
2023
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18. Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study

Author

Wang, Aizhen, Wan, Yanjian, Mahai, Gaga, Qian, Xi, Li, Yuanyuan, Xu, Shunqing, and Xia, Wei

Subjects
Pregnancy -- Analysis, Infants -- Analysis, Metabolites -- Analysis, Pregnant women -- Analysis, Insecticides -- Analysis, Environmental issues, Health
Abstract

Background: Widespread insecticide exposure might be a risk factor for neurodevelopment of our children, but few studies examined the mixture effect of maternal coexposure to organophosphate insecticides (OPPs), pyrethroids (PYRs), and neonicotinoid insecticides (NNIs) during pregnancy on child neurodevelopment, and critical windows of exposure are unknown. Objectives: We aimed to evaluate the association of prenatal exposure to multiple insecticides with children's neurodevelopment and to identify critical windows of the exposure. Methods: Pregnant women were recruited into a prospective birth cohort study in Wuhan, China, from 2014-2017. Eight metabolites of OPPs (mOPPs), three metabolites of PYRs (mPYRs), and nine metabolites of NNIs (mNNIs) were measured in 3,123 urine samples collected at their first, second, and third trimesters. Children's neurodevelopment [mental development index (MDI) and psychomotor development index (PDI)] was assessed using the Bayley Scales of Infant Development at 2 years of age (N = 1,041). Multivariate linear regression models, generalized estimating equation models, and weighted quantile sum (WQS) regression were used to estimate the association between the insecticide metabolites and Bayley scores. Potential sex-specific associations were also examined. Results: Single chemical analysis suggested higher urinary concentrations of some insecticide metabolites at the first trimester were significantly associated with lower MDI and PDI scores, and the associations were more prominent among boys. Each 1-unit increase in ln-transformed urinary concentrations of two mOPPs, 3,5,6-trichloro-2-pyridinol and 4-nitrophenol, was associated with a decrease of 3.16 points [95% confidence interval (CI): -5.59, -0.74] and 3.06 points (95% CI: -5.45, -0.68) respectively in boys' MDI scores. Each 1-unit increase in that of trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (trans-DCCA; an mPYR) was significantly associated with a decrease of 2.24 points (95% CI: -3.89, -0.58) in boys' MDI scores and 1.90 points (95% CI: -3.16, -0.64) in boys' PDI scores, respectively. Significantly positive associations of maternal urinary biomarker concentrations [e.g., dimethyl phosphate (a nonspecific mOPP) and desmethyl- clothianidin (a relatively specific mNNI)] with child neurodevelopment were also observed. Using repeated holdout validation, a 1-quartile increase in the WQS index of the insecticide mixture (in the negative direction) at the first trimester was significantly associated with a decrease of 3.02 points (95% CI: -5.47, -0.57) in MDI scores among the boys, and trans-DCCA contributed the most to the association (18%). Conclusions: Prenatal exposure to higher levels of certain insecticides and their mixture were associated with lower Bayley scores in children, particularly in boys. Early pregnancy may be a sensitive window for such an effect. Future studies are needed to confirm our findings. https://doi.org/10.1289/EHP12097, Introduction Maternal exposure to environmental chemicals during pregnancy might impair fetal development and increase the future health risks of the children. (1-4) Organophosphates (OPPs), pyrethroids (PYRs), and neonicotinoids (NNIs) are [...]

Published
2023
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37. Associations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China

Author

Li, Juxiao, primary, Tu, Fengqin, additional, Wan, Yanjian, additional, Qian, Xi, additional, Mahai, Gaga, additional, Wang, Aizhen, additional, Ma, Jiaolong, additional, Yang, Zong, additional, Xia, Wei, additional, Xu, Shunqing, additional, Zheng, Tongzhang, additional, and Li, Yuanyuan, additional

Published
2023
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