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2. Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial

Author

Ackland, Gareth, Martin, Tim, Fernandez, Maria, Seidu, Fatima, Pakats, Mari-Liis, Mahr, Otto, MacDonald, Neil, Santos, Filipa Dos, Garcia, Amaia Arrieta, Uddin, Ruzena, Begum, Salma, Pearse, Rupert, Subhedar, Emily, Wan, Yize, Patel, Akshaykumar, Shahid, Tasnin, Gooneratne, Mevan, Trainer, Charlotte, Griffiths, Bethan, Dunkley, Steven, May, Shaun, Walker, Sophie, Fowler, Alexander, Stephens, Timothy, Oliveira, Monica, Januszewska, Marta, Niebrzegowska, Edyta, Amaral, Vanessa, Kassam, Jamila, Young, Sophie, Ahmad, Shanaz, Whalley, Jan, Haines, Ryan, Hui, Sara, Hammond, Rob, Crane, David, Brealey, David, Bampoe, Sohail, Stephens, Robert, Reyes, Anna, Martir, Gladys, Diaz, Chimverly, Cleland, Stuart, Minto, Gary, Wilmshurst, Natasha, Affleck, Debbie-Claire, Ward, Tracy, Werrett, Gavin, Cummins, Susan, Amber, Alan, Biffen, Andrew, Boumphrey, Stephen, Cann, Elizabeth, Eglinton, Charlotte, Jones, Elaine, Mwadeyi, Memory, Piesley, Sam, Cowan, Richard, Alderton, Julie, Reed, Fiona, Smith, Joanne, Turner, Amy, Madziva, Lorraine, Patrick, Abigail, Harris, Penny, Lang, Harry, Middleditch, Alexander, Pickering, Anthony, O’Donovan, Catherine, Houlihan, Rebecca, Jarvis, Rosina, Shrimpton, Andrew, Farmery, Toni, Tucker, Katy, Davis, Danielle, Somanth, Sameer, Duncan, Louise, Melsom, Helen, Clark, Sarah, Kent, Melanie, Wood, Michelle, Laidlaw, Ami, Matheson-Smith, Tracy, Potts, Kathryn, Kay, Andrea, Hobson, Stefanie, Sear, John, Kapil, Vikas, Archbold, Andrew, Wilson, Matt, Dndrejaj, Drilona, Ly, Dennis, Gutierrez del Arroyo, Ana, Abbott, Tom E.F., Dias, Priyanthi, Somanath, Sameer, Pearse, Rupert M., and Ackland, Gareth L.

Published
2024
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9. Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial

Author

Pearse, Rupert, Ranieri, Marco, Abbott, Tom, Pakats, Mari-Liis, Piervincenzi, Edoardo, Patel, Akshaykumar, Kahan, Brennan, Rhodes, Andrew, Dias, Priyanthi, Hewson, Russell, Jammer, Ib, Chew, Michelle, Aldecoa, Cesar, Rodseth, Reitze, Biccard, Bruce, Stephens, Tim, Payne, Sara, Hepworth, David, Pischke, Soeren, Asvall, Joerund, Hausken, John, Jhanji, Shaman, Rooms, Martin, Flint, Neil, Hales, Dawn, Szakmany, Tamas, Leitch, Andrew, Spadaro, Savino, Chiumello, Davide, Johnston, Paul, Yeung, Joyce, Tellan, Guglielmo, Veenith, Tonny, Macmillan, Josep, Terragni, Pierpaolo, Sander, Caroline, Kasipandian, Vidya, Ahmad, Tahania, Lee, Aaron, Tammaro, Marcello, McAuley, Danny, Skene, Simon, Vohra, Ravinder, Wilson, Matt, Edwards, Mark, Griffiths, Ewen, Pritchard, Naomi, Filippini, Claudia, Aasmundstad, Tor, Aksnes, Einar, Alpers, Lise-Merete, Barratt-Due, Andreas, Dahl, Anita, Feldt, Linda, Figari, Elisa, Flåten, Eva, Granheim, Karen, Hagring, Minna, Haugaa, Håkon, Kjoesen, Gisle, Klaevahaugen, Inge, Lenz, Harald, Myhre, Marianne, Orrem, Hilde, Stitt, Emily, Toennessen, Tor Inge, Al-Kadhimi, Samuel, Anker, Robert, Balint, Mihaela, Barraclough, Lauren, Black, Ethel, Clayton, Matt, Conneely, Leonora, Edwards, Zara, Eeles, Alex, Evans, Matthew, Gerstman, Michelle, Greenshields, Nicole, Harvey, Eleanor, Hegarty, Aoife, Hester, Natalie, Hutchinson, Jenna, Kasivisvanathan, Ramanathan, Lawrence, Helen, Marsh, Veronica, Matthews, Laura, Mazzola, Francesca, McCanny, Jamie, Morrison, Ben, O'Mahony, Michelle, Pang, Ching Ling, Parkinson, David, Pirie, Katrina, Rao Baikady, Ravishankar, Shovel, Louisa, Smith, Lorna, Tatham, Kate, Thomas, Peter, Uren, Sophie, Walker, Susanna, Wills, Alasdair, Andreou, Prematie, Howson, Alex, Kaur, Jasmin, Lewszuk, Adam, Molina, Esther, Ramsamy, Nirmalabaye, Roberts, Emma, Amaral, Vanessa, Begum, Salma, Bekele, Soliana, Cashmore, Richard, Correia, Carmen, Dunkley, Steven, Fernandez, Maria, Fowler, Alexander, Garcia, Amaia, Della Giovampaola, Maria, Greaves, Kathryn, Griffiths, Bethan, Haines, Ryan, Haslop, Richard, Hu, Ying, Hui, Sarah, Januszewska, Marta, Manon, Vasi, Martin, Tim, May, Shaun, Minicozzi, Annamaria, Niebrzegowska, Edyta, Oliveira, Monica, Pates, Katherine, Santos, Filipa, Shahid, Tasnin, Simili, Paolo, Somerville, Alastair, Subhedar, Emily, Uddin, Ruzena, Walker, Sophie, Wan, Yize, Whalley, Jan, Zolfaghari, Parjam, Gunter, Una, Hodkinson, Gemma, Howe, Gwenllian, Baratozzi, Valentina, Casotto, Giulia, Darai, Giulia, Ferrari, Erica, Mistraletti, Giovanni, Palmaverdi, Valentina, Furlani, Stefano, Priani, Paolo, Ragazzi, Riccardo, Salmaso, Marco, Verri, Marco, Volta, Carlo, Nutt, Chris, McKay, Emma, O'Neill, Orla, Patel, Jaimin, Atterbury, Katie, Ballinger, Sarah, Carling, Natalie, Ellis, Kaytie, Gresty, Jo, Melody, Teresa, Monk, Jade, Norman, Chloe, Reeves, Eleanor, Sampson, Julia, Sutton, Peter, Thomas, Marie, Bamford, Amy, Bergin, Colin, Carrera, Ronald, Cooper, Lauren, Despy, Liesl, Ellis, Karen, Fellows, Emma, Goundry, Stephanie, Harkett, Samantha, Ip, Peter, Mason, Tracy, McGhee, Christopher, McLaughlin, Aisling, Neal, Aoife, Pope, Martin, Porter, Stephanie, Smith, Hazel, Snelson, Catherine, Spruce, Elaine, Vigo, Ylenia, Whitehouse, Arlo, Whitehouse, Tony, Donatiello, Maria, Gazzanelli, Sergio, Mezzapesa, Mario, Savino, Martina, Settesoldi, Giacomo, Kunst, Gudrun, Birch, Sian, Greig, Louise, Noble, Harriet, Pappa, Evita, Penhaligon, Bethany, Cossu, Andrea, Floris, Leda, Piredda, Davide, Racca, Alberto, Brattstrom, Olof, Heggelund, Bente, Flodberg, Magnus, Månsson, Sandra, Ahmed, Mamoona, Allen, Jonathan, Bell, Paula, Genetu, Roman, Glennon, Julia, Hanley, Janice, Jenner, Katy, Jogi, Summayyah, Mahjoob, Parisa, McGovern, Clare, Murphy, Anthony, Nazari, Roonak, Routledge, Jacki, Uttamlal, Trishna, Ward, Sinead, Iotti, Giorgio, Picchioni, Raffaella, Poma, Silvia, Navalesi, Paolo, Bruni, Andrea, De Leonardis, Brunella, Garofalo, Eugenio, Patel, Panna, McArthur, Carol, Burns, Karen, Peters, Steven, Foti, Giuseppe, Calcinati, Serena, Grassi, Alice, Villa, Silvia, Berridge, John, Kanakaraj, Muthuraj, Cahill, Hazel, Forshaw, Greg, Gibson, Andy, Grainger, Lia, Howard, Kate, James, Katherine, Murphy, Zoe, Sweeting, Helen, Tait, Rebecca, Wilcock, Danielle, Yates, David, Cope, Sean, Allan, Ashley, Betts, Rebecca, Cornell, Sarah, Sheriff, Julie, Woods, Lindsey, Grasselli, Giacomo, Brioni, Matteo, Castagna, Luigi, von Rahden, Richard, Farina, Zane, Green, Samantha, Gumede, Simphiwe, Rajah, Chantal, Ramkillawan, Arisha, Moug, Susan, Alcorn, David, Dalton, Carol, Dickinson, Natalie, Edwards, Jennifer, Henderson, Steven, McIlveen, Erin, Ramsaran, Richard, Bell, Joanne, Fleming, Lorna, Monks, Kathleen, Parker, Jane, Stamper, Sean, Stokes-Denson, Jo, Elías, Elisa, Guerra, Yessica, Rico-Feijoo, Jesus, Kidel, Carlos, Filipe, Helder, Asis, Gretchelle, Gleeson, Yvonne, Harvey, Alice, Jackson, Christine, McNeil, Margaret, Mingo, Sara, Pakou, Glykeria, Pinto, Manuel, Wright, Stephen, Babio-Galan, Maite, Buckley, David, Calder, Verity, Chishti, Ahmad, Cosgrove, Joseph, Cullen, Katherine, Dunn, Leigh, Faulds, Matthew, Fortune, Jonathan, Gardner, Matthew, Harrison, Abigail, Hays, Carole, Jones, Gerry, Macfie, Caroline, Mccullagh, Iain, Nesbitt, Ian, O'Neil, Suzanne, Phoenix, Catherine, Rangaswamy, Girish, Samson, Craig, Scott, Carmen, Shrestha, Tara, Singh, Rita, Soulsby, Graham, Walton, Jon, Zwiggelaar, Kimberley, Lynch, Ceri, Clarke, Heidi, Deacon, Bethan, Ivatt, Helen, Jones, Leanne, Latif, Ahmed, Oram, Shaun, Perman, Chris, Roche, Lisa, Duys, Rowan, Flint, Margot, Bhagwan, Kamal, Coetzee, Ettienne, Joubert, Ivan, Montoya-Pelaez, Felipe, Navsaria, Pradeep, Picken, Guy, Porrill, Owen, Strathie, Grant, Zungu, Thembinkosi, Aluri, Sireesha, Chau, Simon, Cooper, Deborah, Cunningham, Mishell, Daniels, Allison, Hope, Susan, Nicholson, Alice, Walker, Laura, Giarratano, Antonino, Accurso, Giuseppe, Raineri, Santi, Tricoli, Giuseppe, Innes, Richard, Doble, Patricia, Hutter, Joanne, Pawley, Corinne, Tait, Moira, Hamilton, Mark, Andrade, Edward, Barnes, Veronica, Dalton, Claire, Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Howlett, Luisa, Joseph, Gipsy, Krupa, Monika, Leaver, Susannah, Macedo, Joao, Maher, Karen, Mellinghoff, Johannes, Oguntimehin, Rachel, Pereira, Joel, Robinson, Frances, Ryan, Christine, Shah, Nirav, Shirley, Paula, Torborg, Alexandra, Biyase, Thuli, Drummond, Leanne, Kusel, Belinda, Mbuyisa, Mbalenhle, Solala, Sivuyisiwe, Taylor, Jenna, Ezihe-Ejiofor, Adanma, Aduse-Poku, Maame, Colville, Gary, Davies, Louise, Kang, Soo, Phillips, Alex, Kirk-Bayley, Justin, Kelliher, Leigh, Carvelli, Paula, Daysal, Gokce, Dickinson, Matthew, Doyle, Nancileigh, Hughes, Christina, Montague, Laura, Potter, Elizabeth, Salberg, Armorel, Sibug, Sheena, Sivarajan, Sinduja, Thomson, Milo, Wakeford, Nichola, Rocco, Monica, Alampi, Daniela, Conway, Daniel, Clark, Richard, Maria, Jashmin, Pomeroy, Fiona, Quraishi, Tanviha, Williams, Abigail, Chukkambotla, Srikanth, Aherne, Caroline, Harrison-Briggs, Donna, Fitchett, Jill, Duberley, Stephen, Zanoni, Andrea, Cardinale, Daniela, Righi, Claudia, Blunt, Mark, Fuller, Tracy, Hodgson, Ruth, Rosbergen, Melissa, Brennan, Andrew, Akeroyd, Louise, Boardman, Victoria, Bull, Christopher, Carrick, Mike, Chadderton, Ian, Cooper, Sarah, Goellner, Sarah, Graham, Laura, Ilyas, Carl, King, James, Laklouk, Muhammad, Lawton, Tom, Macrow, Christopher, Munro, Michael, Neep, Adam, Northey, Martin, Peacock, Victoria, Pye, Kate, Radley, Lydia, Sira, James, Smithson, Beth, Syddall, Stuart, Tooth, David, White, Thomas, Hoel, Sindre, Aakre, Elin, Bakke, Monica, Hoivik, Tone, Makowski, Arystarch, Alcock, Harry, Cardoso, Sean, Coetzee, Samantha, Everett, Mary, Ibrahim, Mohamed, Kouridaki, Christina, Ogbeide, Vongayi, Bertellini, Elisabetta, Bertolotti, Valentina, Buono, Antonio, Fanigliulo, Maria, Kumar, Ram, Richards, Nicole, Allana, Alisha, Bacciarelli, Samantha, Barker, Helen, De Bois, Jessica, Bradley, Isabel, Crooks, Jennifer, Daum, Peter, Feben, Alex, Gannon, Lizzie, Kipling, Sarah, Peetamsingh, Andrew, Quamina, Charlotte, Sethi, Sahiba, Sivadhas, Harry, Sollesta, Kathryn, Swain, Andrew, Tan, Evalyn, Willis, Joan, Zou, Maggie, Cranshaw, Julius, Barratt, Nina, Bowman, Katie, Branney, Debbie, Letts, Maria, Pitts, Sally, Day, Christopher, Benyon, Sarah, Eddy, Sara, Green, Adam, Grice, Anna, Kelly, Sinéad, Mackle, Daisy, Mariano, Victor, Park, Linda, Sibley, Pauline, Spencer, William, Bignami, Elena, Bellini, Valentina, Forfori, Francesco, Curci, Maria, Leo, Alessandra, Jackson, Matthew, Awolesi, Jennifer, Hodgkinson, Sheila, Kent, Alissa, Leonard, Dee, Stapleton, Claire, Tibke, Clare, Alexander-Sefre, Farhad, Campey, Lorraine, Hall, Kathryn, Spimpolo, Jennifer, Nilsson, Malin, Didriksson, Helen, Hamilton, Emma, Carnahan, Mandy, Mowatt, Chris, Stickley, Jo, Corcione, Antonio, Rossi, Giuseppe, Fladby, Hege, Andersen, Nina, Bjoernå, Gunhild, Reite, Mads, Roertveit, Linda, Seidel, Philipp, Arnold, Glenn, Benavente, Melissa, Chattersingh, Anjalee, Chironga, Nyasha, Hornzee, Gillian, Kibaru, Joyce, Malik, Ihtisham, McLeavy, Laura, Pathmanathan, Byiravey, Prior, Florence, Strudwick, Rhea, Vezyrgiannis, Marios, Sinha, Aneeta, Babu, Sheeba, Batuwitage, Bisanth, Daly, Zoe, Ellinor, Katharine, Hawes, Elizabeth, Holmes, Ann, Hudson, Karen, Nightingale, Jeremy, Le Poidevin, Alison, Roberts, Lindsey, Kubisz-Pudelko, Agnieszka, Allison, Joanna, Pippard, Lucy, Hamlyn, Vincent, Organ, Angie, Prabhahar, Thaventhran, Bridger, Hayley, Dvorkin, Lee, Manhas, Vitul, Vincent, Rachel, Laha, Shondipon, Cromie, Terri-Louise, Doyle, Donna, Howarth, Rachel, Verlander, Mark, Watt, Ailsa, Williams, Alexandra, Antonelli, Massimo, Cutuli, Salvatore, Montini, Luca, Graterol, Juan, Adams, Benita, Bean, Sarah, Burt, Karen, Hammonds, Fiona, Jigajinni, Suyogi, Fulton, Laura, Kinghorn, Stephen, Mullenheim, Jost, Baillie, Kirsty, Cain, Martyn, Colling, Kerry, Hannaway, Carol, Corso, Ruggero, Calli, Morena, Ferrando, Carlos, Romero, Esther, Jorge-Monjas, Pablo, Soria-García, María, Gómez-Herreras, José, Rodríguez-Jiménez, Rita, and De Prada-Martín, Blanca

Published
2021
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14. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

A'Court, Alicja, Abdel-Gadir, Dina, Abdu, Ayman, Abisogun, Caroline, Aboud, Zainab, Abrams, Judith, Ackerman, Andrea, Adamso, Christine, Addison, Rachel, Adeyeye, Adedayo, Adler, Rachel, Aduse-Poku, Maame, Adyanthaya, Siddharth, Ahmad, Najmiah, Ahmed, Dabeeruddeen, Ahmed, Atif, Akindele, Bucky, Akindele, Olubukola, Akrimi, Sonia, Al-Rawi, Samar, Ali, Yousif, Allam, Jo, Allana, Alisha, Allen, Kellie, Allen, Orlanda, Amaradasa, Natasha, Amarasekara, Lareina, Amoakwa-adu, Freda, Anandageetha, Padmanabhan, Anandakrishnan, Suresh, Anandanadesan, Rathai, Anderson, Michelle, Apps, Simon, Aquilina, Audrey, Arbane, Gill, Arch, Alice, Armstrong, Sarah, Arya, Rita, Ashiru, Gloria, Ashpole, Keri, Atkinson, Claire, Atkinson, Francesca, Auer, Elizabeth, Avery, Ben, Babio-Galan, Maite, Bader, Hareth, Badham, George, Bagchi, Subha, Bailey, Sarah, Baird, Yolanda, Balaka, Cristina, Baldwin, Melissa, Balfour, Paul, Bali, Shreya, Banks, Samantha, Barclay, Philip, Barnes, Lucy, Barnes, Thomas, Barot, Niraj, Barrett, Stephen, Barrett, Venetia, Barrett, Kate, Bates, Louise, Batte, Katherine, Baytug, Beki, Behravesh, Mona, Bell, Suzanne, Benloch, Raul, Bentley, Richard, Berg, Jennifer, Berwick, Charlotte, Berwick, Richard, Bhadange, Rashmi, Bhattacharyya, Sanjoy, Bielskute, Egidija, Birch, Sian, Bird, Scott, Bird, Ruth, Birts, William, Black, Becky, Blagova, Tatyana, Blake, Holly, Blightman, Oliver, Blunden, Susara, Bolton, Richard, Borkett-Jones, Caroline, Boselli, John, Bowen, Manuella, Bowen, Ruth, Bowye, James, Boyle, Henry, Brar, Zameen, Bray, Jo, Brayshaw, Samantha, Bressington, Catherine, Brewer, Alison, Brice, Naomi, Bridge, Laura, Briscoe, James, Brocklesby, Sonia, Brown, Harry, Brown, Sarah, Brunnen, Derek, Burijintichenna, Keshavareddy, Burnard, Sara, Burtt, Agnieszka, Buswell, Victoria, Bykar, Hannah, Cairney, Matthew, Calvert, Clare, Camarasa, Laura, Campbell, Natasha, Campbell-Jones, Frederick, Cantliffe, Jane, Carrol, William, Carvalho, Joanna, Cashell, Catherine, Cassie, Sarah, Cassim, Kadu, Chandler, Marika, Chapman, Rachel, Charles, Robert, Chen, Ping, Cheyne, Deanne, Chima, Kiran, Chin, Floju, Chirvasuta, Radu, Shao Chong, Martin, Choudhury, Sadia, Chowdhury, Priyakam, Christmas, Tracey, Chughwani, Shilpa, Ciechanowicz, Sarah, Clarey, Emma, Coe, Rob, Cohen, Jolyon, Coker, Nicholas, Collins, Karen, Collis, Lauren, Comar, Jasna, Conroy, Marianne, Constantin, Kathy, Corfe, Jeremy, Coulborn, Elaine, Cowie, Vanessa, Crone, Rachel, Cronin, James, Crooks, Jennifer, Crowther, Nicola, Crowther, Elizabeth, Cruz, Carina, Curtis, Alexa, Curtis, Sarah, Curtis, Sam, Dabrowicz, Adrian, Daines, Nick, Dalal, Viral, Dannatt, Peter, Das, Dinesh, Dash, Jennifer, Davidson, Katherine, Davies, Sarah, Davis, Yvette, Dawson, James, Dean, Jonathan, Dean, Caroline, Denman, Jane, Desai, Neel, Dewan, Preeti, Dimont, Sarah, Donovan, Clare, Doraiswami, Mano, Doughty, Kate, Douglass, Jamie, Dower, Michelle, Downing, Samantha, Duberry, Wendy, Duckham, Emily, Dudgeon, Lucy, Dukes, Stephanie, Dunn, Leigh, Duraiswamy, Venkat, O' Dwyer, Anthony, Dyer, Kristyn, Eapen, Suresh, Earl, Mark, Eason, Sally, Edwards, Kylie-Ellen, Edwards, Zara, Egole, Osinachi, Ekpa, John, El-Amin, Olivia, El-Boghdadly, Kariem, Elbasir, Okba, Eldridge, James, Elgie, Laura, Ellington, Matt, Elliott, Katharine, Elliott, Justine, Elmi, Mohamed, Elnoumeir, Ramy, Emeakaraoha, Eunice, Evans, Matt, Everett, Mary, Fabb, Philippa, Farooq, Hadia, Farrimond, Rohan, Faulds, Fiona, Fawcett, Erik, Feneley, Andrew, Fernando, Dinushi, Ferns, Janis, Finlay, Claire, Fitzgerald, Simon, O'Flaherty, Doireann, Fleet, Mark, Fletcher, Lydia, Fludder, Vanessa, Follet, Terri, Forbes, Jane, Forth, Mark, Foster, Greg, Francis, John, Fraser, Kate, Friedman, Lauren, Fruggeri, Luca, Fulton, Laura, Funnell, Sam, Gadre, Amit, Gandhi, Ajay, Gardiner, Harriet, Garner, Zoe, Garvey, Gráinne, Gately, Tom, George, Richard, Gillespie, Siobhan, Glover, Stephanie, Goddard, Jennifer, Goodman, Ben, Gopal, Tarikere, Graham, George, Green, David, Griffin, Denise, Griffith, Jessica, Grigsby, Stephanie, Grindey, Julie, Griffiths, Huw, Groome, Jonathan, Grother, Christine, Grounds, Gabrielle, Groves, Alice, Guha, Abhik, Gunawardhana, Amila, Gupta, Aman, Gupta, Rekha, Gutsell, James, Haddon, Richard, Hadi, Dina, Hadjipavlou, Nicola, Hammerbeck, Henry, Hammon, Laura, Hammond, Sarah, Hampanna, Hampesh, Hancock, Holly, Handapangoda, Hemantha, Haroon-Mowahed, Yumna, Harpham, Dawn, Harris, Grant, Harrison, Abigail, Harshan, Divya, Hartopp, Andrew, Harty, Eoin, Haslam, Nick, Hawkins, Gemma, Hawkins, Edith, Hawksey, Sarah, Hays, Carole, Hazelton, Tracy, Heavyside, Andrew, Hemeson, Chibuzo, Henderson, Katrina, Henry, Oliver, Herbert, Lara, Higgins, Nikki, Hilton, James, Hindmoor, Claire, Hitchcock, Rachael, Hobbs, Laura, Homsy, Michele, Honeywell, Cassandra, Hoque, Nazima, House, Kirsty, Howle, Ryan, Tiller, Amanda, Huniak, Matthew, Hunte, Jeremy, Husain, Tauqeer, Huson, Coralie, Hussain, Catriona, Hussain, Tawhida, Hussein, Zainab, Hyams, Jeremy, Hyde, Eleanor, Iaverdino, Marina, Ignacka, Alex, Innes, Erin, Ioannidis, Stefanos, Iqbal, Rehana, Ismail, Fahja, Jackson, Jenny, Jackson, Michael, Jackson, Guy, Jacobs, Robyn, Jadhav, Poonam, Jalaly, Aisha, James, Lorraine, James, Monica, Jani, Surekha, Jeganathan, Chandran, Joannides, Claire, Johnson, Robert, Johnson, Thosa, Johnston, Carolyn, Jones, Reeanne, Jones, Tom, Kadr, Miran, Kainth, Rasmeet, Kane, Jenna, Kanji, Rafiq, Kannanparambil, Sunil, Kar, Girish, Kasianandan, Theanalli, Kaskos, Husam, Kavanagh, Lisa, Kaye, Richard, Kelliher, Leith, Kelliot, Serena, Kelly, Jemma, Kelly, Jenna, Kenyon, Carol, Kessack, Laura, Kestner, Samuel, Khaku, Mohammed, Khaleeq, Sophia, Khan, Pervaz, Khan, Sabeen, Kidwai, Usamah, King, Christopher, King, Helen, Kingston, Elizabeth, Kok, Waisun, Konig, Rebekka, Konstantinova, Zheyna, Krishnan, Priya, Kua, Justin, Kuntumalla, Kavitha, Kursumovic, Emira, Kurzatkowski, Krzysztof, Kuttambakam, Hariprasad, Lane, Katherine, Lane, Sophie, Langton, Andrew, Latif, Hamad, Lau, Norlan, Laxman, Shyam, Laycock, Helen, Lee, Rachel, Leonardi, Silvia, Light, Karen, Lightfoot, Heidi, Liu, Shuang, Liyanage, Sanduni, Lowe, Jessica, Lucas, Nuala, Lungu, Miyoba, Lunn, Marianne, Lynes, Heather, Machavarapu, Kishore, Mackenzie, Matthew, Major, Jonathan, Male, Victoria, Malik, Zain, Manso, Katarina, Maquinana, Myrna, Marciniak, Katarzyna, Maronge, Lizzie, Marsh, Chris, Martella, Carmela, Martin, Nicki, Martins, Nicole, Marway, Jaspreet, Mason, Louisa, Mason, Lucy, Masood, Nadia, Masters, James, Maton-Howarth, Matthew, Mazzola, Francesca, McAllister, Tamsin, McCarthy, Rachel, McCormick, Claire, McCready, Sharon, McDougall, Steffan, Mcewan, Lorna, McGarry, Jon, McKevitt, Helen, Mckinley, Stephanie, Mckskeane, Anna, McMaster, Eloise, McMonagle, Martina, McNamara, Helen, McPhee, Hannah, McRae, Laura, Mead, Dee, Meadows, Emma, Mehta, Madhur, Meikle, Joanne, Metodiev, Yavor, Michael, Chloe, Millar, Victoria, Miller, Sarah, Miller, Gregg, Milne, Sezanne, Miltsios, Kostas, Misquita, Lucia, Misquita, Simone, Mittal, Manasi, Mohamed, Mohamed, Powell Monaghan, Katherine, Monk, Joanna, Monkhouse, Alexandra, Monks, David, Montague, Laura, Moon, Angela, Moran, Jennifer, Moreton, Annette, Morgan, Endaf, Morgan, Oliver, Morland, Danny, Morosan, Monica, Morris, Kimberley, Morris, Andrea, Moser, Clare, Mount, Manulella, Muir, Carol, Mupudzi, McDonald, Murali, Mayur, Murdoch, Iona, Murray, Heather, Murray, Theresa, Murrell, Karen, Narasimha Murthy, Girish, Neeley, Diana, Nei, Hannah, Neil, Kerry, Nejim, Tara, Nel, Mark, Nicholson, Anne, Nicklin, Angela, Nolan, Catherine, Nolan, Tracey, Nurmi, Eveliina, O'Neill, Bridie, Oakes, Christie, Oakes, Neil, Ochoa-Ferraro, Maria, Odeleye, Nike, Oliver, Katy, Oliver, Mark, Onslow, Julie, Onwochei, Desire, Oommen, Thomas, Orr, Tim, Osagie, Osato, Osborn, Hannah, Overend, Jennie, Owston, Hazel, Pack, Emma, Padhi, Pulak, Palani, Prabvathy, Pandey, Rajesh, Pandya, Dhruti, Panesar, Navjot, Papageorgiou, Con, Papanastasiou, Georgios, Papoutsos, Costas, Pararajasingham, Suji, Parry, James, Patel, Hasita, Patel, Jaishel, Patel, Jiten, Patel, Kaumudi, Patel, Kiran, Patel, Mitul, Patel, Reshma, Patel, Ruchira, Patel, Nimisha, Pathak, Sangeeta, Pearson, Fiona, Peciulene, Viktorija, Peers, Beth, Peirce, Benjamin, Pepper, Stacey, Perinpanayagam, Jasmina, Perry, Hollie, Petrova, Nadya, Phillips, Trudie, Phillips, Sioned, Phylactides, Leonidas, Pilkington, Felicity, Plumb, James, Poimenidi, Evangelia, Sau Kuk Poon, Anna, Potter, Thomas, Poultney, Una, Powell, Lucy, Prenter, Andrew, Preston, Katie, Price, Anna, Pritchard, Naomi, Pullen, Jenny, Purohit, Manishi, Quamina, Charlotte, Qureshi, Jibran, Rajput, Zahra, Ramage, Stephen, Ramanathan, Tamilselvi, Ranasinghe, Upeka, Ranatunga, Kalum, Rand, Abby, Randive, Seema, Rangarajan, Desikan, Rao, Chandana, Rao Pelluri, Sambasiva, Ratnasingham, Antony, Razzaque, Jamil, Reddy, Anuvidya, Redington, Katie, Reel, Emma, Remeta, Peter, Ricco, Francesca, Riccoboni, Anna, Rice, Polly, Rich, Mel, Richards, Nicole, Riches, Joanne, Ripoll, Simon, Roberts, Fleur, Roberts, Kitty, Robins, Kay, Robinson, Susie, Roche, Samantha, Rojo, Maria, Carmela Romano, Milena, Rosser, Hilary, Roughley, Lindsay, Routley, Catriona, Rowley, Christine, Rudra, Pallab, Russell, Robin, Ryan, Christine, Saad, Chloe, Sadeghi, Abtin, Salberg, Armorel, Samuel, Matt, Samuels, Rebecca, Sanapala, Suresh, Sanusi, Seliat, Sarao, Sarbpreet, Sathyabhama, Sathyabhama, Saunders, Zoe, Sawarzynska-ryszka, Bernadetta, Sceales, Panagiota, Sceales, Penny, Schumacher, Natasha, Schwartz, Nuala, Sellers, Claudia, Sellers, Heather, Sellick, Jessica, Sen, Soumen, Senaratne, Dhaneesha, Senbeto, Sarah, Seneviratna, Dineth, Setty, Thunga, Shah, Raj, Shah, Sonia, Shambly, James, Sharafudeen. Imran Sharieff, Saju, Sharifi, Laurence, Sharpe, Lisa, Shaw, Michael, Sheldrake, Ian, Shinde, Priya, Shonfeld. Jonathon Short, Adam, Siah, Julian, Sibug. Omar Siddique, Sheena, Siew, Sara, Simpson, Matthew, Singleton, Georgina, Sinha, Kathryn, Sinha, Aneeta, Sinnott, Matthew, Sivadhas, Harry, Sivakumar, Sivanth, Sivarajan, Boopathi, Sivarajan, Sinduja, Skeoch, Chris, Slade, Samuel, Slater, Paul, Smith, Camilla, Smith, Carys, Smith, Christopher, Smith, James, Smith, Lorraine, Smith, Annika, Smith, Edward, Smith, Ruth, Smith, Sue, Smith, Tim, Smithers, Helen, Smolen, Sue, Smyth, Claire, Snel, Toni, Snipe, Carol, Soltanifar, Sam, Sonawane, Nilesh, Soundararaja, Andal, Spence, Emily, Spiliopoulos, Mark, Srivastava, Chhavi, Stacey, Karen, Stafford, Helena, Staines, Nikki, Stead, Richard, Stevens, Emma, Stilwell, Alex, Stocks, Gary, Stokes, Aaron, Stone, Christopher, Straughan, Ben, Subbarathnam, Vanitha, Sudunagunta, Srinath, Sultan, Pervez, Suppiah, Puvan, Surve, Priyanka, Sutherland, Angus, Swanton, Rob, Swarbrick, Claire, Swinson, Amy, Syrrakou, Eleni, Tadbiri, Shahrzad, Tamhane, Preetam, Tamilselvan, Perumal, Tan, Andrew, Tanna, Shamil, Tarft, Hayley, Tarry, Laura, Taylor, Ian, Taylor, Suzanne, Tebbot, Julie, Theron, Svetlana, Thomas, Megan, Todd, Sarah, Tolliday, Hermione, Topham, Charlotte, Tovell, Nicholas, Traves, Martyn, Trodd, Dawn, Tufchi, Aseem, Turley, Katie, Turnbull, Marc, Turnbull, Chris, Turner, Oliver, Turner, William, Turney, Sharon, Tyagi, Eleanor, Uncles, David, Unsworth, Vanessa, Vadnere, Pradnya, Varadan, Rama, Vasishta, Vik, Veal, Andrew, Vedham, Lalitha, Venkaya, Jessica, Verghese, Miriam, Veronica, Icel, Vidanagamage, Dinesh, Vincent, Rachel, Vyapury, Vinodhan, Wain, Harris, Walbridge, Fiona, Walker, Elaine, Walsh, Pete, Walshe, Eleanor, Walters, Michelle, Wan, Yize, Wang, Cherry, Wankhade, Kavita, Waters, Gareth, Watts, Christopher, Webber, Alex, Wedgwood, Tom, Wee, Michael, Wellstead, Susan, White, Alison, Whitear, Michael, Whitefield, Lucy, Wilkinson, Sarah, Williams, Lauren, Williams, Rhys, Wilson, Dawn, Wilson, Samantha, Wimble, Katie, Winkley, Elaine, Winslow, Luke, Winwright, Paul, Wloch, Karolina, Wong, Gideon, Wong, Hannah, Man Wong, Jan, Wood, Tim, Wray, Sarah, Wrench, Ian, Wu, James, Wynn, Kynn, Yap, Yeng, Kuan Yeow, Chia, Young, Emily, Yusaf, Alex, Uz Zafar, Saeed, Zeinali, Darius, Zhang, Sheldon, Zope, Sarvesh, Zucco, Liana, Anwar, Sibtain, Blunt, Nadia, Cronin, John, Grover, Vimal, Grailey, Kate, Grey, Martin, Highton, David, Hopkins, Phil, Kemp, Harriet, Lo, Queenie, Martin, Daniel, Morkane, Clare, O'Carroll, James, Oliver, Charles, Post, Benjamin, Visram, Anil, Wickham, Alex, Odor, P.M., Bampoe, S., Lucas, D.N., Moonesinghe, S.R., Andrade, J., and Pandit, J.J.

Published
2020
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15. Improving decision-making for timing of surgery for high-risk comorbid patients.

Author

Wan, Yize I. and Savonitto, Stefano

Subjects
*MAJOR adverse cardiovascular events, *COMORBIDITY, *CAUSAL inference, *DECISION making
Abstract

Deciding the optimal time for surgery in patients with pre-existing comorbid disease is complex. A careful balance of risks is required to weigh up the therapeutic benefits of surgery against an increased risk of perioperative adverse outcomes, whereas the subsequent risk of adverse events and mortality is more dependent on pre-existing conditions. A study in a recent issue of BJA shows that people with a previous cardiovascular or cerebrovascular event within 10 yr of elective surgery were at a higher risk of major adverse cardiovascular events within 1 yr from surgery and that an at-risk period existed if surgery occurred within 37 months of the preoperative event. Before this observation can be used to inform clinical decision-making, caution is needed to interpret these findings because of biases introduced by the analytical approach and potential confounding. [ABSTRACT FROM AUTHOR]

Published
2025
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16. Characteristics and Outcomes of Patients With Frailty Admitted to ICU With Coronavirus Disease 2019: An Individual Patient Data Meta-Analysis

Author

Subramaniam, Ashwin, Anstey, Christopher, Curtis, J. Randall, Ashwin, Sushma, Ponnapa Reddy, Mallikarjuna, Aliberti, Márlon Juliano Romero, Avelino-Silva, Thiago Junqueira, Welch, Carly, Koduri, Gouri, Prowle, John R., Wan, Yize I., Laurent, Michaël R., Marengoni, Alessandra, Lim, Jun Pei, Pilcher, David, and Shekar, Kiran

Published
2022
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20. Genetic epidemiology of atopy and asthma

Author

Wan, Yize Isalina

Subjects
616.238, WD Disorders of systemic, metabolic or environmental origin
Abstract

The evidence for genetic contributions to the development of asthma and atopy has been well established. Refining the major genetic factors underlying these contributions will lead to a greater understanding of the pathophysiology of these conditions and potentially identify novel therapeutic targets. This thesis describes a series of studies designed primarily using genome-wide association (GWA) approaches to examine common single nucleotide polymorphisms (SNPs) contributing to these phenotypes in the Caucasian population. Susceptibility to atopy was assessed using both non-parametric association tests of SNPs across the genome and focused analysis of two regions on chromosomes 3p22.1-q22.1 and 17p12-q24.3 previously identified through a meta-analysis of genome-wide linkage studies (GSMA). The discovery cohort consisted of 1,083 cases and 2,770 controls, replication analyses were undertaken in four independent population cohorts. A GWA study of severe asthma was carried out in 933 cases and 3,346 controls with replication in a further 231 cases and 1,345 controls. The contribution of SNPs within all previously reported asthma susceptibility loci identified using a comprehensive literature search was also evaluated. Overall, there is evidence for a large number of loci influencing both atopy and severe asthma, each harbouring modest effects. A number of potentially novel loci meeting nominal significance in both GWA studies have been identified requiring further work. Strong evidence was found to support the IL1RL1-IL33 signalling pathway in asthma pathogenesis. Molecular characterisation of the 5’ untranslated regions of IL1RL1 and IL33 suggest a complex regulatory role of identified common variants involving multiple promoters for IL1RL1. A number of asthma specific variants within the chromosome 2q12 and 9p24.1 regions were detected using next generation re-sequencing in homogenised pools of cases and controls warranting further analyses. This work has identified a potentially important pathway in which to focus the development of effective asthma therapies. Future directions will include functional analysis of replicated variants and tests of interactions between the multiple genetic and environmental factors likely to be involved in disease.

Published
2011

21. Elevated urea-to-creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma

Author

Haines, Ryan W., Zolfaghari, Parjam, Wan, Yize, Pearse, Rupert M., Puthucheary, Zudin, and Prowle, John R.

Subjects
Royal London Hospital, Comparative analysis, Skeletal muscle -- Comparative analysis, Urea -- Comparative analysis, Epidemiology -- Comparative analysis, Muscles -- Comparative analysis
Abstract

Author(s): Ryan W. Haines [sup.1] [sup.2], Parjam Zolfaghari [sup.1] [sup.2], Yize Wan [sup.1] [sup.2], Rupert M. Pearse [sup.1] [sup.2], Zudin Puthucheary [sup.1] [sup.2], John R. Prowle [sup.1] [sup.2] [sup.3] Author [...], Purpose Muscle wasting is common amongst patients with persistent critical illness and associated with increased urea production, but reduced creatinine production. We hypothesised that elevated urea:creatinine ratio would provide a biochemical signature of muscle catabolism and characterise prolonged intensive care (ICU) admissions after major trauma. Methods Using pre-specified hypotheses, we analysed two existing data sets of adults surviving [greater than or equal to] 10 days following admission to ICU after major trauma. We analysed trauma-ICU admissions to the major trauma centre serving the North East London and Essex Trauma Network, with a verification cohort of trauma-ICU cases from the MIMIC-III database. We compared serum urea, creatinine, and urea:creatinine ratio (ratio of concentrations in mmol/L) between patients with persistent critical illness (defined as ICU stay of [greater than or equal to] 10 days) and those discharged from ICU before day 10. In a sub-group undergoing sequential abdominal computerised tomography (CT), we measured change in cross-sectional muscle area (psoas muscle at L4 vertebral level and total muscle at L3 level) and assessed for relationships with urea:creatinine ratio and ICU stay. Results are provided as median [interquartile range]. Results We included 1173 patients between February 1st, 2012 and May 1st, 2016. In patients with ICU stay [greater than or equal to] 10 days, day 10 urea:creatinine ratio had increased by 133% [72-215], from 62 [46-78] to 141 [114-178], p < 0.001; this rise was larger (p < 0.001) than in patients discharged from ICU before day 10, 59% [11-122%], 61 [45-75] to 97 [67-128], p < 0.001. A similar separation in trajectory of urea:creatinine ratio was observed in 2876 trauma-ICU admissions from MIMIC-III. In 107 patients undergoing serial CTs, decrease in L4 psoas and L3 muscle cross-sectional areas between CTs significantly correlated with time elapsed (R.sup.2 = 0.64 and R.sup.2 = 0.59, respectively). Rate of muscle decrease was significantly greater (p < 0.001 for interaction terms) in 53/107 patients with the second CT during evolving, current or recent persistent critical illness. In this group, at the second CT urea:creatinine ratio negatively correlated with L4 psoas and L3 muscle cross-sectional areas (R.sup.2 0.39, p < 0.001 and 0.44, p < 0.001). Conclusion Elevated urea:creatinine ratio accompanies skeletal muscle wasting representing a biochemical signature of persistent critical illness after major trauma. If prospectively confirmed, urea:creatinine ratio is a potential surrogate of catabolism to examine in epidemiological and interventional studies.

Published
2019
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27. Unravelling the effect of anaesthesia provider sex on patient outcomes: statistical analyses for sound conclusions.

Author

Kasza, Jessica and Wan, Yize I.

Subjects
*GENDER differences (Sociology), *CAUSAL inference, *TREATMENT effectiveness, *ANESTHESIA, *STATISTICS
Abstract

Unravelling the impact of the sex of the anaesthesia provider on the outcomes of patients requires careful statistical analysis and the validity of many assumptions. A recent study in the British Journal of Anaesthesia investigates the effect of anaesthesia provider sex on patient outcomes, using data from two academic healthcare networks in the USA. The authors show that female provider sex was associated with a lower risk of intraoperative complications. They also show that there was no meaningful difference between male and female providers with respect to postoperative outcomes. There have been several recent studies considering the effect of healthcare provider sex on outcomes. We will discuss the interpretation of these results and the validity of the underlying assumptions. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Association between energy surplus and intensive care unit length of stay in critically ill patients: A retrospective cohort study.

Author

Page, Alexandria, Langan, Anne, Wan, Yize I., McNelly, Angela, Prowle, John, Pearse, Rupert, and Puthucheary, Zudin

Subjects
INTENSIVE care units, CRITICALLY ill, COVID-19, NUTRITIONAL requirements, PATIENT experience, PATIENTS' attitudes
Abstract

Background: Patients experiencing persistent critical illness have poor short‐term and long‐term outcomes and consume disproportionate amounts of health care resources. Nutrition optimization may improve outcomes, though few data exist on resting energy expenditure and nutrition requirements. We hypothesized that increased energy surplus per day is associated with increased intensive care unit (ICU) length of stay (LoS) in critically ill patients. Methods: Patients from a single ICU at Royal London Hospital were included in this retrospective cohort study. Exposure: energy surplus measured by serial indirect calorimetry (IC) and nutrition intake. Inclusion criteria: mechanical ventilation of ≥3 days and expected to remain ventilated. Primary outcome: ICU LoS. Results: Across 30 patients (median LoS 21 days), increased ICU LoS was associated with actual daily energy intake surplus to resting energy expenditure (REE) (R2 0.16; P < 0.005). Median REE was less than predicted energy requirements: 24 kcal per day per kilogram of ideal body weight (IBW) (interquartile range [IQR], 20–28) vs 28 kcal/day/kg IBW (IQR, 26–29) (P < 0.001). Patients with COVID‐19 had a median energy surplus (actual intake‐ REE) + 344 kcal/day (IQR 35–517) vs −57 kcal/day (IQR −324 to 211) in other patients (P = 0.011); however, they had a median LoS of 44 days (IQR 26–58) vs 10 days (IQR 7–24), respectively (P < 0.001). Patients with obesity had a median energy deficit of −32 kcal/day (IQR −384 to 335) vs +234 kcal/day (IQR −79 to 499) for nonobese patients (P = 0.021). Conclusion: Overfeeding represents an easily modifiable factor to improve outcomes in patients experiencing persistent critical illness, for which IC may be useful. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Characteristics and Outcomes of Frail Patients with COVID-19 Admitted to ICU: An Individual Patient Data Meta-Analysis

Author

Subramaniam, Ashwin, primary, Anstey, Christopher, additional, Curtis, J Randall, additional, Ashwin, Sushma, additional, REDDY, Mallikarjuna PONNAPA, additional, ALIBERTI, Márlon Juliano Romero, additional, AVELINO-SILVA, Thiago Junqueira, additional, Welch, Carly, additional, Koduri, Gouri, additional, Prowle, John R, additional, Wan, Yize I, additional, LAURENT, Michaël R, additional, Marengoni, Alessandra, additional, Lim, Jun Pei, additional, Pilcher, David, additional, and Shekar, Kiran, additional

Published
2021
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39. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

Odor, P.M., primary, Bampoe, S., additional, Lucas, D.N., additional, Moonesinghe, S.R., additional, Andrade, J., additional, Pandit, J.J., additional, A'Court, Alicja, additional, Abdel-Gadir, Dina, additional, Abdu, Ayman, additional, Abisogun, Caroline, additional, Aboud, Zainab, additional, Abrams, Judith, additional, Ackerman, Andrea, additional, Adamso, Christine, additional, Addison, Rachel, additional, Adeyeye, Adedayo, additional, Adler, Rachel, additional, Aduse-Poku, Maame, additional, Adyanthaya, Siddharth, additional, Ahmad, Najmiah, additional, Ahmed, Dabeeruddeen, additional, Ahmed, Atif, additional, Akindele, Bucky, additional, Akindele, Olubukola, additional, Akrimi, Sonia, additional, Al-Rawi, Samar, additional, Ali, Yousif, additional, Allam, Jo, additional, Allana, Alisha, additional, Allen, Kellie, additional, Allen, Orlanda, additional, Amaradasa, Natasha, additional, Amarasekara, Lareina, additional, Amoakwa-adu, Freda, additional, Anandageetha, Padmanabhan, additional, Anandakrishnan, Suresh, additional, Anandanadesan, Rathai, additional, Anderson, Michelle, additional, Apps, Simon, additional, Aquilina, Audrey, additional, Arbane, Gill, additional, Arch, Alice, additional, Armstrong, Sarah, additional, Arya, Rita, additional, Ashiru, Gloria, additional, Ashpole, Keri, additional, Atkinson, Claire, additional, Atkinson, Francesca, additional, Auer, Elizabeth, additional, Avery, Ben, additional, Babio-Galan, Maite, additional, Bader, Hareth, additional, Badham, George, additional, Bagchi, Subha, additional, Bailey, Sarah, additional, Baird, Yolanda, additional, Balaka, Cristina, additional, Baldwin, Melissa, additional, Balfour, Paul, additional, Bali, Shreya, additional, Banks, Samantha, additional, Barclay, Philip, additional, Barnes, Lucy, additional, Barnes, Thomas, additional, Barot, Niraj, additional, Barrett, Stephen, additional, Barrett, Venetia, additional, Barrett, Kate, additional, Bates, Louise, additional, Batte, Katherine, additional, Baytug, Beki, additional, Behravesh, Mona, additional, Bell, Suzanne, additional, Benloch, Raul, additional, Bentley, Richard, additional, Berg, Jennifer, additional, Berwick, Charlotte, additional, Berwick, Richard, additional, Bhadange, Rashmi, additional, Bhattacharyya, Sanjoy, additional, Bielskute, Egidija, additional, Birch, Sian, additional, Bird, Scott, additional, Bird, Ruth, additional, Birts, William, additional, Black, Becky, additional, Blagova, Tatyana, additional, Blake, Holly, additional, Blightman, Oliver, additional, Blunden, Susara, additional, Bolton, Richard, additional, Borkett-Jones, Caroline, additional, Boselli, John, additional, Bowen, Manuella, additional, Bowen, Ruth, additional, Bowye, James, additional, Boyle, Henry, additional, Brar, Zameen, additional, Bray, Jo, additional, Brayshaw, Samantha, additional, Bressington, Catherine, additional, Brewer, Alison, additional, Brice, Naomi, additional, Bridge, Laura, additional, Briscoe, James, additional, Brocklesby, Sonia, additional, Brown, Harry, additional, Brown, Sarah, additional, Brunnen, Derek, additional, Burijintichenna, Keshavareddy, additional, Burnard, Sara, additional, Burtt, Agnieszka, additional, Buswell, Victoria, additional, Bykar, Hannah, additional, Cairney, Matthew, additional, Calvert, Clare, additional, Camarasa, Laura, additional, Campbell, Natasha, additional, Campbell-Jones, Frederick, additional, Cantliffe, Jane, additional, Carrol, William, additional, Carvalho, Joanna, additional, Cashell, Catherine, additional, Cassie, Sarah, additional, Cassim, Kadu, additional, Chandler, Marika, additional, Chapman, Rachel, additional, Charles, Robert, additional, Chen, Ping, additional, Cheyne, Deanne, additional, Chima, Kiran, additional, Chin, Floju, additional, Chirvasuta, Radu, additional, Shao Chong, Martin, additional, Choudhury, Sadia, additional, Chowdhury, Priyakam, additional, Christmas, Tracey, additional, Chughwani, Shilpa, additional, Ciechanowicz, Sarah, additional, Clarey, Emma, additional, Coe, Rob, additional, Cohen, Jolyon, additional, Coker, Nicholas, additional, Collins, Karen, additional, Collis, Lauren, additional, Comar, Jasna, additional, Conroy, Marianne, additional, Constantin, Kathy, additional, Corfe, Jeremy, additional, Coulborn, Elaine, additional, Cowie, Vanessa, additional, Crone, Rachel, additional, Cronin, James, additional, Crooks, Jennifer, additional, Crowther, Nicola, additional, Crowther, Elizabeth, additional, Cruz, Carina, additional, Curtis, Alexa, additional, Curtis, Sarah, additional, Curtis, Sam, additional, Dabrowicz, Adrian, additional, Daines, Nick, additional, Dalal, Viral, additional, Dannatt, Peter, additional, Das, Dinesh, additional, Dash, Jennifer, additional, Davidson, Katherine, additional, Davies, Sarah, additional, Davis, Yvette, additional, Dawson, James, additional, Dean, Jonathan, additional, Dean, Caroline, additional, Denman, Jane, additional, Desai, Neel, additional, Dewan, Preeti, additional, Dimont, Sarah, additional, Donovan, Clare, additional, Doraiswami, Mano, additional, Doughty, Kate, additional, Douglass, Jamie, additional, Dower, Michelle, additional, Downing, Samantha, additional, Duberry, Wendy, additional, Duckham, Emily, additional, Dudgeon, Lucy, additional, Dukes, Stephanie, additional, Dunn, Leigh, additional, Duraiswamy, Venkat, additional, O' Dwyer, Anthony, additional, Dyer, Kristyn, additional, Eapen, Suresh, additional, Earl, Mark, additional, Eason, Sally, additional, Edwards, Kylie-Ellen, additional, Edwards, Zara, additional, Egole, Osinachi, additional, Ekpa, John, additional, El-Amin, Olivia, additional, El-Boghdadly, Kariem, additional, Elbasir, Okba, additional, Eldridge, James, additional, Elgie, Laura, additional, Ellington, Matt, additional, Elliott, Katharine, additional, Elliott, Justine, additional, Elmi, Mohamed, additional, Elnoumeir, Ramy, additional, Emeakaraoha, Eunice, additional, Evans, Matt, additional, Everett, Mary, additional, Fabb, Philippa, additional, Farooq, Hadia, additional, Farrimond, Rohan, additional, Faulds, Fiona, additional, Fawcett, Erik, additional, Feneley, Andrew, additional, Fernando, Dinushi, additional, Ferns, Janis, additional, Finlay, Claire, additional, Fitzgerald, Simon, additional, O'Flaherty, Doireann, additional, Fleet, Mark, additional, Fletcher, Lydia, additional, Fludder, Vanessa, additional, Follet, Terri, additional, Forbes, Jane, additional, Forth, Mark, additional, Foster, Greg, additional, Francis, John, additional, Fraser, Kate, additional, Friedman, Lauren, additional, Fruggeri, Luca, additional, Fulton, Laura, additional, Funnell, Sam, additional, Gadre, Amit, additional, Gandhi, Ajay, additional, Gardiner, Harriet, additional, Garner, Zoe, additional, Garvey, Gráinne, additional, Gately, Tom, additional, George, Richard, additional, Gillespie, Siobhan, additional, Glover, Stephanie, additional, Goddard, Jennifer, additional, Goodman, Ben, additional, Gopal, Tarikere, additional, Graham, George, additional, Green, David, additional, Griffin, Denise, additional, Griffith, Jessica, additional, Grigsby, Stephanie, additional, Grindey, Julie, additional, Griffiths, Huw, additional, Groome, Jonathan, additional, Grother, Christine, additional, Grounds, Gabrielle, additional, Groves, Alice, additional, Guha, Abhik, additional, Gunawardhana, Amila, additional, Gupta, Aman, additional, Gupta, Rekha, additional, Gutsell, James, additional, Haddon, Richard, additional, Hadi, Dina, additional, Hadjipavlou, Nicola, additional, Hammerbeck, Henry, additional, Hammon, Laura, additional, Hammond, Sarah, additional, Hampanna, Hampesh, additional, Hancock, Holly, additional, Handapangoda, Hemantha, additional, Haroon-Mowahed, Yumna, additional, Harpham, Dawn, additional, Harris, Grant, additional, Harrison, Abigail, additional, Harshan, Divya, additional, Hartopp, Andrew, additional, Harty, Eoin, additional, Haslam, Nick, additional, Hawkins, Gemma, additional, Hawkins, Edith, additional, Hawksey, Sarah, additional, Hays, Carole, additional, Hazelton, Tracy, additional, Heavyside, Andrew, additional, Hemeson, Chibuzo, additional, Henderson, Katrina, additional, Henry, Oliver, additional, Herbert, Lara, additional, Higgins, Nikki, additional, Hilton, James, additional, Hindmoor, Claire, additional, Hitchcock, Rachael, additional, Hobbs, Laura, additional, Homsy, Michele, additional, Honeywell, Cassandra, additional, Hoque, Nazima, additional, House, Kirsty, additional, Howle, Ryan, additional, Tiller, Amanda, additional, Huniak, Matthew, additional, Hunte, Jeremy, additional, Husain, Tauqeer, additional, Huson, Coralie, additional, Hussain, Catriona, additional, Hussain, Tawhida, additional, Hussein, Zainab, additional, Hyams, Jeremy, additional, Hyde, Eleanor, additional, Iaverdino, Marina, additional, Ignacka, Alex, additional, Innes, Erin, additional, Ioannidis, Stefanos, additional, Iqbal, Rehana, additional, Ismail, Fahja, additional, Jackson, Jenny, additional, Jackson, Michael, additional, Jackson, Guy, additional, Jacobs, Robyn, additional, Jadhav, Poonam, additional, Jalaly, Aisha, additional, James, Lorraine, additional, James, Monica, additional, Jani, Surekha, additional, Jeganathan, Chandran, additional, Joannides, Claire, additional, Johnson, Robert, additional, Johnson, Thosa, additional, Johnston, Carolyn, additional, Jones, Reeanne, additional, Jones, Tom, additional, Kadr, Miran, additional, Kainth, Rasmeet, additional, Kane, Jenna, additional, Kanji, Rafiq, additional, Kannanparambil, Sunil, additional, Kar, Girish, additional, Kasianandan, Theanalli, additional, Kaskos, Husam, additional, Kavanagh, Lisa, additional, Kaye, Richard, additional, Kelliher, Leith, additional, Kelliot, Serena, additional, Kelly, Jemma, additional, Kelly, Jenna, additional, Kenyon, Carol, additional, Kessack, Laura, additional, Kestner, Samuel, additional, Khaku, Mohammed, additional, Khaleeq, Sophia, additional, Khan, Pervaz, additional, Khan, Sabeen, additional, Kidwai, Usamah, additional, King, Christopher, additional, King, Helen, additional, Kingston, Elizabeth, additional, Kok, Waisun, additional, Konig, Rebekka, additional, Konstantinova, Zheyna, additional, Krishnan, Priya, additional, Kua, Justin, additional, Kuntumalla, Kavitha, additional, Kursumovic, Emira, additional, Kurzatkowski, Krzysztof, additional, Kuttambakam, Hariprasad, additional, Lane, Katherine, additional, Lane, Sophie, additional, Langton, Andrew, additional, Latif, Hamad, additional, Lau, Norlan, additional, Laxman, Shyam, additional, Laycock, Helen, additional, Lee, Rachel, additional, Leonardi, Silvia, additional, Light, Karen, additional, Lightfoot, Heidi, additional, Liu, Shuang, additional, Liyanage, Sanduni, additional, Lowe, Jessica, additional, Lucas, Nuala, additional, Lungu, Miyoba, additional, Lunn, Marianne, additional, Lynes, Heather, additional, Machavarapu, Kishore, additional, Mackenzie, Matthew, additional, Major, Jonathan, additional, Male, Victoria, additional, Malik, Zain, additional, Manso, Katarina, additional, Maquinana, Myrna, additional, Marciniak, Katarzyna, additional, Maronge, Lizzie, additional, Marsh, Chris, additional, Martella, Carmela, additional, Martin, Nicki, additional, Martins, Nicole, additional, Marway, Jaspreet, additional, Mason, Louisa, additional, Mason, Lucy, additional, Masood, Nadia, additional, Masters, James, additional, Maton-Howarth, Matthew, additional, Mazzola, Francesca, additional, McAllister, Tamsin, additional, McCarthy, Rachel, additional, McCormick, Claire, additional, McCready, Sharon, additional, McDougall, Steffan, additional, Mcewan, Lorna, additional, McGarry, Jon, additional, McKevitt, Helen, additional, Mckinley, Stephanie, additional, Mckskeane, Anna, additional, McMaster, Eloise, additional, McMonagle, Martina, additional, McNamara, Helen, additional, McPhee, Hannah, additional, McRae, Laura, additional, Mead, Dee, additional, Meadows, Emma, additional, Mehta, Madhur, additional, Meikle, Joanne, additional, Metodiev, Yavor, additional, Michael, Chloe, additional, Millar, Victoria, additional, Miller, Sarah, additional, Miller, Gregg, additional, Milne, Sezanne, additional, Miltsios, Kostas, additional, Misquita, Lucia, additional, Misquita, Simone, additional, Mittal, Manasi, additional, Mohamed, Mohamed, additional, Powell Monaghan, Katherine, additional, Monk, Joanna, additional, Monkhouse, Alexandra, additional, Monks, David, additional, Montague, Laura, additional, Moon, Angela, additional, Moran, Jennifer, additional, Moreton, Annette, additional, Morgan, Endaf, additional, Morgan, Oliver, additional, Morland, Danny, additional, Morosan, Monica, additional, Morris, Kimberley, additional, Morris, Andrea, additional, Moser, Clare, additional, Mount, Manulella, additional, Muir, Carol, additional, Mupudzi, McDonald, additional, Murali, Mayur, additional, Murdoch, Iona, additional, Murray, Heather, additional, Murray, Theresa, additional, Murrell, Karen, additional, Narasimha Murthy, Girish, additional, Neeley, Diana, additional, Nei, Hannah, additional, Neil, Kerry, additional, Nejim, Tara, additional, Nel, Mark, additional, Nicholson, Anne, additional, Nicklin, Angela, additional, Nolan, Catherine, additional, Nolan, Tracey, additional, Nurmi, Eveliina, additional, O'Neill, Bridie, additional, Oakes, Christie, additional, Oakes, Neil, additional, Ochoa-Ferraro, Maria, additional, Odeleye, Nike, additional, Oliver, Katy, additional, Oliver, Mark, additional, Onslow, Julie, additional, Onwochei, Desire, additional, Oommen, Thomas, additional, Orr, Tim, additional, Osagie, Osato, additional, Osborn, Hannah, additional, Overend, Jennie, additional, Owston, Hazel, additional, Pack, Emma, additional, Padhi, Pulak, additional, Palani, Prabvathy, additional, Pandey, Rajesh, additional, Pandya, Dhruti, additional, Panesar, Navjot, additional, Papageorgiou, Con, additional, Papanastasiou, Georgios, additional, Papoutsos, Costas, additional, Pararajasingham, Suji, additional, Parry, James, additional, Patel, Hasita, additional, Patel, Jaishel, additional, Patel, Jiten, additional, Patel, Kaumudi, additional, Patel, Kiran, additional, Patel, Mitul, additional, Patel, Reshma, additional, Patel, Ruchira, additional, Patel, Nimisha, additional, Pathak, Sangeeta, additional, Pearson, Fiona, additional, Peciulene, Viktorija, additional, Peers, Beth, additional, Peirce, Benjamin, additional, Pepper, Stacey, additional, Perinpanayagam, Jasmina, additional, Perry, Hollie, additional, Petrova, Nadya, additional, Phillips, Trudie, additional, Phillips, Sioned, additional, Phylactides, Leonidas, additional, Pilkington, Felicity, additional, Plumb, James, additional, Poimenidi, Evangelia, additional, Sau Kuk Poon, Anna, additional, Potter, Thomas, additional, Poultney, Una, additional, Powell, Lucy, additional, Prenter, Andrew, additional, Preston, Katie, additional, Price, Anna, additional, Pritchard, Naomi, additional, Pullen, Jenny, additional, Purohit, Manishi, additional, Quamina, Charlotte, additional, Qureshi, Jibran, additional, Rajput, Zahra, additional, Ramage, Stephen, additional, Ramanathan, Tamilselvi, additional, Ranasinghe, Upeka, additional, Ranatunga, Kalum, additional, Rand, Abby, additional, Randive, Seema, additional, Rangarajan, Desikan, additional, Rao, Chandana, additional, Rao Pelluri, Sambasiva, additional, Ratnasingham, Antony, additional, Razzaque, Jamil, additional, Reddy, Anuvidya, additional, Redington, Katie, additional, Reel, Emma, additional, Remeta, Peter, additional, Ricco, Francesca, additional, Riccoboni, Anna, additional, Rice, Polly, additional, Rich, Mel, additional, Richards, Nicole, additional, Riches, Joanne, additional, Ripoll, Simon, additional, Roberts, Fleur, additional, Roberts, Kitty, additional, Robins, Kay, additional, Robinson, Susie, additional, Roche, Samantha, additional, Rojo, Maria, additional, Carmela Romano, Milena, additional, Rosser, Hilary, additional, Roughley, Lindsay, additional, Routley, Catriona, additional, Rowley, Christine, additional, Rudra, Pallab, additional, Russell, Robin, additional, Ryan, Christine, additional, Saad, Chloe, additional, Sadeghi, Abtin, additional, Salberg, Armorel, additional, Samuel, Matt, additional, Samuels, Rebecca, additional, Sanapala, Suresh, additional, Sanusi, Seliat, additional, Sarao, Sarbpreet, additional, Sathyabhama, Sathyabhama, additional, Saunders, Zoe, additional, Sawarzynska-ryszka, Bernadetta, additional, Sceales, Panagiota, additional, Sceales, Penny, additional, Schumacher, Natasha, additional, Schwartz, Nuala, additional, Sellers, Claudia, additional, Sellers, Heather, additional, Sellick, Jessica, additional, Sen, Soumen, additional, Senaratne, Dhaneesha, additional, Senbeto, Sarah, additional, Seneviratna, Dineth, additional, Setty, Thunga, additional, Shah, Raj, additional, Shah, Sonia, additional, Shambly, James, additional, Sharafudeen. Imran Sharieff, Saju, additional, Sharifi, Laurence, additional, Sharpe, Lisa, additional, Shaw, Michael, additional, Sheldrake, Ian, additional, Shinde, Priya, additional, Shonfeld. Jonathon Short, Adam, additional, Siah, Julian, additional, Sibug. Omar Siddique, Sheena, additional, Siew, Sara, additional, Simpson, Matthew, additional, Singleton, Georgina, additional, Sinha, Kathryn, additional, Sinha, Aneeta, additional, Sinnott, Matthew, additional, Sivadhas, Harry, additional, Sivakumar, Sivanth, additional, Sivarajan, Boopathi, additional, Sivarajan, Sinduja, additional, Skeoch, Chris, additional, Slade, Samuel, additional, Slater, Paul, additional, Smith, Camilla, additional, Smith, Carys, additional, Smith, Christopher, additional, Smith, James, additional, Smith, Lorraine, additional, Smith, Annika, additional, Smith, Edward, additional, Smith, Ruth, additional, Smith, Sue, additional, Smith, Tim, additional, Smithers, Helen, additional, Smolen, Sue, additional, Smyth, Claire, additional, Snel, Toni, additional, Snipe, Carol, additional, Soltanifar, Sam, additional, Sonawane, Nilesh, additional, Soundararaja, Andal, additional, Spence, Emily, additional, Spiliopoulos, Mark, additional, Srivastava, Chhavi, additional, Stacey, Karen, additional, Stafford, Helena, additional, Staines, Nikki, additional, Stead, Richard, additional, Stevens, Emma, additional, Stilwell, Alex, additional, Stocks, Gary, additional, Stokes, Aaron, additional, Stone, Christopher, additional, Straughan, Ben, additional, Subbarathnam, Vanitha, additional, Sudunagunta, Srinath, additional, Sultan, Pervez, additional, Suppiah, Puvan, additional, Surve, Priyanka, additional, Sutherland, Angus, additional, Swanton, Rob, additional, Swarbrick, Claire, additional, Swinson, Amy, additional, Syrrakou, Eleni, additional, Tadbiri, Shahrzad, additional, Tamhane, Preetam, additional, Tamilselvan, Perumal, additional, Tan, Andrew, additional, Tanna, Shamil, additional, Tarft, Hayley, additional, Tarry, Laura, additional, Taylor, Ian, additional, Taylor, Suzanne, additional, Tebbot, Julie, additional, Theron, Svetlana, additional, Thomas, Megan, additional, Todd, Sarah, additional, Tolliday, Hermione, additional, Topham, Charlotte, additional, Tovell, Nicholas, additional, Traves, Martyn, additional, Trodd, Dawn, additional, Tufchi, Aseem, additional, Turley, Katie, additional, Turnbull, Marc, additional, Turnbull, Chris, additional, Turner, Oliver, additional, Turner, William, additional, Turney, Sharon, additional, Tyagi, Eleanor, additional, Uncles, David, additional, Unsworth, Vanessa, additional, Vadnere, Pradnya, additional, Varadan, Rama, additional, Vasishta, Vik, additional, Veal, Andrew, additional, Vedham, Lalitha, additional, Venkaya, Jessica, additional, Verghese, Miriam, additional, Veronica, Icel, additional, Vidanagamage, Dinesh, additional, Vincent, Rachel, additional, Vyapury, Vinodhan, additional, Wain, Harris, additional, Walbridge, Fiona, additional, Walker, Elaine, additional, Walsh, Pete, additional, Walshe, Eleanor, additional, Walters, Michelle, additional, Wan, Yize, additional, Wang, Cherry, additional, Wankhade, Kavita, additional, Waters, Gareth, additional, Watts, Christopher, additional, Webber, Alex, additional, Wedgwood, Tom, additional, Wee, Michael, additional, Wellstead, Susan, additional, White, Alison, additional, Whitear, Michael, additional, Whitefield, Lucy, additional, Wilkinson, Sarah, additional, Williams, Lauren, additional, Williams, Rhys, additional, Wilson, Dawn, additional, Wilson, Samantha, additional, Wimble, Katie, additional, Winkley, Elaine, additional, Winslow, Luke, additional, Winwright, Paul, additional, Wloch, Karolina, additional, Wong, Gideon, additional, Wong, Hannah, additional, Man Wong, Jan, additional, Wood, Tim, additional, Wray, Sarah, additional, Wrench, Ian, additional, Wu, James, additional, Wynn, Kynn, additional, Yap, Yeng, additional, Kuan Yeow, Chia, additional, Young, Emily, additional, Yusaf, Alex, additional, Uz Zafar, Saeed, additional, Zeinali, Darius, additional, Zhang, Sheldon, additional, Zope, Sarvesh, additional, Zucco, Liana, additional, Anwar, Sibtain, additional, Blunt, Nadia, additional, Cronin, John, additional, Grover, Vimal, additional, Grailey, Kate, additional, Grey, Martin, additional, Highton, David, additional, Hopkins, Phil, additional, Kemp, Harriet, additional, Lo, Queenie, additional, Martin, Daniel, additional, Morkane, Clare, additional, O'Carroll, James, additional, Oliver, Charles, additional, Post, Benjamin, additional, Visram, Anil, additional, and Wickham, Alex, additional

Published
2020
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46. Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review.

Author

Wan, Yize I., Brayne, Adam B., Haines, Ryan W., Puthucheary, Zudin A., and Prowle, John R.

Subjects
*CRITICAL care medicine, *PLATELET count, *INTENSIVE care units, *NEUTROPHILS, *ERYTHROCYTES, *C-reactive protein
Abstract

To examine reported prognostic associations of routine blood measurements in the intensive care unit. We searched PubMed, EMBASE through 28th May 2020 to identify all studies in adult critical care investigating associations between parameters measured routinely in whole blood, plasma or serum, and length of stay or mortality. Registration: PROSPERO; CRD42019122058. A total of 128 studies, reporting 28 different putative prognostic biomarkers, met eligibility criteria. Those most frequently examined were red cell distribution width, neutrophil-to-lymphocyte ratio, C-reactive protein, and platelet count. A higher red cell distribution width, a lower platelet count, and a higher neutrophil-to-lymphocyte ratio were consistently associated with both increased mortality and length of stay. A lower level of albumin was consistently associated with greater mortality. C-reactive protein was inconsistent. Most studies (n = 110) used regression modelling with wide variation in variable selection and covariate-adjustment; none externally validated the proposed predictive models. Simple regression models have so far proved inadequate for the complexity of data available from routine blood sampling in critical care. Adoption of a direct causal framework may help better assess mechanistic processes, aid design of future studies, and guide clinical decision making using routine data. [ABSTRACT FROM AUTHOR]

Published
2021
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47. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Author

Moffatt, Miriam F. Gut, Ivo G. Demenais, Florence Strachan, David P. Bouzigon, Emmanuelle Heath, Simon von Mutius, Erika and Farrall, Martin Lathrop, Mark Cookson, William O. C. M. and Kumar, Ashish Burney, Peter Jarvis, Debbie Wjst, Matthias and Kogevinas, Manolis Jogi, Rain Janson, Christer Franklin, Karl A. Omenaas, Ernst Leynaert, Benedicte Pin, Isabelle and Heinrich, Joachim Probst-Hensch, Nicole M. Anto, Josep M. and Sunyer, Jordi Maldonado, Jose-Antonio Martinez-Moratalla, Jesus and Urrutia, Isabel Payo, Felix Kauffmann, Francine Dizier, Marie-Helene Siroux, Valerie Boznanski, Andrzej and Braun-Fahrlaender, Charlotte Genuneit, Jon Glas, Juergen and Horak, Elisabeth Kabesch, Michael Pillai, Sreekumar G. and Helms, Peter J. Carlsen, Karin Carlsen, Kai-Hakon Gerritsen, Jorrit Silverman, Michael Sly, Peter Tsanakas, John Von Berg, Andrea Whyte, Moira Blumenthal, Malcolm Imboden, Medea and Rochat, Thierry Thun, Gian Andri Gerbase, Margaret W. and Curjuric, Ivan Gaspoz, Jean-Michel Liu, Lee-Jane S. Wouters, Inge M. Sigsgaard, Torben Heederik, Dick Basinas, Ioannis and Schlunssen, Vivi Omland, Oyvind Cullinan, Paul and Vermeulen, Roel Henderson, John Granell, Raquel McArdle, Wendy L. Smith, George Davey James, Alan L. Hui, Jennie and Palmer, Lyle J. Beilby, John Musk, A. William Laprise, Catherine Hudson, Thomas J. Lemire, Mathieu Daley, Denise and Becker, Allan Chan-Yeung, Moira Sandford, Andrew and Kozyrskyj, Anita L. Pare, Peter Ferguson, Alexander and Dimich-Ward, Helen Watson, Wade T. Freidin, Maxim B. and Bragina, Elena Iu. Deev, Ivan A. Deeva, Eugenia V. and Kobyakova, Olga S. Puzyrev, Valery P. Ogorodova, Ludmila M. and Khusnutdinova, Elza K. Karunas, Alexandra S. Fedorova, Yuliya Y. and Hall, Ian P. Sayers, Ian Tobin, Martin D. Wan, Yize I. and Heaney, Liam G. Al-Momani, Basima A. H. Mansur, Adel H. and Manney, Sarah Thomson, Neil C. Chaudhuri, Rekha Brightling, Christopher E. Bafadhel, Mona Singapuri, Amisha Niven, Robert Simpson, Angela Holloway, John W. Howarth, Peter H. and Polonikov, Alexey V. Ivanov, Vladimir P. Solodilova, Maria A. Melen, Erik Pershagen, Goeran Bergstroem, Anna Kull, Inger Nyberg, Fredrik Wickman, Magnus Soderhall, Cilla and Kere, Juha Postma, Dirkje S. Kerkhof, Marjan Brunekreef, Bert Smit, Henriette A. de Jongste, Johan C. Wijga, Alet and Aalberse, R. C. Hoekstra, Maarten O. Koppelman, Gerard H. and Binia, Aristea Chung, Kian Fan Bhavsar, Pankaj Chow, Florence Macedo, Patricia Menzies-Gow, Andrew van Stiphout, Nicole Bush, Andrew Lee, Young-Ae Esparza-Gordillo, Jorge and Nickel, Renate Wahn, Ulrich Lau, Susanne Marenholz, Ingo and Haahtela, Tari von Hertzen, Leena Jousilahti, Pekka and Laatikainen, Tiina Makela, Mika J. Vartiainen, Erkki and Laitinen, Tarja Balding, David J. Peden, John F. Corda, Eve and Lechner, Doris Besse, Celine Zelenika, Diana Boland, Anne Bacq, Delphine Demonchy, Stephanie Blanche, Helene and Kamatani, Yoichiro von Mutius, Erika Farrall, Martin and Lathrop, Mark Cookson, William O. C. M. GABRIEL Consortium

Abstract

BACKGROUND Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease. METHODS We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of whom were matched for ancestry. We used random-effects pooled analysis to test for association in the overall study population and in subgroups of subjects with childhood-onset asthma (defined as asthma developing before 16 years of age), later-onset asthma, severe asthma, and occupational asthma. RESULTS We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P = 3x10(-9)); rs9273349 on chromosome 6, implicating HLA-DQ (P = 7x10(-14)); rs1342326 on chromosome 9, flanking IL33 (P = 9x10(-10)); rs744910 on chromosome 15 in SMAD3 (P = 4x10(-9)); and rs2284033 on chromosome 22 in IL2RB (P = 1.1x10(-8)). Association with the ORMDL3/GSDMB locus on chromosome 17q21 was specific to childhood-onset disease (rs2305480, P = 6x10(-23)). Only HLA-DR showed a significant genomewide association with the total serum IgE concentration, and loci strongly associated with IgE levels were not associated with asthma. CONCLUSIONS Asthma is genetically heterogeneous. A few common alleles are associated with disease risk at all ages. Implicated genes suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation. Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma.

Published
2010

48. Genome-wide association study to identify genetic determinants of severe asthma

Author

Wan, Yize, Shrine, Nick, Soler Artigas, Maria, Wain, Louise, Blakey, John, Moffatt, Miriam, Bush, A., Chung, Kian Fan, Cookson, William, Brown, Matthew, other, and, Wan, Yize, Shrine, Nick, Soler Artigas, Maria, Wain, Louise, Blakey, John, Moffatt, Miriam, Bush, A., Chung, Kian Fan, Cookson, William, Brown, Matthew, and other, and

Abstract

Background The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear. Objective To identify common genetic variants affecting susceptibility to severe asthma. Methods A genome-wide association study was undertaken in 933 European ancestry individuals with severe asthma based on Global Initiative for Asthma (GINA) criteria 3 or above and 3346 clean controls. After standard quality control measures, the association of 480 889 genotyped single nucleotide polymorphisms (SNPs) was tested. To improve the resolution of the association signals identified, non-genotyped SNPs were imputed in these regions using a dense reference panel of SNP genotypes from the 1000 Genomes Project. Then replication of SNPs of interest was undertaken in a further 231 cases and 1345 controls and a meta-analysis was performed to combine the results across studies. Results An association was confirmed in subjects with severe asthma of loci previously identified for association with mild to moderate asthma. The strongest evidence was seen for the ORMDL3/GSDMB locus on chromosome 17q12-21 (rs4794820, p=1.03×10(-8) following meta-analysis) meeting genome-wide significance. Strong evidence was also found for the IL1RL1/IL18R1 locus on 2q12 (rs9807989, p=5.59×10(-8) following meta-analysis) just below this threshold. No novel loci for susceptibility to severe asthma met strict criteria for genome-wide significance. Conclusions The largest genome-wide association study of severe asthma to date was carried out and strong evidence found for the association of two previously identified asthma susceptibility loci in patients with severe disease. A number of novel regions with suggestive evidence were also identified warranting further study.

Published
2012

49. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Author

Moffatt, Miriam F. Gut, Ivo G. Demenais, Florence Strachan, David P. Bouzigon, Emmanuelle Heath, Simon von Mutius, Erika and Farrall, Martin Lathrop, Mark Cookson, William O. C. M. and Kumar, Ashish Burney, Peter Jarvis, Debbie Wjst, Matthias and Kogevinas, Manolis Jogi, Rain Janson, Christer Franklin, Karl A. Omenaas, Ernst Leynaert, Benedicte Pin, Isabelle and Heinrich, Joachim Probst-Hensch, Nicole M. Anto, Josep M. and Sunyer, Jordi Maldonado, Jose-Antonio Martinez-Moratalla, Jesus and Urrutia, Isabel Payo, Felix Kauffmann, Francine Dizier, Marie-Helene Siroux, Valerie Boznanski, Andrzej and Braun-Fahrlaender, Charlotte Genuneit, Jon Glas, Juergen and Horak, Elisabeth Kabesch, Michael Pillai, Sreekumar G. and Helms, Peter J. Carlsen, Karin Carlsen, Kai-Hakon Gerritsen, Jorrit Silverman, Michael Sly, Peter Tsanakas, John Von Berg, Andrea Whyte, Moira Blumenthal, Malcolm Imboden, Medea and Rochat, Thierry Thun, Gian Andri Gerbase, Margaret W. and Curjuric, Ivan Gaspoz, Jean-Michel Liu, Lee-Jane S. Wouters, Inge M. Sigsgaard, Torben Heederik, Dick Basinas, Ioannis and Schlunssen, Vivi Omland, Oyvind Cullinan, Paul and Vermeulen, Roel Henderson, John Granell, Raquel McArdle, Wendy L. Smith, George Davey James, Alan L. Hui, Jennie and Palmer, Lyle J. Beilby, John Musk, A. William Laprise, Catherine Hudson, Thomas J. Lemire, Mathieu Daley, Denise and Becker, Allan Chan-Yeung, Moira Sandford, Andrew and Kozyrskyj, Anita L. Pare, Peter Ferguson, Alexander and Dimich-Ward, Helen Watson, Wade T. Freidin, Maxim B. and Bragina, Elena Iu. Deev, Ivan A. Deeva, Eugenia V. and Kobyakova, Olga S. Puzyrev, Valery P. Ogorodova, Ludmila M. and Khusnutdinova, Elza K. Karunas, Alexandra S. Fedorova, Yuliya Y. and Hall, Ian P. Sayers, Ian Tobin, Martin D. Wan, Yize I. and Heaney, Liam G. Al-Momani, Basima A. H. Mansur, Adel H. and Manney, Sarah Thomson, Neil C. Chaudhuri, Rekha Brightling, Christopher E. Bafadhel, Mona Singapuri, Amisha Niven, Robert Simpson, Angela Holloway, John W. and Moffatt, Miriam F. Gut, Ivo G. Demenais, Florence Strachan, David P. Bouzigon, Emmanuelle Heath, Simon von Mutius, Erika and Farrall, Martin Lathrop, Mark Cookson, William O. C. M. and Kumar, Ashish Burney, Peter Jarvis, Debbie Wjst, Matthias and Kogevinas, Manolis Jogi, Rain Janson, Christer Franklin, Karl A. Omenaas, Ernst Leynaert, Benedicte Pin, Isabelle and Heinrich, Joachim Probst-Hensch, Nicole M. Anto, Josep M. and Sunyer, Jordi Maldonado, Jose-Antonio Martinez-Moratalla, Jesus and Urrutia, Isabel Payo, Felix Kauffmann, Francine Dizier, Marie-Helene Siroux, Valerie Boznanski, Andrzej and Braun-Fahrlaender, Charlotte Genuneit, Jon Glas, Juergen and Horak, Elisabeth Kabesch, Michael Pillai, Sreekumar G. and Helms, Peter J. Carlsen, Karin Carlsen, Kai-Hakon Gerritsen, Jorrit Silverman, Michael Sly, Peter Tsanakas, John Von Berg, Andrea Whyte, Moira Blumenthal, Malcolm Imboden, Medea and Rochat, Thierry Thun, Gian Andri Gerbase, Margaret W. and Curjuric, Ivan Gaspoz, Jean-Michel Liu, Lee-Jane S. Wouters, Inge M. Sigsgaard, Torben Heederik, Dick Basinas, Ioannis and Schlunssen, Vivi Omland, Oyvind Cullinan, Paul and Vermeulen, Roel Henderson, John Granell, Raquel McArdle, Wendy L. Smith, George Davey James, Alan L. Hui, Jennie and Palmer, Lyle J. Beilby, John Musk, A. William Laprise, Catherine Hudson, Thomas J. Lemire, Mathieu Daley, Denise and Becker, Allan Chan-Yeung, Moira Sandford, Andrew and Kozyrskyj, Anita L. Pare, Peter Ferguson, Alexander and Dimich-Ward, Helen Watson, Wade T. Freidin, Maxim B. and Bragina, Elena Iu. Deev, Ivan A. Deeva, Eugenia V. and Kobyakova, Olga S. Puzyrev, Valery P. Ogorodova, Ludmila M. and Khusnutdinova, Elza K. Karunas, Alexandra S. Fedorova, Yuliya Y. and Hall, Ian P. Sayers, Ian Tobin, Martin D. Wan, Yize I. and Heaney, Liam G. Al-Momani, Basima A. H. Mansur, Adel H. and Manney, Sarah Thomson, Neil C. Chaudhuri, Rekha Brightling, Christopher E. Bafadhel, Mona Singapuri, Amisha Niven, Robert Simpson, Angela Holloway, John W.

Abstract

BACKGROUND Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease. METHODS We carried out a genomewide association study by genotyping 10,365 persons with physician-diagnosed asthma and 16,110 unaffected persons, all of whom were matched for ancestry. We used random-effects pooled analysis to test for association in the overall study population and in subgroups of subjects with childhood-onset asthma (defined as asthma developing before 16 years of age), later-onset asthma, severe asthma, and occupational asthma. RESULTS We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P = 3x10(-9)); rs9273349 on chromosome 6, implicating HLA-DQ (P = 7x10(-14)); rs1342326 on chromosome 9, flanking IL33 (P = 9x10(-10)); rs744910 on chromosome 15 in SMAD3 (P = 4x10(-9)); and rs2284033 on chromosome 22 in IL2RB (P = 1.1x10(-8)). Association with the ORMDL3/GSDMB locus on chromosome 17q21 was specific to childhood-onset disease (rs2305480, P = 6x10(-23)). Only HLA-DR showed a significant genomewide association with the total serum IgE concentration, and loci strongly associated with IgE levels were not associated with asthma. CONCLUSIONS Asthma is genetically heterogeneous. A few common alleles are associated with disease risk at all ages. Implicated genes suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation. Variants at the ORMDL3/GSDMB locus are associated only with childhood-onset disease. Elevation of total serum IgE levels has a minor role in the development of asthma.

Published
2010

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